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Alpha-synuclein is implicated in several neurodegenerative disorders, such as Parkinson's disease and multiple system atrophy, yet its functions remain obscure. When expressed in yeast, alpha-synuclein associated with the plasma membrane in a highly selective manner, before forming cytoplasmic inclusions through a concentration-dependent, nucleated process. Alpha-synuclein inhibited phospholipase D, induced lipid droplet accumulation, and affected vesicle trafficking. This readily manipulable system provides an opportunity to dissect the molecular pathways underlying normal alpha-synuclein biology and the pathogenic consequences of its misfolding. 相似文献
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van Oss CJ 《Science (New York, N.Y.)》1963,139(3559):1123-1125
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[目的]研究甘油/TiO2聚偏氟乙烯(PVDF)微孔膜的制备及其在膜蒸馏中的应用.[方法]采用浸没沉淀相转化法制备PVDF微孔膜,研究了不同TiO2质量分数下加入甘油形成不同比例的混合添加剂对微孔膜结构及性能的影响.[结果]所制备的微孔膜具有较高的牛血清蛋白截留率,基本上都在90%以上;纯水通量集中在3~22 L/(m2·h)之间.[结论]当TiO2为3%、甘油添加量为0.4g时,膜的性能相对较好.随后把该条件下制备的微孔膜应用到膜蒸馏过程中进行NaCl溶液分离的试验研究,脱盐率最高可达30%;并且得到了膜装置运行的最优条件:料液温度为50℃、流量为5L/h、料液浓度为15 g/L. 相似文献
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H Rottenberg 《Science (New York, N.Y.)》1978,199(4328):568-569
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【目的】以大肠杆菌ATCC43889为试材,研究热胁迫处理对其细胞膜和膜蛋白的影响,为高温杀菌技术在食品工业中的应用奠定理论基础。【方法】研究ATCC43889分别经50℃、60℃和70℃热胁迫处理15 min并转接10次培养后,获得的3种抗热性ATCC43889菌株的细胞膜和膜蛋白变化。采用扫描电子显微镜分别观察原始对照菌株和3种抗热性菌株个体形态的变化;采用96孔微量酶标板法测定各菌株生物被膜生成能力的强弱;用气相色谱法测定各菌株细胞膜脂肪酸组成的变化及其差异;用差示扫描量热法测定各菌株细胞膜磷脂相变温度的变化;通过聚丙烯酰胺凝胶电泳(SDS-PAGE)法检测各菌株外膜蛋白表达的变化。【结果】大肠杆菌ATCC43889分别经50℃、60℃和70℃各10次热胁迫处理并转接10次培养后,其个体形态变化明显,经50℃热胁迫后,部分菌株由球状体变为长杆状;经60℃热胁迫后的菌株个体形态较50℃热胁迫处理的菌株细长;经70℃热胁迫处理后大部分菌株变成了更细长的杆状,大量的菌株聚集在一起,菌体表面呈凸凹不平的无规则形态。随着热胁迫温度的提高,ATCC43889抗热性菌株的生物被膜生成活力增大,... 相似文献
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镉对水稻幼苗根系细胞膜电位和膜透性的影响 总被引:1,自引:0,他引:1
镉(Cd)对膜透性、跨膜电势差等膜性质所产生的直接影响是造成Cd胁迫下植物对营养元素吸收异常的重要原因。以对Cd2+敏感性不同的两个水稻品种(淮稻11号和扬稻6号)作为试验材料,采用玻璃微电极技术原位考察了水稻幼苗根细胞膜电位对Cd2+胁迫的响应,同时分析了Cd2+对水稻根系细胞膜透性的影响。结果表明,Cd2+可使根表皮细胞膜电位在短时间内发生明显的去极化,去极化程度随Cd2+浓度提高而增加;相同浓度Cd2+所诱导的膜电位去极化程度与水稻品种有关,扬稻6号幼苗根系膜电位的去极化程度明显高于淮稻11号;在迅速的去极化之后,随后的30min内是否发生复极化与水稻品种和Cd2+浓度有关;就更长时间(0~12h)来看,膜电位在经过了去极化阶段后仍有缓慢的恢复,淮稻11号在1.0mmo1·L-1Cd2+处理6h后已接近初始的膜电位值,而扬稻6号在处理12h后仍不能恢复到处理前的水平;Cd2+处理增大了水稻根细胞膜透性,且扬稻6号比淮稻11号膜透性增加的程度要大。 相似文献
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采用0.05μm 陶瓷膜对洗浴污水进行分离效果试验,对比过滤前后洗浴污水常规指标的变化情况,分析膜通量的变化规律.探究膜污染后膜通量恢复的最佳条件,运用物理、化学及物理化学联合方法进行清洗,得出最佳的清洗方法.试验结果表明,0.05μm 的陶瓷膜对洗浴污水的浊度、悬浮物、COD、BOD、微生物去除效果较好,洗浴污水循环过滤后可就地直接回用于池水;膜通量恢复方法中,利用单步物理清洗和化学清洗正交试验得出物理-化学复合清洗的最佳条件,即先超声5 min,再用2%的柠檬酸反冲洗30 min,清洗后膜通量恢复率高达99%. 相似文献
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W Stoeckenius 《Science (New York, N.Y.)》1968,160(827):561-562
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SHANES AM 《Science (New York, N.Y.)》1963,140(3568):824-825
A model of permeation of living membranes is proposed in which penetration by polar molecules takes place through islands composed of limited numbers of lipoidal molecules in a state comparable to that of certain compressed monolayers. These islands are visualized as scattered within a rigid, relatively impervious matrix. Relationships for penetration of monolayers by gases have been applied to this membrane model. Calculations on this basis demonstrate that the permeabilities relative to water are described at least as well by this model as by that assuming rigid pores of 4.25 A radius. 相似文献
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Myelin Membrane: a molecular abnormality 总被引:2,自引:0,他引:2
Myelin was isolated from cerebral white matter from a patient who had died of metachromatic leukodystrophy, and its lipid composition was analyzed. Although the lipid content was nearly normal, the myelin contained a three- to fourfold excess of cerebroside sulfate and a threefold deficiency of cerebroside compared to normal myelin. The deficiency of cerebroside and the excess of cerebroside sulfate may account for defective myelination in this disease. 相似文献
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