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A 7-year-old, spayed female, Wheaton terrier dog was icteric, lethargic, and anorexic with increased activity of hepatocellular and cholestatic liver enzymes and an extreme hyperbilirubinemia level of 609 micromol/L (reference interval: 1.0-4.0 micromol/L). Necropsy findings included profound icterus and red and yellow mottling of the liver. Yellow discoloration of the thalamic and subthalamic nuclei was detected on subgross examination of the formalin-fixed brain. Histologic examination of the brain revealed neuronal necrosis within the discolored nuclei, necrosis of Purkinje cells, and Alzheimer type II astrocytes in the cerebrocortical gray matter and in the nuclei, with gross discoloration. Histologic examination of the liver revealed extensive necrosis in a periacinar-to-bridging pattern and often extending to portal triads. A case of naturally occurring kernicterus in an adult dog secondary to extreme hyperbilirubinemia resulting from fulminant hepatic failure is reported. The few reports of this disease in domestic species involved neonates, namely 1 foal and 1 kitten. 相似文献
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Abstract Extract Hypertrophic osteodystrophy is a skeletal disease of growing dogs (Meier et al., 1957), usually affecting the larger breeds. There is subperiosteal haemorrhage followed by periosteal hyperplasia and calcification. Low levels of ascorbic acid in the blood have been associated with the syndrome. Differential diagnosis includes trauma, panosteitis, systemic viral or bacterial infection with joint involvement, secondary nutritional hyperparathyroidism, and pulmonary osteoarthropathy (Dueland, 1974). 相似文献
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A case of an adult dog with multifocal, progressive neurological signs caused by Neospora caninum is reported. Pathological studies showed cerebellar lesions due to the parasite, which was also present in other parts of the nervous system and muscle. Cerebellar atrophy related to Neospora infection has been rarely reported in veterinary medicine, and has been shown to affect ruminants and dogs. The cerebellar involvement and the age of the present dog make this case uncommon. 相似文献
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Gastro-oesophageal intussusception in an adult dog 总被引:1,自引:0,他引:1
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Intestinal malabsorption and cryptosporidiosis in an adult dog 总被引:2,自引:0,他引:2
C E Greene G J Jacobs D Prickett 《Journal of the American Veterinary Medical Association》1990,197(3):365-367
Chronic intestinal cryptosporidiosis was diagnosed as the cause of chronic diarrhea and weight loss in an adult dog without obvious signs of immunosuppression. Results of tests for digestive function suggested that the dog had impaired intestinal absorption or bacterial overgrowth. The nutrient malabsorption might have resulted in or have been caused by the cryptosporidiosis. Temporary clinical improvement without reduction in fecal oocyst concentration was noticed following treatment with clindamycin. The dog was euthanatized. At necropsy, the dog was found to have chronic lymphoplasmacytic enteritis and cryptosporidiosis. A veterinary student that worked in the ward where the dog was kept developed cryptosporidal diarrhea. 相似文献
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K S Schulz J T Payne E Aronson 《Journal of the American Veterinary Medical Association》1991,199(9):1170-1173
Escherichia coli bacteremia was detected in a dog that had hypertrophic osteodystrophy. The dog improved after treatment with cephalothin sodium, iv fluid therapy, and cage rest. The cause of hypertrophic dystrophy has not been determined, although an infectious cause has been suggested. Dogs that are suspected of having hypertrophic osteodystrophy should be monitored closely for evidence of septicemia, and the administration of prophylactic antibiotics may be advisable. 相似文献
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Holmberg TA Vernau W Melli AC Conrad PA 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2006,35(2):235-238
A 7-year-old, male neutered Rhodesian Ridgeback dog was referred to the University of California-Davis Veterinary Medical Teaching Hospital with a 4-month history of peritonitis and episodic abdominal discomfort, lethargy, and weakness. Marked abdominal distension with a prominent fluid wave was noted on physical examination. Cytologic analysis of the abdominal fluid indicated a septic exudate with mixed bacteria and many protozoal zoites. Differentials for the identity of the protozoal zoites included Toxoplasma gondii, Sarcocystis neurona, and Neospora caninum. Indirect latex agglutination antigen testing, standard indirect fluorescent antibody testing, and PCR analysis were performed to identify the zoites. The dog's serum antibody titer for N caninum tachyzoites was 1:20,480, known polysera to N caninum reacted against zoites in the abdominal fluid, and PCR analysis of the abdominal fluid was positive for the presence of a known gene of N caninum. Based on the morphologic, immunologic, and molecular findings, the zoites were identified as N caninum. It remains unclear how the tachyzoites gained access to the peritoneal cavity. To the authors' knowledge, there are no reports of free N caninum in abdominal fluid of any species. 相似文献
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K R Boschert N Allison T L Allen R B Griffin 《Journal of the American Veterinary Medical Association》1988,192(6):791-792
Bacillus piliformis infection (Tyzzer's disease) was diagnosed in a 7-year-old spayed dog that had icterus, hepatosplenomegaly, and polyuria. Hematology revealed regenerative anemia, leukocytosis, lymphopenia, and thrombocytopenia. Serum chemical analyses indicated hypocalcemia, high alkaline phosphatase activity, hypoalbuminemia, and hyperglobulinemia. At necropsy, the liver was stippled with gray-white focal lesions. Microscopically, the liver lesions were necrotic and inflammatory. Warthin-Starry-stained sections revealed rod-shaped bacteria in crisscrossing patterns characteristic of B piliformis. This dog was considerably older than dogs previously reported to have Tyzzer's disease and had a concurrent systemic hyphomycosis, suggesting it had been immunocompromised. 相似文献
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A 20-month-old, entire male boxer dog was presented with lethargy and intermittent shifting limb lameness. Diagnostic tests revealed aortic valve vegetations suggestive of infective endocarditis causing severe aortic outflow obstruction, and hypertrophic osteopathy of all four limbs. The dog was treated symptomatically and euthanased four days later. The association of infective endocarditis and hypertrophic osteopathy has been poorly documented in the veterinary literature. The pathogenesis of hypertrophic osteopathy is unknown; however, four theories have been put forth to explain this disease: pulmonary shunting, vagal nerve stimulation, humoral substances produced by neoplastic cells and megakaryocyte/platelet clump hypothesis. 相似文献
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An 8-year-old Labrador retriever was diagnosed with a unilateral malignant nephroblastoma and hypertrophic osteopathy. The histopathologically malignant tumor was confined to the renal capsule, but the sarcomatous component was anaplastic, resulting in its classification as a Stage I tumor with unfavorable histopathology. The dog was treated with unilateral nephrectomy, vincristine, and doxorubicin. This dog has remained disease free for >25 months. Reported treatments of renal nephroblastoma in the dog have not described disease-free intervals of >8 months. 相似文献
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A 7-year-old neutered female English Setter presented with syncope, anemia, and weight loss. Clinical examination revealed a systolic murmur and echocardiography demonstrated a mass on the pulmonic valve. Postmortem examination confirmed the presence of a pulmonic valve mass that extended along the pulmonary trunk and into the left pulmonary artery. Multiple pale nodules were observed in the right lung. Microscopic examinations of the pulmonary artery mass and the lung nodules revealed a pleomorphic population of spindle cells often arranged in broad bands containing strap-like nuclei and eosinophilic cytoplasm devoid of cross striations. The neoplastic cells expressed vimentin and alpha-smooth muscle actin but did not express desmin, CD31, factor VIII, or S100. The presentation, histological features, immunocytochemical profiles, and behavior of this tumor were indicative of a primary pulmonary artery leiomyosarcoma with lung metastasis. 相似文献
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A case of oesophageal intussusception of the stomach in a 9–year–old 351b cross–bred male dog is reported. This condition has previously been recorded only in young animals, often in the first few weeks of life. The history and post mortem findings are described, the aetiology is discussed and the literature briefly reviewed. 相似文献
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A cutaneous melanocytoma-acanthoma was diagnosed in a 7-year-old intact female mixed breed dog. Grossly, this tumor was a solitary and darkly pigmented nodule located in the face. Histologically, the lesions consisted of melanocytic and epithelial tumor cells. The melanocytic component consisted predominantly of large round-to-polygonal and heavily pigmented melanocytic cells arranged in nests and clusters. These melanocytes were positive for S-100 and vimentin. The epithelial component was composed of multiple small horn cysts with concentric keratin within the cyst lumina and was positive for cytokeratin. Atypism was not observed in both components. Since this tumor has previously been reported in only two dogs, this report adds to the data that will help determing predilections of age, breed, sex and site. 相似文献
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Objective: To report surgical planning, technique, and outcome of stabilization surgery in an adult dog with occipitoatlantoaxial malformation (OAAM). Study Design: Clinical report. Animal: A 19‐month‐old, 25.5 kg, male castrated, Shiba Inu. Methods: Radiographic and magnetic resonance imaging were used to identify and characterize OAAM. Using a ventral approach to the cranial cervical region 2 cortical bone screws were inserted from the axis into the malformed atlas and occiput. Results: Ambulation was conserved postoperatively. Within 4 weeks, neurologic examination was mostly normal except for decreased proprioception in the right pelvic limb. At 9 months, the dog retained an extended neck posture, but had no neurologic abnormalities. Conclusion: OAAM should be considered as a differential diagnosis in an adult dog with cervical myelopathy. Surgical fixation with cortical bone screws using a ventral approach can be successful. 相似文献
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Sandra P. Tou DVM Bruce W. Keene DVM Piers C.A. Barker MD 《Journal of Veterinary Cardiology》2011,13(4):271-275
Pulmonary atresia and ventricular septal defect (PA-VSD) was diagnosed in a 2-year-old castrated male Terrier mix. Transthoracic echocardiography identified a large ventricular septal defect, overriding aorta and severe right ventricular hypertrophy. A main pulmonary artery could not be identified, consistent with pulmonary atresia or persistent truncus arteriosus. Transesophageal echocardiography and angiography confirmed PA-VSD with aortopulmonary collateral circulation arising from the descending thoracic aorta. This case report describes the antemortem diagnosis of the rare congenital defect PA-VSD in an adult dog. 相似文献
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Kayla M. Perry DVM Brittany D. Enders DVM DACVECC Tatiane Terumi Negrão Watanabe DVM MS PhD DACVP 《Journal of Veterinary Emergency and Critical Care》2023,33(2):257-262