Corneal squamous cell carcinoma in a dog: a case report

Purpose:  To report a case of primary corneal squamous cell carcinoma (SCC) in an English Bulldog. In addition, immunohistochemistry of the corneal tissue mass was performed using a panel of antibodies. A prominent feature of the present case was the clinical history of chronic keratitis due to eyelid abnormalities.
Results:  No papillomavirus antigen was detected in section of normal or neoplastic corneal tissue. The corneal epithelial cells were positive for pancytokeratins AE1/AE3 and MNF116, and E-cadherin. The neoplastic cells in close proximity to the normal epithelial lining were positive for both pancytokeratins and E-cadherin with gradual loss of staining toward the center of the neoplastic mass. Rare neoplastic cells demonstrated positive staining for caspase 3 and a large number was strongly positive for GADD45 and p53.
Conclusion and discussion:  The observed loss of the various cytokeratins, the strong p53 expression, and low numbers of caspase 3 positive cells were suggestive that a p53 mutation may have caused this primary corneal SCC. Over-expression of the tumor-suppressor gene p53 is likely to be a consequence of ultraviolet radiation exposure. Two factors, however, may have played a role in the formation of this primary corneal SCC: chronic irritation of the corneal surface (microtrauma) and exposure to UV radiation.     

Mast cell sarcoma of the larynx in a dog: a case report

An 8-year-old, spayed, female miniature poodle was presented to the University of Pennsylvania Veterinary Hospital (UPVH) with signs of mild respiratory distress related to increasing laryngeal obstruction. The dog was found to have a unicentric mast cell sarcoma involving the larynx, with tumour infiltration of the tissues between the thyroid and arytenoid cartilages as well as subglottic narrowing. Treatment and differential diagnosis are described.     

Granular cell myoblastoma in the tongue of a dog: A case report

A granular cell myoblastoma was found in the dorsal side of the tongue of a 9‐year‐old female mongrel Pinscher. Macroscopically the tumour was white, well circumscribed, and 1½> cm in diameter. Microscopically the tumour cells were arranged in small compact nests or cords with delicate, poorly vascularized collagen bundles in between. A cinar structures were found, also a few mitotic figures were present. Cytoplasmic granules showed a positive periodic acid Schiff reaction. Ultrastructural features included indented nuclei and small‐sized vesicular cytoplasmic granules.

The histogenesis of the neoplasm remains uncertain.     

Treatment of metastatic granulosa cell tumor in a dog

A 10-year-old female dog with endocrine abnormalities and abdominal distention was found to have a functional ovarian tumor. Exploratory laparotomy and histologic examination of excised specimens led to a diagnosis of granulosa cell tumor with widespread metastasis. The prognosis appeared grave because tumor tissue remained on the liver and parietal peritoneum. An immunotherapeutic regimen was instituted and was continued for 4 months. The dog appeared to be free of disease on periodic examinations and continued to do well 2 years after diagnosis and surgery.     

Hyperadrenocorticism in a dog: A case report

A case of hyperadrenocorticism (Cushing's Syndrome) in a 7-year-old female Miniature Poodle is presented. The methods of diagnosis and treatment are also described. The case was complicated by respiratory problems associated with probable dystrophic calcification of the lungs.     

Traumatic urothorax in a dog: a case report

Pleural effusion caused by post-traumatic extravasation of urine from the abdominal cavity to the pleural cavity (urothorax) is an uncommon complication following traumatic injury. To the authors' knowledge, this is the first report of a case of traumatic urothorax in a dog presented with pleural and abdominal urine effusion. Combined urothorax and uroabdomen should be included in the differential-diagnosis list for dogs with recent trauma and a bicavitary effusion. The diagnosis can be confirmed by elevated creatinine concentrations in both effusates, compared to its serum concentration.     

Generalized osteomyelitis in a dog: a case report

Osteomyelitis of the cervical and thoracic vertebrae and ribs was diagnosed in a mature German Shepherd dog. Klebsiella pneumoniae and Clostridium sp. were isolated from a rib biopsy. Treatment with an extended course of chloramphenicol resulted in recovery, both clinically and radiographically.     

Functional islet cell tumour in the dog

A 7½-year-old male Pointer had episodes of disorientation, ataxia and collapse due to persistent hypoglycaemia. A solitary islet cell tumour was removed surgically from the tail of the pancreas. Hyperglycaemia and glycosuria persisted for 6 days after pancreatic resection but thereafter recovery was uneventful and blood glucose levels were in the normal range 3 months later. The literature on the clinical aspects of canine islet cell tumours is summarized.
Résumé. Un pointer, mâle, âgé de 7 ans ½ avait des épisodes de désorientation, d'ataxie et de collapsus dûs à une hyperglycémie persistante. On a fait l'ablation d'une tumeur solitaire des îlots de Langerhans de la queue du pancréas. L'hyperglycémie et la glycosurie ont persisté pendant 6 jours après resection pancréatique, mais après cela, la guérison s'était déroulée sans incidents et les taux de glycémie étaient de nature normale 3 mois plus tard. On a fait le résumé des exposés sur les aspects cliniques des tumeurs des îlots de Langerhans chez le clien.
Zusammenfassung. Ein 7½ Jahr alter Pointer hatte Episoden von Disorientierheit, Ataxie und Kollaps, die einer anhaltenden Hyperglykämie zuzuschreiben waren. Ein einzelner Langerhansschen Inselzellentumor wurde chirurgisch von der Cauda pancreatis entfernt. Hyperglykämie und Glykosurie hielten für 6 Tage nach pankreatischer Resektion an, aber danach war die Genesung ohne besondere Ereignisse und Blutzuckerspiegel waren 3 Monate später im normalen Bereich. Die Literatur über klinische Aspekte von Hunde-Inselzellen Tumore wurde zusammengefasst.     

Multiple cutaneous mast cell tumors in a dog: a case report and brief review

A spayed female yellow Labrador Retriever was presented to the small animal clinic at the Western College of Veterinary Medicine with an ulcerated, draining mass on the caudal aspect of the right thigh. Multiple small, hairless masses were also present on the thorax and in the flank folds. Fine-needle aspiration and cytological examination revealed well-differentiated mast cells and numerous eosinophils. A diagnosis of multiple cutaneous mast cell tumors was made. The clinical and cytological findings of this case are discussed, as well as the treatment and prognosis for mast cell tumors in general.