共查询到20条相似文献,搜索用时 15 毫秒
1.
Transcription factor OTF-1 is functionally identical to the DNA replication factor NF-III 总被引:49,自引:0,他引:49
E A O'Neill C Fletcher C R Burrow N Heintz R G Roeder T J Kelly 《Science (New York, N.Y.)》1988,241(4870):1210-1213
2.
Isolation of a rel-related human cDNA that potentially encodes the 65-kD subunit of NF-kappa B 总被引:117,自引:0,他引:117
S M Ruben P J Dillon R Schreck T Henkel C H Chen M Maher P A Baeuerle C A Rosen 《Science (New York, N.Y.)》1991,251(5000):1490-1493
3.
Sequence-specific binding of human Ets-1 to the T cell receptor alpha gene enhancer 总被引:48,自引:0,他引:48
I C Ho N K Bhat L R Gottschalk T Lindsten C B Thompson T S Papas J M Leiden 《Science (New York, N.Y.)》1990,250(4982):814-818
4.
5.
6.
Identification of a zinc finger protein that binds to the sterol regulatory element 总被引:36,自引:0,他引:36
T B Rajavashisth A K Taylor A Andalibi K L Svenson A J Lusis 《Science (New York, N.Y.)》1989,245(4918):640-643
7.
Association of human papillomavirus types 16 and 18 E6 proteins with p53 总被引:175,自引:0,他引:175
Human papillomavirus type 16 (HPV-16) is a DNA tumor virus that is associated with human anogenital cancers and encodes two transforming proteins, E6 and E7. The E7 protein has been shown to bind to the retinoblastoma tumor suppressor gene product, pRB. This study shows that the E6 protein of HPV-16 is capable of binding to the cellular p53 protein. The ability of the E6 proteins from different human papillomaviruses to form complexes with p53 was assayed and found to correlate with the in vivo clinical behavior and the in vitro transforming activity of these different papillomaviruses. The wild-type p53 protein has tumor suppressor properties and has also been found in association with large T antigen and the E1B 55-kilodalton protein in cells transformed by SV40 and by adenovirus type 5, respectively, providing further evidence that the human papillomaviruses, the adenoviruses, and SV40 may effect similar cellular pathways in transformation. 相似文献
8.
9.
Repression of HIV-1 transcription by a cellular protein 总被引:28,自引:0,他引:28
10.
11.
12.
The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product 总被引:265,自引:0,他引:265
Deletions or mutations of the retinoblastoma gene, RB1, are common features of many tumors and tumor cell lines. Recently, the RB1 gene product, p105-RB, has been shown to form stable protein/protein complexes with the oncoproteins of two DNA tumor viruses, the adenovirus E1A proteins and the simian virus 40 (SV40) large T antigen. Neither of these viruses is thought to be associated with human cancer, but they can cause tumors in rodents. Binding between the RB anti-oncoprotein and the adenovirus or SV40 oncoprotein can be recapitulated in vitro with coimmunoprecipitation mixing assays. These assays have been used to demonstrate that the E7 oncoprotein of the human papilloma virus type-16 can form similar complexes with p105-RB. Human papilloma virus-16 is found associated with approximately 50 percent of cervical carcinomas. These results suggest that these three DNA viruses may utilize similar mechanisms in transformation and implicate RB binding as a possible step in human papilloma virus-associated carcinogenesis. 相似文献
13.
Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA 总被引:117,自引:0,他引:117
J P Hoeffler T E Meyer Y Yun J L Jameson J F Habener 《Science (New York, N.Y.)》1988,242(4884):1430-1433
14.
Multiple global regulators control HIS4 transcription in yeast 总被引:63,自引:0,他引:63
15.
A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter 总被引:42,自引:0,他引:42
H C Liou M R Boothby P W Finn R Davidon N Nabavi N J Zeleznik-Le J P Ting L H Glimcher 《Science (New York, N.Y.)》1990,247(4950):1581-1584
16.
Redox regulation of fos and jun DNA-binding activity in vitro 总被引:109,自引:0,他引:109
17.
Identification of Ets- and notch-related subunits in GA binding protein 总被引:47,自引:0,他引:47
K LaMarco C C Thompson B P Byers E M Walton S L McKnight 《Science (New York, N.Y.)》1991,253(5021):789-792
18.
19.
A cDNA for a protein that interacts with the human immunodeficiency virus Tat transactivator 总被引:44,自引:0,他引:44
The human immunodeficiency virus (HIV) tat protein (Tat) is a positive regulator of virus gene expression and replication. Biotinylated Tat was used as a probe to screen a lambda gt11 fusion protein library, and a complementary DNA encoding a protein that interacts with Tat was cloned. Expression of this protein, designated TBP-1 (for Tat binding protein-1), was observed in a variety of cell lines, with expression being highest in human cells. TBP-1 was localized predominantly in the nucleus, which is consistent with the nuclear localization of Tat. In cotransfection experiments, expression of TBP-1 was able to specifically suppress Tat-mediated transactivation. The strategy described may be useful for direct identification and cloning of genes encoding proteins that associate with other proteins to modulate their activity in a positive or negative fashion. 相似文献
20.
Cloning of a transcriptionally active human TATA binding factor 总被引:72,自引:0,他引:72
C C Kao P M Lieberman M C Schmidt Q Zhou R Pei A J Berk 《Science (New York, N.Y.)》1990,248(4963):1646-1650