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玉米赤霉烯酮是一种非甾体雌激素样作用的霉菌毒素。大量研究表明,玉米赤霉烯酮具有生殖发育毒性、免疫毒性,对肿瘤发生也有一定影响。本文综述了玉米赤霉烯酮的毒性毒害作用及对种猪繁殖性能的影响,以引起养殖者的高度重视。 相似文献
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本文要介绍的主题是"为什么对某些产后牛要镇痛和使用非固醇类抗炎药物"?值得欣慰的是,勃林格殷格翰动物保健的翁立楠在其"非甾体类抗炎药物(NSAIDs)在牛场的应用"和"炎症控制对乳房炎治疗的重要性"两文中对此主题已做了非常清晰的阐述,这自然大大减轻了本人的文字负担(非甾体类=非固醇类)。本文只是从产后牛监护的临床角度对翁文做进一步补充和扩展。 相似文献
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The general pharmacology of the non-steroidal anti-inflammatory drugs (NSAIDs) used in dogs and cats has been described in part 1 of this review (Lees and others 1991). This paper outlines the properties of the individual agents as they are used in small animal practice. The NSAIDs which have been used extensively in small animals include the older agents such as Aspirin, cinchophen and phenylbutazone. These agents have previously been used empirically by extrapolation of dosages from other species and by clinical experience. Studies are now available which provide a scientific rationale for the dosage rate recommended. A number of new drugs have recently been licensed for use in the dog or may be licensed in the near future. These include flunixin, carprofen and tolfenamic acid and the data generated from these products provides very useful information for formulating I effective dosage regimens. There are also some NSAIDs such as piroxicam which have been investigated in the dog because they have particular properties which may be of use in common clinical conditions and others, such as Paracetamol and Ibuprofen, which are readily available to the public and which owners may administer to dogs or cats at toxic doses. 相似文献
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J. ESPINASSE J. P. THOUVENOT S. DALLE‡ J. GARCIA F. SCHELCHER O. SALAT J. F. VALARCHER S. DAVAL 《Journal of veterinary pharmacology and therapeutics》1994,17(4):271-274
An acute non-immune inflammation model was used to compare the action of two non-steroidal anti-inflammatory drugs, flunixin meglumine and tolfenamic acid, on prostaglandin E2 , (PGE2 ) synthesis in bovine inflammatory exudate. The tissue cage model used involves subcutaneous implantation of polypropylene cages and subsequent stimulation by carrageenan injection of the granulation tissue which develops within the cage. Twelve calves were randomly assigned to three groups receiving placebo, flunixin meglumine and tolfenamic acid, respectively. Inflammatory exudate was sampled 30 min after carrageenan injection and at seven subsequent time points. PGE2 , levels were determined by radioimmunoassay. At each time point post-carrageenan injection, flunixin meglumine inhibited PGE2 , synthesis to a greater extent than tolfenamic acid. At 4, 8,12 and 24 h these differences were statistically significant. 相似文献
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Khwanjai V Chuthatep S Durongphongtorn S Yibchok-Anun S 《Journal of veterinary pharmacology and therapeutics》2012,35(1):13-18
The objective of this study was to evaluate the effects of the nonsteroidal anti-inflammatory drugs vedaprofen and tolfenamic acid on renal function after oral administration for 2 weeks in healthy cats. Experiments were performed using nineteen domestic short-haired cats randomly divided into one control (n=6) and two treatment groups. All cats in the first (n=6) and second treatment groups (n=7) received vedaprofen (0.5 mg/kg/day) and tolfenamic acid (4 mg/kg/day), respectively. During the experiment, renal function was evaluated using percent renal uptakes of (99m)Technetium-diethylenetriamine-pentaacetic acid ((99m)Tc-DTPA) collected from renal scintigraphy and blood samples used to determine complete blood count and biochemical profiles. Renal scintigraphy and blood collections were performed at days 0, 5, 11, 15, and 45. The percent of renal uptake after the administration of vedaprofen and tolfenamic acid were not significantly different compared to pretreatment (day 0) and control group levels. In addition, significant changes were not observed in hematological and biochemical profiles within or between groups, with the exception of slightly lower numbers in red blood cell counts compared to the normal value on day 45 in the tolfenamic acid-treated group. Taken together, we conclude 14-day administration of vedaprofen and tolfenamic acid might not cause any adverse effects on renal function, hematological and serum biochemical variables. 相似文献
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Lascelles BD Court MH Hardie EM Robertson SA 《Veterinary anaesthesia and analgesia》2007,34(4):228-250
OBJECTIVE: To review the evidence regarding the use of nonsteroidal anti-inflammatory drugs (NSAIDs) in cats. DATABASES USED: PubMed, CAB abstracts. CONCLUSIONS: Nonsteroidal anti-inflammatory drugs should be used with caution in cats because of their low capacity for hepatic glucuronidation, which is the major mechanism of metabolism and excretion for this category of drugs. However, the evidence presented supports the short-term use of carprofen, flunixin, ketoprofen, meloxicam and tolfenamic acid as analgesics in cats. There were no data to support the safe chronic use of NSAIDs in cats. 相似文献
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The level within the central nervous system where non-steroidal anti-inflammatory drugs (NSAIDs) produce analgesia and the mechanisms by which they mediate this effect are still uncertain. This study assessed the central analgesic effects of ketoprofen, phenylbutazone, salicylic acid and tolfenamic acid in sheep implanted with indwelling intrathecal (i.t.) catheters and submitted to mechanical noxious stimulation. The sheep received i.t. cumulative concentrations (0.375-200 microM; 100 microL) as well as a single intravenous (i.v.) dose (3, 8, 10 and 2 mg/kg, respectively) of each NSAID. The sheep were also given i.t. naloxone (5.49 mM; 100 microL) and atipamezole (4.03 mM; 100 microL) prior to i.v. ketoprofen. None of the i.t. NSAIDs increased mechanical thresholds. Intravenously, only ketoprofen and tolfenamic acid raised the pain thresholds. The hypoalgesic effect of i.v. ketoprofen was prevented by i.t. naloxone or atipamezole. Although NSAIDs had no direct effect on the spinal cord, their analgesic action appeared to be spinally mediated. 相似文献
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P. J. Murison S. Tacke C. Wondratschek I. MacQueen H. Philipp R. Narbe L. Brunnberg 《The Journal of small animal practice》2010,51(10):526-532
Objectives : To investigate the efficacy of meloxicam or tolfenamic acid administered preoperatively and postoperatively (five days in total) to cats undergoing surgical fracture repair. Methods : Eighty-eight otherwise healthy cats were matched according to fracture site and then randomly allocated to one of two groups, receiving 0·2 mg/kg meloxicam by subcutaneous injection (group M) or 1·5 to 3 mg/kg tolfenamic acid orally (group T) before anaesthesia. Analgesia was continued with 0.05 mg/kg oral meloxicam once daily or 1·5 to 3 mg/kg oral tolfenamic acid twice daily for four days postoperatively. Pain was assessed by a blinded observer using visual analogue scales and a functional limb score. The drug administrator assessed feed intake and palatability of the treatment. Results : Data from 66 cats were analysed. Visual analogue scale pain scores and functional limb scores decreased over time in both groups but were not significantly different between treatments. Feed intake was similar in both groups. Meloxicam was significantly more palatable than tolfenamic acid on all treatment days. Clinical Significance : Meloxicam and tolfenamic acid demonstrated comparable analgesia, without clinically observable side effects. Meloxicam may be associated with superior compliance in clinical practice due to the higher palatability and once daily treatment resulting in better ease of administration. 相似文献
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灌胃给药(ig)研究桉油溶液剂对大鼠的急性毒性。安全药理学试验以高剂量(30%)、中剂量(18%)、低剂量(6%)分别给予大鼠0.3 m L/只涂抹桉油溶液剂,观察其对大鼠神经系统、心血管系统和呼吸系统的影响。桉油溶液剂对大鼠的经口半数致死量(LD50)为3811.5 mg/kg。桉油溶液剂对大鼠的中枢神经系统、呼吸系统和心率等均无明显影响。桉油溶液剂是一种较安全的局部外用药,适合在临床上推广应用。桉油溶液剂经生产实践和兽医临床试验证明具有良好的治疗动物疥螨病效果。 相似文献