共查询到20条相似文献,搜索用时 31 毫秒
1.
Lee BB Cha MR Kim SY Park E Park HR Lee SC 《Plant foods for human nutrition (Dordrecht, Netherlands)》2007,62(2):79-84
Organic solvent (methanol, ethanol, and acetone) extracts and water extracts of cherry (Prunus serrulata var. spontanea) blossoms were prepared, and antioxidant activities of the extracts were evaluated. Methanolic CBE (100 μg/ml) showed the
highest total phenol content (104.30 μM), radical scavenging activity (34.2%), and reducing power (0.391). The effect of CBE
on DNA damage induced by H2O2 in human leukocytes was evaluated by Comet assay. All CBE was a potent dose dependent inhibitor of DNA damage induced by
200 μM of H2O2, methanolic CBE showed the most strong inhibition activity. The methanolic CBE of 500 μg/ml showed 38.8% inhibition against
growth of human colon cancer cell line HT-29. These results indicated that cherry blossoms could provide valuable bioactive
materials. 相似文献
2.
Tundis R Loizzo MR Menichini F Bonesi M Conforti F Statti G De Luca D de Cindio B Menichini F 《Plant foods for human nutrition (Dordrecht, Netherlands)》2011,66(3):261-269
The present study aimed to evaluate for the first time the phenols, flavonoids, carotenoids, capsaicin and dihydrocapsaicin
content and the antioxidant and hypoglycemic properties of Capsicum annuum var. acuminatum small and C. annuum var. cerasiferum air-dried fruits. The ethanol extract of C. annuum var. acuminatum small, characterized by the major content of total poliphenols, flavonoids, carotenoids and capsaicinoids, showed the highest
radical scavenging activity (IC50 of 152.9 μg/ml). On the contrary, C. annuum var. cerasiferum showed a significant antioxidant activity evaluated by the β-carotene bleaching test (IC50 of 3.1 μg/ml). The lipophilic fraction of both C. annuum var. acuminatum and C. annuum var. cerasiferum exhibited an interesting and selective inhibitory activity against α-amylase (IC50 of 6.9 and 20.1 μg/ml, respectively). 相似文献
3.
Jalal Pourahmad Mohammad Reza Eskandari Rashin Shakibaei Mohammad Kamalinejad 《Plant foods for human nutrition (Dordrecht, Netherlands)》2010,65(1):83-89
Mango (Mangifera indica L.) and their components are commonly used in folk medicine for many curative effects. The protective
effects of different concentrations of aqueous extract of Mangifera indica L. fruit (Mango Extract) (20, 50 and 100 μg/ml)
and also gallic acid (100 μM) as a pure compound in the extract were examined against oxidative stress toxicity induced by
cumene hydroperoxide (CHP) in isolated rat hepatocytes. The extracts and gallic acid (100 μM) protected the hepatocyte against
all oxidative stress markers including cell lysis, ROS generation, lipid peroxidation, glutathione depletion, mitochondrial
membrane potential decrease, lysosomal membrane oxidative damage and cellular proteolysis. Mango Extracts (20, 50 and 100 μg/ml)
were more effective than gallic acid (100 μM) in protecting hepatocytes against CHP induced lipid peroxidation. On the other
hand gallic acid (100 μM) acted more effective than Mango Extracts (20, 50 and 100 μg/ml) at preventing lysosomal membrane
damage. In addition H2O2 scavenging effect of all extracts were determined in hepatocytes and compared with gallic acid (100 μM). There were no significance
differences (P<0.05) between all plant extracts and gallic acid (100 μM) in H2O2 scavenging activity. These results suggest a hepatoprotective role for Mango Extract against liver injury associated with
oxidative stress. 相似文献
4.
Tea is a popular beverage whose consumption is associated with prevention of certain disorders. The objective of the study
was to investigate the potential neuroprotective effect of white tea extract (WTE) on hydrogen peroxide induced toxicity in
PC12 cells. Cells were treated with various doses of WTE (10–250 μg/ml) before exposition to 250 μM hydrogen peroxide and
cell survival was determined through the MTT and LDH assays. Oxidative stress was quantified in the cells after treatments
as intracellular reactive oxygen species (ROS) production and the antioxidant activity of the extract was assessed in a cell
free system in terms of free radical scavenging capacity. Results showed that WTE has a significant protective effect in the
PC12 cell line against hydrogen peroxide as cell survival was significantly superior in WTE-treated cells compared to hydrogen
peroxide-treated cells. A reduction on intracellular oxidative stress as well as radical scavenging properties were produced
by WTE. Results suggest that WTE protects PC12 cells against H2O2-induced toxicity, and that an antioxidant mechanism through ROS scavenging may be in part responsible for cells neuroprotection. 相似文献
5.
To identify the potential of green leafy vegetables (GLV) as antioxidants, methanolic extracts of Amaranthus sp., Centella asiatica, Murraya koenigii and Trigonella foenum graecum were studied for their antioxidant activity in different systems at multiple concentrations. Total antioxidant activity assessed
by phosphomolybdenum method, free radical scavenging activity by 1,1-diphenly-2-picryl hydrazyl (DPPH), reducing power and
ferrous ion chelating activity were determined. The GLV were analyzed for ascorbic acid, total and β-carotene and total polyphenol
contents. The ascorbic acid, total carotene, β-carotene and total phenolic content (tannic acid equivalents) of the GLV ranged
between 15.18–101.36, 34.78–64.51, 4.23–8.84 and 150.0–387.50 mg/100 g GLV, respectively. The extracts were found to have
significantly different levels of antioxidant activities in the systems tested. The total antioxidant activity was highest
in Murraya koenigii (2,691.78 μmol of ascorbic acid/g sample) and least in Centella asiatica (623.78 μmol of ascorbic acid/g sample). The extract concentration causing 50% inhibition of DPPH (IC50) was determined (M. koenigii < C.asiatica < Amaranthus sp. < T. graecum). The maximum DPPH scavenging activity and reducing power was exhibited by Murraya koenigii. Multiple regression analysis showed that the relationship of total antioxidant activity, free radical scavenging activity,
and reducing power with polyphenol and total and β-carotene was highly significant.
Paper awarded the Young Scientist Award in Experimental Nutrition at the Young Scientist Award Session of the 39th Annual
Meet of the Nutrition Society of India, Hyderabad, India on 15–16th Dec 2007. 相似文献
6.
Jarinyaporn Naowaboot Patchareewan Pannangpetch Veerapol Kukongviriyapan Bunkerd Kongyingyoes Upa kukongviriyapan 《Plant foods for human nutrition (Dordrecht, Netherlands)》2009,64(2):116-121
In Thailand, beverages containing mulberry leaf (Morus alba L.) are believed to promote good health, especially in people with diabetes. We examined the effects of long-term administration
of an ethanolic extract of mulberry leaf (MA) on blood glucose, oxidative damage, and glycation in streptozotocin-induced
diabetic rats. Daily administration of 1 g/kg MA for six weeks decreased blood glucose by 22%, which was comparable to the
effect of 4 U/kg insulin. Lipid peroxidation, measured as malondialdehyde and lipid hydroperoxide concentrations (3.50 ± 0.33
and 3.76 ± 0.18 μM, respectively) decreased significantly (P < 0.05) compared to nontreated control diabetic rats (8.19 ± 0.45 and 7.50 ± 0.46 μM, respectively). Hemoglobin A1C, a biomarker for chronic exposure to high concentration of glucose, was also significantly decreased in the MA-treated group
(6.78 ± 0.30%) in comparison to untreated group (9.02 ± 0.30%). The IC50 of in vitro antiglycation and free radical scavenging activities of MA were 16.4 ± 5.6 μg/ml and 61.7 ± 2.1 μg/ml, respectively. These
findings support that long-term administration of MA has antihyperglycemic, antioxidant and antiglycation effects in chronic
diabetic rats, which may be beneficial as food supplement for diabetics. 相似文献
7.
Yoshinori Okada Mizue Okada Yumi Sagesaka 《Plant foods for human nutrition (Dordrecht, Netherlands)》2010,65(3):225-232
To search for dried plant seeds with potent anti-diabetes activity, we conducted a large scale screening for inhibitory activity
on tumor necrosis factor-alpha and facilitating activity on adiponectin production in vitro. These activities in 3T3-L1 adipocytes were screened from ethanol extracts of 20 kinds of dried plant seed marketed in Japan.
komatsuna (Brassica rapa var. perviridis), common bean (Phaseolus vulgaris L.), qing geng cai (Brassica rapa var. chinensis), green soybean (Glycine max), spinach (Spinacia oleracea L.) and sugar snap pea (Pisum sativum L.) markedly enhanced adiponectin production (11.3 ~ 12.7 ng/ml) but Japanese radish (Raphanus sativus), edible burdock (Arctium lappa L.), bitter melon (Momordica charantia) and broccoli (Brassica oleracea var. italica) did not (0.9 ~ 2.7 ng/ml). All adiponectin-production-enhancing seeds except spinach (2.7 pg/ml) and okra (Abelmoschus esculentus) (6.6 pg/ml) effectively decreased tumor necrosis factor-alpha levels (0.0 pg/ml). We further examined the effects on free
radical scavenging activities in the dried seed extracts. Although scavenging activity correlated well with total phenolic
content of samples, no correlation was observed with adiponectin production. These results point to the potential of dried
seed extracts as a means to modify the activity of tumor necrosis factor-alpha for the adiponectin production. 相似文献
8.
A. F. de Faria V. V. de Rosso A. Z. Mercadante 《Plant foods for human nutrition (Dordrecht, Netherlands)》2009,64(2):108-115
Carotenoids are pigments responsible for the yellow-reddish color of many foods and are related to important functions and
physiological actions, preventing several chronic-degenerative diseases. The objective of this study was to confirm the carotenoid
composition of jackfruit by high-performance liquid chromatography connected to photodiode array and mass spectrometry detectors
(HPLC-PDA-MS/MS). The main carotenoids were all-trans-lutein (24–44%), all-trans-β-carotene (24–30%), all-trans-neoxanthin (4–19%), 9-cis-neoxanthin (4–9%) and 9-cis-violaxanthin (4–10%). Either qualitative or quantitative differences, mainly related to the lutein proportion, were found
among three batches of jackfruit. Since the fruits from batch A showed significantly lower contents for almost all carotenoids,
it also had the lowest total carotenoid content (34.1 μg/100 g) and provitamin A value, whereas the total carotenoid ranged
from 129.0 to 150.3 μg/100 g in the other batches. The provitamin A values from batches B and C were 3.3 and 4.3 μg RAE/100 g,
respectively. The carotenoid composition of jackfruit was successfully determined, where 14 of the 18 identified carotenoids
were reported for first time. Differences among batches may be due to genetic and/or agricultural factors. 相似文献
9.
Apostolidis E Karayannakidis PD Kwon YI Lee CM Seeram NP 《Plant foods for human nutrition (Dordrecht, Netherlands)》2011,66(4):313-319
Ascophyllum nodosum is a brown seaweed that grows abundantly in the US Northeast coastal region. This study examined the seasonal variation of
A. nodosum in phenolic contents and subsequent antioxidant, α-glucosidase and α-amylase inhibitory activities. A. nodosum was harvested monthly and extracted in hot water and the resulting extracts were spray-dried. The results indicate a clear
seasonal variation in terms of phenolic content, with June and July being the highest (36.4 and 37 mg/g, respectively) and
May the lowest (21.8 mg/g). The antioxidant activities, in terms of 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging
activity, correlated with the phenolic contents observed (r = 0.81), with the month of July being the highest (58%) and April the lowest (26%). Similarly in terms of Trolox equivalent,
July had the highest activity (15.53 μM) and April and May the lowest (8.40 and 8.27 μM, respectively). α-glucosidase inhibitory
activity exhibited a pattern similar to the phenolic contents observed with July having the highest inhibitory activity (IC70 2.23 μg) and April the lowest (IC70 26.13 μg), resulting in an inverse correlation between IC70 values and total phenolic content (r = −0.89). Such seasonal variation is believed to be caused by temperature-related stress considering that A. nodosum is a cold water species. 相似文献
10.
Karki R Sahi N Jeon ER Park YS Kim DW 《Plant foods for human nutrition (Dordrecht, Netherlands)》2011,66(1):27-33
Oxidation susceptibility of serum lipid and the proliferation and migration of vascular smooth muscle cells (VSMC) from tunica
media to the sub endothelial region are the key steps in the progression of atherosclerosis. The objective of this study was
to determine the effects of Chungtaejeon (CTJ) on oxidation and cytokine induced proliferation and migration of human aortic
smooth muscle cells (HASMC). The antioxidative effects of CTJ were evaluated by using 1,1-diphenyl-2-picryl hydrazyl (DPPH)
scavenging assay, nitric oxide (NO) scavenging assay and thiobarbituric acid reactive substance (TBARS) assay. Similarly,
the proliferation, migration and expression of matrix metalloproteinases (MMPs) in HASMC were assessed by MTT assay, transwell
Boyden chamber assay and gelatin zymography, respectively. Western blotting was done to determine the protein expression of
MMP-9, phospho extracellular regulated kinase (pERK1/2) and phospho c-Jun N-terminal kinase (pJNK). In results, the IC50 values for DPPH and NO scavenging activities were 8.91 μg/ml and 14.32 μg/ml, respectively. Furthermore, CTJ inhibited TBARS
formation dose dependently. The pretreatment of CTJ dose dependently inhibited the tumor necrosis factor-α (TNF-α) induced
proliferation and MMP-9 expression and platelet derived growth factor (PDGF) induced migration of HASMC. Thus, CTJ can be
suggested to have beneficial effect in the prevention of atherosclerosis. 相似文献
11.
Xiao-ming Yang Wei Yu Zhong-ping Ou Hai-le Ma Wei-ming Liu Xue-lin Ji 《Plant foods for human nutrition (Dordrecht, Netherlands)》2009,64(2):167-173
The antioxidative activities of water extract (WE) and crude hot-water soluble polysaccharide (PS) from Ficus carica L. fruit were investigated using various assays in vitro, including scavenging abilities on DPPH, superoxide and hydroxyl radicals and reducing power. The immunity activities of
PS were evaluated using the carbon clearance test and serum hemolysin analysis in mice. In addition, total phenolics and flavonoids
contents were also determined. Both WE and PS have notable scavenging activities on DPPH with the EC50 values of 0.72 and 0.61 mg/ml, respectively. The PS showed higher scavenging activity than WE on superoxide radical (EC50, 0.95 mg/ml) and hydroxyl anion radical (scavenging rate 43.4% at concentration of 4 mg/ml). The PS (500 mg/kg) also has
a significant increase in the clearance rate of carbon particles and serum hemolysin level of normal mice. The results indicate
that both WE and PS might be applicable in healthy medicine and food industry. 相似文献
12.
Monica Rosa Loizzo Ataa Said Rosa Tundis Usama W. Hawas Khaled Rashed Federica Menichini Natale Giuseppe Frega Francesco Menichini 《Plant foods for human nutrition (Dordrecht, Netherlands)》2009,64(4):264-270
The object of the study was to determine the chemical composition of Diospyros lotus L. extract and their antioxidant and antiproliferative properties. Eight compounds were isolated from D. lotus and identified as gallic acid, methylgallate, ellagic acid, kaempferol, quercetin, myricetin, myricetin 3-O-β-glucuronide, and myricetin-3-O-α-rhamnoside. D. lotus extract tested in different in vitro systems (DPPH, ABTS, FRAP, and Fe2+ chelating activity assay) showed significant antioxidant activity. The potential antiproliferative properties of D. lotus extract and isolated compounds against nine human cancer cell lines such as COR-L23, CaCo-2, C32, ACHN, A375, A549, Huh-7D12,
MCF-7, and LNCaP were investigated in vitro by SRB assay. D. lotus extract demonstrated the highest inhibitory activity against COR-L23 with an IC50 value of 12.2 μg/ml. Among identified hydrolysable tannins, ellagic acid evidenced strong antiproliferative activity against
both C32 and A375 cells with IC50 values of 0.8 and 4.1 μg/ml, respectively. Interesting results were observed, also, with gallic acid that showed the highest
cytotoxic activity against CaCo-2 (IC50 2.6 μg/ml). Overall, the results of this study suggest that D. lotus displays a good antioxidant activity and has antiproliferative effects. Both activities are related to identified phenolic
compounds. 相似文献
13.
Juan Fernando Pío-León Gabriela López-Angulo Octavio Paredes-López Magdalena de Jesús Uribe-Beltrán Sylvia Páz Díaz-Camacho Francisco Delgado-Vargas 《Plant foods for human nutrition (Dordrecht, Netherlands)》2009,64(3):181-187
Bromelia pinguin L. is a plant native to Sinaloa, Mexico, where its fruit is used as food or as a phytotherapeutic agent. The fruits of B. pinguin were characterized and they could be considered as a functional food. These fruits show an average weight of 13.7 g and a
yellow color of high luminosity (b* = 43.2, L* = 74.5). The values for acidity (4.6%, as citric acid) and pH (3.7) of B. pinguin fruit are similar to those of citrics. The edible portion is characterized by a high content of vitamin C (126 mg/100 g),
ash (10.6 g/100 g d.w.), crude fiber (3.4 g/100 g d.w.), calcium (1290 mg/100 g d.w.), magnesium (500 mg/100 g d.w.), manganese
(2.95 mg/100 g d.w.) and it is a good source of zinc (2.8 mg/100 g d.w.). Polar fractions extracted from the pulp fruit showed
activity against several genera of human pathogenic-bacteria (Staphylococcus, Streptococcus, Enterococcus, Salmonella, Shigella, Escherichia and Pseudomonas). 相似文献
14.
Jimenez M Guzman AP Azuara E Garcia O Mendoza MR Beristain CI 《Plant foods for human nutrition (Dordrecht, Netherlands)》2012,67(1):57-63
Porophyllum tagetoides is an annual warm-weather herb that has an intense typical smell. Its leaves are commonly used in soup preparation and traditional
medicine for treatment of inflammatory diseases. Its volatile compounds and antioxidant properties were evaluated in crude,
aqueous and ethanol leaf extract and an oil emulsion using different antioxidant assays in vitro, such as: DPPH radical scavenging activity, redox potential, polyphenol content, reducing power and optical density. A high
antioxidative activity was found when comparing leaves with stems. The crude extract from leaves showed a very high reducing
power (2.88 ± 0.20 O.D.) and DPPH radical-scavenging activity (54.63 ± 4.80%), in concordance with a major concentration of
vitamin C (23.97 ± 0.36 mg/100 g). Instead, the highest polyphenol content (264.54 ± 2.17 mg GAE/g of sample) and redox potential
(561.23 ± 0.15 mV) were found by the ethanol and aqueous extract, respectively. Aldehydes and terpenes such as nonanal, decanal,
trans-pineno, β-myrcene and D-limonene were the major volatiles found. This study suggests that Porophyllum tagetoides extracts could be used as antioxidants. 相似文献
15.
Jae-Hee Park Yoo Kyoung Park Eunju Park 《Plant foods for human nutrition (Dordrecht, Netherlands)》2009,64(4):244-249
This study describes the antioxidant activities and antigenotoxic effects of garlic extracts prepared by different processing
methods. Aged-garlic extract (AGE) showed a significantly higher total phenolic content (562.6 ± 1.92 mg/100 g garlic acid
equivalents) than those of raw garlic extract (RGE) or heated garlic extract (HGE). The SC50 for DPPH RSA in HGE was significantly the highest at 2.1 mg/ml. The SC50 for SOD-like activity in garlic extracts was, in decreasing order, RGE (7.3 mg/ml) > AGE (8.5 mg/ml) > HGE (9.2 mg /ml).
The ED50 of AGE was the highest (19.3 μg/ml) regarding H2O2 induced DNA damage and its inhibition rate was 70.8%. The ED50 of RGE for 4-hydroxynonenal (a lipid peroxidation product) induced DNA damage was 38.6 μg/ml, followed by AGE > HGE. Although
the heat treatment of garlic tended to decrease the TPC and SOD-like activity and increased DPPH RSA, garlic, in general,
has significant antioxidant activity and protective effects against oxidative DNA damage regardless of processing method. 相似文献
16.
Korekar G Stobdan T Arora R Yadav A Singh SB 《Plant foods for human nutrition (Dordrecht, Netherlands)》2011,66(4):376-383
Fourteen apricot genotypes grown under similar cultural practices in Trans-Himalayan Ladakh region were studied to find out
the influence of genotype on antioxidant capacity and total phenolic content (TPC) of apricot kernel. The kernels were found
to be rich in TPC ranging from 92.2 to 162.1 mg gallic acid equivalent/100 g. The free radical-scavenging activity in terms
of inhibitory concentration (IC50) ranged from 43.8 to 123.4 mg/ml and ferric reducing antioxidant potential (FRAP) from 154.1 to 243.6 FeSO4.7H2O μg/ml. A variation of 1–1.7 fold in total phenolic content, 1–2.8 fold in IC50 by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and 1–1.6 fold in ferric reducing antioxidant potential among the examined
kernels underlines the important role played by genetic background for determining the phenolic content and antioxidant potential
of apricot kernel. A positive significant correlation between TPC and FRAP (r = 0.671) was found. No significant correlation was found between TPC and IC50; FRAP and IC50; TPC and physical properties of kernel. Principal component analysis demonstrated that genotypic effect is more pronounced
towards TPC and total antioxidant capacity (TAC) content in apricot kernel while the contribution of seed and kernel physical
properties are not highly significant. 相似文献
17.
Syed Sultan Beevi Mangamoori Lakshmi Narasu Bandi Boje Gowda 《Plant foods for human nutrition (Dordrecht, Netherlands)》2010,65(1):8-17
Aerial parts (leaves and stem) of Raphanus sativus, which are usually discarded were found to possess potent antioxidant and radical scavenging activity, as measured by standard
antioxidant assays. Methanolic and acetone extracts of R. sativus leaves had total polyphenolic content of 86.16 and 78.77 mg/g dry extract, which were comparable to the traditional rich
sources such as green tea and black tea. HPLC identification of polyphenolics indicated the presence of catechin, protocatechuic
acid, syringic acid, vanillic acid, ferulic acid, sinapic acid, o-coumaric acid, myricetin, and quercetin in leaves and stem. Among the different extraction solvents, methanolic extract of
leaves and stem showed potent reductive capacity, significantly inhibited linoleic acid peroxidation and displayed metal chelating
activity. Further, they scavenged free radicals effectively with IC50 (half maximal inhibitory concentration) of 31 and 42 μg/ml for DPPH radical, 23 and 52 μg/ml for superoxide radical, 67 and
197 μg/ml for hydrogen peroxide, and 56 and 62 μg/ml for nitric oxide, respectively. Leaves showed most potent antioxidant
and radical scavenging activity as compared to stem, which may be accounted for the high polyphenolic content. Leaves and
stem of R. sativus, often under-utilized part of this vegetable, thus possessed considerable amount of polyphenolics. Hence, it should be regarded
as a potential source of natural antioxidants and could be effectively employed as an ingredient in health or in functional
food. 相似文献
18.
Nevcihan Gursoy Bektas Tepe 《Plant foods for human nutrition (Dordrecht, Netherlands)》2009,64(2):135-140
This study was designed to examine the in vitro antimicrobial and antioxidant activities and the amount of total phenolics of the methanol extracts of Ballota rotundifolia L. and Teucrium chamaedrys C. Koch. In the case of antimicrobial activity tests, polar sub-fractions of the methanol extracts of plant species exhibited
weakest antimicrobial activity when compared with the non-polar ones. While, non-polar sub-fraction of B. rotundifolia showed moderate activity against A. lwoffii, C. perfringens and the yeasts, T. chamaedrys performed excellent activity pattern against all of the tested microorganisms. The sub-fractions were also screened for their
possible antioxidant activities by two complementary tests, namely DPPH free radical-scavenging and β-carotene/linoleic acid assays. Non-polar extracts of the plant species remained inactive in both test systems. On the other
hand polar extracts showed remarkable antioxidant activities. In DPPH system, free radical scavenging effect of T. chamaedrys was measured as 18.00 ± 1.42 μg.mg−1. It is extremely important to point out that, polar sub-fraction of T. chamaedrys is found as effective as the positive control BHT. Non-polar sub-fraction of T. chamaedrys found to have the highest total phenolic amount (97.12 ± 1.28 μg/mg). Results obtained from this experiment confirm the relationship
between the amount of phenolics and biological activities. 相似文献
19.
Total Phenolics Level,Antioxidant Activities and Cytotoxicity of Young Sprouts of Some Traditional Korean Salad Plants 总被引:2,自引:2,他引:0
Sang-Uk Chon Buk-Gu Heo Yong-Seo Park Dong-Kwan Kim Shela Gorinstein 《Plant foods for human nutrition (Dordrecht, Netherlands)》2009,64(1):25-31
The aim of this investigation was to study the antioxidant and anticancer activities of young sprouts of some traditional
Korean salad plants. Total phenolics, antioxidant and anticancer activities of the methanol extracts from young sprouts of
11 salad plants were determined. The highest amount of phenolics was found in methanol extracts of Euonymus alatus (235.7 mg kg−1), followed by Hypericum ascyron (197.1 mg kg−1), Zanthoxylum piperitum (194.1 mg kg−1) and Zanthoxylum schinifolium (142.5 mg kg−1). Methanol extracts of E. alatus, H. ascyron, and Z. piperitum at 63 mg kg−1 exhibited the highest dose-depend DPPH radical scavenging activity by 91.2, 91.2 and 83.9%, respectively. According to the
MTT results, the methanol extracts from Stellaria aquatica, Eleutherococcus sessilifolrus and Z. schinifolium showed the highest anticancer activities against Calu-6 (IC50 < 25.0 μgml−1) and from S. aquatica—the highest anticancer activities against SNU-601 (153.3 μgml−1), following by E. sessilifolrus (196.7 μg ml−1) and Amaranthus mangostanus (303.1 μgml−1). Total phenolics were highly correlated with the DPPH, suggesting that they contribute to the antioxidant properties of
the studied plants. In conclusion: young sprouts of Korean salad possess antioxidant and anticancer properties and could be
used as a supplement to proper drugs. 相似文献
20.
Morihara N Hayama M Fujii H 《Plant foods for human nutrition (Dordrecht, Netherlands)》2011,66(1):17-21
There is increasing evidence to suggest that many degenerative or pathological processes, such as aging, cancer, and coronary
heart disease, are related to reactive oxygen species and radical-mediated reactions. We examined the effectiveness of aged
garlic extract (AGE), a garlic preparation rich in water-soluble cysteinyl moieties, and its component for scavenging of superoxide
by using the hypoxanthine-xanthine oxidase and human neutrophils. In the hypoxanthine-xanthine oxidase system, electron spin
resonance showed that aged garlic extract scavenged superoxide radicals in a dose-dependent manner up to 54%. The EC50 value of aged garlic extract for the superoxide radical scavenging effect was 0.80 mg/ml. N-α-(1-deoxy-D-fructos-1-yl)-L-arginine
(25.9%) and (1S, 3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-1,3-dicarboxylic acid (20.8%), water-soluble moieties of AGE,
also exerted superoxide scavenging effects. Phorbol 12-myristate 13-acetate-activated human neutrophils produced superoxide
radical of 56.6 ± 9.27 nmol/min/107 cells. Aged garlic extract (3 mg/ml) significantly inhibited superoxide production in comparison to the control. These data
suggest that aged garlic extract may be useful for preventing diseases associated with reactive oxygen species. 相似文献