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A severe outbreak of psoroptic mange in beef cattle is described. Up to half the animals in some groups were extensively affected and debilitated. Performance was poor with days to slaughter weight increased. Ivermectin was the most effective form of treatment. The possible origin of the infestation and the ways of controlling the condition are discussed. 相似文献
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Lewis C 《The Veterinary record》2010,167(21):835; author reply 835
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The clinical signs, treatments used and spread of psoroptic mange in cattle from October 2007 until March 2011 are described. The disease was first diagnosed in South West Wales, having not been reported in Great Britain since the 1980s. The likely source was identified as a farm that had imported two animals from mainland Europe in the summer of 2006. Since that time, disease has been diagnosed on a further 22 premises, the majority in South West Wales but also in South East and Mid Wales and on one farm in England. Bought in animals harbouring the Psoroptes species mite but not showing clinical signs were considered the greatest risk of introducing the infestation into a herd. This, together with the difficulties of treatment to eliminate the parasite, means that it is unlikely that this outbreak has been controlled. There is also a continuing threat of importing the disease from abroad. The disease is not notifiable in the UK. 相似文献
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The efficacy of topically administered ivermectin against Chorioptes bovis and Sarcoptes scabiei var bovis on cattle was evaluated in five studies involving a total of 68 cattle. Treatment with ivermectin solution at a dose rate of 500 micrograms/kg bodyweight topically once was fully effective against C bovis and S scabiei when applied to healthy skin. Efficacy against S scabiei was impaired when the formulation was applied over areas of severe lesions caused by this parasite, presumably due to reduced absorption of ivermectin. 相似文献
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Cadiergues MC Laguerre C Roques M Franc M 《American journal of veterinary research》2004,65(2):151-154
OBJECTIVE: To evaluate efficacy of 2 deltamethrin emulsifiable concentrates that differed on the basis of vehicle (methyl glycol acetate [AMG] or 2-propylene glycol 1-methyl ether acetate [AMP]) for the treatment of sheep with mange. ANIMALS: 30 ewes between 11 months and 7 years old that weighed 16 to 71 kg and were naturally infested with Psoroptes ovis. PROCEDURE: Sheep were randomly allocated into 3 groups (13 sheep in group AMP, 13 sheep in group AMG, and 4 negative-control sheep). Each sheep was dipped twice (10-day interval between dippings) in the assigned formulation. Assessment of efficacy was performed on days 3, 7, 14, 21, 28, 35, 42, 49, 56, and 63 after the first dipping. Efficacy was assessed by determining the number of eggs or live mites on those days, as well as regrowth of wool at the end of the study. RESULTS: Psoroptic mange infestation was maintained in the 4 control sheep throughout the study. We did not detect live Psoroptes mites in scrapings after day 7 (AMP group) or after day 14 (AMG group). No parasites were seen after day 14 in either treatment group. Therefore, efficacy was 100% for both treatment groups from days 14 to 63. CONCLUSIONS AND CLINICAL RELEVANCE: The 2 formulations of deltamethrin were equally able to eradicate Psoroptes infestation of sheep after 2 dippings performed in accordance with the label recommendations. 相似文献
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Lavigne C Smith HJ 《The Canadian veterinary journal. La revue veterinaire canadienne》1983,24(12):389-390,391
In 1982, approximately 13,000 Canadian cattle were treated once for sarcoptic mange with ivermectin at a dose of 10 mg per 45.4 kg of body weight. The results showed 100% efficacy against Sarcoptes scabiei and other ectoparasites present. All cattle showed marked improvement in general condition with new hair growth and apparent weight gains by 31 days posttreatment. Surveillance of treated herds for a year following treatment showed that one parenteral treatment with ivermectin eradicated the disease from closed herds. 相似文献
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M. D. Soll I. H. Carmichael G. E. Swan H. Scherer 《Tropical animal health and production》1987,19(2):93-102
Seven trials including 768 cattle were conducted in South Africa and Namibia to evaluate the efficacy of the systemic parasiticide ivermectin when administered subcutaneously at a dose rate of 200 micrograms/kg against sarcoptic (Sarcoptes scabiei var. bovis), chorioptic (Chorioptes bovis) and psoroptic (Psoroptes ovis var. bovis) mange mites. The efficacy of a single treatment against Psoroptes and Sarcoptes was greater than against Chorioptes. There was marked clinical cure in all treated cases with loss of crusts and hair regrowth. The number of cases of psoroptic mange in two large herds, of which 42.4% of 724 animals were clinically affected prior to mass treatment, was reduced by 99.3% following a single subcutaneous treatment with ivermectin; a single animal from which mites were recovered may not have been treated. The apparent prevalence and prospects for control and eradication of cattle mange in South Africa and Namibia are discussed. 相似文献
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Concentration of ivermectin in bovine serum and its effect on the fecundity of psoroptic mange mites
The concentration-time profile of ivermectin in serum was determined for 3 Hereford heifers. The mean maximum serum concentration, 29 ng of ivermectin/ml, was obtained 48 hours after single subcutaneous injection of 200 micrograms/kg of body weight. The fecundity of mites placed on 9 treated animals at 5, 9, 12, 15, 18, and 21 days after injection was reduced by 96% to 99%. At 24 days after treatment, when serum concentration had decreased to about 2 ng/ml, the capability of mites to produce eggs increased to 50% of mites from nontreated calves. At 27 and 30 days after the drug was injected, egg production by mites on treated calves was equivalent to that of mites on nontreated calves. The reduced fecundity resulted from an almost complete cessation of oviposition by females after only a 1-day exposure to ivermectin-treated calves. 相似文献
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Lifschitz A Pis A Alvarez L Virkel G Sanchez S Sallovitz J Kujanek R Lanusse C 《Journal of veterinary pharmacology and therapeutics》1999,22(1):27-34
The vehicle in which endectocide compounds are formulated plays a relevant role in their absorption kinetics and resultant systemic availability. The pharmaceutical bioequivalence and comparative plasma disposition kinetics of ivermectin (IVM), following the subcutaneous administration of two injectable formulations to pigs and cattle were investigated using parallel experimental designs. Sixteen parasite-free male Duroc Jersey-Yorkshire crossbred pigs (90-110 kg) (Expt 1) and 16 parasite-free male Holstein calves (100-120 kg) (Expt 2) were divided into two groups and treated subcutaneously at either 300 (pigs) or 200 (calves) microg/kg with two different propylene glycol/glycerol formal (60: 40) based IVM formulations; in both experiments pigs or calves in Group A received the test (IVM-TEST) formulation and those in Group B were treated with the reference formulation (IVM-CONTROL). Heparinized blood samples were taken from 0 h up to either 20 (pigs) or 30 (calves) days post-treatment and plasma was extracted, derivatized and analysed by high performance liquid chromatography (HPLC) using fluorescence detection. Early detection of IVM (12 h) with a peak plasma concentration (C(max)) between 33 and 39 ng/mL was observed in pigs. The drug was detected in plasma up to 20 days post-administration of either formulation, resulting in elimination half-lives between 3.47 and 3.80 days. There were no differences between the IVM-TEST and IVM-CONTROL formulations in the kinetic parameters (except t(max)) obtained in pigs. IVM was detected in plasma between 12 h and 30 days post-administration of both formulations under investigation in cattle. The plasma disposition kinetics of IVM in calves was similar following treatment with both formulations. C(max) values (between 40.5 and 46.4 ng/mL) were achieved at 2 days post-administration of both formulations. None of the estimated kinetic parameters were statistically different between drug formulations. The injectable IVM formulations investigated were bioequivalent after their subcutaneous administration to both pigs and calves at recommended dose rates. 相似文献
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Efficacy of ivermectin in injectable and oral paste formulations against eight-week-old Strongylus vulgaris larvae in ponies 总被引:2,自引:0,他引:2
T R Klei B J Torbert M R Chapman M A Turk 《American journal of veterinary research》1984,45(1):183-185
A controlled test method was used to evaluate the efficacy of injectable micelle and oral paste formulations of ivermectin (22,23-dihydroavermectin B1) against 8-week-old Strongylus vulgaris larvae in experimentally infected pony foals. The dosage level of the drug in both formulations tested was 0.2 mg/kg. Ponies were euthanatized and necropsied 5 weeks after treatment. Based on the recovery of live vs dead S vulgaris from mesenteric arteries, both formulations were greater than 99% effective. Increased weight gains and marked reductions in the severity of arterial lesions were observed in treated ponies. 相似文献
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A test was begun in November 1982 to evaluate the development of Psoroptes ovis, the severity of psoroptic mange of cattle, and the incidence of transfer of P. ovis from artificially infested cattle to non-infested cattle held in feed lots in either an endemic (Bushland, TX) or non-endemic region (Kerrville, TX). The 2 herds each consisted of 24 Hereford steers. The 24 steers were randomly assigned to 3 pens of 8 steers per pen. Two steers from each pen that were randomly selected were artificially exposed to ca. 1000 P. ovis (AINF). The development of mange on these 6 AINF steers and the incidence of transfer to the other steers (INF) were monitored approximately every 3 weeks for 17 weeks. The 6 AINF steers at Bushland (endemic region) developed significantly more lesions than the 6 AINF steers at Kerrville. Three AINF steers in Bushland died from hypothermia and mange while no deaths were recorded at Kerrville. The numbers of mites sampled from affected skin areas of AINF steers from both regions were not significantly different. All 18 of the naturally exposed steers (INF) in Bushland contracted mange; whereas, only 9 INF steers in Kerrville did. The severity (% lesions) and number of mites per sample from affected skin were significantly greater on the INF steers in Bushland. These differences among INF steers in Bushland and Kerrville may be attributed to the higher level of parasitism attained in Bushland on the AINF steers. We propose that the extremely cold weather in Bushland contributed to the greater level of parasitism attained on AINF steers in Bushland by stressing the host steers. 相似文献
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The efficacy of injectable and pour-on formulations of moxidectin against lice on cattle 总被引:1,自引:0,他引:1
B. CHICK D. MCDONALD† R. COBB† PJ KIERAN§ I. WOOD¶ 《Australian veterinary journal》1993,70(6):212-213
SUMMARY The efficacy of one administration of moxidectin against natural infestations of the 3 common species of cattle lice in Australia: Linognathus vitull, Damallnla bovls and Haematoplnus eurysternus, was determined. A high degree of control of L vituli (too long-nosed sucking louse) was achieved with both the cattle Injection (96.7% and 100%) at 0.2 mg/kg and the cattle pour-on formulation (94.6% and 100%) at 0.5 mg/kg on the 2 farms where this louse occurred. An Injection of moxidectin at 0.2 mg/kg did not eliminate D bovis. In these trials efficacy ranged from nll to 85.2%. In contrast the pour-on formulation at 0.5 mg/kg provided consistently high efficacy (83.6 to 100%) against D bovis on 3 farms. Infestations of H eurysternus (the short-nosed sucking louse) were low and no significant difference was recorded between treatment groups In a single trial, however, lice persisted on 3 to 7 cattle In the untreated group at each Inspection, whereas none were found on any animals in the 2 groups treated with moxidectin on Inspection after treatment. 相似文献
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《Veterinary parasitology》2015,207(1-2):125-133
In cattle, infestation with Psoroptes ovis mites may cause severe dermatitis (psoroptic mange) which compromises the health and welfare of the animals and may lead to significant economic losses. To investigate yet undocumented effects of psoroptic mange mite infestations and how successful therapy promotes animal health, the present study examined alterations of the skin, lymph nodes and adrenal glands of P. ovis infested Fleckvieh (Simmental) bulls treated with either ivermectin long-acting injection (IVM LAI; IVOMEC® GOLD, Merial; 3.15% ivermectin w/v) or saline (n = 16 each). Approximately 8 weeks subsequent to experimental infestation with P. ovis, the bulls had developed mange and were administered either IVM LAI or saline once at 1 mL/50 kg body weight by subcutaneous injection. Mite counts were conducted in weekly intervals for determination of efficacy of treatment, and following humane euthanasia of the animals 8 weeks after treatment, skin samples from affected (mangy or previously mangy) and unaffected areas, prescapular lymph nodes and adrenal glands were collected for gross and pathohistological examination. In addition, four age-matching, uninfested Simmental bulls were sampled as controls for comparison.No P. ovis mites were detected on any IVM LAI-treated bull after 28 days following treatment whereas saline-treated bulls maintained infestation throughout the study. At sampling (approximately 16 weeks after experimental infestation and 8 weeks following saline or IVM LAI treatment), saline-treated bulls displayed a severe, exsudative dermatitis with significantly increased skin thickness and inflammatory cell infiltration, significantly enlarged, hyperplastic prescapular lymph nodes, as well as significantly increased adrenal gland weights and volumes as compared to P. ovis-infested, IVM LAI-treated bulls and uninfested controls. Quantitative stereological analysis revealed that the adrenal gland enlargement in P. ovis-infested, saline-treated bulls was due to a selective increase of the volume of the zona fasciculata in the adrenal cortex. Compared to uninfested controls and P. ovis-infested, IVM LAI-treated bulls, the number of epithelial cells in the zona fasciculata was significantly increased in P. ovis-infested, saline-treated bulls, while the zona fasciculata cell volumes did not differ between the three groups of cattle. While the single point determination of serum cortisol concentrations did not reveal significant differences between the three groups of cattle at tissue sampling, the hyperplastic growth of the adrenal cortex in the P. ovis-infested, saline-treated bulls provides morphologic evidence that a chronic stress reaction is one consequence of mange mite infestations that can be prevented by efficacious acaricidal treatment. 相似文献
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Comparative cost-effectiveness of ivermectin versus topical organophosphate in feedlot calves 总被引:1,自引:1,他引:0
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Bauck SW Jim GK Guichon PT Newcomb KM Cox JL Barrick RA 《The Canadian veterinary journal. La revue veterinaire canadienne》1989,30(2):161-164
A study was conducted in a commercial feedlot in western Canada to evaluate the impact of treatment with ivermectin versus a topical organophosphate on growth rate and feed efficiency in calves entering a feedlot at an average 275 kg liveweight.
A total of 9527 head of cattle was used. Variables measured included average daily gain, average days occupation, and feed conversion.
Ivermectin treated animals gained an average 0.08 kg per day more than those treated with topical organophosphate. In addition, they required an average 0.23 kg less feed/kg gain. Based on an average 227 kg of gain, this would result in 11 fewer days occupation and 52.3 kg less feed for ivermectin treated animals. This equaled a net benefit of $7.04 per head over treatment costs for ivermectin treatment versus topical organophosphate.
相似文献20.
Comparative cost-effectiveness of ivermectin versus topical organophosphate in feedlot yearlings
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Schunicht OC Guichon PT Booker CW Jim GK Wildman BK Ward TI Bauck SW Gross SJ 《The Canadian veterinary journal. La revue veterinaire canadienne》2000,41(3):220-224
A replicated-pen field trial was performed under commercial feedlot conditions in western Canada to determine the cost-effectiveness of administering ivermectin to yearling beef cattle upon entry to the feedlot after the grazing season, and to establish the level of trichostrongylid gastrointestinal parasite infection in this population, as estimated by fecal egg counts. Six thousand eight hundred and eighty-three, mixed breed, yearling steers were randomly allocated upon arrival at the feedlot to one of 2 experimental groups as follows: Ivermectin, which received topical ivermectin (0.5%) at the rate of 1.0 mL/10 kg body weight; or Fenthion, which received topical fenthion (20%) at the rate of 12 mL/295 kg body weight. There were 15 pens in each experimental group. Final weight, weight gain, average daily gain, and dry matter intake to gain ratio were significantly (P < 0.05) improved in the Ivermectin group as compared with the Fenthion group. There were no significant (P > or = 0.05) differences in initial weight, days on feed, or daily dry matter intake between the experimental groups. The geometric mean fecal egg counts at the time of allocation were 14.7 eggs/5 g and 16.6 eggs/5 g for the Ivermectin and Fenthion groups, respectively (P > or = 0.05). There were no significant (P > or = 0.05) differences in morbidity or mortality between the experimental groups. In the economic analysis, the significant improvements in feedlot performance in the Ivermectin group resulted in a net economic advantage of $4.20 CDN per animal. 相似文献