Panniculitis associated with pancreatic necrosis in a dog

A seven-year-old male labrador cross was presented with lethargy, pyrexia and multiple nonpruritic draining skin lesions. The dog had sterile nodular panniculitis which, at necropsy, was found to be associated with a bile duct carcinoma leading to pancreatic necrosis.     

A case of spontaneous myocardial necrosis and cerebral ischemic lesions in a laboratory beagle dog

A beagle dog treated with saline as a control animal in a preclinical study was euthanized due to sudden systemic deterioration. On histopathological examination, contraction band necrosis of myocardial cells was observed widely in the left ventricular wall, including the papillary muscle and apex, and observed slightly in the ventricular septum and left atrium. In the brain, necrosis was observed in neurons and glia of the cerebral cortex, hippocampal pyramidal cells, glial cells of the rostral commissure and Purkinje cells of the cerebellar vermis. It is highly probable that the marked systemic deterioration was caused by cardiac dysfunction due to the spontaneous contraction band necrosis of the myocardial cells, although the pathogenesis of the myocardial lesions remains unclear. Given the distribution of neuronal necrosis in the brain, it is likely that these lesions resulted from the ischemia responsible for acute cardiac failure.     

A case of neurofibromatosis in the dog

A 6-month-old male Great Dane had suffered from regular bouts of vomiting ever since it was a pup. Pathological investigation disclosed tumours, classified as neurofibromatosis, in nerves of the neck region and in the heart.     

Diagnosis of Amanita toxicosis in a dog with acute hepatic necrosis.

Poisoning with amanitin-containing hepatotoxic mushrooms demands extensive efforts from clinicians, toxicologists, and pathologists. Presumptive diagnoses are established by positive identification of the suspect mushroom along with the occurrence of consistent clinical signs. If the animal dies, hepatic lesions may suggest exposure to amanitin-containing mushrooms; however, lesions are nonspecific. A 15-week-old female Dachshund was presented to the referring veterinarian for acute onset of lethargy that quickly progressed to sternal recumbency. Despite supportive care, the dog remained lethargic and died approximately 12 hours after initial presentation. A pale tan liver was noted at necropsy. Microscopically, the liver showed panlobular coagulative necrosis of hepatocytes. A presumptive diagnosis of amanitin poisoning was based on suspect history of exposure to mushrooms, clinical signs, and pathologic findings. Exposure to amanitin was confirmed through detection of alpha-amanitin in the liver by liquid chromatography/mass spectrometry. The objective of this case report is to illustrate the essential components to a successful diagnostic work-up of a suspect case of hepatotoxic mushroom poisoning. Although hepatotoxic mushroom poisoning has been documented in dogs before, confirmatory techniques for biologic specimens have not been used previously in diagnostic investigations.     

A case of tracheal collapse in the dog.

An eight-year-old male Yorkshire terrier which had had a cough for two years was presented and a diagnosis of tracheal collapse was made after examination with a bronchoscope. It was decided to try to correct the tracheal defect by plication. Two weeks after the operation the dog was examined under general anaesthesia. Although traction had exposed a part of the thoracic trachea it was not sufficient in this case to achieve a complete repair. In view of a grave prognosis, the dog was destroyed.     

1例罕见的犬网状细胞肉瘤

网状细胞肉瘤又称网状细胞增殖症，是淋巴网状系统的一种肿瘤。本病多见于鸡，猫也曾有过报道，国内在犬还未见报道，现介绍如下。１　病史１只２岁北京狮子犬，在包皮表面有红枣大小的肿块，经手术切除后，送病理室作组织病理学和电镜检查。２　肉眼观察患犬包皮表面有红枣大小的肿块，其大小为５－５ｃｍ×２－５ｃｍ，分叶，呈桑椹状，呈粉红色鱼肉样外观。质地柔软，脆弱，与周围组织界限明显，血管很丰富，一碰即出血，见图１。图１　包皮表面的肿块（↑）３　组织病理学变化肿瘤组织由大量形态和大小各异、呈圆形、梭形或星形的淋巴样…     

A case of hypospadias in a dog

: This clinical case report described a three-month-old mongrel dog that had the urethral orifice opening 3 cm from the tip of the penis and lacked a completely formed preputial sheath. It was presented to the clinic with an exposed penile shaft that was dry. The dog had urinary incontinence that was not of neurological origin. It also had unilateral agenesis of the right testicle. The preputial sheath was successfully reconstructed. Urinary incontinence stopped soon after surgery, suggesting that it had been probably due to an ascending urethritis. A large preputial opening was left because of the location of the urethral opening.     

Metabolic epidermal necrosis in a dog associated with pancreatic adenocarcinoma, hyperglucagonaemia, hyperinsulinaemia and hypoaminoacidaemia

A case of metabolic epidermal necrosis associated with a pancreatic carcinoma is described. Normoglycaemia, reduced serum fructosamine, and hypoaminoacidaemia were identified. Hyperinsulinaemia and hyperglucagonaemia were documented. Immunohistochemistry documented strong tumour expression of both insulin and glucagon supporting combined paraneoplastic production of both hormones by the tumour. Enteral protein and fatty acid supplementation and parenteral amino acid supplementation proved ineffective. Metastasis to regional lymph nodes was identified and the patient was euthanased.