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黄荣春 《畜牧兽医科技信息》2022,(2):37-38
抗菌肽因具有抗菌谱广,无耐药、无残留,对正常体细胞无毒性等特点,在畜牧业中有望成为替代抗生素的新一代抗菌添加剂.本试验旨在探究抗菌肽对断奶仔猪生产性能、腹泻、抵抗力、经济效益等的影响,以期为进一步使用和推广抗菌肽提供依据. 相似文献
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抗菌肽研究进展及其在饲料中的应用 总被引:1,自引:0,他引:1
抗菌肽(anti—bacterial peptides),又称抗微生物肽(peptide antibiotics),是生物体在抵抗病原微生物的防御反应过程中产生的一种具有抗微生物功能的小分子多肽,它们多为1345个氨基酸组成的短肽(肖建光等,2005;Bulet等,2004)。抗菌肽广泛存在于植物、细菌、动物体内,是生物先天性免疫的重要效应分子。抗菌肽除具有广谱的抗菌活性外,还具有抗原虫、抗真菌、抗病毒和抑制或杀伤肿瘤细胞等作用。动物抗菌肽与青霉素等传统抗生素作用机制完全不同,病原菌不易产生对抗菌肽的耐药性。此外,抗菌肽一般情况下只作用于原核细胞和发生病变的真核细胞,而对正常的真核细胞无影响。 相似文献
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Constable PD 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2004,18(1):8-17
Calves with diarrhea often have small intestinal overgrowth with Escherichia coli bacteria, regardless of the inciting cause for the diarrhea, and 30% of systemically ill calves with diarrhea have bacteremia, predominantly because of E coli. Antimicrobial treatment of diarrheic calves should therefore be focused against E coli in the small intestine and blood, the 2 sites of infection. Fecal bacterial culture and antimicrobial susceptibility testing is not recommended in calves with diarrhea because fecal bacterial populations do not accurately reflect small intestinal or blood bacterial populations and because the break points for susceptibility test results have not been validated. Antimicrobial efficacy is therefore best evaluated by the clinical response of a number of calves to treatment, with calves randomly assigned to treatment groups. Amoxicillin, chlortetracycline, neomycin, oxytetracycline, streptomycin, sulfachloropyridazine, sulfamethazine, and tetracycline administered PO are currently labeled in the United States for the treatment of calf diarrhea. On the basis of published evidence for the oral administration of these antimicrobial agents, only amoxicillin can be recommended for the treatment of diarrhea. Dosage recommendations are amoxicillin trihydrate (10 mg/kg PO q12h) or amoxicillin trihydrate-clavulanate potassium (12.5 mg combined drug/kg PO q12h) for at least 3 days; the latter constitutes extra-label drug use. Parenteral administration of broad-spectrum beta-lactam antimicrobials--ceftiofur (2.2 mg/kg IM or SC q12h) and amoxicillin or ampicillin (10 mg/kg IM q12h)--or potentiated sulfonamides (25 mg/kg IV or IM q24h) is recommended for treating calves with diarrhea and systemic illness; both constitute extra-label drug use. In calves with diarrhea and no systemic illness (normal appetite for milk, no fever), it is recommended that the health of the calf be monitored and that oral or parenteral antimicrobials not be administered. 相似文献
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抗菌肽可抵御细菌、病毒和真菌的入侵,在人类和家畜的先天性防御系统中具有重要的作用,是有望用于预防和治疗的药物,因此,抗菌肽被称为"新一代的抗生素"。抗菌肽是一个阳离子肽,其中的一个大家族就是防御素。防御素的结构中普通带有一个β-片状结构,其中包含3个分子内二硫键,可分为α-防御素、β-防御素和θ-防御素,其中β-防御素是最大的一个家族,在人类和家畜的组织内均有表达。结合已有的研究成果,作者主要对家畜体内防御素的表达、多态性及其作为健康和生产性能的遗传标记的潜在应用作一综述。 相似文献
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Foraging activity of Acanthochitona garnoti was studied during spring and neap tides in three different habitats: an aeolian sandstone platform, a permanent high-shore rock pool (aeolian shore) and a quartzitic sandstone boulder shore. On exposed rock, A. garnoti was active only during nocturnal low tides, although some individuals were active during early morning low tides when in shade. Chitons from upper-shore pools were active during both day and night low tides. At all sites chitons foraged for longer (x? = 5.5 h) and travelled further (x? = 313 mm) during a spring tide new moon and least on a spring tide full moon (x? = 4.0 h; x? = 182 mm). Chitons on the boulder beach travelled greater distances (x? = 367 mm) during foraging than those from aeolian shores (x? = 105 mm). It is suggested that this is a result of boulder beach chitons having further to travel to find a grazing patch. Finally, A. garnoti was found to have a ranging pattern of activity on boulder shores and a homing pattern on aeolian shores. 相似文献
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Background – Antimicrobial peptides (AMPs) have a pivotal role in cutaneous innate immunity. They are present in the skin of many animals, including mammals, and are both constitutively present and inducible by infection and injury. Functions – Antimicrobial peptides exhibit antimicrobial activity against bacteria, viruses, fungi and parasites, with different potencies depending on their peptide structure. They also act as multifunctional effector molecules that influence diverse cellular processes, including cell migration, proliferation and differentiation, cytokine production, angiogenesis and wound healing. Suppressed AMP production has been associated with increased susceptibility to microbial insults and the pathogenesis of atopic dermatitis. This review highlights recent observations on the expression and role of AMPs, particularly the AMPs cathelicidin and β‐defensin, in healthy and diseased skin. 相似文献
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抗菌肽抗病的研究进展 总被引:3,自引:2,他引:1
抗菌肽具有广谱杀菌,对病毒、真菌、某些肿瘤具有一定的抑制作用,抗菌肽还具有不产生耐药性,对正常细胞无毒害作用,是一种理想的生物制剂。作者综述了近些年来抗菌肽在抗细菌、病毒、真菌和癌症等方面的相关研究,并就抗菌肽在当前存在的问题和未来巨大的应用前景进行了探讨。 相似文献
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M. Martinez J. Blondeau C. E. Cerniglia J. Fink‐Gremmels S. Guenther R. P. Hunter X.‐Z. Li M. Papich P. Silley S. Soback P.‐L. Toutain Q. Zhang 《Journal of veterinary pharmacology and therapeutics》2014,37(1):e1-e16
Antimicrobial resistance is a global challenge that impacts both human and veterinary health care. The resilience of microbes is reflected in their ability to adapt and survive in spite of our best efforts to constrain their infectious capabilities. As science advances, many of the mechanisms for microbial survival and resistance element transfer have been identified. During the 2012 meeting of Antimicrobial Agents in Veterinary Medicine (AAVM), experts provided insights on such issues as use vs. resistance, the available tools for supporting appropriate drug use, the importance of meeting the therapeutic needs within the domestic animal health care, and the requirements associated with food safety and food security. This report aims to provide a summary of the presentations and discussions occurring during the 2012 AAVM with the goal of stimulating future discussions and enhancing the opportunity to establish creative and sustainable solutions that will guarantee the availability of an effective therapeutic arsenal for veterinary species. 相似文献