犬细小病毒性肠炎的诊断与治疗

自1998年以来，犬细小病毒性肠炎在马龙县城区大面积暴发，给犬业养殖场、户造成了一定的经济损失。该病是由犬细小病毒感染犬引起的以大心肌炎、肠炎为特征的一种急性传染病。尤其对哈巴犬、肉犬、外地引进品种危害相当严重，本地品种不易传染。不同季节、各种年龄的犬均可感染。……     

犬细小病毒性肠炎的诊断与治疗

犬细小病毒性肠炎是由犬细小病毒起的一种急性传染病。临床上以呕吐 ,便血 ,严重脱水、自体中毒 ,心力衰竭或失液性休克为特征 ,发病率死亡率达 10 %～ 5 0 %。1　病犬情况　收治狼犬 8例、京巴犬 6例、腊肠犬 6例、巴哥犬 5例 ;6月龄以下的犬 2 0例 ,6至 12月龄犬 3例 ,1～ 8岁犬 2例。经治疗后死亡 6例 ,死亡率 2 4 %。2　临床症状　精神沉郁 ,饮食欲废绝 ,呕吐 ,呕吐物为食物或透明黏状胃液 ,腹泻如水或粥样 ,有特殊恶臭气味 ,便中带有粘液或伪膜呈高梁汤、西红柿酱状或酱油渣状。体温在 39.6℃以上 ,脉搏在 12 0～ 180次 /ｍｉｎ ;危重…     

犬细小病毒性肠炎的诊治

近年来,宠物业的兴起和肉用犬产业的迅猛发展,大量世界名犬引入我国。犬病也随之增多,尤其是犬细小病毒性肠炎时常发生。据我院病例资料统计,一些名犬如大丹、圣伯纳、纽波利顿、马士提夫、麦丁、斗牛、考卡等对该病较土种犬敏感。因此,在尚无有效治疗药物的情况下,形成一套标本兼治的综合疗法尤为重要。犬细小病毒性肠炎是由犬细小病毒ＣＰＶ(主要是ＣＰＶ-2型)引起的一种传染病,该病毒可引起两种类型病变,一种为心肌炎型(ＣＰＶ-1型),4～6周龄小犬多发,发病少,发病急,死亡率很高,没有多少治疗价值。一种为肠炎型。本文主要对此作以介绍和…     

犬细小病毒性肠炎的诊治

在我院小动物门诊病例中以犬细小病毒病的发病率最高，危害最大。临床表现以急性出血性肠炎和化脓性心肌炎为特征，其中又以出血性肠炎型发病较为普遍，占犬细小病毒病病例的81．25％。现简要介绍我们对本病的诊治体会和经验。     

犬细小病毒性肠炎的诊断和治疗

犬细小病毒性肠炎又叫犬传染性出血性肠炎 ,是由犬细小病毒引起的犬的烈性传染病。本病主要由病犬与健犬的直接接触或污染的饲料经消化道传染。其传播快 ,病死率高 ,对养犬业危害较大。1　临床症状病犬的主要特征是呕吐和腹泻。呕吐物早期为食物或白色的粘液 ,以后随病情的发展变为黄绿色 ,带有血丝。腹泻是本病的主要症状之一 ,发病初期的粪便为灰色或灰黄色 ,覆有大量伪膜和粘液 ,而后呈番茄汁样 ,带有血液 ,后期粪便呈酱油色 ,特别腥臭难闻。多数病犬表现为精神沉郁、食欲丧失 ,体温高达 40～ 41℃ ,很快呈现眼球凹陷 ,鼻镜干燥、龟裂 ,…     

犬细小病毒性肠炎的诊治

犬细小病毒病是由犬细小病毒2型（Canine parvovirus 2,CPV-2）导致的以急性出血性肠炎和非化脓性心肌炎为主要临床特征的具有高度接触性的烈性传染病,是犬的第二大传染性疾病。其中以肠炎型发病较为普遍,约占70%以上,对宠物犬和肉用犬的危害很大。目前治疗犬细小病毒性肠炎没有特效药物。本文根据病犬发病情况、临床症状、剖检变化和实验室手段进行综合诊断,确诊为细小病毒性肠炎后,采用了综合疗法进行治疗,获得良好效果。     

浅谈诊治犬细小病毒性肠炎

犬细小病毒性肠炎又称犬病毒性肠炎 ,是由犬细小病毒引起的一种接触性急性致死性疾病。临床特征以出血性肠炎或非化脓性心肌炎为主。几年来给宠物犬诊疗过程中 ,共诊治过犬细小病毒性肠炎 2 0多例 ,现介绍如下。1　临床症状早期 :多卧少动 ,呕吐 ,粪便稀稠、恶臭 ,呈消化不良状 ,体温 4 0℃左右。中期 :排便次数增多 ,粪便稀薄 ,常混有气泡或脱落的肠粘膜碎片 ,腥臭难闻 ,并出现血样下痢 ,频频排出少量粘液状鲜红或暗红色粪便。多数病犬出现反复呕吐 ,呕吐物为黄绿色粘液。晚期 :步态不稳 ,眼窝下陷 ,可视粘膜潮红 ,肛门失禁 ,反应迟钝 ,拉…     

犬细小病毒性肠炎的综合诊治

犬细小病毒性肠炎是由犬细小病毒引起的一种急性传染病。临床上以发热、呕吐、出血性肠炎 ,白细胞显著减少 ,严重脱水为特征。目前 ,该病在治疗上尚无特效药物。笔者近 8年来采用“抗、消、补、止、灌”综合疗法 ,共收治患犬 87例 ,治愈 79例 ,治愈率达 91% ,收到满意效果。1　临床症状多见于 3～ 5月龄犬 ,病初先呕吐后腹泻 ,粪便呈黄色或灰黄色 ,内含多量粘液和伪膜。经过 2～3ｄ后 ,粪便呈番茄汁样 ,混有血丝并有特殊的腥臭味 ,病犬精神沉郁 ,食欲废绝 ,即使饮少量水也易出现呕吐 ,体温升高达 4 0～ 4 1℃ ,渴欲增加 ,可视粘膜苍白。2　…     

Biomarkers in canine parvovirus enteritis

Canine parvovirus (CPV) enteritis has, since its emergence in 1978, remained a common and important cause of morbidity and mortality in young dogs. The continued incidence of parvoviral enteritis is partly due to the virus' capability to evolve into more virulent and resistant variants with significant local gastrointestinal and systemic inflammatory sequelae. This paper reviews current knowledge on historical-, signalment-, and clinical factors as well as several haematological-, biochemical- and endocrine parameters that can be used as diagnostic and prognostic biomarkers in CPV enteritis. These factors include season of presentation, purebred nature, bodyweight, vomiting, leukopaenia, lymphopaenia, thrombocytopaenia, hypercoagulability, hypercortisolaemia, hypothyroxinaemia, hypoalbuminaemia, elevated C-reactive protein and tumour necrosis factor, hypocholesterolaemia and hypocitrullinaemia. Factors contributing to the manifestations of CPV infection are multiple with elements of host, pathogen, secondary infections, underlying stressors and environment affecting severity and outcome. The availability of several prognosticators has made identification of patients at high risk of death and their subsequent targeted management more rewarding.     

Breed-related risk factors for canine parvovirus enteritis

Case records of 305 dogs with canine parvovirus (CPV) enteritis, seen at the Veterinary Hospital of the University of Pennsylvania from July 1, 1981 to Aug 31, 1982, were selected on the basis of admitting diagnoses or signs of diarrhea and vomiting. The case records were subdivided into 3 diagnostic categories, based on final diagnoses and laboratory test results. There were 96 dogs with definite CPV enteritis, 139 with possible CPV enteritis, and 70 with unlikely CPV enteritis. These cases were then stratified by animal's age (less than or equal to 6 months or greater than 6 months) and specific hospital service (medicine or emergency). A control group was selected from all canine case records from the Veterinary Hospital of the University of Pennsylvania for conditions other than the criteria used in selecting the case group. Approximately 2 hospital patients were selected for each CPV enteritis case by frequency matching for hospital service and age. The proportion of dogs with definite CPV enteritis that had each of the clinical signs that were studied was greater than that of dogs in the other CPV enteritis diagnostic categories. The overall survival rate for dogs with definite CPV enteritis was 64.0%; survival was not associated with any given clinical sign of disease. Odds ratios (OR) for the risk of CPV enteritis were calculated for breeds with 3 or more dogs with definite CPV enteritis. The Doberman Pinschers (OR = 3.1), Rottweilers (OR = 6.0), and English Springer Spaniels (OR = 8.1) had a significantly increased risk of CPV enteritis.(ABSTRACT TRUNCATED AT 250 WORDS)     

犬细小病毒性肠炎的诊治

犬细小病毒性肠炎又称犬传染性肠炎,是由细小病毒引起犬的一种急性热性接触性传染病,各种品种、年龄的犬都有发生,多发生于4月龄～6月龄的幼犬.该病发病迅速、来势猛、病程短,死亡率高.以发热、呕吐、腹泻、烦渴为主要临床表现.在近几年工作中,我们共治疗22例,治愈18例.     

Serum protein electrophoresis in canine parvovirus enteritis

The serum protein concentrations of dogs with confirmed canine parvovirus enteritis were determined by agarose gel electrophoresis before treatment. A significant decrease was detected in the mean concentration and percentage of albumin and gammaglobulin and the percentage of alpha-1-globulin. The mean concentration and percentage of alpha-2-globulin were significantly increased.     

Latex agglutination test for canine parvovirus

Canine parvovirus (CPV) was detected in faeces from dogs with diarrhoea by a specific slide agglutination test using latex particles coated with anti-CPV monoclonal antibody (LA-anti-CPV). The agglutination of LA-anti-CPV with CPV on a glass slide was evident macroscopically within 2 min. The sensitivity of the latex agglutination (LA) test was similar to that of the hemagglutination test. The LA test is available for the rapid diagnosis of CPV infection at an animal hospital.     

Apoptosis in feline panleukopenia and canine parvovirus enteritis

Tissue samples of cats and dogs with panleukopenia and parvovirus enteritis, respectively, were examined for the presence of viral antigen-positive cells and apoptotic cells by immunohistochemistry and by TUNEL assay (Terminal Transferase-Mediated dUTP Nick End Labelling). Compared to control animals, infected cats and dogs generally had more TUNEL-positive cells. Cell types positive for parvovirus antigen, for example digestive tract epithelial and mesenchymal cells, and lymphocytes and macrophages in lymphoid tissues were also positive for TUNEL signals. Occasionally, TUNEL signal and viral antigen were present in the same tissue areas, suggesting a direct viral trigger of apoptosis. More frequently, however, there was no complete overlap of antigen and TUNEL-positive areas. The results of this study indicate that apoptotic cell death contributes significantly to the widespread tissue damage of parvovirus infection in cats and dogs.     

犬肠炎综合症型细小病毒病的诊治

犬细小病毒病可分为肠炎综合症和心肌炎综合症两种类型。肠炎综合症型以呕吐、下痢、脱水为主要症状。我区丹阳办事处某养狗场 2 0只狼狗从 8月 2 7日至 9月 5日相继全部发生该病 ,经治疗全部治愈。1　症状2 0只狼狗体重均在 1 5～ 2 0ｋｇ之间。病犬开始时精神沉郁 ,食欲废绝、呕吐。继而出现腹泻 ,粪便呈黄色或灰黄色 ,混有大量粘液和粘膜 ,恶臭。其中有 8只狗出现血痢和呕血。病犬迅速脱水 ,眼窝下凹 ,皮肤弹性差 ,体温稍高或正常 (均在 39～ 39 6℃之间 )。心跳、呼吸正常。根据临床症状及流行情况 ,初步诊断为肠炎综合症型细小病毒病。…     

Pathogenesis of canine parvovirus enteritis: the importance of viremia

The clinical signs, hematologic changes, serum and fecal virus titers, specific antibody production and the occurrence of histologic lesions were studied in 22 nine-week-old seronegative beagle dogs inoculated by the oral and intravenous route with canine parvovirus. Approximately 30% of the dogs had clinical signs of pyrexia, depression, vomiting, and diarrhea irrespective of the route of inoculation. Events in the dogs inoculated intravenously preceded those in dogs inoculated orally by approximately two days. Only one dog died. Lymphopenia was the most consistent hematologic change. Viremia always preceded the initiation of fecal virus shedding. Viral titers in the serum and feces were significantly greater in symptomatic dogs compared to asymptomatic dogs. Termination of the plasma viremia coincided with the onset of the humoral immune response, but viremia persisted one day longer in symptomatic dogs. The severity of lymphoid tissue and intestinal infection, assessed by tissue immunofluorescence and histology, was also greater in symptomatic dogs. The severity of intestinal disease was highly correlated with the magnitude and duration of viremia.