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食蟹猴的养殖——越南猴场考察报告徐汉涛（南京农业大学动物科技学院２１００９５１９９６年８月,笔者应邀对越南猴场进行为期４０天的实地考察和学术交流。越南猴场位于胡志明市以东约３０公里的龙城县境内,饲养食蟹猴５０００余只和少量恒河猴、平顶猴、红面猴等,至... 相似文献
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广西某野生动物保护站下属养猴场发生一起食蟹猴其症状呈急性经过、死亡率高的疾病,经临床观察、病理剖检及实验室检验,确诊为食蟹猴肺炎球菌病。１发病情况该养猴场于１９９８年４月２３日凌晨,从中越边境长途运输引进一批野外捕获的食蟹猴共１２４只,在到场６个小时... 相似文献
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为提供食蟹猴一般生理指标,本实验测定124只食蟹猴的肛温、呼吸率、血压和脉搏,比较不同性别和不同年龄组之间测定参数的差异.结果表明,1～1.8岁青幼年组、3～6岁成年组食蟹猴的体温、呼吸率、血压和脉搏均无明显性别差异.青幼年组与成年组相比较,血压无明显差异,但肛温、呼吸率明显高于成年组食蟹猴,而脉搏则明显低于成年组(P<0.01) .结论:食蟹猴上述生理参数性别之间差异不明显,随着年龄的变化血压变化不大,但肛温和呼吸率随着年龄的增长而减少,脉搏数则随着年龄的增长而增多,呈现较为复杂的年龄相关性. 相似文献
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在药物安全性评价过程中,许多试验操作都需要进行动物麻醉。但是,麻醉是一个复杂,并伴有风险的过程,麻醉意外时有发生。2010年笔者曾遇到2例麻醉意外,现报告如下。1案例1．1案例l2010年硼,检查约9．8kg比格犬左肩胛处时,发现有一伤口,化脓。遂采用戊巴比妥钠（iv,30mg／kg）麻醉,进行伤口处理。处理过程中该犬挣扎并苏醒。采用速眠新（im,0．1mL／kg）麻醉,不久即进入麻醉状态。 相似文献
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广西地区猕猴和食蟹猴麻疹病毒感染调查王建飞，邵伟娟，王晓明，符明泰，赖玉梅，刘自民，杨晓明（中国科学院上海实验动物中心）（广西林业厅动物保护站）猕猴和食蟹猴广泛用于生物医学的研究和疫苗的生产，但它们携带着的多种病原体给疫苗生产、科学研究和饲养管理带来... 相似文献
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Hirowatari C Kodama R Sasaki Y Tanigawa Y Fujishima J Yoshikawa T Yabuuchi K Kuwamura Y Hirakawa K Kamimura Y Maeda H 《Journal of toxicologic pathology》2012,25(1):45-49
Porencephaly was observed in a female cynomolgus monkey (Macaca fascicularis) aged 5 years and 7 months. The cerebral hemisphere exhibited diffuse brownish excavation with partial defects of the full thickness of the hemispheric wall, and it constituted open channels between the lateral ventricular system and arachnoid space. In addition, the bilateral occipital lobe was slightly atrophied. Histopathologically, fibrous gliosis was spread out around the excavation area and its periphery. In the roof tissue over the cavity, small round cells were arranged in the laminae. They seemed to be neural or glial precursor cells because they were positive for Musashi 1 and negative for NeuN and GFAP. In the area of fibrous gliosis, hemosiderin or lipofuscin were deposited in the macrophages, and activated astroglias were observed extensively around the excavation area. 相似文献
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Sasaki Y Kodama R Iwashige S Fujishima J Yoshikawa T Kamimura Y Maeda H 《Journal of toxicologic pathology》2011,24(1):69-73
Severe bilateral cataract was found in a 7 year-old naïve female cynomolgus monkey
(Macaca fascicularis) 3 months before necropsy. During macroscopic
examination, severe opacity and thinning of the lens were observed in both eyes.
Histopathology revealed that the lens nuclei and majority of cortex lens fibers had
disappeared and become excavated, while the lens fibers in the subcapsular area were
swollen and distorted. Other observations included atrophy and vacuolation in the lens
epithelial cells and proliferation of spindle cells and collagen fiber beneath the
anterior capsule of the right eye. Immunohistochemical staining of these spindle cells
revealed the presence of vimentin, cytokeratin and α-smooth muscle actin (α-SMA), which
were considered to be derived from lens epithelial cells. This is a rare case of
spontaneous, bilateral, hypermature cataract in a cynomolgus monkey. 相似文献
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A 6-year-old intact male cynomolgus monkey of Chinese origin was received at the Sierra Biomedical Facility. While physical examination revealed good body condition with no abnormalities, routine ophthalmic examination revealed bilateral proliferative optic neuropathy involving the dorsal aspect of the optic disc. No changes were noted in the appearance of the lesions over 8 months, and fluoroescein angiography revealed no abnormalities other than obstruction of the view of the retinal vessels by the lesions. Histopathologic studies revealed characteristics consistent with a diagnosis of bilateral neuroepithelial choristoma. 相似文献
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Lymphoplasmacytic gastritis is a concern for toxicological pathologists reading preclinical, non-human primate toxicity studies because subtle gastric changes which could be treatment-related may be masked and gastritis lesions may be confused with treatment-related effects and thus a gastric finding may be incorrectly assigned as a treatment-related lesion. This paper discusses the incidence of lymphoplasmacytic gastritis in cynomolgus monkeys at a contract research organization. The incidence of lymphoplasmacytic gastritis in the fundus and antrum of control cynomolgus monkeys on 18 non-gastric compound studies, was scored. The average fundus score ranged from 0.3 to 1.5 and the average antral score ranged from 0.9 to 3.5 in the cynomolgus monkey stomachs examined. The number of affected control animals in a study ranged from 0 to 5 control animals. No correlation between the route of vehicle administration and the severity or incidence of the lesions was noted. The percentage incidence of affected animals ranged from 0 to 100%. An increased incidence lymphoplasmatic gastritis from 2000 to 2004 was noted. The implications of lymphoplasmacytic gastritis in cynomolgus monkeys used for acute toxicity studies are discussed. 相似文献
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Yoshikazu Taketa Akira Inomata Jiro Sonoda Kazuhiro Hayakawa Kyoko Nakano-Ito Etsuko Ohta Yuki Seki Aya Goto Satoru Hosokawa 《Journal of toxicologic pathology》2013,26(4):419-422
Malakoplakia is a rare form of chronic granulomatous inflammation in mammals, and usually affects the urinary tract in humans. In this report, we present a case of granulomatous nephritis consistent with malakoplakia in a 4-year-old male cynomolgus monkey. Gross examination showed that the kidney was markedly enlarged and adhered to the surrounding organs. Histology showed that there was diffuse interstitial infiltration of histiocytes with abundant foamy eosinophilic cytoplasm resembling von Hansemann cells, PAS-positive granular cytoplasm and occasional PAS- and iron-positive intracellular small inclusion bodies. Electron microscopy showed that these histiocytes contained abundant lysosomes and phagolysosomes but no obvious Michaelis-Gutmann bodies. Based on these findings, a diagnosis of granulomatous nephritis consistent with early malakoplakia was made. This is the first report in a monkey of a renal lesion consistent with malakoplakia. 相似文献
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Akio SEKIYA Kazufumi KAWASAKO Takuya DOI 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2021,83(3):469
A 6-year-old male cynomolgus monkey showed chronic wasting. No gross abnormalities were observed in necropsy except for changes secondary to wasting. Microscopic examination revealed pigment granules deposition in systemic smooth muscles. They were observed as brown or basophilic in hematoxylin and eosin stain, and were positive for periodic acid-Schiff, Schmorl and Ziehl-Neelsen. Ultrastructurally, they consisted of residual bodies surrounded with varying amounts of solitary ribosomes. Thus, these granules were considered as lipofuscin. Unlike brown bowel syndrome in humans, the pigment granules were distributed systemically not only in the digestive tract but also in the blood vessels predominantly in the veins. To our knowledge, this is the first report on vascular smooth muscle lipofuscinosis occurring predominantly in the veins of primates. 相似文献
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Hataitip TRISOMBOON Suchinda MALAIVIJITNOND Wichai CHERDSHEWASART Gen WATANABE Kazuyoshi TAYA 《Animal Science Journal》2007,78(4):378-386
We investigated a non‐invasive method of specimen collection for determining the changes of reproductive hormones in aged menopausal monkeys after a long‐term feeding of the Thai herb Pueraria mirifica (PM) containing phytoestrogens. Three groups of aged menopausal monkeys (n = three in each group) were fed daily with 10, 100, or 1000 mg of PM for a 90 day treatment period, and fed with distilled water for 30 and 60 days of the pre‐ and post‐treatment periods, respectively. Urine samples were collected for 14 h daily every 5 days and assayed for follicle stimulating hormone (FSH), luteinizing hormone (LH) and estradiol levels. The result showed that monkeys fed with PM 10, PM 100, and PM 1000 had a decrease in urinary FSH levels during the treatment period, followed by a rebound increase during the post‐treatment period. Urinary estradiol levels tended to decrease and fluctuated between 4.28 and 266.71, 2.85–42.27, and 6.24–203.50% of the pre‐treatment levels in those three groups, respectively. Decreases in urinary LH levels could not be observed in all the three groups. These results suggest that FSH could be a candidate marker to detect the estrogenic effects of phytoestrogens in aged menopausal monkeys when changes of urinary hormones need to be used as an indicator. 相似文献
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《Veterinary anaesthesia and analgesia》2020,47(3):309-314
ObjectiveTo evaluate a veterinary-specific oscillometric noninvasive blood pressure (NIBP) system according to the guidelines of the American College of Veterinary Internal Medicine (ACVIM) Consensus Statement.Study designProspective clinical study.AnimalsA total of 33 client-owned cats (20 females and 13 males).MethodsCats were premedicated with methadone (0.3 mg kg−1) and alfaxalone (2 mg kg−1) intramuscularly. After 15 minutes anesthesia was induced with isoflurane (3%) in 100% oxygen by facemask while breathing spontaneously. A 22 gauge catheter was placed in the median caudal artery and systolic (SAP), diastolic (DAP) and mean (MAP) arterial pressures were measured. NIBP measurements were collected by placing the cuff (40% of limb circumference) on the right or left antebrachium. The agreement between the two methods was evaluated with the Bland–Altman methods, and the oscillometric NIBP device was evaluated using the ACVIM guidelines for validation of devices.ResultsData from 30 of the 33 cats were analyzed. Five paired measurements were taken from each cat, totaling 150 paired measurements. Mean bias (limits of agreements) for SAP, DAP and MAP were 2.7 (−22.7 to 28.1), 0.9 (−22.3 to 24.2) and 1.3 (−20.4 to 23.0). The oscillometric NIBP passed all validation criteria, except correlation which was <0.9 for SAP, DAP and MAP.Conclusions and clinical relevanceThe Vet20 did not meet all validation criteria by the ACVIM. However, all criteria except correlation were met. 相似文献
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Objective: To determine the accuracy of indirect blood pressure (BP) measurements obtained with a pulse oximeter as compared with direct measurements in dogs under isoflurane anesthesia. The Doppler and oscillometric BP monitors were included for comparison. Design: Prospective, experimental study. Animals: Twenty healthy dogs (23 ± 8 kg) anesthetized for research or teaching. Interventions: Dogs were anesthetized with propofol or thiopental and maintained using positive pressure ventilation with isoflurane in 100% O2. Random adjustment of BP was achieved by inhalant adjustment or dopamine infusion to achieve low (≤85 mmHg), normal (90–120 mmHg), or high systolic BP (≥125 mmHg). Triplicate measurements for BP were taken with direct (dorsal pedal artery), Doppler (forelimb), oscillometric (same forelimb), and plethysmographic (pulse oximeter on tongue) methods. Measurements and main results: Using regression analysis and a modified Bland–Altman's technique, the lowest bias was achieved with the Doppler. Systolic BP readings at low, normal, and high BP were within 10 mmHg of direct recordings 95%, 70%, and 30% of the time for pulse oximetry; 95%, 85%, and 55% of the time for Doppler; 42%, 65%, and 30% of the time for oscillometric determination, respectively. Oscillometric mean BP readings were within 10 mmHg of direct measurements 53%, 60%, and 45% of the time, respectively. Conclusions: The pulse oximeter is an acceptable method for measuring BP in anesthetized dogs if assessment of trends is sufficient. All indirect methods showed greater bias and poorer precision at high BP. The Doppler may be the preferred indirect method. 相似文献