共查询到18条相似文献,搜索用时 60 毫秒
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非甾体抗炎药残留检测方法研究进展 总被引:2,自引:1,他引:1
介绍了国内外目前检测非甾体抗炎药(Non-steroidal anti-inflammatory drugs,NSAIDs)的几种主要方法,包括高效液相色谱法、液相色谱-质谱法、气相色谱-质谱法、毛细管电泳法、薄层色谱法、分光光度法等,其检测样品基质以血液、尿液为主,动物组织(肌肉、肝脏等)中NSAIDs残留的检测方法报道较少。 相似文献
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与其它畜禽一样,犬类也容易受到一些疾病的侵扰,如果治疗不及时的话,不仅仅会影响到正常的生长发育,甚至还有导致患病犬的死亡.为此,文章以“非甾体抗炎药在犬病治疗中的应用”为主要研究对象,展开探讨与分析,希望能为今后更加科学应用这类药物提供一定的依据和参考. 相似文献
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《科技视界》2016,(27)
目的 :探讨昆明市某民营医院2014-2015年门诊60岁以上老年人非甾体抗炎药物的应用情况,进行用药合理性评价。方法:收集该院2014-2015年60岁以上老年人非甾体抗炎药物门诊处方,采用用药频度(DDDs)、日均费用(DDC)对各品种、规格、剂型的药物进行统计分析。结果:2014-2015年处方中用药频度排名前三位的是:阿司匹林肠溶片(100mg)、洛索洛芬钠片、阿司匹林肠溶片(25mg);日均费用排名前三位的是:塞来昔布胶囊、注射用赖氨匹林、洛索洛芬钠片。结论:门诊患者非甾体抗炎药使用合理,其中价格低廉、副作用小和药效显著的传统药物仍占绝大比例。 相似文献
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1奶牛乳房炎的临床症状以乳房和乳汁有无肉眼可见变化可分为隐性乳房和临床型乳房炎。隐性乳房炎即无临床症状可见,但用特殊的试验可以检出乳汁的变化。临床型乳房炎,乳房和乳汁均有肉眼可见的异常。轻度时乳汁中有絮片、凝块,有时乳汁呈水样。乳房轻度发热和疼痛,或不发热不痛,可能肿胀。重度的,患病乳区急性肿胀、热、硬、痛。乳汁异常,分泌减少。出现高温、脉搏增数、病牛抑郁、衰弱、食欲衰失等全身症状。慢性乳房炎,由乳房持续感染,通常无临床症状,偶尔可 相似文献
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Carrie C. Jacobs Lauren V. Schnabel C. Wayne McIlwraith Anthony T. Blikslager 《Equine veterinary journal》2022,54(4):636-648
Orthopaedic disorders are commonly encountered in equine veterinary medicine, and non-steroidal anti-inflammatory drugs (NSAIDs) play an important role in the management of many equine orthopaedic disorders. There are multiple NSAIDs available for use in horses, including both non-selective and selective NSAIDS, and the body of literature evaluating the efficacy of these medications, their effects on normal and inflamed musculoskeletal tissues, and their side effects is broad. This review aims to summarise the current literature on the use of NSAIDs for equine orthopaedic disorders and examines new and future avenues for the management of inflammation in equine orthopaedics. 相似文献
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抗菌药物的合理应用研究进展 总被引:1,自引:1,他引:0
自从抗菌药物在医学、兽医临诊实践中被广泛应用以来,已取得良好的疗效。但抗菌药既能发挥防治疾病的有利作用,也会对动物产生损害作用。盲目、滥用抗菌药物带来的危害值得人们关注和反思。抗菌药物的不良反应和滥用抗菌药物的危害,主要表现为细菌产生耐药性、动物体内菌群平衡失调等,其次是药物残留对公共卫生和环境的负面影响。论文强调在了解药动学和药效学原理(峰时间、峰浓度、药时曲线下面积、防突变浓度、抗菌后效应、最小抑菌浓度等)的基础上,指出应该坚持病因学诊断,制定科学的治疗方案,同时要遵守国家相关的法规和条例,做到依法防控疾病。 相似文献
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氟尼辛葡甲胺对大鼠小鼠的抗炎镇痛作用研究 总被引:1,自引:2,他引:1
氟尼辛葡甲铵盐是一种动物专用的非甾体抗炎药,具有镇痛和解热功能,但抗炎是其主要功效。本试验通过对鸡蛋清诱导的大鼠踝关节炎性肿胀模型和冰醋酸所致小鼠疼痛扭体反应来研究其抗炎镇痛效果。与对照组相比,FM高中低各剂量组(0.55、1.1、2.2 m g/kg)对大鼠足关节炎症均有显著的对抗作用(P<0.05,P<0.01),呈明显的量效关系。高剂量组(2.2m g/kg)抗炎功效明显优于吲哚美辛组(2.25 m g/kg)和地塞米松组(2.52 m g/kg)。中剂量组(1.1 m g/kg)作用堪比吲哚美辛,而低剂量组(0.55 m g/kg)稍逊于地塞米松。与同类对照药双氯芳酸钠(16.25 m g/kg)和安乃近(32.5 m g/kg)相比,结果显示FM(2.5 m g/kg)对小鼠扭体抑制作用最强,抑制率高达82.69%。 相似文献
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Karol A. Mathews DVM DVSc DACVECC 《Journal of Veterinary Emergency and Critical Care》2002,12(2):89-97
Objective: This review is intended to update the reader on the clinical aspects of the non‐steroidal anti‐inflammatory analgesics (NSAIAs) currently used in veterinary practice. Most NSAIAs act by selectively, or preferentially, inhibiting the synthesis of cyclooxygenase (COX)‐1 or COX‐2, or both COX‐1 and COX‐2 enzymes which oxidize arachadonic acid to a series of prostenoids. The prostenoids are precursors of various prostaglandins required for many homeostatic functions throughout the body. The COX‐1 and COX‐2 enzymes are constitutive, however the COX‐2 enzyme is also induced following injury or inflammation facilitating the transmission of pain. As the newer NSAIAs focus on the inhibition of COX‐2, this review offers a more detailed discussion of this enzyme. Data synthesis: This data was obtained from recent review articles and original published reports in both the veterinary and human literature. A CAB and Medline search was also used. Conclusions: The NSAIAs are effective analgesics for managing moderate to severe pain in many species of animals; however, potential adverse effects may occur if used inappropriately. Guidelines, including indications, contraindications and dosing regimens for the commonly available NSAIAs are included. 相似文献
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美洛昔康作为非甾体类抗炎药(NSAIDs),不仅可广泛用于抗炎、镇痛、解热,还具有安全高效、副作用小、半衰期长等优点。研究显示,此药具有较好的抗炎及解热镇痛作用,无毒或低毒性,在美国已广泛应用于犬、猫等宠物临床疾病治疗。由于目前兽用美洛昔康剂型较为单一,且临床应用靶动物种类较少,因此未来需开发更多种类剂型,同时应增加不同靶动物的临床应用研究。本文对兽用美洛昔康的理化性质、作用机理、药理作用、药代动力学、不良反应和临床应用等方面的研究进行综述,旨在为开发新型的兽用美洛昔康及其临床安全、合理用药提供参考。 相似文献
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Michael D. Kleinhenz Nicholas K. Van Engen Patrick J. Gorden Katie E. Kleinhenz Butch Kukanich Suzanne M. Rajewski Philip Walsh Johann F. Coetzee 《Veterinary anaesthesia and analgesia》2018,45(6):849-857
Objective
To study the influence of pain on the pharmacokinetics and anti-inflammatory actions of transdermal flunixin administered at dehorning.Study design
Prospective, crossover, clinical study.Animals
A total of 16 male Holstein calves, aged 6–8 weeks weighing 61.3 ± 6.6 kg.Methods
Calves were randomly assigned to one of two treatments: transdermal flunixin and dehorning (PAIN) or transdermal flunixin and sham dehorning (NO PAIN). Flunixin meglumine (3.33 mg kg?1) was administered topically as a pour-on concurrently with hot iron dehorning or sham dehorning. The calves were subjected to the alternative treatment 14 days later. Blood samples were collected at predetermined time points up to 72 hours for measurement of plasma flunixin concentrations. Pharmacokinetics parameters were determined using noncompartmental analysis. Prostaglandin E2 (PGE2) concentration was determined using a commercial enzyme-linked immunosorbent assay. The 80% inhibition concentration (IC80) of PGE2 was determined using nonlinear regression. Pharmacokinetic data were statistically analyzed using paired t tests and Wilcoxon rank sums for nonparametric data. Flunixin and PGE2 concentrations were log transformed and analyzed using repeated measures.Results
A total of 15 calves completed the study. Plasma half-life of flunixin was significantly longer in PAIN (10.09 hours) than NO PAIN (7.16 hours) (p = 0.0202). Bioavailability of transdermal flunixin was 30% and 37% in PAIN and NO PAIN, respectively (p = 0.097). Maximum plasma concentrations of flunixin were 0.95 and 1.16 μg mL?1 in PAIN and NO PAIN, respectively (p = 0.089). However, there was a treatment (PAIN versus NO PAIN) by time interaction (p = 0.0353). PGE2 concentrations were significantly lower in the PAIN treatment at 48 and 72 hours (p = 0.0092 and p = 0.0287, respectively). The IC80 of PGE2 by flunixin was similar in both treatments (p = 0.88).Conclusion and clinical relevance
Pain alters the pharmacokinetics and anti-inflammatory effects of transdermally administered flunixin. 相似文献18.
本试验旨在研究和探讨抗类风湿性关节炎(rheumatoid arthritis,RA)药物花艽-6的抗炎作用及其抗炎机理。采用二甲苯致小鼠耳肿胀法、醋酸致小鼠毛细血管通透性增高法、甲醛和蛋清致小鼠足跖肿胀法,以及棉球致小鼠肉芽组织增生法分别研究了该药物的抗急性、亚急性和慢性炎症的作用。通过复制佐剂性关节炎(adjuvant arthritis,AA)大鼠模型研究花艽-6对其血清中IL-1β、IL-6和TNF-α含量的影响。花艽-6对小鼠二甲苯所致的耳肿胀、醋酸所致的腹腔毛细血管通透性增高、甲醛和蛋清所致的足跖肿胀和棉花所致的肉芽组织增生均具有显著或极显著的抑制作用。花艽-6具有抗炎作用,可显著降低AA大鼠血清中IL-1β、IL-6和TNF-α的表达,对RA具有治疗作用。 相似文献