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复方氟苯尼考可溶性粉对人工诱发雏鸡大肠杆菌病的疗效试验 总被引:1,自引:0,他引:1
氟苯尼考是动物专用的氯霉素类药物,强力霉素则是常用的半合成四环素类抗生素,二者对致病的革兰氏阳性菌、革兰氏阴性菌及支原体等均有良好的抑杀作用,但抗菌谱侧重点,临床细菌耐药情况也不同。复方氟苯尼考可溶性粉是以二者为主组成的复方制剂。本文在联合药敏试验基础上,用雏鸡人工感染大肠杆菌病的方法,评价其临床疗效,为实际临床推广使用提供依据。 相似文献
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本试验利用人工诱发猪气喘病的动物模型,设计高、中、低剂量(剂量分别为400、200、100mg/kg饲料)的替米考星治疗试验组和阳性对照组(不用药、强毒感染)、阴性对照组(不用药不感染),通过观察、检测试验猪在试验前后的增重变化和试验治疗后肺部病变率来判定替米考星的治疗效果。结果成功建立了人工诱发的猪气喘病模型,替米考星高、中剂量组的治疗效果显著,在增重和肺部病变率方面和阴性对照组差异不显著(P>0.05),而替米考星低剂量组的治疗效果略差,在增重方面和阴性对照组差异不显著(P>0.05),但在肺部病变率方面和阴性对照组差异显著(P<0.05)。这些结果为临床合理地使用替米考星防治猪气喘病提供了科学依据。 相似文献
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咳喘停注射液对猪气喘病的疗效试验 总被引:1,自引:0,他引:1
采用试管2倍稀释法测定咳喘停注射液对猪肺炎支原体的最小菌浓度(MIC)和最低杀菌浓度(MBC),并进行了咳喘停注射液的临床疗效试验,结果表明:该制剂对猪肺炎支原体的最小抑菌浓度和最低杀菌浓度分别为0.04ug/mL和0.081.1g/mL;该制剂高、中、低剂量对猪气喘病的总有效率分别为100%、100%、95%,与硫酸卡那霉素相比较差异极显著(P〈0.01),与青霉素加链霉素相比较差异亦显著(P〈0.05)。 相似文献
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采用试管二倍稀释法测定咳喘停注射液对猪肺炎支原体的最小菌浓度(MIC)和最低杀菌浓度(MBC),并进行了咳停注射液的临床疗效试验,结果表明:该制剂对猪肺炎支原体的最小抑菌浓度和最低杀菌浓度分别为0 04μg/mL和0 08μg/mL;该制剂高、中、低剂量对猪气喘病的总有效率分别为100%、100%、95%,与硫酸卡那霉素相比较差异极显著(P<0 01),与青霉素加链霉素相比较差异亦显著(P<0 05)。 相似文献
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复方氟苯尼考口服液对人工诱发鸡大肠杆菌病的疗效试验 总被引:2,自引:0,他引:2
采用 5%复方氟苯尼考口服液对人工诱发的鸡大肠杆菌病进行治疗试验。结果表明 ,5%复方氟苯尼考口服液在剂量为 0 .6 ,0 .3 ,0 .1 5m L/ L给药时 ,能有效的控制鸡大肠杆菌感染 ,缓解症状 ,降低大肠杆菌感染鸡只的发病率和死亡率 ,并在一定程度上减少成活鸡的体重下降 ,效果优于单方的氟苯尼考口服液 ,在临床上有一定的实用价值 ,值得推广使用。临床应用治疗鸡大肠杆菌病推荐剂量为每升水 0 .3 m L。 相似文献
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通过复方泰乐菌素注射液对仔猪气喘病例的治疗来评价复方泰乐菌素注射液对防治猪气喘病的应用效果,为临床使用提供依据。结果表明:复方泰乐菌素注射液治疗猪气喘病的效果明显,推荐剂量按体重0.1mL/kg肌肉注射。 相似文献
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Tomoyuki Shimazu Liushiqi Borjigin Yuki Katayama Meihua Li Takumi Satoh Kouichi Watanabe Haruki Kitazawa Sang‐gun Roh Hisashi Aso Kazuo Katoh Yoshihito Suda Akiko Sakuma Mituru Nakajo Keiichi Suzuki 《Animal Science Journal》2013,84(10):683-692
This study was conducted to evaluate immunological changes in peripheral blood leukocytes in pigs that were genetically selected for their improved resistance to mycoplasmal pneumonia of swine (MPS), using MPS vaccine as an antigen. Twelve castrated MPS‐selected Landrace pigs were compared with the same number of pigs from a nonselected line by using a time‐course analysis at the hematological level. After the second sensitization with MPS vaccine, the percentages of B cells, CD4+ T cells, and natural killer (NK) cells in total leukocytes were lower in the selected line than in the nonselected line, whereas the percentage of granulocytes in total leukocytes increased in the MPS‐selected line. We also assessed the proliferative ability of peripheral blood mononuclear cells (PBMCs) stimulated with Mycoplasma hyopneumoniae, lipopolysaccharide or concanavalin A, and found that although the proliferative ability of the PBMC was not different between the two lines at a steady state, the nonselected line showed a significantly higher proliferative ability after sensitization with MPS vaccine than the selected line regardless of antigens used. These results thus indicate that the selection of pigs on the basis of MPS resistance changes their immunophenotype, and would give us beneficial information for the prevention of MPS infection. 相似文献
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Pathogenesis of mycoplasmal pneumonia in swine 总被引:14,自引:0,他引:14
C W Livingston E L Stair N R Underdahl C A Mebus 《American journal of veterinary research》1972,33(11):2249-2258
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猪地方流行性肺炎,又称为猪支原体性肺炎,俗称猪气喘病,是由猪肺炎支原体所引起的一种慢性接触性呼吸道传染病,临床上主要以咳嗽和气喘为特征性症状,发病率高,死亡率低,病猪生长发育迟缓,饲料转化率低,生猪抵抗力下降,极易并发其他呼吸道疾病。近年来,本病的发生在当地呈上升态势,是养猪生产中极为顽固的呼吸道传染病。一、病原体与流行特点:1、猪地方流行性肺炎的病原体是由猪肺炎支原引起,该病原体是一种无细胞壁的多形性微生物。存在于病猪的呼吸器官内,随咳嗽、喷嚏等分泌物排出体外,污染猪舍、饲具和用具。通过空气、接触、环境污染等… 相似文献
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Tomoyuki Shimazu Liushiqi Borjigin Yuki Katayama Meihua Li Takumi Satoh Kouichi Watanabe Haruki Kitazawa Sang‐gun Roh Hisashi Aso Katoh Kazuo Yoshihito Suda Akiko Sakuma Mituru Nakajo Keiichi Suzuki 《Animal Science Journal》2014,85(4):365-373
We recently developed a Landrace line that is resistant to mycoplasmal pneumonia of swine (MPS) infection by genetic selection for five generations, and we reported that the immunophenotype of this line is different from that of the non‐selected line in terms of changes in peripheral blood leukocyte population after MPS vaccination. This study followed up previous findings demonstrating changes in soluble factors in blood, namely, hormones, Mycoplasma hyopneumoniae‐specific immunoglobulin G (IgG), and cytokines. These two lines were injected with MPS vaccine on days ?7 and 0 after blood sampling on those days, and blood samples were collected on days ?14, ?7, 0, 2, 7 and 14. We found changes in the levels of many hormones and cytokines in both lines. However, we found that only growth hormone (GH) and interferon (IFN)‐γ levels were statistically different between these two lines. GH concentration was reduced (day 0) and IFN‐γ concentration was increased (day 14) in the MPS‐selected line compared with the non‐selected line, despite unchanged IFN‐γ messenger RNA expression in blood cells. Although detailed mechanisms underlying these phenotypes remain unsolved, these traits would be useful to improve MPS resistance in pig production and provide an insight into MPS infection. 相似文献
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Immunogenic properties and mycoplasmal pneumonia of swine (MPS) lung lesions in Large White pigs selected for higher peripheral blood immune capacity 下载免费PDF全文
Liushiqi Borjigin Tomoyuki Shimazu Yuki Katayama Meihua Li Takumi Satoh Kouichi Watanabe Haruki Kitazawa Sang‐gun Roh Hisashi Aso Kazuo Katoh Takafumi Uchida Yoshihito Suda Akiko Sakuma Mituru Nakajo Keiichi Suzuki 《Animal Science Journal》2016,87(5):638-645
Immunogenic properties and mycoplasmal pneumonia of swine (MPS) lung lesions were compared between the immunity‐selected Large White line and the non‐selected Large White line. The selected Large White line showed a higher level of pulmonary MPS lesions compared with the non‐selected Large White line. Subsequent to vaccination, the percentage of natural killer cells and T cells (CD3+CD4+CD8‐ and CD3+CD4?CD8+ T cells) were significantly increased in the non‐selected line but remained unchanged in the immunity‐selected Large White line. Secretion of Mycoplasma hyopneumoniae vaccine‐specific immunoblogulin G and phagocyte activity in peripheral blood were significantly higher in the immunity‐selected Large White line than in the non‐selected line. Expression of interleukin (IL)‐4 and IL‐6 messenger RNA in hilar lymph nodes was significantly lower in the immunity‐selected Large White line than in the non‐selected line. However, expression of IL‐10 in all immune tissues was significantly higher in the immunity‐selected Large White line. These results suggest that the selection for high immunity was not effective in increasing resistance to MPS lung lesions. 相似文献
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Effects of mycoplasmal pneumonia of swine (MPS) lung lesion‐selected Landrace pigs on MPS resistance and immune competence in three‐way crossbred pigs 下载免费PDF全文
Liushiqi Borjigin Tomoyuki Shimazu Yuki Katayama Kouichi Watanabe Haruki Kitazawa Sang‐gun Roh Hisashi Aso Kazuo Katoh Masahiro Satoh Yoshihito Suda Akiko Sakuma Mituru Nakajo Keiichi Suzuki 《Animal Science Journal》2017,88(4):575-585
To clarify the genetic influence of mycoplasmal pneumonia of swine (MPS) lesion‐selected Landrace (La) on MPS resistance and immune characteristics in three‐way crossbred pigs (LaWaDa), the LaWaDa pigs were compared with the non‐selected crossbred (LbWbDb) and purebred (La) pigs. The MPS lesion score in the three lines was as follows: La line < LaWaDa line < LbWbDb line, with significant differences among the lines. The proportions of myeloid cells and T cells were lower and higher, respectively, in the LaWaDa pigs compared with those in the other two lines. Messenger RNA (mRNA) expression of interleukin (IL)‐6, IL‐10, transforming growth factor‐β, and interferon‐γ in peripheral blood was significantly increased after vaccination in the La and LaWaDa lines. IL‐4 mRNA expression in the LaWaDa line was intermediate to the La and LbWbDb lines. Furthermore, principal component analysis for immune traits and MPS lesions was executed to clarify the characteristics of each pig line. These findings suggest that the immune responses in the three pig lines are genetically distinct and that MPS resistance and some immunity characteristics from the La line were transmitted to the three‐way crossbred pigs. 相似文献
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1999年 1 1月以来 ,北京郊区某规模化养猪场发生以咳嗽、气喘、体温升高、消瘦为主要症状的疾病。该病的发病率、死亡率均较高 ,经病理剖检、细菌学及血清学检验诊断为支原体和巴氏杆菌混合感染 ,临床采取组织灭活苗紧急接种 ,结合泰乐菌素、支原净等药物治疗使病情得到了有效的控制。1 发病情况 发病猪群在 35~ 60日龄之间 ,病猪气喘、咳嗽、呼吸困难 ,呈腹式呼吸 ,口鼻流出泡沫样液体 ,尤以清晨和夜间症状严重 ,病猪耳根、腹侧和四肢内侧的皮肤出现红斑 ,可视粘膜发绀 ,病初食欲正常 ,随着病情的发展食欲减退至废绝 ,某些育肥猪往往不… 相似文献