共查询到20条相似文献,搜索用时 15 毫秒
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Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3 总被引:1,自引:0,他引:1
Cha TL Zhou BP Xia W Wu Y Yang CC Chen CT Ping B Otte AP Hung MC 《Science (New York, N.Y.)》2005,310(5746):306-310
Enhancer of Zeste homolog 2 (EZH2) is a methyltransferase that plays an important role in many biological processes through its ability to trimethylate lysine 27 in histone H3. Here, we show that Akt phosphorylates EZH2 at serine 21 and suppresses its methyltransferase activity by impeding EZH2 binding to histone H3, which results in a decrease of lysine 27 trimethylation and derepression of silenced genes. Our results imply that Akt regulates the methylation activity, through phosphorylation of EZH2, which may contribute to oncogenesis. 相似文献
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Translating the histone code 总被引:7,自引:0,他引:7
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LEHNINGER AL WADKINS CL COOPER C DEVLIN TM GAMBLE JL 《Science (New York, N.Y.)》1958,128(3322):450-456
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植物组培新方向——开放组培与无糖暴露组培研究概况 总被引:1,自引:0,他引:1
植物组织培养始于20世纪初,是以德国植物学家G.Haberlandt的植物细胞具有全能性的理论发展起来的一项新技术。作为一种十分有效的植物快繁方式,植物组织培养具有普通繁殖方法无法比拟的技术和产量优势,在当前倡导高效现代化农业发展模式的形势下,通过植物组织培养技术生产高质量的种苗具有十分广阔的市场前景。但一直以来,植物组培产业流传着一句话就是“组培组培越组越赔”,这其中的原因除了发展思路和经营不善之外,还有一个重要原因就是组培成本太高,无法满足市场对高质量组培苗低价位成本的需求。因此,如何降低组培成本是决定组培效益的… 相似文献
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Struvite, MgNH(4)PO(4).6H(2)O, rather than apatite or amorphous calcium phosphate is precipitated when phosphate is added to seawater containing more than 0.01M NH(4)(+) ions. Struvite may have precipitated from evaporating seawater on the primitive earth, and may have been important for prebiotic phosphorylation. 相似文献
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卡特丽亚兰的组织培养 总被引:6,自引:0,他引:6
以卡特丽亚兰(Cattleya)种子和茎尖为试验材料,研究卡特丽亚兰的组织培养。结果表明,种子萌发可采用不含激素的MS培养基,圆球茎增殖与分化可采用不同浓度的细胞分裂素与生长素的组合,其中以6-BA3mg/L NAA0.5-1.0mg/L的组合效果较佳,低浓度的生长调节剂Ms 6-BA0.5mg/L NAA0.4mg/L GA,0.2mg/L有利于芽丛快速增殖,添加适量浓度的椰子汁和活性炭有明显的增效作用,高浓度反而起抑制作用。生根培养基用MS NAA0.5mg/,L或IBA0.5mg/L可达到100%生根率。 相似文献
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E C Uberbacher J M Harp E Wilkinson-Singley G J Bunick 《Science (New York, N.Y.)》1986,232(4755):1247-1249
The conformation of the histone octamer is shown to depend upon the specific salt used to solubilize it. In 2M sodium chloride the octamer is similar in size and shape to the histone component of crystallized core nucleosomes. In contrast, in 3.5M ammonium sulfate the octamer is elongated, resembling an ellipsoid with approximate dimensions of 114 by 62 by 62 angstroms. These results indicate that the elongated conformation seen in the 3.3 angstroms electron density map of the histone octamer crystallized in ammonium sulfate is due to the particular salt conditions used. 相似文献
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水果型番木瓜组织培养的研究 总被引:1,自引:0,他引:1
[目的]研究水果型番木瓜的组织培养。[方法]以经预处理的种子为试材,通过MS基本培养基附加不同浓度的6-BA和IBA,对水果型番木瓜组培快繁技术进行了研究。[结果]无菌条件下用75%酒精均匀擦拭水果型番木瓜果皮表面,取出种子,用无菌水冲洗3次是较好的灭菌方法,种子污染率仅为2.52%;水果型番木瓜种子经1000mg/LGA3+1mg/L6-BA(等体积混合)浸泡18h后接种于MS培养基中培养,种子发芽率、胚芽长度、胚根长度和苗高达到较高值,分别为68.42%、2.25、0.80和1.52cm,幼苗整体生长较好;继代增殖培养基为MS+0.5mg/L6-BA+0.1mg/LIBA时增殖系数最高(7.92),幼苗长势较好;组培苗玻璃化随着光照强度的增强而呈减弱趋势,3000lx处理下玻璃化苗比率最低(3.21%)。[结论]该研究为水果型番木瓜的组培快繁研究提供了参考。 相似文献