Neutropenia in cats with the Chediak-Higashi syndrome.

Thirteen cats with Chediak-Higashi syndrome and 22 control cats from the same colony, were evaluated for neutropenia. The absolute neutrophil counts of the Chediak-Higashi syndrome cats were significantly less (P less than 0.05) than those of the control cats. It is concluded that Chediak-Higashi syndrome cats, like Chediak-Higashi syndrome humans, have a neutropenia associated with the other manifestations of the syndrome. Lysozyme activity which was undetectable in the serum of both Chediak-Higashi syndrome and control cats was not of use for determining if the neutropenia was the result of neutrophil destruction.     

Hemophagocytic syndrome in dogs: 24 cases (1996-2005)

OBJECTIVE: To determine the frequency, potential causes, and clinical and clinicopathologic features of hemophagocytic syndrome in dogs. DESIGN: Retrospective study. ANIMALS: 24 client-owned dogs. PROCEDURES: Records for dogs in which diagnostic bone marrow specimens (including an aspiration smear and core biopsy material) were obtained from 1996 to 2005 were reviewed. Inclusion criteria were presence of bicytopenia or pancytopenia in the blood and > 2% hemophagocytic macrophages in the bone marrow aspirate. RESULTS: Of 617 bone marrow specimens evaluated, evidence of hemophagocytic syndrome was detected in 24 (3.9%). The Tibetan Terrier breed was overrepresented among dogs with hemophagocytic syndrome. Clinical signs associated with hemophagocytic syndrome included fever, icterus, splenomegaly, hepatomegaly, and diarrhea. Hemophagocytic syndrome was associated with immune-mediated, infectious, and neoplastic-myelodysplastic conditions and also occurred as an idiopathic condition. Overall, dogs with infection-associated hemophagocytic syndrome had better 1-month survival rates than dogs with immune-associated and idiopathic hemophagocytic syndrome. CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that hemophagocytic syndrome may occur more frequently in dogs than has previously been suspected on the basis of the paucity of reported cases. Although most dogs had definable underlying disease conditions, idiopathic hemophagocytic syndrome was also identified. Hemophagocytic syndrome of any cause is potentially life-threatening; however, the prognosis should be adjusted on the basis of the associated disease process and potential for successful treatment.     

Studies on effect of lighting on "Sudden death syndrome" in broiler chickens.

Broiler chicken flocks were studied to determine the mortality from sudden death syndrome occurring in the flocks. The difference in the incidence of the syndrome in pullets and cockerels, and the age at which the most birds are affected were also studied. The weight of sudden death syndrome birds was compared with the flock average and the effect of continuous lighting as opposed to intermittent lighting was examined.The results suggest that; continuous lighting produces more sudden death syndrome deaths than intermittent lighting; that the incidence of sudden death syndrome is higher in cockerels than pullets; that the highest death rate occurred during the third and fourth weeks of life, and that sudden death syndrome birds on the average were heavier than the flock average.     

Studies on Effect of Lighting on “Sudden Death Syndrome” in Broiler Chickens

Broiler chicken flocks were studied to determine the mortality from sudden death syndrome occurring in the flocks. The difference in the incidence of the syndrome in pullets and cockerels, and the age at which the most birds are affected were also studied. The weight of sudden death syndrome birds was compared with the flock average and the effect of continuous lighting as opposed to intermittent lighting was examined.

The results suggest that; continuous lighting produces more sudden death syndrome deaths than intermittent lighting; that the incidence of sudden death syndrome is higher in cockerels than pullets; that the highest death rate occurred during the third and fourth weeks of life, and that sudden death syndrome birds on the average were heavier than the flock average.

     

黄芪多糖对血虚模型鸡外周血的影响

为探讨黄芪多糖对血虚模型鸡外周血的影响,本试验采用腹腔注射环磷酰胺（cyclophosphamide,CTX）复制鸡的血虚模型(以80 mg/kg剂量连续腹腔注射6 d）,分别用高、中、低3个浓度的黄芪多糖给血虚模型鸡连续饮水7 d,然后分别测定各组鸡外周血中红细胞数、血红蛋白含量和血小板数的变化并进行比较。结果发现, 与健康不用药对照组相比,在饮水中添加100 μg/mL黄芪多糖能极显著提高血虚模型鸡外周血中红细胞数、血红蛋白含量和血小板数（P＜0.01）, 并使其恢复至正常水平（P＞0.05）。     

The "barker" (neonatal respiratory distress) syndrome in the pig: its occurrence in the field.

A new syndrome, characterised by acute respiratory distress and by abnormalities of the skin, hair and thyroid, was the apparent cause of neonatal death in 35 (24 per cent) of 146 piglets sired by a large white boar in four small commercial pig units. The syndrome appears to be of genetic origin, inherited as an autosomal recessive trait. Its similarities with the respiratory distress syndrome (RDS) of the newborn infant and the "barker" syndrome of the newborn foal are discussed.     

仔猪断奶应激的原因及防治

对仔猪断奶应激综合症产生的原因进行了阐述，并着重对仔猪断奶应激综合症的防治作了详细的阐明。希望能为仔猪断奶应激综合症的进一步研究积累资料。     

仔猪断奶应激的探析及其防治措施

作者从仔猪断奶应激综合征产生的原因及对生产性能的影响进行了阐述,并着重对断奶仔猪应激综合征的防治作了探讨性的阐明。希望能为仔猪断奶综合征的进一步研究积累资料。     

A survey for torovirus in New Zealand cats with protruding nictitating membranes

Faecal samples from 51 cats were examined by negative stain electron microscopy to investigate a possible association between the syndrome of bilateral protrusion of the nictitating membranes and torovirus infection. Although toroviruses were not observed in any sample, other viruses or virus-like particles were observed in faeces from one of 15 cats with the syndrome, six of 21 cats which had experienced prior episodes of the syndrome and four of 15 healthy control cats. The findings of this study do not support the hypothesis that the syndrome is associated with torovirus infection.     

Diagnosis of canine Cushing's syndrome based on multiple steroid analysis and dexamethasone turnover kinetics

A comparison of cortisol concentrations, determined by high-performance liquid chromatography (HPLC) and radioimmunoassay, was made in healthy, mixed-breed dogs and in dogs with clinical signs of Cushing's syndrome. Absolute concentration of cortisol was less in resting, dexamethasone-suppressed, and ACTH-stimulated plasma samples, when measured by HPLC relative to cortisol concentrations determined by radioimmunoassay. Diagnosis of Cushing's syndrome could be made using either method. Plasma concentrations of cortisone and corticosterone were determined by HPLC. Cortisone and corticosterone concentrations alone were not diagnostic of Cushing's syndrome; but when used in conjunction with cortisol determinations, they provided additional criteria for laboratory confirmation of the clinical diagnosis of Cushing's syndrome. The clearance of exogenous dexamethasone used in the dexamethasone-suppression test was examined in the normal and cushingoid dogs. Plasma concentrations of exogenous dexamethasone were constant during the 3-hour test in the normal dogs. However, in 75% of the dogs with Cushing's syndrome, exogenous dexamethasone was cleared completely in the 3-hour test. Thus, dexamethasone clearance rates were excessively fast in most dogs with Cushing's syndrome.     

The epidemiology of the "collapse syndrome" in suckled calves.

Cases of a diarrhoeic syndrome characterised by acute collapse were seen in single-suckled beef calves on hill farms during a three year period. The association between the occurrence of this syndrome, which we have termed the "collapse syndrome", and various epidemiological parameters, is investigated and discussed.     

Harada's disease in the Japanese Akita

A case of Harada's disease (uveodermatological syndrome) in a 14-month old female Japanese Akita is reported, the first record of this syndrome in the United Kingdom. This case was characterized by uveitis, dermatitis and some CNS involvement. The neurological component in this syndrome has not previously been reported in the dog. The Japanese Akita is a breed only recently introduced into the United Kingdom and in view of the small gene pool available the recognition of a syndrome with an apparently hereditary basis is of particular importance.     

高致病性猪蓝耳病的实验室诊断

采用猪繁殖与呼吸综合征病毒NSP2基因RT-PCR检测方法和猪繁殖与呼吸综合征病毒变异毒株试剂盒检测方法,对六盘水市钟山区某猪场发生的一起疑似高致病性猪蓝耳病进行实验室诊断,确诊为由猪繁殖与呼吸综合征病毒变异毒株引起的高致病性猪蓝耳病。     

猪繁殖与呼吸综合征病毒抗体依赖增强作用研究进展

猪繁殖与呼吸综合征(PRRS)是猪繁殖与呼吸综合征病毒(PRRSV)引起母猪繁殖障碍和仔猪的呼吸道症状而导致高病死率的传染病,PRRSV抗体依赖增强作用(ADE)是造成PRRS免疫失败的重要因素,受到国内外学者的高度重视。近年来,对ADE的机理已进行了深入的研究,主要是巨噬细胞通过FcγR介导摄取PRRSV引发ADE现象。论文综述了PRRSV的结构蛋白和ADE机理,为PRRS的进一步研究和疫苗的研发提供参考。     

Assessment of the ultrasonographic characteristics of the podotrochlear apparatus in clinically normal horses and horses with navicular syndrome

OBJECTIVE: To characterize the normal ultrasonographic appearance of the podotrochlear apparatus in horses by use of standardized measurements and identify soft tissue changes associated with navicular syndrome. DESIGN: Prospective study. ANIMALS: 7 clinically normal horses and 28 horses with navicular syndrome. PROCEDURE: The feasibility of identifying and measuring the soft tissue structures of the podotrochlear apparatus ultrasonographically via the transcuneal approach was assessed in 2 additional horses without navicular syndrome; both horses were euthanatized, and the structures identified ultrasonographically were confirmed at necropsy. Ultrasonographs were obtained in the study horses. Objective and subjective data were obtained to characterize ultrasonographic changes associated with navicular syndrome. RESULTS: Abnormalities of the flexor surface of the distal sesamoid (navicular) bone, the impar ligament, the distal digital annular ligament, deep digital flexor tendon (DDFT), and the podotrochlear (navicular) bursa were assessed via the transcuneal ultrasonographic approach. No significant differences were found between the measurements of the podotrochlear apparatus in normal horses and those with navicular syndrome; however, important subjective differences were detected ultrasonographically in horses with navicular syndrome. In horses with navicular syndrome, ultrasonographic findings were indicative of navicular bursitis, dystrophic mineralization of the DDFT and impar ligament, tendonitis and insertional tenopathy of the DDFT, desmitis of the impar ligament, and cortical changes in the flexor surface of the navicular bone. CONCLUSIONS AND CLINICAL RELEVANCE: Findings of ultrasonographic evaluation of the hoof appear to be useful in determining the cause of caudal heel pain and characterizing the components of navicular syndrome in horses.     

Hemorrhagic syndrome induced in chicken embryos by intravenous inoculation of ground chicken embryo extract

The hemorrhagic syndrome which occurred after the IV inoculation of ground embryo extract into living chicken embryos resulted from rapid activation and depletion of the clotting mechanism. The syndrome was prevented by the addition of heparin to the ground embryo inoculum. The characteristics of the hemorrhagic syndrome suggest that the phenomenon is the result of disseminated intravascular coagulation.     

Severe extrapyramidal syndrome in a dog caused by a Haloperidol (Serenase®) intoxication

Summary The case history of a one-year-old male mongrel dog intoxicated with 120 mg haloperidol is described. The dog showed a coma with a severe extrapyramidal syndrome and was treated with orphenadrine. Symptoms, occurrence, and therapy of the extrapyramidal syndrome are discussed. Emphasis is laid on the importance to differentiate this syndrome from epilepsy and other neurological disorders.     

Transient Horner's syndrome following routine intravenous injections in two horses

Horner's syndrome developed in 2 horses after routine jugular venipuncture. Signs included unilateral sweating of the face in both horses and ptosis in 1 horse. The signs resolved within 14 hours. Signs of a perivascular injection did not develop in either horse. Although Horner's syndrome has been reported after perivascular jugular injections these cases illustrate that the syndrome may develop following routine intravenous injections.     

Investigation of a syndrome of sudden death, splenomegaly, and small intestinal hemorrhage in farmed deer

A newly recognized syndrome, characterized by sudden death of farmed deer that are in good to excellent nutritional condition, with lesions of small intestinal mucosal hemorrhage and splenomegaly, is described. Other frequently observed lesions were small intestinal mucosal necrosis, abomasal hemorrhage, random hepatic necrosis, and multifocal hepatic congestion. Clostridium perfringens type A was isolated in high numbers from the intestines of many of the deer affected by the syndrome; however, the numbers were not significantly different from those of control deer. The syndrome did not appear to be related to dietary or any other specific management factors and a definitive cause of the syndrome was not identified.     

腹水综合征肉鸡氧自由基变化规律

利用自然病例，采取分组（对照组，轻度腹水综合征组和重度腹水综合征组）对比的方法，分别用硫代巴比妥酸法和羟胺法测定了肉鸡血清和主要组织（心脏、肝脏、肺脏、肾脏）丙二醛（malondialdehyde,MDA)含量和超氧化物歧化酶（superoxide dismutase,SOD)活性。结果表明，与对照组肉鸡比较，轻度腹水综合征组肉鸡血清和主要组织MDA含量降低（P＜0．05）或显著降低（P＜0．01），SOD活性升高（P＜0．05）或显著升高（P＜0．01）；而重度腹水综合征组肉鸡血清和主要组织MDA含量升高（P＜0．05）或显著升高（P＜0．01），SOD活性显著降低（P＜0．01）。间接证明了氧自由基和氧化损伤参与了肉鸡腹水综合征的病理过程，氧自由基产生水平与肉鸡腹水综合征病情的轻重有关。