犬瘟热的综合疗法与体会

犬瘟热是由副粘病毒科的犬瘟热病毒所引起的一种犬科动物的烈性传染病。其特点是传播速度快,流行范围广,死亡率高。另     

犬瘟热研究进展

犬瘟热是由犬瘟热病毒引起的一种高度接触性败血性传染病,患病动物早期表现呼吸道和消化道症状,后期出现神经症状,康复后仍有麻痹、抽搐、癫痫样发作等后遗症,本文在结合前人研究基础上。针对犬瘟热发病机理、病理变化及诊断技术的研究情况进行了综述．     

犬瘟热病毒感染的研究现状

犬瘟热（Canine distemper）是由犬瘟热病毒（Canine distemper virus,CDV）引起犬的一种急性、高度接触性传染病。早期表现以双相热、急性鼻卡他、卡他性肺炎和胃肠炎为特征,后期出现神经症状,少数病犬出现鼻和足垫过度角化现象。CDV感染是犬科动物最常见的、最主要的病毒性疾病之一,发病率高、治愈率低,是食肉动物病毒病的典型代表。笔者就近年来我国CDV感染的研究现状简述如下。     

犬瘟热预后状况之我见

本文结合临床经验，对肠炎型、肺炎发热型及神经型的犬瘟热的临床症状及预后做了全面的介绍，并指出了与其他易混淆疾病的鉴别诊断的方法，特别是对神经型犬瘟热的诊断，有相当一部分用试剂盒采进行确诊时显示为阴性。     

Lead poisoning and canine distemper

Clinical signs of lead poisoning are rather nonspecific and have often been confused with those of canine distemper. Described is a case of canine distemper which on clinical examination, haematology and biochemical test (U-ALA) indicated intoxication with lead. The case demonstrates the value of taking blood samples for the purpose of estimation of lead level in suspect cases of lead poisoning.     

Anosmia associated with canine distemper

The sense of smell in dogs infected with canine distemper virus (CDV) was examined by use of EEG olfactometry, behavioral olfactometry, and electro-olfactography. Infection with CDV was confirmed by a direct immunofluorescence technique in 8 active cases and was suggested by clinical history compatible with canine distemper 10 to 26 weeks earlier in 6 cases. Pathologic alterations of the olfactory mucosa in 3 clinically affected dogs was examined by light microscopy. Infection with CDV was found to be associated with anosmia and lack of recorded responses on electro-olfactogram in 8 of 8 dogs with clinical signs of acute distemper from naturally acquired infections. Anosmia was found in 5 of 6 dogs that had recovered from acute distemper 10 to 26 weeks earlier. The sixth dog had hyposmia, with abnormalities on the electro-olfactogram. Histologic examination was not performed on the 6 dogs that had recovered. Histologic lesions observed at necropsy in 3 dogs that had had clinical signs of acute distemper were those of subacute purulent rhinitis and atrophy of the olfactory epithelium. Altered olfactory function could be explained by mucopurulent exudate blocking odors from olfactory receptors in the acutely affected dogs, but alteration of olfactory function in the dogs that had recovered without clinical evidence of rhinitis could not be explained.     

犬瘟热的治疗

犬瘟热是犬瘟热病毒引起的犬科、鼬科和浣熊科动物的一种急性、热性传染病。临床上以呈现双相热型、鼻炎、严重的消化道障碍以及呼吸道炎症等为特征。本病常呈地方性流行,成为犬的主要传染病之一。且以幼犬发病较多。笔者自从1995年从事动物诊疗工作以来,治疗犬瘟热34例,治愈31例,治愈率94％,现简介如下。     

犬瘟热免疫失败的原因分析

犬瘟热是由犬瘟热病毒引起的主要危害1岁以内幼犬的传染性极强的急性传染病。由于发病率高、致死率高，给养犬者带来严重损失。长期以来，人们在治疗犬瘟热上进行了很多努力，但收效甚微。目前，接种疫苗预防犬瘟热已是众望所归，但由于种种原因，仍有许多免疫过的犬只发病。造成犬疫苗失败的原因是多方面的，主要原因有以下几种。     

犬瘟热诊断方法的研究进展

犬瘟热（Canine distemper,CD）是由犬瘟热病毒（Canine distempervirus,CDV）感染引起的急性、高度接触性传染病。CD的死亡率可高达80％,索有“毁灭性传染病”之称。CDV自然感染宿主除食肉目所有8个科外,还扩展到偶蹄目猪科、灵长目的猕猴属和鳍足目海豹科等多种动物,CDV自然感染的动物范围还有不断扩大的趋势,其危害性也越来越大。     

犬瘟热的诊断与治疗

犬瘟热是由副粘病毒科麻疹病毒属的犬瘟热病毒（CDP）引起的一种高度接触性传染病。 1发病情况 2007年9月甘肃某地一狗贩从青海某狗市买进30多只犬,年龄大小不一,买进时犬有不同程度流鼻涕的现象,眼周围有分泌物。     

犬瘟热病毒的静水压灭活

以250MPa的静水压力对犬瘟热病毒（CDV）处理30min之后，CDV被灭活，由其制成的灭活疫苗诱导犬产生中和抗体的能力明显优于传统的福尔马林灭活疫苗，免疫保护率达90％。电镜观察显示，经不同程度静水压力处理后的CDV粒子均发生变形，表面呈现凸起，但CDV H基因部分片段的RT－PCR扩增结果揭示，高达510MPa的静水压力作用30min也未能使其基因片段受到破坏。