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1.
Sub-clinical parasitism in spring-born single suckled beef calves was investigated from the middle of their first grazing season until weaning or housing later the same year. The study was conducted on four beef suckler herds in southern England over a 3-year period and involved a total of 334 spring-born beef suckler calves and their dams. The animals were grazed extensively on pastures naturally infected with nematode larvae. At the start of each period of observation, faecal samples were taken from calves and cows and subjected to routine worm egg counts; calves were re-sampled at the end of the grazing season.In July in each year and at each location the calves were ranked by initial weight within sex, paired according to rank and randomly allocated to either an untreated control group or a group in which the calves were each treated with an ivermectin sustained-release (SR) bolus. The calves in both trial groups, and their dams, were grazed together until weaning or housing. The calves were weighed at the initial allocation and at the end of the study. The adult cows were not treated with any anthelmintic during the study.The faecal nematode egg counts (FECs) conducted in July showed that the suckler cows were excreting worm eggs at low concentrations: range 0-100 eggs per gram (epg), with one individual count of 500epg, 88% of the cows sampled had counts of <50epg. Similarly, the counts from the calf samples were fairly low in July: range 0-250epg, 73% of the calves sampled had counts of <50epg. By the end of the grazing season, the faecal samples from the untreated control calves showed higher values: range 0-650epg, with only 58% having an epg of <50.The average rate of daily liveweight gain in the untreated heifer calves was 0.79kg per day, the corresponding figure for the heifer calves treated with the ivermectin SR bolus in mid-summer was 0.88kg per day; the difference of 90g per day was significantly different (P=0.0118). The average rate of daily liveweight gain in the untreated bull calves was 0.91kg per day, the corresponding figure for the bull calves treated with the ivermectin SR bolus in mid-summer was 1.01kg per day; the difference was significantly different (P=0.0169).  相似文献   

2.
The efficacy of the morantel sustained release bolus (MSRB) in controlling gastrointestinal parasitism in beef cattle was assessed during the 1982 spring-autumn grazing season. Forty-eight cows and their calves were allotted to three equal groups. One group (T-1) served as a nonmedicated control group. One MSRB was administered to each calf of the T-2 group, and to each cow and calf of the T-3 group at the beginning of the study. The efficacy of the bolus was assessed by comparison of weight gain performance and parasitological data (fecal worm egg counts, herbage larval counts, worm counts from tracer and principal trial calves, and plasma pepsinogen level determinations). Though not statistically significant, treated calves from Group T-2 had a numerical mean weight gain advantage of 2.6 kg, and those from Group T-3 of 4.7 kg, over control calves. Average daily gains (ADG) for the three groups of calves were 0.69, 0.72, and 0.73 kg, respectively. Untreated cows from Group T-2 and treated cows from Group T-3 outperformed the control cows by 12.3 and 7.5 kg, respectively. Fecal worm egg counts from both groups of treated calves were significantly (P less than 0.01) lower than counts from control calves during the entire 169-day trial; notably, egg counts were reduced by 99% 28 days after MSRB administration to both groups of calves. There were no significant differences in the number of eggs counted from the three groups of cows, probably because of the very low numbers of eggs encountered. Mean total worm burdens of principal calves (six per group) necropsied at trial termination indicated a 91% (P less than 0.01) reduction in Group T-2 and an 87% reduction (P less than 0.01) in Group T-3. Worm-free tracer calves were introduced onto pastures every 28 days to monitor availability of infective larvae. The mean number of worms recovered at necropsy from tracer calves that grazed with control cattle increased as the season progressed. However, the numbers of parasites recovered each month from mid-August through mid-October from tracers that grazed pastures with treated cattle were lower (P less than 0.05) than those levels displayed at trial initiation. In addition, the mean numbers of worms from treated group tracers were lower than from the controls for each necropsy period.(ABSTRACT TRUNCATED AT 400 WORDS)  相似文献   

3.
The epidemiology and the effects of nematode infections on cow-calf systems were followed from 3 weeks before calving to 7 months afterwards. Two groups, each of 15 cow-calf pairs grazed on separate lucerne pastures. Group I (GI) were treated monthly with oxfendazole (4.5 mg kg-1), cows being dosed from calving and calves starting 45 days later. Animals in Group II (GII) were not treated. The egg output of the cows was very low. An increase was recorded 2 months after parturition, consisting mainly of Ostertagia spp. The egg output and worm burdens of calves remained low until late summer and reached a peak in autumn. Ostertagia, Cooperia and Haemonchus were the main genera recovered from slaughtered calves. The pasture contamination and tracer calf worm counts remained consistently low until autumn when they began to increase. Inhibited early fourth stage larvae of Ostertagia were recovered during spring. After calving, the live-weight gains (LWG) of treated GI cows were significantly higher (P less than 0.004) than those of GII cows, whereas the LWG of GI calves were significantly higher during December (P less than 0.037) and March (P less than 0.029) than those of GII calves. There were significant (P less than 0.04) cumulative LWG responses between GI and GII calves with no differences in cow cumulative LWG at the end of the trial. For spring-born calves, these results suggest that strategic deworming programs in cow-calf systems may produce benefits.  相似文献   

4.
The efficacy of moxidectin was determined against ivermectin-susceptible and resistant strains of Haemonchus contortus. At the onset of the trial, 40 lambs were each infected with 5000 third stage larvae of one of two strains of Haemonchus contortus. The lambs were randomly sorted into eight treatment groups 28 days post-infection and were treated as follows: Group 1, susceptible strain with no treatment; Group 2, resistant strain with no treatment; Group 3, susceptible strain treated with 0.2 mg moxidectin kg-1 body weight; Group 4, resistant strain treated with 0.2 mg moxidectin kg-1; Group 5, resistant strain treated with 0.4 mg moxidectin kg-1; Group 6, susceptible strain treated with 0.2 mg ivermectin kg-1; Group 7, resistant strain treated with 0.4 mg ivermectin kg-1; Group 8, resistant strain treated with 0.8 mg ivermectin kg-1. The lambs were killed 1 week post-treatment. Comparisons were made among groups based on the number of eggs per gram of feces on the day of treatment and the numbers of worms recovered from each lamb. Both moxidectin and ivermectin were effective in removing susceptible Haemonchus with efficacies of 100% and 99.7%, respectively. The efficacy of moxidectin against the resistant strain was 99.9% and 100% at 0.2 mg kg-1 and 0.4 mg kg-1, respectively, whereas there were only 38.8% and 53.1% efficacies in the lambs treated with 0.4 mg ivermectin kg-1 and 0.8 mg kg-1 body weight, respectively.  相似文献   

5.
The effect of ivermectin delivered from a sustained-release bolus (I-SRB) on the weight gain of beef cattle through a grazing season was evaluated using 20 yearling beef steer calves randomly divided into two groups of ten animals each. Calves in the control group each received a placebo bolus, while those in the treatment group each received an I-SRB designed to release 12 mg ivermectin day-1 for approximately 90 days. All animals were weighted and samples of feces were collected from the rectum at monthly intervals, beginning on Day 0, until trial termination (Day 148). Pasture larval counts were also conducted on herbage collected on each sampling date. On Day 119, two control and two treated calves were removed from pasture, housed in isolation for 3 weeks, then necropsied for recovery of gastrointestinal nematodes. Three sets of parasite-naive tracer calves were utilized to evaluate the initial, interim and final levels of pasture contamination by nematode larvae. A fourth set was used to evaluate the level of pasture contamination the following spring. The use of the I-SRB resulted in a greater than 99% reduction in fecal egg counts of trichostrongyles and numbers of gastrointestinal nematodes in the treated principals, as well as an average daily gain advantage of 0.114 kg over the 148 day period. A 67-98% reduction in pasture larval nematode contamination occurred on pastures grazed by the treated animals, as indicated by the parasite burden in tracer calves and pasture larval counts. The treatment effect was eventually lost by the following spring since tracer calves on the treated pasture had only 33% fewer nematodes than those on the control pasture.  相似文献   

6.
The safety and anthelmintic efficacy of clorsulon (7 mg/kg of body weight, orally) given concurrently with ivermectin (0.2 mg/kg, subcutaneously) for control of Fasciola hepatica were evaluated in 75 crossbred beef cattle. Twenty-three control animals were given only ivermectin. Fluke egg counts were significantly lower (P less than 0.0001) in clorsulon-treated animals by day 14 after treatment than before treatment (base line) and were significantly lower (P less than 0.005) after treatment in clorsulon-treated animals than in controls. There was no significant change in fluke egg counts of controls after treatment. The efficacy of clorsulon in reducing F hepatica egg counts was 99%. Clorsulon showed poor efficacy against paramphistomes. Adverse reactions were not observed.  相似文献   

7.
Effect of ivermectin on performance of beef cattle on Georgia pastures   总被引:2,自引:0,他引:2  
A total of 469 cows and calves from 2 herds, each on 6 pastures, was used to evaluate the anthelmintic efficacy and animal-performance benefits of ivermectin given subcutaneously at a dosage of 200 micrograms/kg to nursing beef calves and their dams during a grazing season. Pastures were paired across the 2 herds. Three pasture groups from 1 herd were randomly assigned to either a nonmedicated control or to a medicated group. Treatment assignments were reversed in the other herd. The control groups comprised 110 cows and 108 calves, whereas 127 cows and 124 calves were treated with ivermectin (200 micrograms/kg). The cows were treated once, in late spring, and the calves were treated twice, once in late spring and again in midsummer. Cattle from one herd were weighed on days - 12, 21, 49, 77 (day of 2nd treatment for calves), and 105, and the other herd was weighed on days - 6, 23, 57, 86 (day of 2nd treatment for calves), and 113. Rectal fecal samples for nematode egg counts were obtained from approximately 25% of the cattle in each pasture on weighing days; usually, the same cattle were sampled each time. Calves treated with ivermectin gained (P less than 0.05) more weight than control calves up to the 2nd treatment date and up to the termination of the study. There was no significant difference between treated and control cows, with regard to weight gain over either interval. Treated calves had fewer positive fecal egg counts (P less than 0.01) and passed fewer eggs (P less than 0.05) after both treatments than did control calves. There were no differences in either number of eggs or number of negative cows between treatment groups. Adverse reactions attributable to treatment were not seen.  相似文献   

8.
Larger livestock units, a decline in the farm labor force, animal welfare concerns, and a trend toward more selective use of drugs have increased the focus on animal handling, time management, convenience, and compliance in administering veterinary therapeutics. This study was undertaken to quantify and compare the time needed to treat commercial beef cattle with three fluke and worm combination products with different administration profiles. Young beef cattle (n = 270) weighing approximately 400 kg were allocated to batches of five, which were randomly assigned to receive ivermectin + clorsulon injection, ivermectin + closantel injection, or levamisole + triclabendazole oral drench. The mean time needed to administer ivermectin + clorsulon (single injection) to five cattle was 31 seconds, which was significantly less than the 100 seconds needed for ivermectin + closantel (two injections) and the 126 seconds needed for levamisole + triclabendazole (P less than .001). Such quantitative data can allow for better planning and selection of parasiticide treatment approaches at the farm level.  相似文献   

9.
The efficacy of a treatment schedule using ivermectin, given subcutaneously at the rate of 200 micrograms kg-1, to control gastrointestinal parasitism and its effect on liveweight gains was assessed. Two herds with a total of 466 Hereford X Brangus cow/calf pairs were used. Each herd was on six pasture plots of comparable size, stocking rate, and quality and quantity of forage. Pasture groups were paired across the two herds. Pasture groups from one herd were randomly assigned to nonmedicated control and the other three to ivermectin treatment. Treatment assignments per pasture group were reversed in the other herd. The control group contained 118 cows and 112 calves and the medicated group 121 cows and 115 calves. Cows were treated in early July and the calves in late July or early August. Cattle from one herd were weighed on Days -28, 0 (day of cow treatment), 30 (day of calf treatment), 58, and 86, while the other herd was weighed on Days -29, 0 (day of cow treatment), 27 (day of calf treatment), 61, and 89. Day 0 was not the same calendar day for the two herds. Fecal samples for parasite egg counts were obtained from the rectum on weight days from five cows and six calves from each pasture; in most cases the same cattle were sampled each time. Calves treated with ivermectin gained (P less than 0.05) more weight than control calves between day of treatment for cows and the end of the trial.(ABSTRACT TRUNCATED AT 250 WORDS)  相似文献   

10.
Spring born, crossbred beef heifers (n=372) were utilized over four years to measure reductions in body weights, reproductive performance and calf weights caused by gastrointestinal nematodes (primarily Ostertagia ostertagi) and the bovine liver fluke (Fasciola hepatica) and to differentiate losses attributable to each type of parasitism. Each year, weaned heifers were allotted to one of the four treatment regimens: Group 1, untreated controls; Group 2, treated for nematodes; Group 3, treated for liver fluke; and Group 4, treated for both nematodes and liver fluke. Nematodes were controlled with subcutaneous injections of either ivermectin (Ivomec, Merial) or doramectin (Dectomax, Pfizer), both at the recommended dose of 200 ug/kg bodyweight. Clorsulon (Curatrem, Merial) drench was given at the recommended rate of 7 mg/kg bodyweight to control flukes. Treatments and fecal collections were initiated at allotment each year and were repeated at 28-84-day intervals until palpation for pregnancy diagnosis. Open heifers were removed from the study at this time. Treatment dates were based on expected length of treatment efficacy, the stage of growth of the heifers and the seasonal risk of infection by the parasites. Pregnant females were pooled and received their assigned treatments prior to their calving and breeding seasons and remained together until their calves were weaned. Heifers treated for nematode infections were heavier and had higher condition scores (P<0.01) than untreated control heifers at initiation of breeding, and maintained that difference through pregnancy diagnosis. Liver fluke infection did not affect heifer gains or condition scores prior to palpation (P<0.01). At palpation, heifers treated for both forms of parasitism had the highest condition scores and weight gains (P<0.01), and also higher pregnancy rates than control heifers and heifers treated for nematodes only (P<0.01). Pregnancy rates for heifers treated for flukes only were not significantly different from those treated for both nematodes and flukes. Heifers treated for nematodes weaned heavier calves than those not treated for nematodes (P<0.05).  相似文献   

11.
A daily oral 5 mg kg-1 dose of clorsulon for 28 days in calves given Fasciola hepatica cysts at 3, 5, and 7 days after initiation of treatment was highly effective in reducing worm burdens (98%) and preventing liver pathology. In similarly infected and treated sheep, clorsulon showed little effect as a prophylactic for delaying the onset of liver pathology. The size of flukes recovered from treated sheep was reduced. Although clorsulon prevented development of fascioliasis in treated calves, the host antibody response was qualitatively similar to that of untreated infected calves, but the magnitude of the response was reduced. Blood clorsulon levels in calves rose to 2.90 micrograms ml-1 within the first week of treatment then fluctuated between 2.65 and 2.90 micrograms ml-1 for the next two weeks. Clorsulon levels in sheep were 0.50-0.60 micrograms ml-1 lower than those in calf blood. The difference in bioavailability of clorsulon between sheep and calves may have contributed to differences in efficacy of the drug.  相似文献   

12.
Clorsulon (3.5 or 7 mg/kg of body weight) was given orally to mature cows (dairy or beef) and to mature mixed-breed sheep harboring patent infections of Fasciola hepatica. Eighteen animals of each species were assigned to a control group (drug vehicle) or to 1 of 2 treatment (3.5 or 7.0 mg/kg) groups of 6 animals each. On posttreatment days 8 (cows) or 14 (sheep), the animals were slaughtered for recovery of flukes. In cows, the efficacy (P values for treatment groups vs control) of clorsulon against infections of mature F hepatica was 99.21% (P less than or equal to 0.0065) at 3.5 mg/kg and was 100% (P less than or equal to 0.0039) at 7 mg/kg. In sheep, the efficacy was 93.33% (P less than or equal to 0.0104) at 3.5 mg/kg and was 100% (P less than or equal to 0.0039) at 7 mg/kg. These results indicate that clorsulon is a highly effective compound for the treatment of mature F hepatica in cows and sheep.  相似文献   

13.
Twenty calves at each of 2 Arkansas locations were inoculated with infective Fasciola hepatica metacercariae. After 56 days, the calves at each site were randomly assigned by weight to 2 treatment groups of 10 calves/group; vehicle control or clorsulon at the rate of 7 mg/kg of body weight. All treatments were given orally as a suspension. Calves were killed 6 weeks after treatment and F hepatica counts were performed for all animals. At the 2 sites, mean levels of efficacy were 96% and 91%. Adverse reactions to clorsulon or the vehicle were not observed in the calves.  相似文献   

14.
OBJECTIVE: To compare growth performance, animal health characteristics, and carcass characteristics of feedlot calves treated with ivermectin topically with that of feedlot calves treated with a combination of fenbendazole orally and permethrin and fenthion topically. DESIGN: Clinical trial. ANIMALS: 14,184 British crossbred steer calves (mean weight, 286 kg [630 lb]) in 30 pens at a commercial feedlot in Nebraska. PROCEDURE: On arrival at the feedlot, calves were randomly assigned to be treated with ivermectin topically or with a combination of fenbendazole orally and permethrin and fenthion topically (control). At the time of assignment to treatment groups, fecal samples were collected from 5% of the calves. Growth performance, carcass characteristics, and health information were recorded. RESULTS: Geometric mean fecal egg counts at the time of arrival at the feedlot were not significantly different between groups. Final weight, weight gain, average daily gain, and the dry matter intake-to-gain ratio were significantly improved for calves in the ivermectin group. The percentage of carcasses classified as quality grade choice was higher for the ivermectin group than the control group; however, the percentage of carcasses classified as yield grade 1 and the dressing percentage were higher for the control group than for the ivermectin group. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that topical administration of ivermectin to feedlot calves is relatively more cost-effective than administration of a combination of fenbendazole orally and permethrin and fenthion topically.  相似文献   

15.
The anti-parasitic effect of the orally administered paste formulation of ivermectin (Ivomec) in reindeer was evaluated by means of a trial designed to compare the efficacies of orally and s.c. administered ivermectin at the same dosage (0.2 mg kg-1 body weight) in naturally infected adult reindeer (n = 92). Both formulations were 100% effective against larvae of the warble fly, Oedemagena tarandi, while oral treatment was less efficacious than s.c. injection against parasitic nematodes. Both formulations, but particularly the injectable ivermectin treatment, increased the weight gain of pregnant females compared to that of those not treated.  相似文献   

16.
On the basis of the hypothesis that the peak numbers of infective nematode third-stage larvae (L3) on herbage in winter months results from fall contamination of pastures, 2 methods to reduce fall contamination were tested. In trial 1, morantal sustained-release boluses were administered to 15 fall-calving cows on Sept 7, 1982. Fifteen untreated cows (controls) were placed on separate pastures. Numbers of L3 on herbage during the winter and spring were assessed by use of worm-free tracer calves. In trial 2, 19 cattle due to calve in the fall were administered 200 micrograms of invermectin/kg of body weight, SC, on Sept 2, 1983. Also, 17 cattle similarly were given a placebo injection and served as control animals. Treated cattle were placed on the pasture used by control cattle in trial 1 and control cattle on the pasture used by treated cattle in trial 1. Worm-free tracer calves were again used to assess numbers of L3 on herbage. In trial 1, tracer calves grazing the control animal pasture from January 14 to 28 acquired 37 times as many nematodes as did those grazing the treated animal pasture. In trial 2, the greatest difference observed was a 10-fold increase of nematodes in calves grazing control animal pastures, compared with worm numbers in tracer calves grazing the treated animal pasture.  相似文献   

17.
Four groups of 17 crossbred beef weaners were used in an experiment which extended from 14 November 1985 to 8 October 1986 (328 days). All groups began grazing on separate, contaminated pastures at a stocking rate of 5.3 cattle ha-1 and the different treatments were: Group 1, ivermectin (IVM) injectable X 1 (200 micrograms kg-1) on 14 November only, with provision for individual salvage treatment; Group 2, IVM X 3 on 14 November, 4 February and 2 July; Group 3, IVM X 2 on 14 November and 2 July; Group 4, fenbendazole (FBZ) paste X 2 (5 mg kg-1) on 14 November and 2 July. Pairs of parasite-free tracer calves were grazed on all group pastures for 1 month at the beginning of the experiment (13 November-12 December and in spring (1 April-1 May). Yearling cattle from each group were randomly selected and removed from pasture during spring (n = 2 per group, 3 April) and at the end of the experiment (n = 3 per group, 8 October) for slaughter analysis of worm population characteristics and observation of gross pathology in the abomasum and intestinal tract. At monthly intervals, all cattle were weighed and fecal egg counts, pasture larval counts and plasma pepsinogen values were determined. The results of this investigation demonstrated that three IVM treatments of weaner-yearling beef cattle during year-long grazing, were more effective than a single IVM treatment or two treatments with IVM or FBZ in the enhancement of productivity and protection from the effects of infection with nematode parasites.  相似文献   

18.
The long-term effects of a toltrazuril treatment against natural Eimeria bovis and/or Eimeria zuernii infections were investigated in comparison with diclazuril and untreated controls on two dairy (Italian Friesian breed) and two beef (Chianina breed) farms. At each trial site, 30 calves were allocated into three groups of 10 calves each: T (treated with toltrazuril), D (treated with diclazuril) and C (left untreated). For 40 weeks post-treatment, the calves were weighed and examined clinically and parasitologically. The oocyst counts as well as the number of scour days were significantly lower in the T group than in the D and C groups. Final bodyweights and body condition scores of the T group exceeded those of groups C and D. The results confirmed that toltrazuril was highly efficacious, safe and provided productive benefits in dairy and beef calves.  相似文献   

19.
The effect of an ivermectin sustained-release bolus (I-SRB) on the epidemiology of nematode parasites and on calf productivity was evaluated in a field trial under Northwestern European conditions. Twenty parasite-naive female Friesian calves (principals) aged 5–9 months were used together with six male Friesian tracer calves. Principal calves were allocated by restricted randomization on day 0 body weight to either an untreated control group or a group given one I-SRB, designed to deliver 12 mg ivermectin per day for 135 days, orally on day 0. Each group was grazed on adjacent paddocks, naturally contaminated with parasitic nematode larvae, from 13 May 1991 (day 0) until housing on 30 September (day 140). Body weights of principal calves were recorded and individual blood and faecal samples taken at regular intervals throughout the trial. Pasture nematode contamination was monitored by larval counts on herbage and by worm counts of tracer calves grazed on each paddock from day 126 to day 140. Nematode contamination levels on the control paddock did not rise until the end of the grazing season, as a result of a mid-summer drought period. The period of exposure to a high larval challenge was too short to provoke body weight losses and clinical parasitic gastroenteritis in control calves. Use of the I-SRB resulted in zero faecal egg counts of trichostrongyles during the whole pasture season, thereby preventing a build-up of parasitic gastrointestinal nematodes on pasture. During the second grazing season no signs of parasitic gastroenteritis were detected in any animal, but an outbreak of parasitic bronchitis (PB) was observed in both experimental groups, indicating that PB can occur in older cattle regardless of the control measures taken to prevent clinical parasitism during the first grazing season.  相似文献   

20.
[目的]通过试验探究科尔沁肉牛犊牛最佳的饲养模式,为后续科尔沁肉牛早期补饲的推广和普及提供理论支持。[方法]选取体型相近,初生体重在34~50 kg之间健康的科尔沁肉牛犊牛60头,分为对照组、补饲组1、补饲组2,每组20头,补饲组按试验方案进行早期补饲,对照组按传统饲养模式饲养,对比6月龄各项数据及试验牛母牛产后发情情况,进行分析总结。[结果]补饲组与对照组相比,犊牛生长发育效果差异显著,试验母牛产后恢复明显加快,产后90 d内发情母牛占比显著提高。[结论]科尔沁肉牛犊牛早期补饲更利于犊牛后期生长发育,促进母牛早发情提高繁殖能力,结合数据分析得出早期补饲至6月龄是更为适合科尔沁肉牛犊牛的饲养模式。  相似文献   

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