共查询到20条相似文献，搜索用时 15 毫秒
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Roback H 《Science (New York, N.Y.)》1969,165(3888):36-43
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Walsh J 《Science (New York, N.Y.)》1970,170(3962):1065-1066
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Kueppers LM 《Science (New York, N.Y.)》2005,310(5752):1278-1279
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Holden C 《Science (New York, N.Y.)》1978,199(4328):512
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Lawler A 《Science (New York, N.Y.)》2007,315(5818):1484
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Cho A 《Science (New York, N.Y.)》2006,313(5795):1872-1875
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Toward a science of metabolic engineering 总被引：43，自引：0，他引：43
J E Bailey 《Science (New York, N.Y.)》1991,252(5013):1668-1675
Application of recombinant DNA methods to restructure metabolic networks can improve production of metabolite and protein products by altering pathway distributions and rates. Recruitment of heterologous proteins enables extension of existing pathways to obtain new chemical products, alter posttranslational protein processing, and degrade recalcitrant wastes. Although some of the experimental and mathematical tools required for rational metabolic engineering are available, complex cellular responses to genetic perturbations can complicate predictive design. 相似文献
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de Castro Moreira I 《Science (New York, N.Y.)》2003,301(5630):141
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Robinson AL 《Science (New York, N.Y.)》1979,205(4405):477-479
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Roccanova L 《Science (New York, N.Y.)》2003,300(5623):1236; author reply 1236