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Objectives We have documented the histomorphological features of feline primary open angle glaucoma. Design A retrospective morphologic study of eight affected eyes from eight cats, from 1992 to 2006 extracted from a pathology collection, which includes 4000 feline submissions and 1100 cases of feline glaucoma. Procedure Sections of affected globes, stained with H&E or with alcian blue were examined with a light microscope. Eyes that did not fulfill the criteria for primary open angle glaucoma were excluded from the study. Results The mean age was 9.1 years. Five cats were female and three cats were male. The breeds included five DSH, two Burmese, and one DLH cat. Significant histomorphological findings included an open irido‐corneal angle with an open ciliary cleft in all cases, loss of ganglion cells in eight of eight cases, cupping and gliosis of the optic nerve head in four of four cases in which the optic nerve was adequately sampled, and myxomatous changes of the stroma surrounding the vortex veins in seven of eight cases. Conclusions Primary open angle glaucoma in cats is a rare disease that should be taken into consideration when investigating cases of feline glaucoma. The pathogenesis of aqueous outflow obstruction in these cases is not known. This study describes eight additional cases of feline primary open angle glaucoma in cats without an identified cause. 相似文献
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《African Zoology》2013,48(2):239-245
The effects of timing, frequency and duration of mouth opening and marine overwash events on fish assemblages in two, adjacent temporarily open/closed estuaries were investigated. Sampling was conducted biannually over two years during summer and winter, using selective sampling gear to target estuarine-associated marine species. During this period the East Kleinemonde Estuary opened more frequently than the West Kleinemonde Estuary and it also experienced a greater number of bar overwash events when larval recruitment can occur. The timing of mouth opening and the frequency of marine overwash events did not influence species richness of marine-spawning species but had a pronounced effect on abundances (catch-per-unit-effort) of species. The species composition of both estuaries was similar, but the catch-per-unit-effort in the East Kleinemonde Estuary was more than three times greater than that of the West Kleinemonde Estuary. The East Kleinemonde also supported a greater proportion of immature individuals of Rhabdosargus holubi and Monodactylus falciformis, and the length frequency distributions of both these species differed significantly between the two estuaries. The larger fish sizes in the West Kleinemonde Estuary were attributed to the prolonged mouth closure that resulted in the trapping of larger juveniles and mature fish within the estuary. 相似文献
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鲁西黄牛是中国优良的地方品种,为了更有效的制定适宜的育种方案,加快鲁西黄牛肉用品系的选育,本研究在鲁西黄牛青年公牛体系和核心群育种方案的基础上,分别设定开放和闭锁核心群育种方案,采用确定性模型评估了开放和闭锁核心群育种体系的育种效果。结果表明,开放与闭锁核心群育种方案相比,综合遗传进展提高了0.80%;育种产出量提高了9.39%;育种效益提高了10.64%;世代间隔延长了0.90%,开放核心群体系优于闭锁核心群体系。这充分说明,在鲁西牛核心群育种方案中,开放核心群育种体系优于闭锁核心群育种体系。 相似文献
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Takashi HASEGAWA Manabu KAWATA Mitsuharu OTA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(12):1625-1631
By using ultrasound biomicroscopy (UBM), the cross-sectional structures of the entire
iridocorneal angle (ICA) which are unable to assess with gonioscopic examination were
evaluated objectively and quantitatively in live healthy and glaucomatous dogs. The ICAs
of normotensive eyes in healthy dogs with normal open angle (NOR), a predisposition to
primary closed angle glaucoma (PCAG) (PREDIS) and suffering from unilateral PCAG (UNI), as
well as the ICAs of hypertensive eyes with acute and chronic PCAG (ACG and CRG), were
assessed. The opening of the ciliary cleft in PREDIS was smaller than that in NOR. In UNI,
the opening and area of the ciliary cleft were significantly decreased compared with those
of NOR and PREDIS. ACG had widespread structural abnormalities including marked decrease
in the ciliary cleft and scleral venous plexus, and a thinner sclera than those in
normotensive eyes, whereas the ICA collapsed in CRG with the thinnest sclera. Medical
therapy-responsive glaucomatous cases had wider ciliary cleft and scleral venous plexus
than unresponsive ones. These findings suggest that the ciliary cleft and scleral venous
plexus of the ICA are key structures contributing to not only the pathophysiology of
canine glaucoma but also the responsiveness to medical therapy in glaucomatous eyes, and
cross-sectional entire structures of the ICA should be evaluated quantitatively with UBM
when diagnosing and managing canine glaucoma. 相似文献
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Objective The canine iridocorneal angle contains an operculum, which is similar to that in nonhuman primates and consists of a peripheral extension of the inner cornea that overlies the anterior‐most portion of the corneoscleral trabecular meshwork. This region contains cells, the Schwalbe line’s (SL) cells, that have been found to have secretory and epithelial characteristics. This region of the iridocorneal angle represents the nonfiltering portion and becomes altered early during spontaneous glaucoma in the Beagle. The present study describes the SL cell for the first time in the dog and changes associated with canine primary open angle glaucoma. Procedures The iridocorneal angles from 18 Beagles with inherited glaucoma (3 months–8 years old) and 17 normal, age‐matched Beagles were placed in 10% buffered formalin for light microscopic evaluation, or 2.5% glutaraldehyde for ultrastructural evaluation. Using at least three fields from each region of the iridocorneal angle (opercular, corneoscleral, and uveal) at ×1000 magnification, trabecular cell nuclei were counted. Results The operculum in the canine iridocorneal angle consisted of the peripheral extension of the corneal endothelium and underlying anterior‐most corneoscleral meshwork, having no direct contact with the angular aqueous plexus. The SL cells associated with operculum‐retained epithelial morphology (polyhedral in shape with rER, Golgi apparatus, and secretory vesicles) in both normal, pre‐and early glaucomatous dogs. In animals with moderate and advanced stages the SL cells often became less epithelial and secretory in appearance. The number of SL cells in normal dogs declined by approximately one‐third by the end of their first year with gradual loss thereafter. In the glaucoma group the decline was more substantial and continuous through the first three years. Conclusions The SL cell is morphologically a distinct cell type within the canine iridocorneal angle that is specifically associated with the nonfiltering portion of the corneoscleral trabecular meshwork. Changes in the SL cells of the glaucomatous dog occurred with regard to age and progression of the disease. 相似文献
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Purpose To date, our knowledge of the canine trabecular meshwork (TM) with regard to contractility is incomplete. It is important to understand the potential contractile capability within the TM and possible changes associated with spontaneous hypertensive glaucoma. To that end we have examined the presence of actin, including smooth muscle (SM) actin, in the normal and glaucomatous canine iridocorneal angle (ICA) morphologically and immunohistochemically. Methods Sections from the ICAs of 12 Beagles with inherited glaucoma (3 months to 6 years old) and age‐matched normal Beagles were treated with target retrieval, protein and power blocked and sequentially incubated with the primary antibody (rat anticanine SM actin) and the secondary antibody (rabbit antirat immunoglobulin), followed by peroxidase labeled streptavidin and incubation with substrate‐chromogen solution (AEC). Smooth muscle fibers that lined an artery within canine heart tissue were used as positive controls. Separate specimens were prepared for ultrastructual observation. Results Ultrastructurally, cells within the inner, posterior region of the corneoscleral TM and outer, posterior region of the uveal TM contained many microfilaments, 6 nm in diameter (i.e. actin). Immunohistochemistry demonstrated that cells within these regions possessed SM actin, having been greatest posteriorly, but extended anteriorly to a lesser extent. In the preglaucomatous affected dog the localization pattern for SM actin was identical to that seen in the normal dogs. With the progression of the disease the pattern disappeared. Conclusions The interior presence of myofibroblastic cells within the canine ICA suggests that these cells and the smooth muscle cells of the ciliary body along the same plane of orientation function to facilitate the removal of aqueous humor and are likely to be influenced by vascular mediators. The contractile apparatus for the ICA in the dog with inherited glaucoma appeared identical to that of the normal dog prior to expression of the disease, but weakened as the disease progressed. 相似文献
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以吉林省通榆县付老文泡和二百方子湿地为对象,对比研究了封闭性和开放性湿地土壤全磷含量的季节变化特征及其与土壤理化性状的关系。结果表明:付老文泡湿地0~100cm深度的土壤全磷含量范围为48.77~377.19mg/kg,二百方子为45.65~574.17mg/kg,随季节变化呈现先减后增的变化趋势,即12月-次年5月土壤全磷含量较高,5-7月逐渐下降,在7和8月出现最低值,9和10月含量较低且变化不大,10-12月含量又逐渐回升。土壤全磷主要分布在0~40cm土层,深层含量较低且差异不大;2类湿地土壤全磷含量均未达到生态毒性效应水平。植物地上部分全磷量与土壤全磷之间存在显著的正相关关系,付老文泡湿地植被生长受氮磷协同限制,而二百方子湿地植被主要受氮含量限制。2类湿地土壤全磷与土壤全氮、有机质及粘粒显著正相关,与土壤C/N无显著相关关系;但pH值仅与二百方子湿地土壤全磷显著负相关,与付老文泡湿地土壤全磷无显著相关关系。 相似文献
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《African Zoology》2013,48(2):202-217
The population dynamics of the estuarine isopod, Exosphaeroma hylocoetes, was investigated monthly from February 2006 to August 2007 in three temporarily open/closed Eastern Cape estuaries, the East and West Kleinemonde and Kasouga Estuaries. Mean isopod abundances and biomasses ranged between 0 and 4791 ind/m2 and 0 and 9.65 mg/dwt/m2 in the West Kleinemonde Estuary and between 0 and 108 ind/m2 and 0 and 0.318 mg/dwt/m2 in the nearby East Kleinemonde Estuary. In the Kasouga Estuary, the values ranged between 0 and 3650 ind/m2 and 0 and 5.105 mg/dwt/m2. Temporal changes in the abundance and biomass of E. hylocoetes within the three systems was primarily linked to mouth phase, with populations crashing when the mouth was open and to a lesser extent, seasonality. In all three estuaries maximum abundance and biomass was recorded in the middle reaches, which could be ascribed to the presence of submerged macrophytes. E. hylocoetes demonstrates strong sexual dimorphism, with males being significantly larger than females (P < 0.05). Sex ratios were skewed in favour of females in all three estuaries. Females were encountered carrying young from an overall length of 2.5 mm throughout the year 相似文献
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Tara M. Stonex Tatiane Terumi Negrao Watanabe James B. Robertson Hans D. Westermeyer 《Veterinary ophthalmology》2023,26(3):225-230
Purpose
To evaluate the correlation between equine pectinate ligament descemetization and ocular disease.Methods
The pathology database of the North Carolina State University Veterinary Medical Center was searched from 2010–2021 for all equine globes. Disease status was then assigned as affected by glaucoma, uveitis, or “other” based upon clinical records. The iridocorneal angles (ICA) of each globe were evaluated for the presence of pectinate ligament descemetization, the length of descemetization, as well as for the degree of angle collapse and the extent of cellular infiltrate or proteinaceous debris. One slide from each eye was evaluated by two separate, blinded investigators (HW & TS).Results
A total of 66 eyes from 61 horses were identified, with a total of 124 sections of ICA of sufficient quality to review. 16 horses were affected by uveitis, 8 by glaucoma, 7 by both glaucoma and uveitis, and 30 horses by other ocular disease, most commonly ocular surface disease or neoplasia, which served as controls. Pectinate ligament descemetization was most prevalent in the control group compared to the glaucoma and uveitis groups. Pectinate ligament descemetization length was positively correlated with age, with an increase of 13.5 μm per year of age (p = .016). Infiltrate scores and angle closure scores were higher in both the glaucoma and uveitis group compared to the control group (p < .001).Conclusions
Equine pectinate ligament descemetization appears to be correlated with increased age and should not be used as a histologic marker for the presence of glaucoma. 相似文献13.
Pectinate ligament dysplasia (PLD) in dogs is a congenital ocular abnormality affecting the iridocorneal angle, the presence of which may be associated with adult-onset primary glaucoma. This paper describes the objectives, methods and results of a survey of PLD in Flat Coated Retrievers in the UK, including the technique used for gonioscopic assessment of the degree of PLD. In a random sample of 389 Flat Coated Retrievers, 34.7% were found to have a degree of PLD. In a 'target' sample of 48 Flat Coated Retrievers (close relatives of dogs from the random sample with high degrees of PLD, or dogs presented with primary glaucoma), 83.3% were found to have a degree of PLD. The percentage of animals with a degree of PLD was only 6.0% in a 'control' sample of 100 dogs from other breeds. The relationship between PLD and canine glaucoma is discussed. 相似文献
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Pectinate ligament dysplasia (PLD) in dogs is a congenital ocular abnormality affecting the iridocorneal angle, the presence of which may be associated with adult-onset primary glaucoma. This study demonstrates a significant association between PLD and glaucoma in Flat Coated Retrievers, and also a higher prevalence of PLD in Flat Coated Retrievers compared with other breeds. It is shown that the association between PLD and glaucoma was robust and not due to a small increase in PLD with age. There was also a significant association between PLD in offspring and parents and, using the offspring–parents regression, the heritability of PLD was estimated as approximately 0.7. As glaucoma is significantly related to PLD, glaucoma may also be heritable. Thus, glaucoma can be controlled by gonioscopic examination and elimination of animals with a high degree of PLD from a breeding program. Breeding from only those animals with a moderate or low PLD value or score should limit the expected prevalence of glaucoma in the resulting population to < 0.2%. The preceding study describes in detail the PLD survey, gonioscopic technique and some initial results obtained prior to this epidemiological investigation. 相似文献
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