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目的:观察藏药六味能消胶囊的润肠通便作用.方法:采用正常、失水性便秘模型和地诺芬酯模型为研究对象,观察其对肠推进率以及在便秘模型基础上的第一次排黑便时间、排便粒数和粪便干重的影响.结果:经口给予小鼠不同剂量的六味能消胶囊,各剂量组均能显著提高正常小鼠的小肠墨汁推进率和地芬诺酯模型小鼠的排便粒数;1.8 g/kg剂量能显著缩短失水性便秘模型小鼠的排首粒黑便时间和增加排便的粒数及重量,0.9 g/kg剂量能缩短排首粒黑便时间.结论:六味能消胶囊具有润肠通便作用.Abstract: Objective To investigate the effect of Liuwei Nengxiao capsules, a Tibetan traditional medicine,on loosening bowel and relieving constipation in mice. Method Using normal models and water-losing constipation models or diphenoxylate model, we observed alvine pushing rate in normal models and the time of first dark stools, the granule number and weight of stools in constipation models. Result By orally administrating different dosages, Liuwei Nengxiao capsules could increase alvine pushing rate of normal mice and the granule number and weight of stools in constipation groups, the dosage of 1.8 g/kg shortened the time of first dark stools and significantly increased granule number and weight. The dosage of 0. 9 g/kg shortened the time of first dark stools. Conclusion Liuwei Nengxiao capsules have the effect of loosening bowel to relieve constipation in mice. 相似文献