狂犬病发病机理的研究进展

狂犬病是由狂犬病病毒引起的一种重要的人兽共患传染病,在人主要表现为急性、几乎不可逆转的脑脊髓炎,目前没有有效的治疗方法,病死率几乎100%。目前对狂犬病病毒感染和狂犬病发病机理的认识还很不透彻,但近年来的研究也取得了不少进展,主要涉及狂犬病病毒受体、神经细胞功能失调的原因和神经细胞凋亡机制、狂犬病病毒与机体免疫系统相互作用机制,狂暴型和麻痹型狂犬病的发病机制,这些都将为狂犬病的治疗研究起到推动作用。     

Terminal Dissemination of Rabies Virus in Selected Rat Tissues

Fifty rats were divided into 3 groups and challenged via the foot pad route with a fixed and 2 different strains of street rabies virus in order to study the dissemination of the virus and the affinity for certain tissues of the rat.

The incubation period for rats inoculated with fixed rabies is shorter than with street virus, being 5 to 7 days compared with 10 to 12 days.

Rats inoculated with the fixed strain were less aggressive and irritable than rats inoculated with street virus.

The fixed strain demonstrated a greater affinity for the tissues studied as compared to the street strains of virus.

Both the fixed and street strains revealed a low affinity for the parotid gland since no virus could be demonstrated in 14 of 20 in the fixed virus group and 27 of 30 in the street virus group.

     

狂犬病病毒致神经功能异常机制的研究进展

狂犬病是一种以神经系统感染为特征的高度致死性人兽共患病毒性传染病,危害大,但其致病机制尚不明确.狂犬病病毒(RV)G蛋白与神经细胞表面受体发生特异性结合决定其嗜神经特性,其他RV结构蛋白对RV感染具有保护和调节作用;机体感染RV后神经元结构和机体内与功能相关的部分蛋白及基因表达水平发生改变,而且RV在神经核的分布可能影...     

Rabies in the dog

The presenting signs are described of 19 dogs that were observed from the time of presentation until death. Rabies was confirmed by laboratory tests in each case. Vicious behaviour was seen in only six dogs. Paralytic signs and/or abnormal behaviour--the so-called "dumb" rabies--were more frequent. Six of the dogs had received Flury strain LEP vaccination. Intense conjunctival congestion was an important diagnostic feature.     

Rabies Symposium—III. Aspects of Rabies in Man

Abstract— The author reviews rabies in man. Reference is made to sources of infection, the course of the disease in man, prophylactic vaccination, post-infection prophylaxis and possible complications.
Résumé— –L'auteur examine la question de la rage chez l'homme: sources d'infection, évolution de la maladie, vaccination prophylactique, prophylaxie après contage et complications possibles.
Zusammenfassung— Der Verfasser bespricht das Auftreten von Tollwut bei Menschen. Er weist auf die Infektionsquellen hin, beschreibt den Verlauf der Krankheit bei Menschen, vorbeugende Impfungen, Vorbeugungsmassnahmen nach einer Infektion und mögliche Komplikationen.     

狗年里的狂犬病

农历"狗年"已经过去了.在2006年,借着天时--"狗年"、人和--"人民生活水平不断提高",我国犬业得到了长足的发展.然而,"地利"方面却不怎么配合--缘于狂犬病的"打狗风波"使得在"狗年"红红火火的犬业多多少少留下一点遗憾.     

Demonstration of Rabies Antigen in Salivary Glands of Rabies Suspected Animals

Submaxillary salivary glands from 129 rabies suspected animals were studied by the following methods: a) microscopic examination of frozen sections stained by the Fluorescent antibody technique (FAT), and b) mouse infectivity test (MIT). Flourescent antibody staining of frozen sections from the salivary glands of rabid animals proved to be a satisfactory method for demonstrating rabies antigen, when compared with the mouse infectivity test.     

Rabies

The practicing veterinarian has a key role to play in rabies control in the maintenance of protection in the companion animal populations, in the education of the pet-owning community on rabies, and in the decision-making process that accompanies human exposure to potentially rabid animals. This role encompasses far more than the routine maintenance of health and well-being in pet animal populations. Although it is important to remain diligent in the immunization of domestic pets against rabies to provide a barrier between wildlife, the main reservoir of infection, and man, it is also important to be aware of the current trends in wildlife rabies within a region. Research is currently underway to investigate methods of immunizing wildlife populations, but the effective and widespread control of rabies in these species is still a long way off; in the meantime, there will be an increasing demand for practicing veterinarians to take the lead in the control of this most fearful zoonotic disease.