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疯草及毒性成分研究进展 总被引:2,自引:0,他引:2
疯草是指含苦马豆素的豆科黄芪属和棘豆属有毒植物,能引发家畜疯草病。疯草的分布比较广泛,属于世界性有毒植物,近年来疯草蔓延迅速,在一些地区已经造成草地毒草化,频繁出现放牧家畜中毒死亡现象,严重威胁草地畜牧业发展。研究表明,疯草的毒性与其含有的苦马豆素有关,但苦马豆素却不是疯草自身代谢产物,而是疯草携带内生真菌的代谢产物,此外苦马豆素还是一种良好抗肿瘤药物。笔者结合国内外相关研究对疯草的分布、危害、防治及毒性成分研究进展进行综述,并对疯草分类、研究地域及利用前景进行了讨论。 相似文献
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疯草中毒研究概况及其进展 总被引:7,自引:0,他引:7
疯草中毒研究概况及其进展张洁,刘绪川(中国农业科院学中兽医研究所兰州730050)疯草(Iocoweed)是黄芪属和棘豆属有毒植物的总称,对动物有着几乎相同的毒害作用,国外将这类毒性植物引起的家畜中毒病统称为疯草中毒(Locoism)[1,2]。疯草... 相似文献
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疯草(Locoweed)是黄芪属、棘豆属和苦马豆属中含苦马豆素(swainsonine, SW)有毒植物的统称,具有抗旱耐寒,分布广泛的特性。牲畜长期采食疯草会引起蓄积性中毒,严重时导致死亡,严重危害了我国草原畜牧业的可持续发展。疯草内生真菌是疯草具有毒性的根本原因,其毒性代谢产物即苦马豆素。论文对疯草在中国的种类与分布、疯草与内生真菌互作关系、疯草内生真菌种属及检测方法、疯草内生真菌传播方式与内生真菌育种;苦马豆素的来源、毒理机制及生物合成通路最新研究进展做一综述,以期为疯草植株及其内生真菌的改造利用方面提供参考。 相似文献
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苦马豆素-BSA接种山羊的免疫学研究 总被引:1,自引:0,他引:1
疯草(Locoweed)是世界范围内危害草原畜牧业生产最严重的一类毒草,在我国主要分布于西部的广大草原,危害面积达1100万hm^2,并且日趋蔓延。动物采食疯草后不仅引起大量中毒死亡,更为重要的是导致母畜流产、不孕、胎儿畸形和公畜不育,同时疯草蔓延可促使草场退化,降低草场利用率,给草原畜牧业造成巨大的经济损失。国内外学者自1873年至今对动物疯草中毒做了大量的研究,现已确认的疯草毒素为吲哚兹啶生物碱-苦马豆素(swainsonine,SW)。疯草除含有毒素外,营养学研究也发现,其粗蛋白含量高达11%~12%,有着被作为优良饲草的潜力。 相似文献
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美国动物疯草中毒诊断与防治技术研究进展 总被引:3,自引:0,他引:3
疯草是美国西北部草原上分布最广泛的有毒植物,约有370多种,其中含有毒生物碱苦马豆素的疯草有24种,造成家畜中毒灾害的有11种。动物采食疯草后不仅引起中毒死亡,还影响其繁殖和畜种改良。此外,疯草的蔓延使草地利用率降低,给草原畜牧业造成巨大经济损失,严重威胁当地畜牧业的发展。为减少疯草中毒造成的经济损失,美国投入大量人力、物力和财力致力于疯草的研究,目前已经在疯草的生物学、生态学和生理学、毒物学与毒理学、临床诊断与防治技术等方面取得重大进展。就美国疯草的种类及生态分布、中毒诊断与防治技术方面的最新研究进展进行综述。 相似文献
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Seven healthy, adult, crossbred yearling ewes were given (orally) 340 g of locoweed (Astragalus lentiginosus) every day for 10 weeks. Another 7 ewes were not fed the plant, but were housed similarly (controls). Blood samples were obtained once a week to evaluate the mitogen-induced lymphocytic responsiveness. For the locoweed-exposed ewes, there was decreased activity in the presence of phytohemagglutinin (a T-cell mitogen). This effect, although not statistically significant at all times, was consistent and became significant after 7 weeks. A similar response was observed in the blood cell cultures in the presence of pokeweed mitogen, but the differences were not statistically significant at most time points. For the locoweed-exposed ewes there also were gradual numerical decreases in total leukocyte and lymphocytes in peripheral blood. Peripheral leukocytes had cytoplasmic vacuolation. The results indicated that a selective effect may occur on cell-mediated immune responses. Serum proteins and gamma-globulins were not affected by locoweed treatment. Locoweed, certain species of Astragalus and Oxytropis, causes considerable economic loss to the livestock industry of western United States. Locoweed consumption by livestock can result in neurologic problems, emaciation, habituation, and reproductive alterations. The reproductive alterations include abortions, birth defects, and some interference with spermatogenesis and oogenesis. Signs of poisoning are CNS depression, rough dry coat, dull eyes, irregular gait, and excitement when stressed. The microscopic lesions are neurovisceral cytoplasmic vacuolations. Microscopic lesions are also observed in the fetuses and newborns of dams which were fed locoweed.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
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L F James 《Canadian journal of veterinary research》1976,40(4):380-384
Locoweed, Astragalus lentiginosus, was fed to pregnant ewes for various periods during gestation. The principal gross effects on the developing fetuses were observed to be delayed placentation, decreased vascularization, fetal edema and hemorrhage, and alteration of cotyledon development. Deformed lambs and undersized lambs also occurred. Data from sheep fed locoweed during various periods of the entire gestation period are summarized and indicate that locoweed poisoning in the fetus as with the adult is a chronic type of intoxication. Also, poisoning of the fetus parallels poisoning in the dam. 相似文献
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L F James W J Hartley D Nielsen S Allen K E Panter 《Journal of the American Veterinary Medical Association》1986,189(12):1549-1556
Locoweed (Oxytropis sericea), when fed to calves at high elevations, increased the prevalence and severity of congestive heart failure. Forced exercise did not increase the prevalence of congestive heart failure, but it did increase severity. Calves consuming locoweed at high elevations developed signs and gross lesions of congestive heart failure and microscopic lesions of congestive heart failure and locoweed poisoning. Calves fed locoweed at low elevations developed only signs and lesions of locoweed poisoning. 相似文献
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Locoweed (Astragalus lentiginosus) was fed to ewes from 70 to 100 days of pregnancy. Ewes were killed at 100, 115, 130, and 145 days, and selected tissues were collected from both the dam and the fetus for histologic examination. Neurovisceral cytoplasmic vacuolation and neuroaxonal dystrophy decreased in dam and fetus with time after the feeding of locoweed was discontinued. 相似文献
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Spotted locoweed (Astragalus lentiginosus var. diphysus) is a toxic, perennial plant that may, if sufficient precipitation occurs, dominate the herbaceous vegetation of pinyon-juniper woodlands on the Colorado Plateau. Six cow/calf pairs and four horses grazed a 20-ha pasture with dense patches of locoweed in eastern Arizona during spring 1998. Locoweed density was 0.7 plants/m2 in the pasture. Locoweed averaged 30.4% NDF and 18.4% CP. Concentrations of the locoweed toxin, swainsonine, fluctuated from 1.25 to 2 mg/g in locoweed. Horses ate more (P < 0.01) bites of locoweed than did cows (15.4 and 5.1% of bites, respectively). Horses generally increased locoweed consumption over time since they ate approximately 5% of bites in the preflower stage compared with 25% of bites in the pod stage. Cattle consumed almost no locoweed (< 1% of bites) until the pod stage, when they increased consumption to 15% of bites. Horses were very avid (approximately 65 to 95% of bites) in selecting the small quantities (approximately 40 to 150 kg/ha) of available green grass, and it appeared that their propensity to eat scarce green forage influenced their locoweed consumption as well. Horses ate relatively little dry grass, even when it was abundant, whereas cattle ate large amounts of dry grass until green grasses became more abundant. Calves began eating locoweed on the same day as their dams and ate approximately 20% of their bites as locoweed. Serum concentrations of swainsonine were higher (P < 0.05) in horses than in cattle (433 vs. 170 ng/mL, respectively). Baseline swainsonine was zero in all animals, but swainsonine was rapidly increased to above 800 ng/mL in serum of horses as they ate locoweed. Horses exhibited depression after eating locoweed for about 2 wk; after 5 wk of exposure, horses became anorectic and behaviorally unstable. Although limited in scope, this study indicates that horses should not be exposed to spotted locoweed. 相似文献