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1.
The obliteration processes of the ductus arteriosus of equine foetuses and newborn foals were studied morphometrically and histologically. The length, internal and external diameters and circumference of the ductus in equine foetuses increased progressively and linearly up to 310 days with advancing foetal age, but the values, especially the internal diameter, decreased from 320 to 330 days. After birth, the ductal measurements decreased gradually and ductal closure was found in three of 14 foals examined on the first day post partum, in two of six on the second day and in nine of nine on the third day or later, suggesting that the ductus arteriosus closes physiologically within three days after birth. Microscopical findings of the ductus arteriosus were characterised by the rearrangement of smooth muscle cells in the inner media and intimal thickening in foetuses, and by the central displacement of the intima in newborn foals. It was concluded that the ductus arteriosus begins to undergo preparatory modifications during intrauterine life, when the vessel is still functional, and that the most significant starting point of change in the obliteration processes is the rearrangement of smooth muscle cells in the inner media, which occurs during pre- and post natal life. 相似文献
2.
A A MacDonald A L Fowden M Silver J Ousey P D Rossdale 《Equine veterinary journal》1988,20(4):255-260
Hearts from 24 foals were studied; 10 were from foetuses ranging in gestational age from 230 to 322 days and 14 were from newborn and young foals aged between birth and 17 days. The foramen ovale and associated vena caval and atrial structures were examined by scanning electron microscopy. Additional observations were made by light and transmission electron microscopy. A tube-like flap of tissue was observed, extending from the aperture in the caudal vena cava to the lumen of the left atrium. In the younger foetuses, the distal end of this tube was covered with a thread-like network of tissue. In animals nearer to term, the network was replaced by distal fenestrations. Protrusions were seen on the rim of the opening of the tube as it entered the atrium. The role that these may play, together with the significance of cardiac muscle and non-elastic connective tissue in the wall of the tube, were discussed with respect to possible mechanisms of closure of the foramen ovale. 相似文献
3.
Twelve newborn pony foals underwent cardiovascular examinations (auscultation, arterial blood pressure measurements, electrocardiograms and M-mode echocardiograms) on their first day of life and then on Days 7, 14, 21, 30, 60 and 90. An age dependent, statistically significant, rapid increase of the arterial blood pressure in the first month was documented together with a slower decrease of the resting heart rate after two and three months of life. Innocent soft systolic murmurs were audible over the left heart base in a large number of the foals. The electrocardiograms showed age dependent increases of the PR-, QRS- and QT- intervals and a trend of the mean electrical axis in the frontal plane to rotate towards the left side. The ventricular dimensions, measured by M-mode echocardiography, increased with the growth of the pony foals. Linear regression equations were calculated for the right and left ventricular internal dimensions in relation to body weight (bwt). The other echocardiographic parameter had low correlations with bwt. 相似文献
4.
Raising the orphan foal 总被引:1,自引:0,他引:1
Orphan foals are best reared by fostering them onto a brood mare of appropriate size. If no foster mother is available, they can be reared on 2 per cent fat skimmed cow's milk fortified with dextrose at the rate of 20 gm per L. This should be slowly increased from 10 per cent of body weight at 1 day of age to 25 per cent of body weight at 10 days of age. The amount should then be held constant until weaning. Alternatively, foals can be reared on milk replacers. Manufacturers' feeding instructions rarely mimic the milk intake obtained by a foal nursing her dam, and problems have been observed in milk replacer fed foals. It may be better to feed milk replacers at 1- to 2-hour intervals as a 12.5 per cent solution. The volume fed can be slowly increased from 5 per cent of body weight at day 1 to 20 per cent of body weight at day 10. Fresh water, hay, and good-quality creep feed with at least an 18 per cent crude protein should be offered from 2 weeks of age. Foals can be weaned at 8 to 12 weeks of age. 相似文献
5.
V B Reef P C Mann P G Orsini 《Journal of the American Veterinary Medical Association》1987,191(2):225-228
M-mode, 2-dimensional, and contrast echocardiographic studies were used to detect tricuspid atresia in 2 foals. M-mode echocardiographic findings included a small right ventricle, large left ventricle, large mitral valve excursion, large left atrium (foal 2), dropout of the cranial aspect of the aortic root, and a thick band of echoes in the tricuspid valve region. These findings were confirmed by 2-dimensional echocardiography. In addition, a large right atrium, persistent foramen ovale, ventricular septal defect, and large mitral valve apparatus were imaged. One foal also had a thick right atrial wall. Contrast echocardiography confirmed the intracardiac flow of blood from right to left atrium and then to the left ventricle, followed by simultaneous opacification of the right ventricle and aorta. The use of these echocardiographic techniques enables accurate antemortem diagnosis and prognosis of tricuspid atresia in the foal. 相似文献
6.
J P Lavoie M S Spensley B P Smith J Mihalyi 《American journal of veterinary research》1989,50(9):1598-1603
The uptake of colostral IgG and IgM, their serum half-lives, and the rates of endogenous synthesis of IgG and IgM were evaluated in 6 newborn foals fed bovine colostrum (principals) and 6 foals allowed to suckle their dams (controls). The principal foals were fed 400 ml of bovine colostrum (IgG, 10,000 mg/dl and IgM, 200 mg/dl) at 2-hour intervals, from 2 to 20 hours after foaling (total dose, 4 L). Serum IgG and IgM concentrations were determined by single radial immunodiffusion from birth to 98 days of age. At foaling, principal foals had no detectable serum equine IgG, but 1 control foal had serum equine IgG of 185 mg/dl. After ingestion of colostrum, there was no significant difference in the maximal serum bovine IgG concentration (range, 1,350 to 3,300 mg/dl) in the principal foals, and maximal serum equine IgG concentration in the control foals (range, 500 to 6,000 mg/dl). The calculated biological bovine and equine IgG half-life in the principal and control groups was 9.4 and 26 days, respectively. Endogenous IgG synthesis was first detected in 1 principal foal at 3 days of age, but was detected first between 28 and 42 days in the other principal foals. Starting on day 56 there was no significant difference in serum equine IgG concentration between groups. At foaling, foals in both groups had low equine IgM concentrations. In the control foals, there was marked individual variation in the increases in equine IgM concentration (range, 5 to 73 mg/dl) after ingestion of colostrum.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
7.
8.
Postocclusion survival data from dogs with left-to-right shunting patent ductus arteriosus (PDA) was available from 80 dogs, diagnosed from 1990 to 2000. Of these, 37 had undergone a procedure to close the ductus and were re-evaluated at the time of this study; clinical data from the follow-up examination was compared with that from the original examination. Radiographically, the right ventricle remained apparently enlarged, and the aortic bulge associated with dilation of the descending aorta did not disappear after closure. On M-mode echocardiography, left ventricular chamber diameter in diastole and systole and left ventricular posterior wall in systole decreased significantly. Mitral endocardiosis was a common feature. Residual flow was evident in 46 per cent of the animals. Late closure occurred in 8 per cent of the dogs, and trivial recanalisation in 19 per cent. The maximum survival time postclosure was 168 months and, after non-occlusion, 114 months, suggesting that dogs with PDA follow an unpredictable course. However, there was a significant difference in survival times between the corrected and non-corrected group. 相似文献
9.
REASONS FOR PERFORMING STUDY: Doppler tissue imaging (DTI) is a novel noninvasive method by which myocardial velocity can be assessed directly and it allows regional, rather than global, cardiac function to be evaluated. HYPOTHESIS: That regional differences in myocardial velocities exist within the equine ventricle. OBJECTIVES: To develop a repeatable examination technique for DTI in horses, describe DTI findings in various regions of the normal equine ventricle, compare colour (CDTI) and spectral (SDTI) techniques of DTI, and document regional differences in myocardial velocity. METHODS: Five regions of the ventricles (right ventricular wall, interventricular septum and left, right and caudal regions of the left ventricle) were evaluated using SDTI and CDTI in 20 clinically normal Thoroughbreds age 2 years. Individual repeatability of the method was determined by examination of one 6-year-old Thoroughbred on 6 occasions. RESULTS: Three major movements were observed in the ventricular walls in systole, early diastole and late diastole. The interventricular septum had a complex pattern of movement. The left region of the left ventricle and interventricular septum had the most rapid movement. The individual repeatability of CDTI was poor, while in systole and early diastole, but not late diastole, SDTI produced repeatable estimates of maximal myocardial velocity. The different velocity estimates obtained with SDTI and CDTI are not interchangeable. Regional differences in the peak mean and maximal myocardial velocities were found in systole and early diastole (P<0.05), but were not identified in late diastole. CONCLUSIONS: The SDTI modality appears to produce the most repeatable data. There are regional differences in myocardial velocity within the equine ventricles for systole and early diastole. POTENTIAL RELEVANCE: DTI shows potential as a tool for studying regional myocardial movement both in clinical cases suspected of having myocardial dysfunction and in a research setting. In particular, SDTI offers potential as a direct and noninvasive means to study early diastolic function of the equine ventricles. 相似文献
10.
The intra-erythrocytic parasite Theileria equi is one of two tick-transmitted causative agents of equine piroplasmosis. Piroplasms of T. equi can be transmitted across the equine placenta and once a horse is infected, it appears to remain a lifelong carrier, since anti-theilerial drugs suppress but do not eliminate the parasite. Carrier mares may transmit the organism to their offspring and this may result in abortion or neonatal piroplasmosis, but observations by some researchers suggest that foals may be born as carriers yet remain apparently healthy. Using a T. equi-specific oligonucleotide probe, we have determined that transplacental transmission occurs early in equine foetal development and that carrier mares may give birth to healthy carrier foals. Investigation of parasite levels and the effect of maternal colostrum on the newborn suggests that colostral T. equi antibody may act to suppress parasitaemia in the newborn, reducing the incidence of clinical neonatal piroplasmosis. 相似文献
11.
R Akter AW Stent FM Sansom JR Gilkerson C Burden JM Devlin AR Legione CM El-Hage 《Australian veterinary journal》2020,98(11):570-573
Chlamydia psittaci was detected by PCR in the lung and equine foetal membranes of two aborted equine foetuses and one weak foal from two different studs in Victoria, Australia. The abortions occurred in September 2019 in two mares sharing a paddock northeast of Melbourne. The weak foal was born in October 2019 in a similar geographical region and died soon after birth despite receiving veterinary care. The detection of C. psittaci DNA in the lung and equine foetal membranes of the aborted or weak foals and the absence of any other factors that are commonly associated with abortion or neonatal death suggest that this pathogen may be the cause of the reproductive loss. The detection of C. psittaci in these cases is consistent with the recent detection of C. psittaci in association with equine abortion in New South Wales. These cases in Victoria show that C. psittaci, and the zoonotic risk it poses, should be considered in association with equine reproductive loss in other areas of Australia. 相似文献
12.
The effects of chronic severe anemia on weights and chamber volumes of hearts were studied in 9 spontaneously anemic neonatal pigs (mean hematocrit = 10.1%) and 10 healthy piglets (mean hematocrit = 28.3%) of approximately the same age and similar body weights. All cardiac chamber weights, as well as total heart weight/body weight ratios, were significantly higher in the anemic pigs than in the healthy pigs (P less than 0.001). The left ventricular free wall/right ventricular free wall weight ratio was identical in the 2 groups. Calculated left ventricular volume/body weight ratio also was significantly greater in the anemic pigs (P less than 0.05). It is concluded that cardiac dilatation and hypertrophy occur consistently in chronically anemic neonatal pigs. These changes are independent of age or body weight of the animal. 相似文献
13.
The factors influencing beta cell function in the foetal and neonatal foal have been investigated in chronically catheterised foetal foals and in newborn foals delivered either spontaneously at term or by induction at different gestational ages. Insulin was detected in the foetal plasma from as early as 150 days of gestation (term = 340 days) and during the last third of gestation the foetal beta cells responded to exogenous administration of glucose and arginine and to endogenous variations in the glucose level. Insulin secretion by the foetal beta cells was depressed by anaesthesia and surgery. At birth, there was a significant positive correlation between the plasma concentrations of insulin and glucose irrespective of the maturity at birth or type of delivery (r = 0.86, n = 39, P less than 0.01). The slope of this relationship was significantly less than that relating the postoperative foetal concentration but only when delivery was difficult or prolonged was the beta cell sensitivity to glucose completely abolished. At birth, there were no significant differences in the plasma concentrations of insulin or glucose between full term foals delivered spontaneously or by induction. However, the spontaneously delivered foals showed a transient increase in the insulin concentration 15 mins after birth which was not observed in the full term foals delivered by induction. Plasma glucose concentrations were maintained during the 2 h after birth in the absence of sucking in both the induced and the spontaneously delivered full term foals. Premature foals had significantly lower plasma glucose concentrations at birth than full term foals.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
14.
The growth of the heart, relative to body weight, was measured by M-mode echocardiography in dogs during the first year of life. Echocardiographic measurements were obtained from 16 English Pointers at 1, 2, 4, and 8 weeks of age and at 3, 6, 9, and 12 months of age. Left atrial (LA), aortic (AO), left and right ventricular internal dimensions, interventricular septal and left ventricular wall thickness measurements increased in curvilinear fashion relative to increasing body weight. Least-squares regression analysis, performed on logarithmically transformed data, was used to develop power-law equations describing the relationship of echocardiographic measurements to body weight. Linear dimensions of the LA, AO, left and right ventricular internal dimensions and interventricular septal and left ventricular wall thickness changed proportionally to slightly differing exponential powers of body weight (BW), varying from 0.31 to 0.45 (BW0.31 to BW0.45). Fractional shortening and the LA to AO ratio decreased slightly, but significantly, as body weight increased. Indexing echocardiographic measurements to BW1/3 was more appropriate than indexing such measures linearly to body weight, offering a practical method for developing accurate normative graphs or tables for M-mode echocardiographic dimensions in growing dogs. 相似文献
15.
Ana Muñoz Cristina Riber Pablo Trigo Manuel Gómez-Díez Francisco Castejón 《Journal of Equine Veterinary Science》2012
Equine neonatal septicemia could lead to the release of thrombus and heart valvular endocarditis. A relationship between activation of the renin-angiotensin-aldosterone-vasopressin (RAAV) axis and heart failure has been described in several species. This article describes the echocardiographic, electrocardiographic, and laboratory findings, including RAAV axis, in two Spanish foals with endocarditis after septicemia in comparison with two control groups matched by age and gender. Two Spanish foals (F1, 60-day-old colt; F2, 76-day-old filly) were presented with poor growth rate a month after being hospitalized because of septicemia. Colt F1 had hypercortisolemia and increased left ventricular internal dimensions in systole and diastole, increased left ventricular free wall thickness in diastole, interventricular septum thickness in diastole, and mitral valve thickness. Colt F1 also presented lower fractional shortening, ejection fraction, fractional wall thickness, and fractional septum thickness. Filly F2 showed hyperfibrinogenemia and increased values for aspartate aminotransferase, lactate dehydrogenase, creatin kinase, alkaline phosphatase, interventricular septum at systole, aorta diameter at the level of valve leaflets and sinotubular junction, and mitral and tricuspid valve thickness. The foals did not present systemic signs compatible with heart failure, heart arrhythmias were not found, and RAAV values were within the expected confidence limits. In conclusion, endocarditis without clinical signs of heart failure can appear shortly after septicemia in equine neonates. The measurement of the thickness of the valves by two-dimensional echocardiography is diagnostic. The lack of activation of RAAV in both foals might indicate that the severity of the heart problem was mild. 相似文献
16.
H F Schryver D W Meakim J E Lowe J Williams L V Soderholm H F Hintz 《Equine veterinary journal》1987,19(4):280-287
The effect of level of protein intake on growth and calcium metabolism was studied in 24 foals. Starting at four months old, the foals were fed one of three diets containing all nutrients, with the exception of protein, at levels recommended by the United States National Research Council Subcommittee on Horse Nutrition for a 12 month period. The protein levels in the three diets were 9 per cent (low protein) 14 per cent (NRC recommended level) and 20 per cent (high protein). The foals fed the low protein diet were changed to the high protein diet after 140 days when they were nine months old. There were no significant differences in the rates of growth in weight, height, cannon circumference or in hoof growth and feed utilisation of the horses fed the 14 or the 20 per cent protein diets. However, growth, feed intake and feed utilisation by the foals fed the low (9 per cent) protein diet were significantly depressed. The average daily gains for the first 140 days for the 9, 14 and 20 per cent protein treatment groups were 64, 631 and 687 g in weight, 0.57, 0.83 and 0.87 mm in height and 0.04, 0.13 and 0.14 m in forecannon circumference, respectively. The average daily feed intakes for the 140 day period for the three groups were 2.7, 4.4 and 4.7 kg, respectively. After the change to the high protein diet the foals that had been fed the low protein diet maintained a higher rate of gain in bodyweight, height and cannon circumference, and utilised feed more efficiently than the other two groups throughout the second 140 days of the experiment.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
17.
A skeletal ossification index (SOI) was devised to standardize the radiographic evaluation of the carpal and tarsal regions of newborn foals (less than two weeks of age). This index was based on two radiographic views of a carpus and a tarsus. Four grades of cuboidal bone ossification were discerned: Grade 1 foals had some cuboidal bones with no ossification; Grade 2 was assigned when all cuboidal bones had radiographic evidence of some ossification; in Grade 3 the bones were small and round; in Grade 4 the cuboidal bones were shaped like the adult counterparts. Radiographs were taken of 24 neonatal foals of various gestational ages (range, 297–374 days). The relationships between the SOI and two measures of newborn foal developmental maturity, gestationai age and body weight, were assessed. There was no relationship between the sex of the foal and the SOI, but there was a relationship between the SOI and the gestational age (one-tailed Spearman's rank correlation coefficient, r = 0.748) and between the SOI and body weight (r = 0.77) for the 24 foals. For the ten foals with gestational ages less than 320 days, the relationship between body weight and the SOI was significant (r = 0.953), but the relationship between gestational age and the SOI was not significant (r = 0.605). The degree of ossification of the bones of neonatal foals that are born prematurely (< 320 days of gestation) or are "small-for-gestational age" at birth may be incomplete, and we suggest that radiographs of these regions should be made to assess ossification in foals in these two high risk groups. 相似文献
18.
In connection with reindeer, slaughter 348 foetuses were collected at different foetal developmental stages and studied together with 20 full-term newborn calves with respect to weight, crown-rump length, metacarpal bone length and appearance of ossification foci. On the basis of these measurements polynomial growth curves were constructed. Weight gain was most rapid during the last trimester of gestation, but total and metacarpal bone length gain showed only minor acceleration towards the end of pregnancy. Ossification was apparent at an age of about 6 weeks. Undernutrition during late winter was observed to retard the foetal growth. 相似文献
19.
A study of bovine and equine immunoglobulin levels in pony foals fed bovine colostrum 总被引:1,自引:0,他引:1
As part of a project to raise specific pathogen free (SPF) Welsh Mountain Pony foals, free from exposure to Equid herpesvirus type 1, foals were removed from their dams at birth and fed bovine colostrum. This study characterises the uptake of bovine colostral immunoglobulin and production of endogenous immunoglobulin, in 10 SPF foals. An enzyme-linked immunoadsorbent assay was developed to measure serum concentrations of bovine IgG1 (boIgG1) to assess the efficiency of transfer, and rate of elimination of boIgG1 by the foal. The endogenous production of equine IgG was studied using a single radial immunodiffusion test. Foals were given 1.2 to 2 litres of bovine colostrum achieving peak serum boIgG1 concentrations of 18.9 to 34.2 g/litre (mean 28.0). The mean half-life of boIgG1 in the foals was 7.4 days. Endogenous immunoglobulin production resulted in equine IgG concentrations greater than 2 g/litre in six of 10 foals by 14 to 19 days of age, and greater than 7 g/litre in eight of 10 foals by 37 to 50 days of age. All foals had equine IgG serum concentrations greater than 10 g/litre by 102 to 135 days of age. 相似文献
20.
Hünigen H Butendieck E Berg R 《Berliner und Münchener tier?rztliche Wochenschrift》2001,114(3-4):117-120
The heart of 12 adult llamas, one female and 11 males, 2-7 years of age, was studied gross-anatomically (absolute and relative heart weight) and microscopic-anatomically (left and right ventricular wall, left auricle). Comparing the 9 younger animals (2-3 years old) with the 3 older llamas (5-7 years old) a significant increase of the absolute heart weight and of the number of capillaries per mm2 and a significant decrease of the intercapillary distance in the left ventricular wall was found. This results in an increase of capillarity in the studied heart regions (5.5% compared to 6.9%). The simultaneous increase of the capillary-to-myocyte-ratios from 0.9 to 1.1 shows a significant correlation to the cross-sectional area of the myocytes (r = 0.79) and an also significant but negative correlation to the number of myocytes per mm2 (r = -0.82). In both groups the cross-sectional area of the myocytes and their diameter differs significantly in the three regions of the heart (left ventricular wall--214 micron 2 resp. 17.5 microns; right ventricular wall--156 micron 2 resp. 15.5 microns; left auricle--96 micron 2 resp. 11.5 microns). It is to be supposed, that the morphological conditions of the cardiac vascular supply of llamas living in an altitude of 4000 m are improving with age. 相似文献