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Grant RM Hamer D Hope T Johnston R Lange J Lederman MM Lieberman J Miller CJ Moore JP Mosier DE Richman DD Schooley RT Springer MS Veazey RS Wainberg MA 《Science (New York, N.Y.)》2008,321(5888):532-534
After disappointing results from all efficacy trials conducted to date, the field of microbicides research now faces substantial challenges. Poor coordination among interested parties and the choice of nonvalidated scientific targets for phase III studies have hampered progress and created mistrust about the use of microbicides as a method to prevent HIV-1 sexual transmission. Although new promising strategies are available, there will need to be serious reappraisals of how decisions are made to advance the next generations of candidates into clinical trials, and the use of appropriate animal models in this process will be critical. 相似文献
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Sibley DA Bevier LR Patten MA Elphick CS 《Science (New York, N.Y.)》2007,315(5818):1495-6; author reply 1495-6
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