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Serum alpha1‐proteinase inhibitor concentrations in dogs with systemic inflammatory response syndrome or sepsis 下载免费PDF全文
Romy M. Heilmann Dr med vet PhD DACVIM DECVIM Niels Grützner Dr med vet PhD Brittany E. Thames DVM MPH Jörg M. Steiner Dr med vet PhD DACVIM DECVIM James W. Barr DVM DACVECC 《Journal of Veterinary Emergency and Critical Care》2017,27(6):674-683
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Acute echocardiographic effects of sotalol on ventricular systolic function in dogs with ventricular arrhythmias 下载免费PDF全文
Lance C. Visser Joanna L. Kaplan Satoko Nishimura Catherine T. Gunther‐Harrington Catherine Bélanger Maureen S. Oldach Joshua A. Stern Mikaela S. Mueller 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2018,32(4):1299-1307
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Inflammatory cytokine and C‐reactive protein concentrations in dogs with systemic inflammatory response syndrome 下载免费PDF全文
Kris Gommeren DVM PhD DECVIM Isabelle Desmas DVM DACVIM Alexandra Garcia DVM Natalie Bauer DVM PhD DECVCP Andreas Moritz DVM PhD DECVIM Joachim Roth DVM PhD Dominique Peeters DVM PhD DECVIM 《Journal of Veterinary Emergency and Critical Care》2018,28(1):9-19
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Yunosuke YUCHI Ryohei SUZUKI Takahiro TESHIMA Hirotaka MATSUMOTO Hidekazu KOYAMA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2021,83(12):1918
Pulmonary hypertension (PH) is a common comorbidity in dogs with myxomatous mitral valve disease (MMVD), and can induce various changes in the right heart, such as right ventricular (RV) hypertrophy, dilatation, and dysfunction. We hypothesized that RV function, not only systolic function but also diastolic function, could be worsened with PH progression. We aimed to compare RV systolic and diastolic function in dogs with MMVD. Twenty healthy dogs and sixty-eight dogs with MMVD were enrolled. Dogs with MMVD were classified into the probability of PH. Two-dimensional and Doppler echocardiographic indices for right heart and two-dimensional speckle tracking echocardiography indices were measured. The morphological indicators of the right heart were significantly higher only in the high probability of PH group. The RV strain, early-diastolic and systolic strain rates were significantly lower in the high probability of PH group than those in the low and intermediate probability of PH groups. Multivariate analysis showed that increased RV internal dimension normalized by body weight and RV myocardial performance index were significantly associated with the presence of right-sided congestive heart failure. Speckle tracking echocardiography-derived RV systolic and diastolic function were activated in the low and intermediate probability of PH groups. However, dogs with high probability of PH showed RV myocardial dysfunction and dilatation. Increased RV myocardial performance index and end-diastolic RV internal dimension normalized by body weight were significantly associated with the presence of right-sided congestive heart failure in dogs with MMVD. 相似文献
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Constance Gebhardt Dr med vet ; Johannes Hirschberger Dr med vet DECVIM DECVCP ; Stefanie Rau Dr med vet ; Gisela Arndt Dr rer pol ; Karen Krainer ; Florian J. Schweigert Dr med vet ; Leo Brunnberg Dr med vet ; Bernd Kaspers Dr med vet Barbara Kohn Dr med vet DECVIM 《Journal of Veterinary Emergency and Critical Care》2009,19(5):450-458
Background – There is a high mortality rate in patients with systemic inflammatory response syndrome (SIRS) or sepsis. Therefore, an early diagnosis and prognostic assessment is important for optimal therapeutic intervention. The objective of the study was to evaluate if baseline values and changes in serum C-reactive protein (CRP) might predict survival in dogs with SIRS and sepsis.
Design – Prospective study; July 2004 to July 2005.
Setting – Small Animal Clinic, Berlin, Clinic of Small Animal Medicine, Munich.
Animals – Sixty-one dogs.
Measurements and Main Results – For the CRP analysis blood was drawn on day 0, 1, and 2; CRP was measured using a commercial ELISA test kit. Thirteen dogs suffered from nonseptic SIRS and 48 dogs from sepsis. The 14-day survival rate was 61% (69% nonseptic SIRS, 58% sepsis). Serum CRP was higher in sick dogs compared with controls ( P <0.001). Over the 3-day period surviving dogs ( n =31) displayed a significantly greater decrease in CRP than nonsurvivors ( n =10) ( P =0.001). No correlation was found between the initial CRP concentrations and the survival rate. The changes in CRP corresponded to the survival rate ( P =0.01).
Conclusion – There was no significant relationship between the survival rate in dogs with nonseptic SIRS or sepsis and the initial serum CRP concentrations. There was a correlation between decreasing CRP concentrations and recovery from disease. However, the changes in CRP concentrations over a 3-day period correctly predicted survival in 94% of dogs and death in 30% of the dogs (false positive rate 22%). 相似文献
Design – Prospective study; July 2004 to July 2005.
Setting – Small Animal Clinic, Berlin, Clinic of Small Animal Medicine, Munich.
Animals – Sixty-one dogs.
Measurements and Main Results – For the CRP analysis blood was drawn on day 0, 1, and 2; CRP was measured using a commercial ELISA test kit. Thirteen dogs suffered from nonseptic SIRS and 48 dogs from sepsis. The 14-day survival rate was 61% (69% nonseptic SIRS, 58% sepsis). Serum CRP was higher in sick dogs compared with controls ( P <0.001). Over the 3-day period surviving dogs ( n =31) displayed a significantly greater decrease in CRP than nonsurvivors ( n =10) ( P =0.001). No correlation was found between the initial CRP concentrations and the survival rate. The changes in CRP corresponded to the survival rate ( P =0.01).
Conclusion – There was no significant relationship between the survival rate in dogs with nonseptic SIRS or sepsis and the initial serum CRP concentrations. There was a correlation between decreasing CRP concentrations and recovery from disease. However, the changes in CRP concentrations over a 3-day period correctly predicted survival in 94% of dogs and death in 30% of the dogs (false positive rate 22%). 相似文献
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Amy L. Butler DVM MS Vicki L. Campbell DVM DACVA DACVECC Ann E. Wagner DVM DACVA DACVP Cassidy D. Sedacca DVM Timothy B. Hackett DVM MS DACVECC 《Journal of Veterinary Emergency and Critical Care》2008,18(3):246-257
Objective: Compare cardiac index (CI) and oxygen delivery index (DO2I) in conscious, critically ill dogs to control dogs; evaluate the association of CI and DO2I with outcome. Design: Prospective non‐randomized clinical study. Setting: Veterinary teaching hospital. Animals: Eighteen client‐owned dogs with systemic inflammatory response syndrome (SIRS) and 8 healthy control dogs. Measurements and Main Results: CI of dogs with SIRS was measured using lithium dilution at times 0, 4, 8, 16, and 24 hours. Data collected included physical exam, arterial blood gas (ABG) and hemoximetry. CI of control dogs was measured 3 times with 1 measurement of ABG. Mean CI ± SE in SIRS patients was 3.32 ± 0.95 L/min/m2; lower than controls at 4.18 ± 0.22 L/min/m2 (P<0.001). Mean DO2I ± SE in SIRS patients was 412.91 ± 156.67 mL O2/min/m2; lower than controls at 785.24 ± 45.99 mL O2/min/m2 (P<0.001). There was no difference in CI (P=0.49) or DO2I (P=0.51) for dogs that survived to discharge versus those that did not. There was no difference in mean CI (P=0.97) or DO2I (P=0.50) of survivors versus non‐survivors for 28‐day survival. Survivors had lower blood glucose (P=0.03) and serum lactate concentrations (P=0.04) than non‐survivors. Conclusions: CI and DO2I in conscious dogs with SIRS were lower than control dogs, which differs from theories that dogs with SIRS are in a high cardiac output state. CI and DO2I were not significantly different between survivors and non‐survivors. Similar to previous studies, lactate and glucose concentrations of survivors were lower than non‐survivors. 相似文献
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Reasons for performing study: The use of two‐dimensional speckle tracking (2DST) for quantification of left ventricular (LV) function has recently been described in horses using long‐axis images and short‐axis images at chordal but not at papillary muscle level. Objectives: To compare the feasibility and reliability of 2DST for quantification of circumferential and radial LV function in short‐axis images at papillary muscle and chordal level. Methods: Repeated echocardiographic examinations were performed on 10 healthy trotter horses by 2 observers from a right parasternal short‐axis view at papillary muscle and chordal level. Segmental and averaged peak values and timing of circumferential and radial strain and strain rate, radial displacement and rotation were measured in 6 LV wall segments in each imaging plane. Global peak values were calculated for circumferential strain and strain rate. The inter‐ and intraobserver within‐ and between‐day variability was assessed by calculating coefficients of variation for repeated measurements. Results: 2DST analysis was feasible in each cardiac cycle, although tracking was often inadequate during early diastole. Measurements of averaged systolic circumferential and radial strain and strain rate and radial displacement as well as global circumferential strain and strain rate could be determined with low variability. Early and late diastolic strain rate and systolic rotation showed a moderate variability. Radial segmental measurements were more reliable than circumferential measurements. The interventricular septum showed a higher circumferential and lower radial strain compared with the LV free wall. Peak timing was earlier at papillary muscle compared with chordal level. Conclusions: 2DST measurements of global and regional circumferential and radial LV wall motion are feasible both at papillary muscle and chordal level. Potential relevance: Several measurements had good reliability and should be used for evaluation of the technique in a clinical setting. 相似文献
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Comparison of a computed tomographic pulmonary trunk to aorta diameter ratio with echocardiographic indices of pulmonary hypertension in dogs 下载免费PDF全文
James Sutherland‐Smith Elyshia J. Hankin Suzanne M. Cunningham Amy F. Sato Bruce A. Barton 《Veterinary radiology & ultrasound》2018,59(1):18-26
There are limited criteria for the detection of pulmonary hypertension in dogs undergoing computed tomography (CT) for pulmonary disease. This retrospective analytical exploratory study compared a CT pulmonary trunk to aorta ratio with echocardiographic estimates of pulmonary hypertension. Dogs having both a contrast thoracic CT and echocardiogram were selected and maximal pulmonary trunk and descending aorta diameters were measured by two observers on a single transverse CT image. Computed tomographic diameter ratios were compared with the echocardiographic parameters of tricuspid regurgitation gradient, right ventricular acceleration time‐to‐ejection time ratio, pulmonary insufficiency gradient, and pulmonary artery to aorta diameter. A total of 78 dogs were sampled, with 44 dogs having one or more finding suggestive of pulmonary hypertension. A moderate positive correlation was shown between tricuspid regurgitation gradient and CT pulmonary trunk to aorta ratio (r = 0.61, P‐value < 0.0001). Mean CT pulmonary trunk to aorta ratio of dogs with moderate (P = 0.0132) and severe (P < 0.0003) pulmonary hypertension were significantly higher than normal dogs. There was no significant difference in mean CT pulmonary trunk to aorta ratio between normal and mild pulmonary hypertension dogs (P = 0.4244). The intraclass correlation coefficient (0.72) showed good reproducibility of the ratio. Findings indicated that CT pulmonary trunk to aorta ratio is a reproducible and potentially useful method to predict moderate and severe pulmonary hypertension in dogs, but not mild pulmonary hypertension. In dogs undergoing thoracic CT for pulmonary disease, an increased ratio should prompt follow up echocardiography. 相似文献
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Plasma iron,C‐reactive protein,albumin, and plasma fibrinogen concentrations in dogs with systemic inflammatory response syndrome 下载免费PDF全文
Carlos Torrente DVM MSc PhD Edgar G. Manzanilla DVM PhD MPVM DECPHM Luis Bosch DVM MSc Laura Fresno DVM PhD Montserrat Rivera del Alamo DVM PhD DECAR Anna Andaluz DVM PhD Yolanda Saco DVM PhD Rafael Ruiz de Gopegui DVM PhD DECVIM 《Journal of Veterinary Emergency and Critical Care》2015,25(5):611-619
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Hyeryoung JEONG Hanbin LEE Jaihyun JUNG Hyunryung KIM Jin YU Hyounglok YOON Youngjae LEE Jinhwa CHANG Dongwoo CHANG 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2021,83(4):581
Unlike echocardiography, cardiac magnetic resonance imaging (cardiac MRI) results in a near-exact assessment of cardiac structures and function. However, most veterinary studies have focused on dogs with normal cardiac function. We hypothesized that there would be significant differences in cardiac measurements between cardiac MRI and echocardiography when left ventricular (LV) function was abnormal. This study was undertaken to compare measurements of LV function produced by cardiac MRI and echocardiography in dogs whose LV function was altered by pharmacological agents. This study was conducted with six healthy beagle dogs. We increased left ventricular contractility by administration of dobutamine; we decreased cardiac contractility with esmolol. Stroke volume measurements were made by using both cardiac MRI and echocardiography under seven different conditions with general anesthesia: control, three doses of esmolol (100, 200, and 500 µg/kg/min), and three doses of dobutamine (10, 20, and 50 µg/kg/min). Experiments involving each condition were conducted at least 1 week apart. When LV contractility was normal, ejection fraction (EF) and stroke volume (SV), as measured by echocardiography and cardiac MRI, were not significantly different. However, when contractility was changed by pharmacological agents, EF and SV were overestimated by echocardiography, compared to MRI. Evaluation of cardiac function in patients treated with pharmacological agents should be conducted carefully because EF and SV measured by echocardiography can be overestimated, compared with EF and SV obtained by cardiac MRI. 相似文献