共查询到20条相似文献,搜索用时 15 毫秒
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Cohen J 《Science (New York, N.Y.)》2004,306(5700):1276-1277
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Cohen J 《Science (New York, N.Y.)》2004,305(5690):1545-1547
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Cohen J 《Science (New York, N.Y.)》2001,291(5510):1879-1881
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Vogel G 《Science (New York, N.Y.)》2004,304(5678):1728
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Progress in vaccines against AIDS 总被引:5,自引:0,他引:5
D P Bolognesi 《Science (New York, N.Y.)》1989,246(4935):1233-1234
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Development and testing of AIDS vaccines 总被引:14,自引:0,他引:14
Recent advances in delineating the molecular biology of human immunodeficiency virus type 1 (HIV-1) have led to innovative approaches to development of a vaccine for acquired immunodeficiency syndrome (AIDS). However, the lack of understanding of mechanisms of protective immunity against HIV-1, the magnitude of genetic variation of the virus, and the lack of effective animal models for HIV-1 infection and AIDS have impeded progress. The testing of AIDS vaccines also presents challenges. These include liability concerns over vaccine-related injuries; identification of suitable populations for phase 3 efficacy studies; balancing the ethical obligation to counsel research subjects to avoid high-risk behavior with the necessity to obtain vaccine efficacy data; and the effect of vaccine-induced seroconversion on the recruiting and welfare of trial volunteers. Several candidate AIDS vaccines are nevertheless currently under development, and some are undergoing phase 1 clinical trials. Rapid progress will depend on continued scientific advancement in conjunction with maximum use of resources, open information and reagent exchange, and a spirit of international collaboration. 相似文献
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Barnes DM 《Science (New York, N.Y.)》1986,233(4769):1151
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Abdool Karim SS 《Science (New York, N.Y.)》2000,288(5474):2129
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