Anthropoid origins in Asia? New discovery of amphipithecus from the eocene of burma

A new fossil of the primate Amphipithecus mogaungensis Colbert from the late Eocene of Burma shows that this species has a mandibular and molar morphology very similar to Oligocene and post-Oligocene higher primates. It has an exceptionally deep jaw. Its brachybunodont first and second molars have smooth enamel but lack hypoconulids. The shape of its second molar is nearly square-an advanced higher primate feature. Amphipithecus mogaungensis and related taxon Pondaungia cotteri Pilgrim are the earliest known higher primates. They suggest that Southeast Asia was an early theater of higher primate diversification.     

Lemur social behavior and primate intelligence

Our human intellect has resulted from an enormous leap in capacity above the level of monkeys and apes. Earlier, though, Old and New World monkeys' intelligence outdistanced that of other mammals, including the prosimian primates. This first great advance in intelligence probably was selected through interspecific competition on the large continents. However, even at this early stage, primate social life provided the evolutionary context of primate intelligence. Two arguments support this conclusion. One is ontogenetic: modern monkeys learn so much of their social behavior, and learn their behavior toward food and toward other species through social example. The second is phylogenetic: some prosimians, the social lemurs, have evolved the usual primate type of society and social learning without the capacity to manipulate objects as monkeys do. It thus seems likely that the rudiments of primate society preceded the growth of primate intelligence, made it possible, and determined its nature.     

Purgatorius, an early paromomyid primate (Mammalia)

Fragmentary mandibles of Purgatorius unio Van Valen and Sloan from the Puercan (approximately early Paleocene), Garbani Locality, Montana, preserve associated postcanines. Their morphology indicates that this mammal was an early paromomyid primate and suggests that primate ancestry does not include currently known members of the palaeoryctid and leptictid Insectivora or of the Condylarthra.     

非人灵长类肠道寄生虫研究进展

随着经济社会活动正日益增加,几乎没有非人灵长类的栖息环境能逃脱干扰,这不可避免增加了非人灵长类与人类的接触机会,也极大地增加人兽共患寄生虫交叉感染的风险。我国非人灵长类不仅面临着生境减少的威胁,更为严重的是很多保护区或者旅游景区将野生猴科灵长类作为招揽游客的手段,没有任何防护措施的人猴近距离接触更增加了寄生虫传播的危险。总结了国内外非人灵长类肠道寄生虫的相关研究成果,包括肠道寄生虫的种类、传播途径、危害及预防措施,为濒危非人灵长类的综合保护提供科学依据,对其保护方法和方针提供指导,具有一定的借鉴意义。     

Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease

Lentiviral delivery of glial cell line-derived neurotrophic factor (lenti-GDNF) was tested for its trophic effects upon degenerating nigrostriatal neurons in nonhuman primate models of Parkinson's disease (PD). We injected lenti-GDNF into the striatum and substantia nigra of nonlesioned aged rhesus monkeys or young adult rhesus monkeys treated 1 week prior with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Extensive GDNF expression with anterograde and retrograde transport was seen in all animals. In aged monkeys, lenti-GDNF augmented dopaminergic function. In MPTP-treated monkeys, lenti-GDNF reversed functional deficits and completely prevented nigrostriatal degeneration. Additionally, lenti-GDNF injections to intact rhesus monkeys revealed long-term gene expression (8 months). In MPTP-treated monkeys, lenti-GDNF treatment reversed motor deficits in a hand-reach task. These data indicate that GDNF delivery using a lentiviral vector system can prevent nigrostriatal degeneration and induce regeneration in primate models of PD and might be a viable therapeutic strategy for PD patients.     

Aging in the natural world: comparative data reveal similar mortality patterns across primates

Human senescence patterns-late onset of mortality increase, slow mortality acceleration, and exceptional longevity-are often described as unique in the animal world. Using an individual-based data set from longitudinal studies of wild populations of seven primate species, we show that contrary to assumptions of human uniqueness, human senescence falls within the primate continuum of aging; the tendency for males to have shorter life spans and higher age-specific mortality than females throughout much of adulthood is a common feature in many, but not all, primates; and the aging profiles of primate species do not reflect phylogenetic position. These findings suggest that mortality patterns in primates are shaped by local selective forces rather than phylogenetic history.     

Intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of asthma

Airway eosinophilia, epithelial desquamation, and hyperresponsiveness are characteristics of the airway inflammation underlying bronchial asthma. The contribution of intercellular adhesion molecule-1 (ICAM-1) to eosinophil migration and airway responsiveness was studied. ICAM-1 partially mediated eosinophil adhesion to to endothelium in vitro and was upregulated on inflamed bronchial endothelium in vivo. ICAM-1 expression was also upregulated on inflamed airway epithelium in vitro and in vivo. In a primate model of asthma, a monoclonal antibody to ICAM-1 attenuated airway eosinophilia and hyperresponsiveness. Thus, antagonism of ICAM-1 may provide a therapeutic approach to reducing airway inflammation, hyperresponsiveness, and asthma symptoms.     

Birth of two chimeric genes in the Hominidae lineage

How genes with newly characterized functions originate remains a fundamental question. PMCHL1 and PMCHL2, two chimeric genes derived from the melanin-concentrating hormone (MCH) gene, offer an opportunity to examine such an issue in the human lineage. Detailed structural, expression, and phylogenetic analysis showed that the PMCHL1 gene was created near 25 million years ago (Ma) by a complex mechanism of exon shuffling through retrotransposition of an antisense MCH messenger RNA coupled to de novo creation of splice sites. PMCHL2 arose 5 to 10 Ma by an event of duplication involving a large chromosomal region encompassing the PMCHL1 locus. The RNA expression patterns of those chimeric genes suggest that they have been submitted to strong regulatory constraints during primate evolution.     

D1 dopamine receptors in prefrontal cortex: involvement in working memory

The prefrontal cortex is involved in the cognitive process of working memory. Local injections of SCH23390 and SCH39166, selective antagonists of the D1 dopamine receptor, into the prefrontal cortex of rhesus monkeys induced errors and increased latency in performance on an oculomotor task that required memory-guided saccades. The deficit was dose-dependent and sensitive to the duration of the delay period. These D1 antagonists had no effect on performance in a control task requiring visually guided saccades, indicating that sensory and motor functions were unaltered. Thus, D1 dopamine receptors play a selective role in the mnemonic, predictive functions of the primate prefrontal cortex.     

Cranial anatomy of oreopithecus

Reexamination of the 1958 skull of the late Miocene Oreopithecus bambolii revealed a cranial anatomy different from that widely accepted for this taxon. There is a sagittal crest, a high nuchal crest, a large gonial angle, and alpha high, rather vertical, occiput. This catarrhine was not a very large brained primate compared to known advanced hominoids.     

Multivariate analysis of an early hominid metacarpal from swartkrans

Discriminant analysis permits hand bones of living primate genera to be represented as swarms of points in a multidimensional statistical framework within which intergroup relationships, and the affinities of fossil forms, can be examined. The metacarpal of Paranthropus from Swartkrans, South Africa, was so located with respect to groups of monkeys, apes, and modern man. The results suggest that the fossil metacarpal may be functionally similar to that of chimpanzees.     

Discharge of frontal eye field neurons during eye movements in unanesthetized monkeys

Single unit activity was recorded from the frontal eye fields (area 8) in unanesthetized monkeys seated in a primate chair with the head restrained. The frontal eye field units were identified by antidromic response to stimulation of the cerebral peduncle. The findings indicate that most of the neurons discharge only after initiation of eye movements. These cells showed steady discharge when the eyes were immobile and oriented in a specific direction.     

Visual pigment density in single primate foveal cones

The feasibility is demonstrated of microspectrophotometric studies on primate photoreceptors aligned at right angles to the test beam, rather than axially illuminated. Pigment densities, and hence absorption per unit thickness, are approximately equal in primate rods and foveal cones. These pigment densities are similar to those reported for frog rods and fish cones.     

A cellular microRNA mediates antiviral defense in human cells

In eukaryotes, 21- to 24-nucleotide-long RNAs engage in sequence-specific interactions that inhibit gene expression by RNA silencing. This process has regulatory roles involving microRNAs and, in plants and insects, it also forms the basis of a defense mechanism directed by small interfering RNAs that derive from replicative or integrated viral genomes. We show that a cellular microRNA effectively restricts the accumulation of the retrovirus primate foamy virus type 1 (PFV-1) in human cells. PFV-1 also encodes a protein, Tas, that suppresses microRNA-directed functions in mammalian cells and displays cross-kingdom antisilencing activities. Therefore, through fortuitous recognition of foreign nucleic acids, cellular microRNAs have direct antiviral effects in addition to their regulatory functions.     

Discovery of the oldest known anthropoidean skull from the paleogene of Egypt

A group of primate fossils newly discovered in the Fayum badlands of Egypt is probably of Eocene age. The site is much older than the localities of previously known Egyptian early Tertiary primates. These finds include a crushed cranium that is the oldest skull found to date of a higher primate. This skull shows four characteristics of higher primates: a catarrhine dental formula, an ectotympanic at the rim of the auditory bulla, a fused frontal bone, and postorbital closure. Details of tooth structure (premolars and molars) and a possibly unfused mandibular symphysis resemble these parts in certain Eocene prosimians.     

High efficiency DNA-mediated transformation of primate cells

Tissue culture cells from several mammalian species, including three primate lines, were transfected with recombinant vectors carrying Escherichia coli xanthine-guanine phosphoribosyltransferase or Tn5 aminoglycoside phosphotransferase dominant selectable markers. Human HeLa and SV40-transformed xeroderma pigmentosum cells exhibited stable transformation frequencies of at least 10(-3) (0.1 percent). CV-1, an African green monkey kidney cell line, could be stably transformed with the exceptionally high frequency of 6 X 10(-2) (6 percent).     

Isolation of T-lymphotropic retrovirus related to HTLV-III/LAV from wild-caught African green monkeys

Present evidence suggests that the acquired immune deficiency syndrome (AIDS) emerged in Central Africa as a new disease in recent decades. This disease has recently approached epidemic proportions in many parts of the world. The etiologic agent of AIDS is believed to be the virus HTLV-III/LAV, which has been proposed as having originated from a recent simian-human transmission in Africa. This report describes the isolation of a designated STLV-IIIAGM retrovirus closely related to HTLV-III/LAV from seven healthy wild-caught African Green monkeys (Cercopithecus aethiops) that showed the presence of antibodies designated STLV-IIIAGM. In vitro growth characteristics, ultrastructural morphology, and major proteins of 160,000 kilodaltons (kD), 120 kD, 55 kD, and 24 kD are similar to and cross-reactive with the analogous antigens of HTLV-III/LAV. The use of these serologic markers in the detection of STLV-IIIAGM-infected monkeys may be important in assuring the continued safety of a variety of biologic reagents that are derived from these primate species. The existence of a retrovirus closely related to HTLV-III/LAV that naturally infects an African nonhuman primate in the apparent absence of disease may provide a unique model for the study of human AIDS and the development of an effective vaccine.     

The earliest primates

The known range of the Primates is extended down from the middle Paleocene to the early Paleocene and late Cretaceous by a new genus and two new species from Montana, Purgatorius unio and P. ceratops. These species approach condylarths and leptictid and erinaceoid insectivores in structure. Purgatorius is referred to a new subfamily, Purgatoriinae, of the Paromomyidae, but is probably not the stem primate. The fauna of Purgatory Hill indicates a late early Paleocene age.