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1.
Hideki Senoh Taku Katagiri Kenji Takanobu Yumi Umeda Shigetoshi Aiso Shoji Fukushima 《Journal of toxicologic pathology》2014,27(2):139-142
Harderian gland tumors are extremely rare in female F344 rats. An expansive enlarging lesion of the Harderian gland with compression, distortion and invasion of the surrounding muscle was found in a 110-week-old female F344/DuCrj rat, which was diagnosed as a Harderian gland adenocarcinoma. Epithelial growth patterns such as glandular, lobular, papillary and duct forming patterns were exhibited in most areas of the tumor. The tumor cells were pleomorphic and atypical. In one part of the tumor, poorly differentiated areas were found. This case was observed in the middle dose group of a carcinogenicity study of diphenylamine, which was not carcinogenic, we determine to be this case was a spontaneous tumor. 相似文献
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大鼠乳腺局部免疫的调节机制--泌乳期与静止期乳腺肥大细胞分布的比较 总被引:5,自引:1,他引:5
应用改良甲苯胺蓝染色法(MTB)观察了大鼠泌乳期和静止期乳腺肥大细胞的分布、形态、数量变化规律.并用阿尔新蓝一番红鉴别染色法(AB-S)进行了细胞化学分型研究。结果:AB-S染色显示,大鼠乳腺只存在黏膜型肥大细胞;无论是泌乳期还是静止期。乳腺肥大细胞大多分布于腺泡间和小叶问结缔组织中。细胞的形态各异,但细胞数量在静止期和泌乳期有显著差异。泌乳期的乳腺肥大细胞数量明显减少(P<0.01)。乳腺肥大细胞的动态变化,可能与乳腺泌乳期腺泡上皮的生长和静止期腺泡问结缔组织细胞增生等结构变化有关。 相似文献
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Yusuke Kuroda Seigo Hayashi Soichiro Hagio Masayoshi Abe Satoshi Furukawa Dai Nakae 《Journal of toxicologic pathology》2014,27(2):147-151
There are no reported spontaneous cases of pancreatic ductal adenocarcinoma (PDAC), and there are few reports about chemically-induced PDAC in rats. We encountered a PDAC in a Wistar Hannover GALAS rat that had been subjected to a medium-term multiorgan carcinogenicity bioassay. This article describes the histological and histochemical findings of the tumor. The tumor was located in the pancreatic tissue and had not invaded the liver parenchyma or the mucosal layer of the alimentary tract. The tumor cells were atypical and were mainly arranged in small tubules. In addition, abundant stroma and mucus production were observed in the tumor. In an immunohistochemical examination, the tumor cells were positive for cytokeratin, Sox9 and pancreas duodenum homeobox 1 and negative for amylase 2A and insulin. Therefore, the tumor was diagnosed as a PDAC based on its histological and histochemical findings. We considered that the tumor was caused by the carcinogens administered during the abovementioned bioassay. 相似文献
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Spontaneous hemangiosarcoma in young rats is rare. In this report, we describe a case of a spontaneous hemangiosarcoma in the spleen and liver of young rats. At necropsy, multiple pale red masses were observed in the spleen. Histopathologically, solid growth and haphazardly arranged neoplastic cells were observed, although no characteristic growth pattern was observed. In contrast, irregularly sized small slit-shaped spaces containing erythrocytes were found among the neoplastic cells. Reticular fibers incompletely surrounding the neoplastic cells were observed by silver staining. Immunohistochemistry revealed that the neoplastic cells were positive for vWF and CD34. Electron microscopic examination revealed that the neoplastic cells had erythrocytes in the lumen and Weibel-Palade bodies in the cytoplasm and were arranged along a discontinuous basal lamina. These features indicate that the tumor originated from vascular endothelial cells. Based on these results, the tumor was diagnosed as a hemangiosarcoma in the spleen and liver. 相似文献
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M. Yavuz Gulbahar Tolga Guvenc Murat Yarim Yonca B. Kabak Yuksel Sozgen 《Journal of veterinary science (Suw?n-si, Korea)》2007,8(4):423-425
A fibroadenoma was diagnosed in the left udder of a 3-month-old female Chios lamb. No recurrence was observed after surgery. Grossly, the tumor had a whitish-gray lobular appearance, and the lobules were interlaced with thin septa. Microscopically, the tumor was composed of proliferating fibroepithelial tissue, including differentiated ducts lined by whorls and interlacing bundles of abundant loose fibrovascular stroma. Immunohistochemistry revealed the ductal epithelium to be positive for pancytokeratin (AE1/AE3) and loose fibrovascular stroma was positive for vimentin and basal cells covering the ductal epithelium of alpha-smooth-muscle actin. Immunostaining for the estrogen and progesterone receptors was negative. A diagnosis of mammary fibroadenoma was made based on the histological and immunohistochemical findings. 相似文献
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Kayoko Kudo Toru Hoshiya Tomomi Nakazawa Tsubasa Saito Natsumi Shimoyama Isamu Suzuki Kazutoshi Tamura John Curtis Seely 《Journal of toxicologic pathology》2012,25(4):277-280
Spontaneous renal tubule tumors (RTTs), with a distinctive morphological phenotype, were
present in three Sprague-Dawley rats, 1 male and 2 females, out a total of 120 animals of each
sex from untreated and placebo control groups in a 2-year carcinogenicity study. One female had
one carcinoma, adenoma and hyperplasia, and the other female had five adenomas and many
hyperplastic lesions; the male case had one carcinoma. From these cases, a biological continuum
of hyperplasia, adenoma and carcinoma could be recognized. The tumors were present in the renal
cortex and appeared as solid lobulated growths with occasional central necrosis. The lobules
were divided by a small amount of fibrovascular tissue. Occasionally the larger tumors
contained a cystic area. Tumor cells appeared distinctive and exhibited variable amounts of
eosinophilic/amphophilic and vacuolated cytoplasm. Nuclei were round to oval with a prominent
nucleolus. Mitotic figures were uncommon, and no distant metastasis was noted. The tumors were
seen as multiple and bilateral lesions in two animals and had no apparent relationship to
chronic progressive nephropathy (CPN). Foci of tubule hyperplasia were also noted to contain
the same type of cellular morphology. The morphological and biological features of these 3
cases resembled the amphophilic-vacuolar (AV) variant of RTT that has been posited to be of
familial origin. This is a report of spontaneous familial renal tumors in Sprague-Dawley rats
from Japan. 相似文献
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Shelley J. Newman Stephen A. Smith Kurt Zimmerman 《Journal of veterinary diagnostic investigation》2021,33(3):566
A large, firm, multi-cystic mammary gland mass grew slowly over 4 y in a 12-y-old, female Finn–Shetland cross sheep. A diagnosis of epithelial malignancy was suspected following fine-needle aspiration cytology at 30 mo after initial observation. The sheep was euthanized when the flock was downsized 18 mo later. A field postmortem examination revealed a large mammary mass, but an absence of metastases to internal organs. Imprint cytology of the mammary tissue supported a benign proliferative process. Histologically, mammary tissue was obliterated by cystic, tubular, and papillary adenomatous arrangements of mammary epithelium, with an anaplastic component, consistent with mammary carcinoma arising in an adenoma. IHC showed strong nuclear positivity to the antibody against progesterone receptor and minimal positivity to the antibody against estrogen receptor alpha expression. Intrinsic subtyping for basal or luminal epithelial origin was attempted through adaptation of companion animal IHC classification panels; high- and low-molecular-weight cytokeratins (CK5, CK8, CK18) failed to stain, but p63 expression for basal epithelium was positive. 相似文献
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本试验旨在研究饲粮添加精氨酸(Arg)对娩后Wistar大鼠乳腺组织发育及其酪蛋白合成的影响。采用同窝对照的方法,选择同窝12只已受孕的Wistar大鼠,随机平均分为2组。Arg组在基础饲粮中添加与其等量的Arg(饲粮Arg含量1.280%),对照组饲粮用谷氨酸替代Arg组中的Arg以平衡饲粮氮水平。预试期4 d(分娩前4天)和正试期17 d(分娩后17天),结束后采集泌乳大鼠的乳腺组织,制作组织切片并测定其酪蛋白含量。结果表明:Arg能促进乳腺组织的发育,且乳腺腺泡切面面积的极显著增大(P0.01)。另外,Arg对乳腺β-酪蛋白的含量有显著的提高作用(P0.05),同时娩后大鼠体重也有增加的趋势(P0.05)。结果提示,饲粮添加Arg对Wistar大鼠乳腺组织发育及β-酪蛋白的合成有显著的促进作用。 相似文献
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Yinghua Li Hak-Soo Kim Min-Soo Kang Seo-Ho Shin Kyo-Hwan Koo Chul-Min Kim Kap-Ho Kim Charles Peck Han-Ik Bae Ji Yun Jeong Jin Seok Kang Boo-Hyon Kang 《Journal of toxicologic pathology》2013,26(1):67-72
The present report describes a rare case of spontaneous tumor of the salivary gland in a male Sprague-Dawley rat. The clinically confirmed mass rapidly developed in the cervical region between 19 and 21 weeks of age, and the animal was subsequently euthanized. At necropsy, a well-circumscribed nodule approximately 7 × 6 cm in diameter was found at the site of the salivary gland. The cut surface of the nodule was lobulated and soft and had a pinkish tan fish-flesh appearance. One large cyst (approximately 3 × 2 cm in size) containing reddish fluid was also present in the nodule. Histopathologically, the tumor, with a partially lobulated structure, was surrounded by a thin fibrous capsule. The majority of tumor cells formed a diffuse solid sheet structure that mainly consisted of small ovoid or spindle-shaped cells. In the tumor periphery, some cells were arranged in nest-like structures. Small duct-like structures lined with a monolayer of cuboidal epithelial cells resembling an intercalated duct or large polygonal clear cells with a myoepithelial component were also observed. Mitotic figures and necrotic foci were frequently observed in solid areas. Immunohistochemically, the tumor cells were positive for cytokeratin, epithelial membrane antigen, vimentin, p63, α-smooth muscle actin and calponin. The cells were negative for calcitonin, synaptophysin and chromogranin A. On the basis of these findings, the tumor was diagnosed as an epithelial-myoepithelial carcinoma originating from the luminal epithelial cells and myoepithelial cells in the submandibular gland. 相似文献
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Fifty-two spontaneous canine mammary gland tumours (fibroadenomas (n = 8), tubulopapillary carcinomas (n = 9), solid carcinomas (n = 6), anaplastic carcinomas (n = 7), fibrosarcomas (n = 9), liposarcomas (n = 9) and osteosarcomas (n = 4) were analysed by computer-assisted nuclear morphometry in Hemacolor-stained cytological specimens. Computerized cytomorphometry
was performed and the nuclear area, nuclear perimeter and mean nuclear diameter of investigated tumours were assessed. A minimum
of 100 nuclei per lesion were examined. The statistical analysis revealed statistically significant differences between benign
and malignant neoplasms. The results indicated that computer-assisted nuclear morphometry could be used as an additional method
for differentiation of benign from malignant canine mammary gland tumours in cytological specimens. 相似文献
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Marjorie Bercier David Sanchez-Migallon Guzman Jonathan Stockman Allison Zwingenberger Natalia Vapniarsky Linda Lowenstine Michelle G. Hawkins 《Journal of Exotic Pet Medicine》2013,22(2):218-224
A 2.4 kg, 7-year-old, female Rex rabbit was presented with a 4-month history of a left-sided head tilt, difficulty in mastication, lethargy, and chronic wasting. Diagnostic testing of the patient revealed a severe heterophilic leukocytosis and radiographic images of the skull radiographs indicated irregularity of the left tympanic bulla. A computed tomographic scan highlighted a heterogeneously contrast-enhancing mass, ventral and rostral to the left tympanic bulla, with contrast enhancement of the meninges on the left, consistent with an aggressive neoplasm. The patient was euthanized and the mass was identified as a salivary gland adenocarcinoma. The gland of origin is suspected to be the left parotid, owing to its location and close association with normal parotid tissue. To the authors' knowledge, this is the first report of a salivary gland adenocarcinoma in a domestic rabbit. A computed tomography (CT) scan and histopathology examination were useful modalities for identifying the neoplasm in this case. 相似文献
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不同物种的乳腺分泌物中含有的细胞成分被称为体细胞,其中包括淋巴细胞、白细胞、巨噬细胞和上皮细胞。物种、乳腺感染情况、不同生理阶段和饲养管理条件等因素均会影响乳中的体细胞数量和细胞类型。近年来,乳中体细胞得到了人们的关注和深入研究,显示出广阔的应用前景。人们利用从初乳和常乳中得到的乳腺上皮细胞已经成功进行了乳腺细胞的原代培养和建立了乳腺细胞系,为乳生成、被动免疫转移和乳腺癌的研究提供了良好平台。体细胞中提取的RNA代表了乳腺组织的基因表达,因此为研究乳腺组织的基因表达提供了方便、良好的来源。 相似文献
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[目的]探究水牛泌乳性与乳腺组织的关系。[方法]采用组织切片及显微照相研究摩拉水牛和摩×尼×本三元杂水牛泌乳期的乳腺组织。[结果]泌乳期水牛乳腺结缔组织和脂肪组织较少,腺泡较多。泌乳水牛乳腺组织占62.8%,结缔组织占7.6%,脂肪组织占19.6%。摩拉水牛乳腺小叶区域的乳腺泡数量范围为80~150个/mm2,直径范围为50~100μm。摩×尼×本三元杂水牛泌乳后期乳腺小叶区域的腺泡数量范围为50~100个/mm2,直径范围为50~150μm。[结论]乳腺腺泡数及大小是影响水牛泌乳量的重要内在因素。 相似文献
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半胱胺对奶山羊乳腺发育的影响 总被引:6,自引:0,他引:6
为了研究半胱胺对奶山羊乳腺发育的影响,选6只空怀奶山羊进行自身前后对照试验和8只妊娠奶山羊进行同胎次配对试验.结果表明,空怀奶山羊对照期乳腺的腺泡很少发育,几乎看不到乳导管,试验期乳腺有明显导管生长和少量腺泡发育;妊娠奶山羊对照组乳腺随着妊娠的进行有少量腺泡发育,腺导管有明显的生长,试验组乳腺有大量的腺泡发育,腺导管生长更明显,且有分泌物出现.试验期血浆中与乳腺发育相关的激素水平明显升高.以上结果提示半胱胺在一定程度上促进了奶山羊乳腺发育. 相似文献