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为最大程度地降低药品无菌工艺生产中微生物污染的风险,以重组溶葡萄球菌酶粉的生产过程为例,利用休哈特控制图、饼图统计工具、失效模式及影响分析(FMEA)风险工具对生产中操作人员可能引入微生物污染的五个因素(手套、前臂、胸口、前额、口罩)进行了监控和风险分析.试验结果表明,口罩的微生物检测结果最差,手套为污染的高风险因素.经过最差条件干预的培养基模拟灌装试验,验证了以预防为主的微生物质量控制措施可以有效控制无菌灌装生产工艺中人员对药品污染的风险. 相似文献
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质量控制图是由沃特·休哈特在1928年率先提出的,在后世的各项研究中得到了广泛应用,也得到了大众的认可。质量控制图初期集中用在工业生产的质量控制,现在主要应用在分析实验中,对检测品质量的优劣进行控制。 相似文献
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为了解智能系统在奶牛生产中监测采食行为的研究现状,文章对2000年至2020年的文献进行检索,回顾了智能设备从自动采集数据到自动决策的普遍流程,根据自动数据采集装置的不同应用特点对五类系统,即自动计重料槽、项圈颈部压力传感器、耳标加速度传感器、鼻羁压力传感器和图像信息技术,进行了归纳和总结,同时对实现智能化的大数据分析工具,即统计过程控制中使用的控制图进行了简述,并综述了智能系统通过监测采食行为在牧场中的生产应用。 相似文献
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随着科技技术的快速发展,人工智能的出现,应用到电气工程自动化控制中,打破了传统技术的束缚.大大改变依靠双手生产的生产方式,生产自动化程度越来越高,使得电气自动化迈入一个新的台阶.文章就结合所学知识,对人工智能在电气工程自动化中进行应用分析. 相似文献
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本文应用HACCP,对奶牛养殖小区生产生鲜乳的环境、过程进行了分析,提出了关键控制点,对控制内容进行了详细论述,从管理、服务、质量、效益方面提出应用举措. 相似文献
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本文应用HACCP,对奶牛养殖小区生产生鲜乳的环境、过程进行了危害性分析,提出了关键控制点,对控制内容进行了详细论述,从管理、服务、质量和效益方面提出应用举措. 相似文献
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HACCP体系在乳制品生产中的应用 总被引:1,自引:0,他引:1
本文着重讨论了HACCP体系在乳制品生产中的应用.对乳制品生产的不同类型和环节中HACCP体系的建立进行了分析,阐述了危害分析和关键控制点的建立和控制,以期达到促进乳制品生产和提升产品品质,保证产品安全性的目的. 相似文献
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魏静 《四川畜牧兽医学院学报》2009,(4):28-32
在现代法律秩序中,商会自治规范是制定法的基础和必要的补充,甚至在某些方面替代了制定法;商会自治规范主要包括商会组织规范、行为规范、惩罚规范以及争端解决规范等;其效力仅及于其内部成员;商会自治规范和制定法之间存在冲突,但也存在整合的基础。 相似文献
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本文概述了猪的毛色类型、猪的毛色遗传模式,着重综述了猪毛色基因分子基础的研究进展,指出存在问题并就未来发展方向做了思考。 相似文献
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REASONS FOR PERFORMING STUDY: Centesis of the bicipital bursa using an 8.9 cm long spinal needle has been reported but the alternative of employing a 3.8 cm long hypodermic needle requires validation. OBJECTIVE: To compare the efficacy of 2 different methods of centesis of the bicipital bursa and to evaluate the usefulness of ultrasonographic imaging to determine the location of solution administered when centesis of the bursa is attempted. METHODS: For Trial 1, 6 clinicians, who had no previous experience of centesis of the bicipital bursa, attempted to inject a solution composed of an aqueous radiopaque contrast medium and physiological saline solution (PSS) into the bicipital bursae of 2/12 horses using the previously described distal approach to inject one bursa and a proximal approach to inject the contralateral bursa. The bicipital tendon and bursa were examined ultrasonographically before and after injection; and both shoulders were examined radiographically to identify the location of the medium. In Trial 2, another 6 clinicians, also with no previous experience of centesis, repeated Trial 1, using 6 horses, but the radiopaque contrast medium was mixed with air instead of PSS. RESULTS: Accuracy of centesis using the proximal approach was 39% and that of the distal approach 28%. Ultrasonographic examination of the shoulder allowed the location of solution and air to be accurately predicted in all 12 shoulders examined. CONCLUSIONS: Clinicians who have had no previous experience performing centesis of the bicipital bursa are unlikely to be successful in centesis using either approach. Radiographic examination after injecting a radiopaque contrast medium may be necessary to assess the success of centesis especially if bursal fluid is not obtained during centesis. Injecting air along with the radiopaque contrast medium provides more accurate ultrasonographic confirmation of centesis and better radiographic definition than does injection without air. 相似文献
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以国际标准强毒R株人工感染非免疫产蛋鸡,定时扑杀,分别从鼻窦、眶下孔、气管、肺、气囊、卵巢和输卵管分离MG,并收集感染鸡所产蛋分离MG。结果表明,人工感染48小时后上、下呼吸道及肺已被全面感染,96小时气囊已被感染,120小时输卵管已能分离到MG,卵巢始终分离不到MG。人工感染鸡自144小时便能在其所产蛋中分离出MG。药物治疗能在72小时内消除感染,油乳剂苗则需24天后逐渐降低蛋内MG分离率,药物卵内注射、种蛋药浴、高温处理均能杀死卵内MG,但以研制的种蛋浸泡剂药浴效果为最好。 相似文献
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Effects of size of ingestively masticated fragments of plant tissues on kinetics of digestion of NDF
Ingestively masticated fragments were collected and sized via sieving. Different sizes of esophageal masticate and ruminal digesta fragments, and ground fragments of larger masticated pieces were incubated in vitro, and undigested NDF remaining at intervals of up to 168 h of incubation was determined. The ruminal age-dependent time delay (tau) for onset of digestion of NDF was positively correlated (P < 0.004) with the mean sieve aperture estimated to retain 50% of the fragments between successive sieve apertures (MRA). Degradation rate of potentially degradable NDF (PDF) and level of indigestible NDF were not related (P > 0.10) to MRA of masticated and ground fragments. Estimates of tau were positively related to MRA, with slopes of bermudagrass < corn silage < ruminal fragments of corn silage. It was concluded that fragment size-, and consequently, ruminal age-dependent onset of PDF degradation of a mixture of different fragment sizes results in an age-dependent rate of degradation of the more rapidly degrading of two subentities of PDF. Models are proposed that assume a tau before onset of simultaneous degradation of PDF from two pools characterized as having gamma-modeled age-dependency and age-constant rates. The ruminal age-dependent pool seems to be associated with the faster-degrading pool, and its rate parameter increases with range in MRA in the population of fragments. Conceptually, the ruminal age-dependent rate parameter for PDF degradation seems to represent a composite of several effects: 1) effects of the size-dependent tau; 2) range in MRA of the population of ingestively masticated fragments; and 3) subentities of PDF that degrade via more rapid age-dependent rates compared with subentities of PDF that degrade via age-constant rates. The estimated fractional rates of ruminative comminution of ingestively masticated fragments (0.060 to 0.075/h) were of a magnitude similar to the mean fractional rates of PDF digestion (0.030 to 0.085/h), which implies that ruminative comminution may be first-limiting to fractional rate of PDF digestion. The in vivo roles of ingestive and ruminative mastication of fragments on PDF degradation must be considered in any kinetic system for estimating PDF digestion in the rumen. These results and others in the literature suggest that the rate of surface area exposure rather than intrinsic chemical attributes of PDF may be first-limiting to degradation rate of PDF in vivo. 相似文献