共查询到7条相似文献,搜索用时 15 毫秒
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Anthea L. Katelaris Keira Glasgow Kerryn Lawrence Paul Corben Anthony Zheng Suhasini Sumithra John Turahui Janet Terry Debra van den Berg Daneeta Hennessy Stacey Kane Scott B. Craig Ellena Heading Mary‐Anne Burns Hanisah L. Corner Vicky Sheppeard Jeremy McAnulty 《Zoonoses and public health》2020,67(1):35-43
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Occupational transmission of an Orthopoxvirus infection during an outbreak in a colony of Macaca tonkeana in Lazio Region,Italy, 2015 下载免费PDF全文
V. Puro F. M. Fusco C. Castilletti F. Carletti F. Colavita C. Agrati A. Di Caro M. R. Capobianchi G. Ippolito 《Zoonoses and public health》2018,65(5):578-583
Orthopoxviruses spill over from animal reservoirs to accidental hosts, sometimes causing human infections. We describe the surveillance and infection control measures undertaken during an outbreak due to an Orthopoxvirus occurred in January 2015 in a colony of Macaca tonkeana in the province of Rieti, Latio, Italy, which caused a human asymptomatic infection. According to the epidemiological investigation, the human transmission occurred after an unprotected exposure. The contacts among wild, captive and domestic animals and humans, together with decreased immunity against Orthopoxviruses in the community, may put animal handlers at risk of infection, especially after the cessation of smallpox vaccination. To reduce these threats, standard precautions including respiratory hygiene and transmission‐based precautions should be carefully applied also in veterinary medicine. 相似文献
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Comparison of disinfectant efficacy when using high‐volume directed mist application of accelerated hydrogen peroxide and peroxymonosulfate disinfectants in a large animal hospital 下载免费PDF全文
N. T. Saklou B. A. Burgess D. C. Van Metre K. J. Hornig P. S. Morley S. R. Byers 《Equine veterinary journal》2016,48(4):485-489
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Katherine Smallwood Jean‐Benoit Tanis Iain A. Grant Laura Blackwood David R. Killick Isabel Amores‐Fuster James Elliott Aran Mas Aaron Harper Mary Marrington Riccardo Finotello 《Veterinary and comparative oncology》2019,17(2):165-173
The DMAC protocol (dexamethasone, melphalan, actinomycin‐D, cytarabine) has been evaluated in American studies for the treatment of relapsed canine lymphoma, comparing similarly to other rescue protocols. The aim of this study was to evaluate efficacy and toxicity of DMAC, in a larger UK cohort of resistant canine lymphomas. Medical records of dogs with resistant non‐Hodgkin high‐grade lymphomas that received DMAC as a rescue protocol were reviewed from 2007 to 2017. Response, time from initiation to discontinuation (TTD) and toxicity (Veterinary Cooperative Oncology Group criteria) were assessed. One hundred dogs were included; 86 received CEOP (modified CHOP including epirubicin) as first‐line treatment. Thirty‐five dogs (35%) responded: 21 complete responders (CRs) and 14 partial responders (PRs). Responders had significantly longer TTD (P < 0.001) compared with non‐responders: 62 days (range 28‐952) for CR vs 32 days (range 20‐70) for PR. Six CR received more than six cycles of DMAC (range 7‐36 cycles) and experienced a longer TTD (median 508, range 126‐952 days). Thrombocytopenia occurred in 45% (24 grade 1‐2, 21 grade 3‐4) and neutropenia in 36% of cases (29 grade 1‐2, 7 grade 3‐4). Gastrointestinal toxicity occurred in 42% of dogs (40 grade 1‐2, 2 grade 3‐4). Owing to chemotherapy toxicity, treatment was discontinued in five, and hospitalization required in six cases. In this study, response to DMAC was lower and of generally shorter duration than previously reported. Toxicity was high, but infrequently led to hospitalization or discontinuation of treatment. 相似文献
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Evaluation of a multi‐agent chemotherapy protocol combining lomustine,procarbazine and prednisolone (LPP) for the treatment of relapsed canine non‐Hodgkin high‐grade lymphomas 下载免费PDF全文
J.‐B. Tanis S. L. Mason T. W. Maddox L. Blackwood D. R. Killick I. Amores‐Fuster A. Harper R. Finotello 《Veterinary and comparative oncology》2018,16(3):361-369
The standard of care treatment for canine lymphoma is multi‐agent chemotherapy containing prednisolone, cyclophosphamide, vincristine and an anthracycline such as doxorubicin (CHOP) or epirubicin (CEOP). Lomustine, vincristine, procarbazine, and prednisone (LOPP) has been evaluated as a rescue, with encouraging results; however, resistance to vincristine is likely in patients relapsing on CHOP/CEOP, and this agent may enhance LOPP toxicity without improving efficacy. The aim of this study was to evaluate responses to a modified‐LOPP protocol that does not include vincristine (LPP) and is administered on a 21‐day cycle. Medical records of dogs with high‐grade multicentric lymphoma from 2012 to 2017 were reviewed. Dogs with relapsed lymphoma that received LPP as a rescue protocol were enrolled. Response, time from initiation to discontinuation (TTD) and toxicity of LPP were assessed. Forty‐one dogs were included. Twenty‐five dogs (61%) responded to LPP including 12 complete responses (CR) and 13 partial responses (PR). Responders had a significantly longer TTD (P < .001) compared to non‐responders with 84 days for CR and 58 days for PR. Neutropenia was documented in 20 dogs (57%): 12 grade I to II, 8 grade III to IV. Thrombocytopenia was infrequent (20%): 5 grade I to II, 2 grade III to IV. Twelve dogs developed gastrointestinal toxicity (30%): 10 grade I to II and 2 grade III. Nineteen dogs had elevated ALT (59%): 9 grade I to II, 10 grade III to IV. Treatment was discontinued due to toxicity in 8 dogs (19%). The LPP protocol shows acceptable efficacy and toxicity‐profile and minimizes in‐hospital procedures. 相似文献
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Ana Mendes Bernardo Gomes Luís Sousa Helena Moreira Incia Rosa Sílvia Marques Elsa Machado Graa Cruz Alves Maria Neto 《Zoonoses and public health》2020,67(5):587-590
We report a Brucella outbreak with seven cases in the Northern Region of Portugal in 2018–2019, associated with the consumption of fresh cheese. This outbreak has implications for risk assessment in Portuguese migrants related to this area, and it is an example of cooperation between public institutions, in a One Health based approach. 相似文献