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1.
Poncelet LC Coppens AG Meuris SI Deltenre PF 《American journal of veterinary research》2000,61(11):1343-1348
OBJECTIVE: To evaluate auditory maturation in puppies. ANIMALS: Ten clinically normal Beagle puppies. PROCEDURE: Puppies were examined repeatedly from days 11 to 36 after birth (8 measurements). Click-evoked brain stem auditory-evoked potentials (BAEP) were obtained in response to rarefaction and condensation click stimuli from 90 dB normal hearing level to wave V threshold, using steps of 10 dB. Responses were added, providing an equivalent to alternate polarity clicks, and subtracted, providing the rarefaction-condensation differential potential (RCDP). Steps of 5 dB were used to determine thresholds of RCDP and wave V. Slope of the low-intensity segment of the wave V latency-intensity curve was calculated. The intensity range at which RCDP could not be recorded (ie, pre-RCDP range) was calculated by subtracting the threshold of wave V from threshold of RCDP RESULTS: Slope of the wave V latency-intensity curve low-intensity segment evolved with age, changing from (mean +/- SD) -90.8 +/- 41.6 to -27.8 +/- 4.1 micros/dB. Similar results were obtained from days 23 through 36. The pre-RCDP range diminished as puppies became older, decreasing from 40.0 +/- 7.5 to 20.5 +/- 6.4 dB. CONCLUSION AND CLINICAL RELEVANCE: Changes in slope of the latency-intensity curve with age suggest enlargement of the audible range of frequencies toward high frequencies up to the third week after birth. Decrease in the pre-RCDP range may indicate an increase of the audible range of frequencies toward low frequencies. Age-related reference values will assist clinicians in detecting hearing loss in puppies. 相似文献
2.
The effects of electrode configuration and click polarity on brainstem auditory evoked potentials (BAEP) in dogs were investigated to clarify the inconsistent nomenclature for each peak. Four positive peaks (waves 1, 2, 3 and 4) before a deep negative trough and a fifth positive peak (wave 5) following the trough were the basic components of BAEP in dogs, which were easily identified regardless of recording conditions such as electrode configuration and click polarity. Additional peaks tended to be present when a noncephalic reference electrode and/or single-polarity (rarefaction or condensation) click stimuli were used. The Roman nomenclature for the individual positive peaks of BAEP in dogs is confused owing to variations in the observed waveforms among researchers, but click polarity and/or reference electrode position can explain all the previously reported variations in BAEP waveforms in dogs. When the criteria concerning wave V in the guidelines of BAEP in human beings are applied to avoid further confusion of Roman nomenclature in dogs, it is recommended that the basic five positive peaks (waves 1, 2, 3, 4 and 5 as identified easily with Ai-Vertex configuration and alternating clicks) are designated as waves I, II, III, V and VI, respectively. Wave IV (wave 3b) occurs occasionally before wave V in dogs.Abbreviations BAEP
brainstem auditory evoked potentials
- dBHL
dB hearing level
- IPL
interpeak latency
- Ai
the caudodorsal end of the zygomatic arch ipsilateral to the stimulated ear
- Nape
the neck over the spinous process of the fourth cervical vertebra 相似文献
3.
Poncelet L Coppens A Deltenre P 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2000,14(4):424-428
This study investigated whether Dalmatian puppies with normal hearing bilaterally had the same click-evoked brainstem auditory potential characteristics as age-matched dogs of another breed. Short-latency brainstem auditory potentials evoked by condensation and rarefaction clicks were recorded in 23 1.5- to 2-month-old Dalmatian puppies with normal hearing bilaterally by a qualitative brainstem auditory evoked potential test and in 16 Beagle dogs of the same age. For each stimulus intensity, from 90 dB normal hearing level down to the wave V threshold, the sum of the potentials evoked by the 2 kinds of stimuli were added, giving an equivalent to the alternate click polarity stimulation. The slope of the L segment of the wave V latency-intensity curve was steeper in Dalmatian (-40 +/- 10 micros/dB) than in Beagles (-28 +/- 5 micros/dB, P < .001) puppies. The hearing threshold was lower in the Beagle puppies (P < .05). These results suggest that interbreed differences may exist at the level of cochlear function in this age class. The wave V latency and wave V-wave I latencies differences at high stimulus intensity were different between the groups of puppies (4.3 +/- 0.2 and 2.5 +/- 0.2 milliseconds, respectively, for Beagles; and 4.1 +/- 0.2 and 2.3 +/- 0.2 milliseconds for Dalmatians, P < .05). A different maturation speed of the neural pathways is one possible explanation of this observation. 相似文献
4.
Gonçalves R Freeman J Penderis J 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2008,22(1):234-237
BACKGROUND: The brainstem auditory-evoked response (BAER) is currently the standard evaluation method of hearing in dogs. In asymmetrical hearing loss in human patients, simultaneous presentation of masking noise to the nontest ear is routinely performed during BAER to eliminate the crossover effect. HYPOTHESIS: The crossover effect occurs during canine BAER, and masking noise of 20 decibels (dB) below click stimulus intensity is sufficient to abolish this effect. ANIMALS: Fifty-six Dalmatian puppies with confirmed unilateral deafness. METHODS: The BAER was elicited with 80 and 100 dB normalized hearing level (dBnHL) stimulus intensity in the deaf ear. The 100 dBnHL stimulus was repeated while simultaneously applying 80 dBnHL white masking noise to the nontest ear. RESULTS: Ten dogs were excluded because of BAER trace baseline fluctuation. In the remaining 46 dogs, 8 dogs had no waveforms, but 38 dogs had an identifiable wave-V in the deaf ear BAER at 80 dBnHL intensity stimulus. At 100 dBnHL intensity stimulus, all but 1 dog had a discernible wave-V in the deaf ear BAER. The deaf ear BAER waveforms were abolished by white masking noise at 80 dBnHL in the nontest ear in all dogs. CONCLUSIONS AND CLINICAL IMPORTANCE: Abolition of BAER wave-V in the deaf ear by white masking noise in the nontest ear suggests that this wave is caused by the crossover effect. beta distribution indicates 95% confidence that white masking noise, at 20 dB below click stimulus intensity, would abolish this crossover effect in over 90% of the dogs. This supports using masking noise in the nontest ear during canine BAER. 相似文献
5.
Audiograms estimated from brainstem tone-evoked potentials in dogs from 10 days to 1.5 months of age
Poncelet LC Coppens AG Deltenre PF 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2002,16(6):674-679
The objective of this study was to build audiograms from thresholds of brainstem tone-evoked potentials in dogs and to evaluate age-related change of the audiogram in puppies. Results were obtained from 9 Beagle puppies 10-47 days of age. Vertex to mastoid brainstem auditory-evoked potentials in response to 5.1-millisecond Hanning-gated sine waves with frequencies octave-spaced from 0.5 to 32 kHz were recorded. Three dogs were examined at 10, 13, 19, 25, and 45 days. Four other dogs were examined at 16 days. Data from 7 dogs between 42 and 47 days of age were pooled to obtain audiogram reference values in 1.5-month-old puppies. The best auditory threshold lowered from above 60 dB sound pressure level (SPL) to values close to 0 dB SPL between 13 and 25 days of age and then stabilized. The audible frequency range widened, including 32 kHz in all tested dogs from the 19th day. In the 7 1.5-month-old puppies, the mean auditory threshold decreased by 11 dB per octave from 0.5 to 2 kHz. The auditory threshold was lowest and held the same value from 2 to 8 kHz. The mean auditory threshold increased by 20 dB per octave from 8 to 32 kHz. Near threshold, click-evoked potentials test only a small part of the audible frequency range in dogs. Use of tone-evoked potentials may become a powerful tool in investigating dogs with possible partial hearing loss, including during the auditory system maturation period. 相似文献
6.
Ter Haar G Venker-van Haagen AJ van den Brom WE van Sluijs FJ Smoorenburg GF 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2008,22(4):937-945
BACKGROUND: It is assumed that the hearing of dogs becomes impaired with advancing age, but little is known about the prevalence and electrophysiologic characteristics of presbycusis in this species. HYPOTHESIS: As in humans, hearing in dogs becomes impaired with aging across the entire frequency range, but primarily in the high-frequency area. This change can be assessed quantitatively by brainstem-evoked response audiometry (BERA). ANIMALS: Three groups of 10 mixed-breed dogs with similar body weights but different mean ages were used. At the start of the study, the mean age was 1.9 years (range, 0.9-3.4) in group I, 5.7 years (3.5-7) in group II, and 12.7 years (11-14) in group III. METHODS: In a cross-sectional study, the BERA audiograms obtained with toneburst stimuli were compared among the 3 groups. In a longitudinal study, changes in auditory thresholds of group II dogs were followed for 7 years. RESULTS: Thresholds were significantly higher in group III than in groups I and II at all frequencies tested, and higher in group II than in group I at 4 kHz. The audiograms in group II indicated a progressive increase in thresholds associated with aging starting around 8-10 years of age and most pronounced in the middle- to high-frequency region (8-32 kHz). CONCLUSIONS AND CLINICAL IMPORTANCE: Age-related hearing loss in these dogs started around 8-10 years of age and encompassed the entire frequency range, but started and progressed most rapidly in the middle- to high-frequency area. Its progression can be followed by BERA with frequency-specific stimulation. 相似文献
7.
Arai S Matsui Y 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2008,70(10):1139-1142
This study was performed to examine normal brainstem auditory evoked potential (BAEP) data for adult Japanese Black cattle and to evaluate whether differences exist in the peak latencies, interpeak latencies (IPL) and waveforms of BAEP between Japanese Black and Holstein cattle. The peaks were detected as major waves I, II, III and V in each group. The threshold of the BAEP waves in the Holstein cattle was 65-75 dB nHL, but the threshold in the Japanese Black cattle was 75-85 dB nHL. The I-III and I-V IPLs were significantly shorter in the Japanese Black compared with the Holstein cattle at an intensity of 105 dB nHL. The present findings suggest that the IPL and wave threshold of BAEP are influenced by bovine breed. 相似文献
8.
Effects of analog filter frequency on brain stem auditory-evoked potentials (BAEP) were investigated in 7 non-sedated dogs. The BAEP were recorded successively at various low-pass (LP) and high-pass (HP) filter frequency settings. The analog filters had a rolloff of 6 dB/octave. Decrease of LP filter frequency from 30 kHz to 100 Hz caused prolongation of the peak latency and reduction of the peak-to-peak (from a positive peak to the following trough) and absolute (from a positive peak to the baseline) amplitudes for all peaks, except the peak latency for P5 and the absolute amplitude for P4. Changes in these variables were statistically significant (P less than 0.05) at different cutoff frequencies specific for the individual peaks. The interpeak latency between P1 and P4, and P4/P1 peak-to-peak amplitude ratio were not changed significantly. At the lowest LP filter frequency of 100 Hz, positive peaks (fast waves) seemed to be superimposed on a slow positive wave (slow wave). In contrast, increase of HP filter frequency from 0.53 to 160 Hz did not result in significant changes for any peaks, except for reduction in the absolute amplitude of P4. The various effects of LP filter frequency and negligible effects of HP filter frequency on individual peaks may be attributable to their frequency composition and/or elimination of the slow wave at higher HP filter frequency settings. On the basis of our results, LP filter setting of 3 kHz and HP filter setting of less than or equal to 53 Hz are recommended for recording of BAEP in dogs.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
9.
Brainstem auditory evoked potential (BAEP) waveforms were recorded as a means of objectively evaluating auditory and brainstem function in horses. BAEP recordings were readily and repeatably recorded from horses, under minimal restraint, using signal averaging equipment. Clearly identified BAEP waveforms were obtained with compression clicks of 30-100 dB (HHL) at 10 Hz applied in the external auditory meatus of one ear and masking white noise (10 dB lower) in the other ear. Vertex positive (upwards) waveforms I through V were obtained with an active, subdermal electrode over the ipsilateral and contralateral zygomatic processes of the temporal bones and the reference electrode over the vertex. Recording sweep duration was 10 ms, amplifier sensitivity 10 microV/division, display gain x 10 and low and high amplifier filters set at 200 Hz to 2 kHz. Such recordings can be useful in evaluation of all clinical cases suspected of showing degrees of deafness, vestibular disease or brainstem disease, and in monitoring the progress of such cases. 相似文献
10.
The acoustic reflex (AR) was recorded from 12 healthy mixed-breed dogs. Latency and amplitude were measured from ipsilateral and contralateral AR at stimulus frequencies of 1 and 2 kHz and intensities of 70 to 110 dB sound pressure level for ipsilateral AR and 70 to 120 dB hearing level for contralateral AR. Mean latencies for ipsilateral and contralateral AR were between 33.46 and 206.10 ms and between 45.26 and 180.89 ms, respectively, and amplitudes were between 0.14 and 1.79 cm3 and between 0.31 and 1.86 cm3 of air, respectively. Stimulus frequencies and intensities had significant effects (P less than 0.05) on ipsilateral and contralateral AR latencies and amplitudes. Ipsilateral and contralateral AR decays were determined by measuring compliance change during a 10-s pure-tone stimulation at frequencies of 1 and 2 kHz at an intensity of 10 dB above AR threshold. Reflex decays for 1 kHz and 2 kHz frequencies averaged 5.74% and 9.71%, respectively, for ipsilateral AR and 5.08% and 5.40%, respectively, for contralateral AR. Bilateral tympanograms and brain stem auditory-evoked responses were performed on each dog. Mean normal static compliance of the middle ear, as determined by tympanometry, was 0.15 cm3. Unilateral tenotomy of the tensor tympani muscle was done on 6 of the 12 dogs, and each of the preceding procedures were repeated within 1 week after surgical operation. Transection of the tensor tympani tendon did not alter (P greater than 0.05) the latencies or amplitudes of 1 kHz- or 2 kHz-evoked contralateral AR, the latency or amplitude of 1 kHz-evoked ipsilateral AR, or the amplitude of 2 kHz-evoked ipsilateral AR. However, the latency of 2 kHz-evoked ipsilateral AR was significantly (P less than 0.05) increased. Reflex decay increased significantly (P less than or equal to 0.001) for the contralateral reflex elicited by the 2 kHz stimulus. Neither compliance of the middle ear system nor amplitude and latency of the brain stem auditory-evoked response were affected (P greater than 0.05) by tenotomy. Since tenotomy eliminates participation of the tensor tympani in the AR, these data indicate that contraction of this muscle is not primarily responsible for the compliance changes recorded during an acoustic reflex in dogs. 相似文献
11.
Brain stem auditory-evoked response of the nonanesthetized dog 总被引:1,自引:0,他引:1
A E Marshall 《American journal of veterinary research》1985,46(4):966-973
The brain stem auditory evoked-response was measured from a group of 24 healthy dogs under conditions suitable for clinical diagnostic use. The waveforms were identified, and analysis of amplitude ratios, latencies, and interpeak latencies were done. The group was subdivided into subgroups based on tranquilization, nontranquilization, sex, and weight. Differences were not observed among any of these subgroups. All dogs responded to the click stimulus from 30 dB to 90 dB, but only 62.5% of the dogs responded at 5 dB. The total number of peaks averaged 1.6 at 5 dB, increased linearly to 6.5 at 50 dB, and remained at 6.5 to 90 dB. Frequency of recognizability of each wave was tabulated for each stimulus intensity tested; recognizability increased with increased stimulus intensity. Amplitudes of waves increased with increasing stimulus intensity, but were highly variable. The 4th wave had the greatest amplitude at the lower stimulus intensities, and the 1st wave had the greatest amplitude at the higher stimulus intensities. Amplitude ratio of the 1st to 5th wave was greater than 1 at less than or equal to 50 dB stimulus intensity, and was 1 for stimulus intensities greater than 50 dB. Interpeak latencies did not change relative to stimulus intensities. Peak latencies of each wave averaged at 5-dB hearing level for the 1st to 6th waves were 2.03, 2.72, 3.23, 4.14, 4.41, and 6.05 ms, respectively; latencies of these 6 waves at 90 dB were 0.92, 1.79, 2.46, 3.03, 3.47, and 4.86 ms, respectively. Latency decreased between 0.009 to 0.014 ms/dB for the waves. 相似文献
12.
Gauly M Vaughan J Hogreve SK Erhardt G 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2005,19(5):756-760
Auditory function of llamas and alpacas was assessed objectively by means of brainstem auditory-evoked response audiometry (BAER) to establish the normal hearing range and to test the hypothesis of a correlation between blue eyes, white coat, and deafness. Sixty-three camelids were available for the study. Thirteen animals had blue irides; 1 animal had 1 blue and 1 pigmented iris. Wave latencies, amplitudes, and interpeak latencies were measured under general anesthetic. Click stimuli (dB [HL]) were delivered by an insert earphone. Four to five positive peaks could be detected; waves I, II, and V were reproducible; wave II appeared infrequently; and wave IV generally merged with wave V to form a complex. Peak latencies decreased and peak amplitudes increased as stimulus intensity increased. A hearing threshold level of 10-20 dB (HL) was proposed as the normal range in llamas and alpacas. None of the animals with pigmentation of coat and iris showed any degree of hearing impairment. Seven of the 10 blue-eyed, pure-white animals were bilaterally deaf and one of them was unilaterally deaf. However, 2 blue-eyed, white animals exhibited normal hearing ability. Three blue-eyed animals with pigmented coat did not show any hearing impairment. All white animals with normal iris pigmentation had normal auditory function; so did the 1 animal with 1 normal and 1 blue iris. The high frequency (78%) of bilaterally deaf animals with pure white coat and blue iris pigmentation supports the hypothesis of a correlation between pigmentation anomalies and congenital deafness in llamas and alpacas. 相似文献
13.
Summary Cranium and brainstem dimensions were measured in 32 postmortem dog heads. Positive correlations were found between cranium length (CL) and brainstem length (BL) (r=0.87), between cranium width (CW) and brainstem width (BW) (r=0.83), and between cranium distance (CD = CL CW/2) and brainstem distance (BD = BL+BW/2) (r=0.91). Positive correlation coefficients were also found between CL and CW (r=0.90), and between BL and BW (r=0.85). It was concluded that head size accurately reflected brainstem size. A least squares estimation of the brainstem distance (BD) from CL and CW values was BD = 10.9 + 0.16 (CL CW/2) (BD, CL and CW in mm). Brainstem auditory evoked potentials (BAEPs) and cranium dimensions were measured in 43 dogs (86 ears) with different head size, body size, sex and age. Wave form, absolute and interpeak latencies and correlation coefficients, relating latencies to cranium dimensions and body weight, were analysed CL, CW, and CD were positively correlated with body weight (r=0.93, 0.70 and 0.93, respectively), and CL, CW, and CD were correlated with age (r=0.33, 0.52 and 0.40, respectively). BAEPs consisted of five distinct positive peaks (I to V). Secondary positive peaks following peaks I and II were seen in 60% (I') and 90% (II') of the recordings. Late waves were recorded in 90% (VI), 50% (VII), and 25% (VIII) of the recordings. Latencies increased with decreasing stimulus intensity level (from 90 dB to 10 dB hearing level, HL),especially for peaks I, II, V, and the I‐V interpeak interval Absolute and interpeak latencies were positively correlated with cranium distance and body weight. Correlation coefficients increased as wave latencies increased At 90 dB HL, the highest correlation coefficients, relating cranium distance to peak V and the I‐V interpeak latency, were 0.55 and 0.53 (P < 0.00001), respectively. Regression analysis showed that each 1 cm increase in cranium distance was accompanied by an increase of 0.006 ms in the latency of wave I, 0.03 ms for wave III, 0.05 ms for wave V, and 0.05 ms for the I‐V interpeak interval Regression analysis showed that an increase of 1 kg in body weight was accompanied by an increase of 0.001 ms in the latency of wave I, 0.005 ms for wave III, 0.011 ms for wave V, and 0.01 ms for the I‐V interpeak interval. It is concluded that head size, which accurately reflects brain size, is a relevant source (25%) of intersubject variance of BAEP latencies in the dog. 相似文献
14.
Brain stem auditory-evoked potentials of dogs: wave forms and effects of recording electrode positions 总被引:1,自引:0,他引:1
Wave forms of canine brain stem auditory-evoked potentials (BAEP) and the effects of electrode positions on the wave forms were studied as a basis for experimental and clinical use of BAEP recording. The BAEP regularly consisted of 5 waves (I to V) with latencies and polarities similar to those of other species. In some dogs, waves II, III, and IV contained distinct subpeaks (a, b, c). Waves similar to waves VI and VII of other species were recorded in some dogs. With respect to BAEP, no site on the head was electrically inactive and BAEP could be recorded as far caudally as the caudal cervical region in some dogs. Wave I, positive in recordings from the dorsal midline of the calvaria (vertex) underwent polarity reversal and increased amplitude and duration in recordings made from caudal ventrolateral regions of the head (mastoid region). As a result, wave I partially or totally obscured wave II so that the latter could no longer be clearly identified. Waves IIIa and IIIb were differentially affected by moving the recording site, indicating that their generators were spatially separated. Waves IV and V were also affected by electrode site, consistent with previous reports that they have spatially separated generators in other species. In recordings made with vertex electrodes referenced to the mastoid region ipsilateral to the stimulated ear, wave I appeared as a high-amplitude positive peak with onset latency equalling that in noncephalic reference recordings, but with somewhat later peak latency and longer duration. As a result, wave II was partially or totally obscured so that only 4 major peaks were evident in the BAEP. In contralateral mastoid reference recordings, latency to peak of wave I was unchanged; however, amplitude of all waves was reduced and waves IIa and IIb were not as clearly differentiated as they were in noncephalic reference recordings. 相似文献
15.
Aims
Auditory plasticity in response to unilateral deafness has been reported in various animal species. Subcortical changes occurring in unilaterally deaf young dogs using the brainstem auditory evoked response have not been evaluated yet. The aim of this study was to assess the brainstem auditory evoked response findings in dogs with unilateral hearing loss, and compare them with recordings obtained from healthy dogs.Methods
Brainstem auditory evoked responses (amplitudes and latencies of waves I, II, III, V, the V/I wave amplitude ratio, wave I-V, I-III and III-V interpeak intervals) were studied retrospectively in forty-six privately owned dogs, which were either unilaterally deaf or had bilateral hearing. The data obtained from the hearing ears in unilaterally deaf dogs were compared to values obtained from their healthy littermates.Results
Statistically significant differences in the amplitude of wave III and the V/I wave amplitude ratio at 75 dB nHL were found between the group of unilaterally deaf puppies and the control group. The recordings of dogs with single-sided deafness were compared, and the results showed no statistically significant differences in the latencies and amplitudes of the waves between left- (AL) and right-sided (AR) deafness.Conclusions
The recordings of the brainstem auditory evoked response in canines with unilateral inborn deafness in this study varied compared to recordings from healthy dogs. Future studies looking into electrophysiological assessment of hearing in conjunction with imaging modalities to determine subcortical auditory plasticity and auditory lateralization in unilaterally deaf dogs are warranted.16.
Brain stem auditory-evoked responses were recorded in 9 male and 11 female clinically normal mature dogs, weighing between 2 and 36 kg. Mean wave latency for the entire group of dogs, using 60-dB hearing level click stimuli at 11/s for waves I to VII was: 1.41, 2.21, 2.85, 3.31, 3.71, 5.12, and 6.46 ms, respectively. The mean interpeak latency for waves I and V (IPLIV) was 2.32 ms. Neither gender nor ear effect was detectable. Positive correlation was observed between cranium length, cranium width, nasion-external auditory meatus interval, and body weight for wave-V latency and IPLIV. Such correlation was not documented for wave I. The regression equations for their effects on IPLIV were: cranium length, y = 0.05x + 1.85; cranium width, y = 0.07x + 1.32; nasion-external auditory meatus interval, y = 0.05x + 1.79; and body weight, y = 0.01x + 2.15. On the basis of any of the 3 variables of cranium size or body weight, the study population could be classified into groups of large and small dogs, with the large group having significantly (P less than 0.05) longer latency for wave V and IPLIV. It is recommended that the effect of size variation in dogs on brain stem auditory-evoked responses should be compensated for by use of the regression equation based on cranium length. 相似文献
17.
Brain stem auditory-evoked potentials (BAEP) were recorded in 4 dogs to analyze the relationship between acoustic stimulus intensities and peak latencies of each wave, and to investigate the relative effects of xylazine-atropine, xylazine-atropine-ketamine, and xylazine-atropine-pentobarbital combinations and the time-course effects of the latter 2 drug combinations on BAEP. Click stimulations fixed at a stimulus rate of 10/s and a frequency of 4 kHz were delivered at intensities ranging from 10- to 110-dB sound pressure level (SPL) in 10-dB steps for analyzing the relationship between the acoustic stimulus intensities and the peak latencies and at an intensity of 110-dB SPL for investigating the effects of the sedative and anesthetic drug combinations and their time-course effects on BAEP. Waves I to VI were identified with stimulus intensity of greater than or equal to 50-dB SPL. Wave VII was observed in some records, but was excluded from statistical analysis. As stimulus intensity was increased from 50- to 110-dB SPL, the latency decreased for all waves during xylazine-atropine-ketamine anesthesia. There were no statistically significant differences in the peak latencies of each wave in BAEP among xylazine-atropine, xylazine-atropine-ketamine, and xylazine-atropine-pentobarbital combinations 20 minutes after drug administration, except that the latency of wave VI during xylazine-atropine sedation was significantly (P less than 0.01) shorter than that detected during xylazine-atropine-ketamine or xylazine-atropine-pentobarbital anesthesia.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
18.
We describe a previously un-reported vertex-negative potential evoked by high intensity click auditory stimuli in some dogs and cats with suspected cochleo-saccular deafness. Brainstem auditory evoked potential tracings from 24 unilaterally or bilaterally deaf animals, 22 dogs and 2 cats, among which 21 belonged to breeds with high prevalence of suspected or histologically confirmed cochleo-saccular deafness, were studied retrospectively. Values for latency, amplitude and threshold of this potential in dogs were 2.15+/-0.23 ms, 0.49+/-0.25 microV, and 91.9+/-4.7 dB NHL, respectively (mean+/-SD). Latency and threshold values in cats were in the mean+/-2 SD range of the dog values. Sensitivity to click stimulus polarity and to click stimulus delivery rate pointed towards a neural potential instead of a receptor potential. The vertex-negative wave observed in these animals shares all characteristics with the N3 potential described in some deaf humans with cochlear deafness, where it is presumed to arise from saccular stimulation. The combined degeneration of cochlea and sacculus usually reported in deaf white dogs and cats suggest that N3 may have a different origin in these species. 相似文献
19.
Ter Haar G Venker-van Haagen AJ de Groot HN van den Brom WE 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2002,16(3):274-280
A method was developed to deliver tonebursts ranging in frequency from 1 to 32 kHz for frequency-specific assessment of the canine cochlea. Brainstem auditory-evoked responses (early latency responses, 0-10 ms) to a click (CS) and to 1-, 2-, 4-, 8-, 12-, 16-, 24-, and 32-kHz toneburst stimulations (TS) were compared at 80-dB sound pressure level stimulus (SPL) intensity in 10 adult dogs. All stimulations yielded a 5-7 positive wave pattern, with the exception of the 1-kHz TS, which evoked a frequency-following response (FFR). Thresholds were lowest for the CS and the 12- and 16-kHz TS. All individual peak latencies for TS were significantly (P < or = .05) longer than for CS. Peak I latencies were significantly (P < or = .05) shorter for the 12- and 16-kHz TS than for the other TS. Interpeak latencies I-V were significantly (P < or = .05) longer for the 4- to 32-kHz TS than for CS. Differences in interpeak latencies I-III were not significant. Amplitudes of waves I and V were significantly (P < or = .05) lower for TS than for CS, except for higher wave V amplitude (P < or = .05) at 2- and 32-kHz TS. Peak I-V amplitude ratios were significantly (P < or = .05) higher for the 2-, 4-, 16-, 24-, and 32-kHz TS and lower for the 8- and 12-kHz TS, compared to CS. We conclude that reproducible information on frequency specificity of the canine cochlea can be obtained by TS. This report provides a normative database for parameters needed to evaluate frequency-specific hearing loss in dogs. 相似文献
20.
Reference values were established for frequency-specific electric response audiometry (ERA) in dogs on the basis of the results of ERA examinations of 200 animals with normal hearing. Air-conducting acoustic tubes with foam stoppers were used in the determination of the following: the latencies of waves I, III and V; interpeak latencies (IPL) I-III, III-V and I-V; amplitudes I and V; and the amplitude difference I-V. A frequency-specific stimulus (tone pip) was used for frequency-specific examination (1 to 4 kHz) over the entire frequency range indicated. These reference values were then used for the clinical examination of 50 dogs with hearing defects. A frequency-specific ERA was conducted and the results evaluated. These findings made it possible to draw objective conclusions about the degree, type and site of the hearing defects. Frequency-specific electric response audiometry was shown to be an important diagnostic tool for the detection of partial high- and low-frequency hearing loss and for the characterisation of hearing defects of otological, otoneurological and neurological origin. 相似文献