Primary spinal cord lymphosarcoma in a dog

Primary lymphosarcoma of the spinal cord has been infrequently reported. This tumor was classified as intramedullary, the least common type of spinal cord tumor. The dog had rapid onset of paresis and paralysis, with no sign of spinal pain.     

Peripheral neuropathy associated with lymphosarcoma in a dog

A case of peripheral neuropathy associated with lymphosarcoma in a dog is described. A 6-year-old flat-coated Retriever male was presented with urinary incontinence and lameness of the right hind leg. Five days after hospitalization the dog developed a right-sided facial paralysis. The dog was destroyed 3 weeks after admittance. The post-mortem examination revealed lymphosarcoma in the stomach and a peripheral neuropathy mainly affecting the femoral and facial nerves. The possible connection between the lymphosarcoma and the peripheral neuropathy is discussed.     

Large granular intestinal lymphosarcoma and leukemia in a dog

A rare, large granular lymphocyte (LGL) tumor causing a protein-losing enteropathy and thrombocytopenia was diagnosed in an Irish wolfhound. The case had an aggressive clinical course, like most LGL tumors in humans. Immunophenotyping suggested that the LGL tumor in this dog was derived from a natural-killer cell.     

Specific heart muscle disease secondary to lymphosarcoma in a dog

This case report describes the clinical, imaging, clinical pathology and necropsy findings in a five-year-old male Border collie with low output cardiac failure. The heart was enlarged by infiltrative lymphosarcoma.     

Angiotrophic intravascular lymphosarcoma presenting as bi-cavity effusion in a dog

A 9-year-old German Shepherd cross was presented with a history of dyspnoea, decreased activity, episodic collapse and abdominal distention. Cytological examination of thoracic and abdominal fluid demonstrated neoplastic cells, either round or mesenchymal in nature. The dog was found to have a mass in the heart-base region. Exploratory thoracotomy was performed to identify the exact nature of the mass histologically, and to determine if it was the source of neoplastic cells seen in the effusions. Histological diagnosis of the mass was mesothelioma. Postoperatively the dog developed thrombocytopenia, probably immune-mediated, which was treated with prednisone therapy. The dog developed signs of respiratory distress shortly before discharge and, due to its deteriorating condition, was euthanased. A necropsy was performed and tissues were collected for histological examination. The histological diagnosis was angiotropic intravascular lymphosarcoma. Diagnosis of mesothelioma was not confirmed.     

Central nervous system lymphosarcoma in the dog

Central nervous system lymphosarcoma was diagnosed in 8 dogs with seizures and clinical signs compatible with multifocal central nervous system involvement. Cerebrospinal fluid analysis showed high white cell counts with abnormal lymphoid cells in all dogs, and high protein concentration in 5 dogs. Two dogs were given systemic anticancer chemotherapy, and 4 dogs were given a combination of systemic chemotherapy, intrathecal cytosine arabinoside, and craniospinal irradiation, resulting in marked improvement of the clinical signs.     

Multiple myeloma in a dog

This paper describes a case of multiple myeloma in a 3-year-old mongrel bitch. The diagnosis was established by histopathological examination of post-mortem material. The tumour formed nodular masses on the fourth left rib and third and fourth lumbar vertebrae; it also involved the sternal lymph nodes, spleen, liver and kidneys. Demonstration of amyloid deposits in the kidney was inconclusive.
Résumé. Observation d'un cas de myélome multiple chez une chienne bâtarde de 3 ans. Le diagnostic a été fait d'après les données histopathologiques après autopsie. La tumeur formait des masses nodulaires au niveau de la 4éme côte gauche et des vertèbres L 3 et L 4; elle intéressait aussi les ganglions lymphatiques parasternaux, la rate, le foier et les reins. La présence de dépôts amyloïdes dans le rein n'apportait aucun renseignement complémentaire.
Zusammenfassung. Diese Abhandlung beschreibt einen Fall von multiplem Myelom bei einer 3 Jahre alten Bastardhündin. Die Diagnose beruhte auf der histopathologischen Untersuchung von Autopsiematerial. Der Tumor bildete nodulare Massen an der vierten Rippe links und am dritten und vierten Lendenwirbel; er involvierte auch die sternalen Lymphknoten, Milz, Leber und Nieren. Der Nachweis von Amyloidablagerungen in der Niere war nicht überzeugend.     

Acute bilateral trigeminal neuropathy associated with nervous system lymphosarcoma in a dog

A nine-year-old dog presented with clinical signs consistent with bilateral trigeminal neuropathy. Multicentric lymphoma was diagnosed, and neoplastic lymphocytes were identified in the cerebrospinal fluid. Electromyography revealed spontaneous activity in temporal and masseter muscles. Histopathological examination demonstrated neoplastic cell invasion of temporal and masseter myofibers and of multiple peripheral nerves, including the trigeminal nerve. Central nervous system pathology consisted primarily of spinal root and leptomeningeal lymphoid cell infiltration with relative sparing of spinal cord and brain parenchyma.     

Multiple dermatophyte infections in a dog

A case of multiple infections of the skin of a dog with Microsporum gypseum, Trichophyton mentagrophytes and Candida albicans is reported and described. As immunodepression was suspected, an immunostimulatory course of levamisole, together with the antifungal agent, griseofulvin, was prescribed. Bone marrow depression was countered with anabolic steroids and a vitamin-iron compound. A 10% w/v solution of etisazole (Ectimar, Bayer) was applied topically to the lesions. Complete resolution of the infection was obtained after 5 months therapy.     

Multiple cartilaginous exostoses in a dog

A case of multiple cartilaginous exostoses (osteochondromatosis) in a 9-month-old Kelpie cross dog is described. This uncommon dyschondroplasia, which resembled multiple cartilaginous exostoses in man, involved the radius, the femur, a metacarpal and metatarsal bone, the phalanges of three extremities, the pelvis, the ribs and cervical, thoracic and coccygeal vertebrae.     

Multiple cutaneous ganglioneuromas in a dog

A 3-year-old male Labrador retriever dog was presented with multifocal small cutaneous nodules, distributed mainly over the thoracic wall, the flank and the scrotum. The dog was otherwise in good health and had no significant past medical history. Radio- and sonographic examination revealed no evidence of internal tumours, including endocrine tumours. Histological examination of two excised samples revealed round, non-ulcerated nodules in the superficial corium, characterized by two different neoplastic cell components and mild inflammation. The first tumour cell population showed histomorphological characteristics of mature ganglion cells; the second featured small, spindle-shaped tumour cells with scant cytoplasm. Both neoplastic cell components expressed vimentin, neurofilament protein, pan-neuronal neurofilament, amyloid-precursor protein and chromogranin A. In addition, the spindle-shaped tumour cells were positive for 2', 3'-cyclicnucleotide 3'-phosphodiesterase. The findings had many histological and immunohistochemical features in common with primary cutaneous ganglioneuromas in humans, enabling the canine tumours to be also classified as multiple cutaneous ganglioneuromas.