生长抑素抑制剂-半胱胺的促生长作用机理及应用

本文综述了半胱胺作为一种调控神经内分泌的生长抑素抑制剂的促生长作用机理及国内外学者对半胱胺促生长作用的研究成果，并就半胱胺作为饲料添加剂产品开发应用存在的一些问题进行了讨论。     

真假半胱胺盐酸盐饲料添加剂鉴别比较方法

半胱胺对动物生长抑素的特异性抑制的研究,引发了人们用半胱胺作饲料添加剂的兴趣,因此半胱胺添加在饲料中改善动物生产性能的大量研究报道屡见不鲜。我国自从上海华扩达生化科技有限公司2002年9月取得中国第一张饲料与饲料添加剂新产品证书(新饲证字(2002)01号,半胱胺盐酸盐(C     

免疫再生素对仔猪生产性能及免疫指标的研究

随着人类食品安全意识的提高,对饲料安全的要求也逐步增强,加上贸易壁垒的存在,迫切需要我们改变以往靠饲料中添加抗生素,高剂量铜、锌和砷制剂等有毒有害物质来提高动物生产性能的状况,用安全无公害的替代饲料添加剂产品提高生产性能是当前饲料工业发展的必然趋势。农业部2002年首批批准了安全、有效及无污染环境的新型饲料添加剂,其中由上海华扩达生化科技有限公司生产的半胱胺盐酸盐（CT2000）饲料添加剂（批号新饲证字（2002）01号）为第1号。免疫再生素是含有半胱胺盐酸盐的复合预混料添加剂。CT2000是β—CD-半胱胺盐酸盐的简称,指以β-环糊精（β-CD）和半胱胺盐酸盐等营养活性物质,采用超分子技术、仿生物膜多层包被技术和维持生理稳态技术经特殊工艺生产的生理代谢调控添加剂。     

半胱胺对动物机体的免疫调节及抗氧化作用的研究进展

半胱胺是一种新型的饲料添加剂，具有广泛的生物学功能。它能提高机体免疫球蛋白含量，促进淋巴细胞增殖和细胞因子产生，增强吞噬细胞的吞噬功能及改善机体的抗氧化功能。本文针对半胱胺对动物机体的免疫调节及抗氧化功能进行了阐述。     

半胱胺对美国鹧鸪生长及代谢的影响

通过饲养试验和消化试验的方法,确定美国鹧鸪饲料中半胱胺的最佳添加剂量及添加间隔时间,详细研究和分析了半胱胺对美国鹧鸪体增重、饲料转化率、能量代谢率、蛋白质沉积率的影响情况,从中筛选出了对美国鹧鸪生长及代谢的半胱胺添加剂量与添加间隔时间的最佳组合。     

半胱胺在养猪生产中的应用

半胱胺作为一种饲料添加剂,通过调节机体激素的变化,能达到提高生猪的生长性能,改善肉质,并提高饲料利用率的目的。简述了半胱胺的作用机理以及其在养猪生产中的应用。     

饲料中添加半胱胺对育肥羊增重效果的影响

半胱胺（简称CS）是一种新型饲料添加剂，可以降低大鼠外周和中枢神经生长抑素水平，提高血浆生长激素和降低生长抑素水平，能有效提高饲料利用率、改善家畜的肉质和品质。     

农业部公布首批新饲料添加剂

农业部第２１９号公告通知，根据《饲料和饲料添加剂管理条例》和《新饲料和新饲料添加剂管理办法》的规定，经全国饲料评审委员会审定，批准上海华扩达生化技术研究开发有限公司申请的复合半胱胺盐酸盐（CT２０００），甘肃大圣生物技术有限公司、甘肃大圣生物工程研究所申请的保加利亚乳杆菌添加剂，中国农业科学院畜牧研究所申请的吡啶羧酸铬，福建莆田市神州生物有限公司申请的小球藻粉４个产品作为饲料添加剂在中华人民共和国境内生产、经营和使用，并发给新饲料添加剂证书。农业部公布首批新饲料添加剂     

半胱胺和大豆黄酮对东北细毛羊生长性能和羊毛品质的影响

半胱胺（cysteamine，简称CS），相当于半胱氨酸的脱羧产物，具备未来绿色饲料添加剂所要求的高效性和安全性。研究结果表明，半胱胺可以提高垂体分泌的生长激素（GH），与受体结合后诱导肝细胞产生IGF—Ⅰ，通过IGF—Ⅰ介导生长激素发挥多种生理功能，间接作用于靶细胞。在肉羊精饲料中添加半胱胺可以提高日增重，同时也能提高羊肉品质。     

20.稳定型半胱胺盐酸盐饲料添加剂的研制及其作用机理

南京农业大学与本公司共同研发的稳定型半胱胺盐酸盐添加剂是具有自主知识产权、安全、有效、不污染环境、适用性广的新型饲料添加剂.     

商会自治的基石——商会自治规范研究

在现代法律秩序中,商会自治规范是制定法的基础和必要的补充,甚至在某些方面替代了制定法;商会自治规范主要包括商会组织规范、行为规范、惩罚规范以及争端解决规范等;其效力仅及于其内部成员;商会自治规范和制定法之间存在冲突,但也存在整合的基础。     

癸氧喹酯干混悬剂含量测定的改进

采用高效液相色谱法测定癸氧喹酯干混悬剂的含量,在2-250μg/mL范围内,峰面积的常用对数与进样量浓度的常用对数呈良好的线性关系,R^2=1(n=5),平均回收率为99.24%~99.51%,RSD在0.05%~0.28%。此方法分析时间短,样品前处理简便、定量结果准确,重现性好,结果满意,为其质量控制提供了依据。     

猪毛色遗传的研究进展

本文概述了猪的毛色类型、猪的毛色遗传模式,着重综述了猪毛色基因分子基础的研究进展,指出存在问题并就未来发展方向做了思考。     

Comparison of 2 methods of centesis of the bursa of the biceps brachii tendon of horses

REASONS FOR PERFORMING STUDY: Centesis of the bicipital bursa using an 8.9 cm long spinal needle has been reported but the alternative of employing a 3.8 cm long hypodermic needle requires validation. OBJECTIVE: To compare the efficacy of 2 different methods of centesis of the bicipital bursa and to evaluate the usefulness of ultrasonographic imaging to determine the location of solution administered when centesis of the bursa is attempted. METHODS: For Trial 1, 6 clinicians, who had no previous experience of centesis of the bicipital bursa, attempted to inject a solution composed of an aqueous radiopaque contrast medium and physiological saline solution (PSS) into the bicipital bursae of 2/12 horses using the previously described distal approach to inject one bursa and a proximal approach to inject the contralateral bursa. The bicipital tendon and bursa were examined ultrasonographically before and after injection; and both shoulders were examined radiographically to identify the location of the medium. In Trial 2, another 6 clinicians, also with no previous experience of centesis, repeated Trial 1, using 6 horses, but the radiopaque contrast medium was mixed with air instead of PSS. RESULTS: Accuracy of centesis using the proximal approach was 39% and that of the distal approach 28%. Ultrasonographic examination of the shoulder allowed the location of solution and air to be accurately predicted in all 12 shoulders examined. CONCLUSIONS: Clinicians who have had no previous experience performing centesis of the bicipital bursa are unlikely to be successful in centesis using either approach. Radiographic examination after injecting a radiopaque contrast medium may be necessary to assess the success of centesis especially if bursal fluid is not obtained during centesis. Injecting air along with the radiopaque contrast medium provides more accurate ultrasonographic confirmation of centesis and better radiographic definition than does injection without air.     

不同样本商品蜂蜜中硒含量的测定

用硝酸和高氯酸消化蜂蜜,使硒游离出来,在微酸性环境下,硒和2,3-二氨基萘(DAN)生成有较强荧光的物质,用环己烷萃取,在激发波长378nm,荧光波长518nm处测定其荧光强度。蜂蜜中硒含量范围:0.10～0.82μg/g。表明:蜂蜜应视为天然富硒营养品。     

乳酸杆菌益生作用机制的研究进展

乳酸杆菌作为益生菌广泛用于人和动物。本文综述了乳酸杆菌改善宿主健康的机制。乳酸杆菌可通过产生抗菌物质如乳酸、过氧化氢、细菌素,或者通过竞争营养或肠道黏附位点来抑制致病菌;通过诱导黏附素的分泌或阻止细胞凋亡而增强肠道的屏障功能,从而保护肠道。文章重点讨论了乳酸杆菌表面成分（表面蛋白、脂磷壁酸和肽聚糖）与肠道受体（Ｃ型凝集素受体、Ｔｏｌｌ样受体和 Ｎｏｄ样受体）,阐述了他们结合后启动免疫调节信号,调控肠道免疫功能以发挥改善健康作用的机制。     

中华人民共和国农业部公告 第267号

为贯彻落实《兽药生产质量管理规范》(简称《兽药GMP》),进一步推动兽药GMP实施进程,我部制定了《兽药生产质量管理规范检查验收办法》,现予公告。本公告自2003年6月1日起施行。附件:兽药生产质量管理规范检查验收办法二○○三年四月十日第一章 总则 第一条 为推动《兽药生产质量管理规范》(以下简称兽药GMP)的实施,规范兽药GMP检查验收工作,制定本办法。 第二条 农业部负责全国兽药GMP管理和检查验收工作;负责制修订兽药GMP检查验收管理规定;负责兽药GMP检查员队伍建设和监督管理工作,负责国际兽药贸易中GMP互认工作。 …     

鸡败血支原体垂直传播模式及其阻断方法

以国际标准强毒Ｒ株人工感染非免疫产蛋鸡,定时扑杀,分别从鼻窦、眶下孔、气管、肺、气囊、卵巢和输卵管分离ＭＧ,并收集感染鸡所产蛋分离ＭＧ。结果表明,人工感染４８小时后上、下呼吸道及肺已被全面感染,９６小时气囊已被感染,１２０小时输卵管已能分离到ＭＧ,卵巢始终分离不到ＭＧ。人工感染鸡自１４４小时便能在其所产蛋中分离出ＭＧ。药物治疗能在７２小时内消除感染,油乳剂苗则需２４天后逐渐降低蛋内ＭＧ分离率,药物卵内注射、种蛋药浴、高温处理均能杀死卵内ＭＧ,但以研制的种蛋浸泡剂药浴效果为最好。     

Effects of size of ingestively masticated fragments of plant tissues on kinetics of digestion of NDF

Ingestively masticated fragments were collected and sized via sieving. Different sizes of esophageal masticate and ruminal digesta fragments, and ground fragments of larger masticated pieces were incubated in vitro, and undigested NDF remaining at intervals of up to 168 h of incubation was determined. The ruminal age-dependent time delay (tau) for onset of digestion of NDF was positively correlated (P < 0.004) with the mean sieve aperture estimated to retain 50% of the fragments between successive sieve apertures (MRA). Degradation rate of potentially degradable NDF (PDF) and level of indigestible NDF were not related (P > 0.10) to MRA of masticated and ground fragments. Estimates of tau were positively related to MRA, with slopes of bermudagrass < corn silage < ruminal fragments of corn silage. It was concluded that fragment size-, and consequently, ruminal age-dependent onset of PDF degradation of a mixture of different fragment sizes results in an age-dependent rate of degradation of the more rapidly degrading of two subentities of PDF. Models are proposed that assume a tau before onset of simultaneous degradation of PDF from two pools characterized as having gamma-modeled age-dependency and age-constant rates. The ruminal age-dependent pool seems to be associated with the faster-degrading pool, and its rate parameter increases with range in MRA in the population of fragments. Conceptually, the ruminal age-dependent rate parameter for PDF degradation seems to represent a composite of several effects: 1) effects of the size-dependent tau; 2) range in MRA of the population of ingestively masticated fragments; and 3) subentities of PDF that degrade via more rapid age-dependent rates compared with subentities of PDF that degrade via age-constant rates. The estimated fractional rates of ruminative comminution of ingestively masticated fragments (0.060 to 0.075/h) were of a magnitude similar to the mean fractional rates of PDF digestion (0.030 to 0.085/h), which implies that ruminative comminution may be first-limiting to fractional rate of PDF digestion. The in vivo roles of ingestive and ruminative mastication of fragments on PDF degradation must be considered in any kinetic system for estimating PDF digestion in the rumen. These results and others in the literature suggest that the rate of surface area exposure rather than intrinsic chemical attributes of PDF may be first-limiting to degradation rate of PDF in vivo.