Efficacy of Sarafloxacin in Broilers after Experimental Infection with Escherichia coli

Infections of chickens with Escherichia coli serotypeO78 can be treated with the antibiotic sarafloxacin. Three experiments were conducted on the administration of this drug to chickens that had been experimentally infected with E. coli. The birds were monitored for 10 days after infection for their average daily gain (ADG) and feed conversion ratio (FCR), and the post-mortem pathology was assessed. In the first experiment, sarafloxacin (20 mg/L, equivalent to 5 mg/kg live weight per day), given in the drinking water for 3 days after infection, led to a reduction in the mortality from 75% to 27%, but the ADG of the treated birds was still less than that of the uninfected controls. In the second experiment, when the sarafloxacin was administered at the same dose in the water but over only 2 h, there was also a considerable reduction in mortality, and the ADG and the FCR also improved significantly. In the third experiment, the dose dependence of the drug was tested. The birds were given 5 and 10 mg/kg per day sarafloxacin in each group, starting within 2 h after infection. This rapid administration of the drug completely prevented mortality, while the ADG and FCR were similar to those of the uninfected controls.     

Isometamidium in pigs: disposition kinetics, tissue residues and adverse reactions

The disposition and adverse effects of the anti-trypanosomal drug isometamidium in pigs were evaluated. Following intramuscular administration of the drug at doses of 0.5, 15 and 35 mg kg-1, the drug was rapidly absorbed within 15 to 30 minutes to reach maximum plasma concentrations of 12 to 477 (n = 6), 302 to 655 (n = 4) and 1620 (n = 1) ng ml-1, respectively. No drug was detectable in plasma (less than 5 ng ml-1) 24 hours after drug administration at the three doses used. The half-lives of disappearance of the drug from plasma during the terminal phase were 7.12 h for the pigs given a dose of 15 mg kg-1, and 7.20 h for the pig which received a dose of 35 mg kg-1. At all the intramuscular injection sites, high drug concentrations were found six weeks after administration. The most dramatic adverse reactions observed were: one death after intramuscular administration at a dose of 35 mg kg-1 to two animals, and two deaths after intravenous administration at a dose of 2 mg kg-1 to two animals. For all these cases, the immediate cause of death was acute cardiovascular collapse. Biochemical analyses and gross and histological examinations showed that the animals that tolerated the high doses of 15 and 35 mg kg-1 given intramuscularly had extensive and severe tissue damage at the injection sites. Significant increases in plasma gamma-glutamyltransferase and alanine aminotransferase following drug administration suggested a degree of hepatobiliary damage.     

Level of heavy metals in the liver of sheep in experimental poisoning with copper oxide from industrial emissions

The life span and cumulation of heavy metals in the liver of 12 ewes of the Improved Wallachian breed were investigated in relation to feeding pollutants from a copper works. The total intake of copper, iron, zinc, arsenic, cadmium and lead was 466.8; 1253.93; 111.67; 34.75; 0.091; 2.13 mg per experimental animal/day, respectively. The average life span of ewes in the experimental group was 77 days. The difference between the first and the last animal which died from copper intoxication was 18 days. The concentration of copper in the liver of sheep who died from intoxication by this metal (2138.28 +/- 1090.96 mg. kg-1 in dry matter) was significantly higher (p less than 0.01) if compared with the control ewes (212.9 +/- 58.33 mg. .kg-1 in dry matter). In the course of observations no direct dependence between the concentration of copper in the liver and the life span of experimental animals was confirmed. The content of iron and zinc in the liver of experimental animals was within the reference range; the difference in zinc was statistically significant when compared with the control group (p less than 0.01). The intake of pollutants from the copper works increased significantly the concentration of arsenic and lead in the liver of experimental animals (p less than 0.01) if compared with the control group. The amount of cadmium in the liver of experimental ewes was 0.304 +/- 0.22 mg. .kg-1 and in the control ewes 0.285 +/- 0.10 mg.kg-1 in dry matter; no significant difference was determined at the same time.     

Haemonchus contortus resistance to ivermectin and netobimin in Brazilian sheep.

Suffolk, Texel, Hampshire Down and Ile de France sheep from the municipalities of Porto Amazonas, Piraquara and Araucaria in the State of Paraná, and Bagé in the State of Rio Grande do Sul were brought to Sobral, State of Ceará, to be used in a cross-breeding project. On arrival they had clinical signs of nematode parasitosis, and one Suffolk female died. The animals were treated orally with ivermectin (0.2 mg kg-1) and fifteen days later with netobimin (20.0 mg kg-1). Neither drug reduced the egg counts (measured in eggs per gram, EPG) significantly, and this suggested that the nematodes in the sheep were resistant to the anthelmintics used. Haemonchus contortus was the species involved. The egg counts were reduced after oral treatment with trichlorfon (100.0 mg kg-1). Haemonchus contortus larvae obtained from these animals before trichlorfon treatment and passaged through two nematode-free sheep were used in a further experiment. Twenty 6- to 9-month-old nematode-free lambs were infected with the H. contortus larvae (10,000 per animal) and after the infection was confirmed, were randomly divided into four groups of five animals. Group I was orally treated with ivermectin at 0.2 mg kg-1, Group II with oral netobimin at 20.0 mg kg-1, Group III with oral trichlorfon at 100.0 mg kg-1 and Group IV was a non-treated control. Egg counts and faecal cultures were taken before dosing on the day of treatment and seven days later when all animals were necropsied and the nematodes were collected from the abomasa and counted.(ABSTRACT TRUNCATED AT 250 WORDS)     

Levels of mercury in the organs and tissues of sheep after administration of very low doses]

Experiments were carried out with six sheep of the Slovak Merino breed, weighing 22-28 kg. For 28 days the animals were given 4 mg inorganic Hg2+ in the feed per animal/day. In contrast with the controls, the following residual mercury concentrations were determined in the single organs and tissues: liver 1.580 +/- 0.326 mg.kg-1 Hg2+ and 0.091 +/- 0.014 mg.kg-1 Hg2+, respectively muscle 0.064 +/- 0.009 mg.kg-1 Hg2+, and 0.026 +/- 0.006 mg.kg-1 Hg2+, resp. spleen 0.142 +/- 0.025 mg.kg-1 Hg2+, and 0.022 +/- 0.010 mg.kg-1 Hg2+, resp. kidney 9.054 +/- 3.794 mg.kg-1 Hg2+, and 0.128 +/- 0.080 mg.kg-1 Hg2+, resp. (Fig. 1), abomasal contents 0.309 +/- 0.069 mg.kg-1 Hg2+, and 0.021 +/- 0.007 mg.kg-1 Hg2+, resp. large intestinal contents 0.267 +/- 0.058 mg.kg-1 Hg2+, and 0.043 +/- 0.004 mg.kg-1 Hg2+, resp. The results suggest that the long-term ingestion of mercury with feed leads to a pronounced Hg accumulation in the kidneys and liver. Much lower levels were observed in the muscle tissue and spleen. The affinity of mercury to the kidney and liver is probably related to the preferential bonds of organic mercury compounds to the SH- groups of the plasma proteins in these organs. It is the bond to the sulphydryl groups of proteins that results in the inhibition of proteosynthesis and thus enzyme and antibody inhibition. Under the conditions of continuing chemical contamination of the environment, a permanent supply of low concentrations of heavy metals the animal organism is observed.(ABSTRACT TRUNCATED AT 250 WORDS)     

Effect of feeding supplemental copper on performance, fatty acid profile and on cholesterol contents and oxidative stability of meat of rabbits.

One hundred and four rabbits, five weeks old at the beginning of the experiment, were divided into four groups according to a feed additive treatment. Rabbits of the 1st, 2nd, 3rd and 4th group were fed a basal granulated feed (control), basal feed supplemented with CuSO4.5H2O at 50 mg Cu.kg-1, basal feed supplemented with 150 mg Cu.kg-1, and the latter feed supplemented with 100 mg.kg-1 vitamin E, respectively. The duration of the experiment was 42 days. Addition of Cu at 150 mg.kg-1 increased weight gain non-significantly by 9.1%. This effect was the most pronounced in the first two weeks of fattening. The lowest mortality was observed in rabbits fed the highest amount of additives (7.7% vs. 19.2% in the control). Rabbits were slaughtered at the age of 11 weeks. Neither treatment influenced proportions of saturated, monounsaturated and polyunsaturated fatty acids in lipids extracted from the loin and hindleg muscles. In rabbits fed the highest amount of copper and vitamin E, the cholesterol concentration was significantly decreased by 13.6% and 17.9% in the loin and hindleg meat, respectively. Effects of Cu added at 50 mg.kg-1 were marginal. Copper had no effect on the oxidative stability of meat, measured as thiobarbituric acid-reactive substances in meat stored at 4 degrees C for 0, 3 and 8 days. Vitamin E added in excess of nutritional requirement improved the oxidative stability of meat. In copper-fed rabbits, Cu accumulated in the liver, but not in muscles. Feeding of the basal feed for 7 days to rabbits previously fed copper sulphate decreased the hepatic Cu concentration by 14.0 to 24.4%.     

Efficacy of parvaquone and long-acting oxytetracycline in Theileria annulata infection

Therapeutic and prophylactic efficacies of parvaquone and long-acting oxytetracycline were tested against Theileria annulata infection, induced by injecting a suspension of infected ground tick tissues (GUTS) into groups of 4 or 5 calves. This infection killed two of four control calves, while all the animals given a single intramuscular dose of 20 mg kg-1 parvaquone or long-acting oxytetracycline on the day of infection underwent mild reactions and recovered. Two separate doses of parvaquone of 10 mg kg-1 administered on the first and second days of fever protected four out of five calves. All the recovered animals from both treated and control groups resisted a homologous challenge with GUTS on Day 45 post-infection which killed three out of four susceptible unimmunized control calves.     

Efficacy of a substituted methyl benzimidazole carbamate against developing and adult helminth parasites

The efficacy of a substituted methyl benzimidazole carbamate, methyl 5(6)-[4-N-(2-pyridyl)] piperazino carbamoyl benzimidazole-2-carbamate, was assessed against larval and adult forms of Ancylostoma ceylanicum (hookworm), Nippostrongylus brasiliensis (trichostrongylid), Hymenolepis nana (tapeworm) and Brugia malayi (filariid) in experimentally-infected animals. The compound was found to have high efficacy against the developing stages (L3, L4, L5) of A. ceylanicum in hamsters at a single dose of 12.5 mg kg-1, against larvae of N. brasiliensis at 17.5 mg kg-1 and against cysticercoids of Hymenolepis nana at 100 mg kg-1 daily for 3 days given per os (p.o.) or intraperitoneally (i.p.). All the stages of B. malayi in Mastomys were killed when the compound was given i.p. at a dose of 6.25 mg kg-1 for 5 consecutive days. A dose of 6.25 mg kg-1 eliminated all adult A. ceylanicum from infected hamsters, 100 mg kg-1 resulted in complete removal of Syphacia obvelata adults from 63.6% of infected mice, 25 mg kg-1 X 5 dose eliminated 100% of adult B. malayi from infected Mastomys and a single 50 mg kg-1 dose expelled all H. nana adults from infected rats.     

Anesthesia in dogs and cats with althesin

Tests of the effect of the new steroid anaesthetic alfadion in the drug Althesin are described. Experiments were carried out in three experimental groups. Intramuscular administration of Althesin to dogs at doses 5 to 15 mg. kg-1 does not induce required anaesthesia. After intravenous administration of Althesin to dogs at a dose of 2 mg. kg-1 after diazepam pre-medication at a dose of 0.25 mg.kg-1 i. m., anaesthesia started without excitations immediately after completed application. Anaesthesia lasted on the average 10 minutes and at the time of recovery excitations and side effects occurred. After intravenous administration of Althesin at a dose of 6 mg. kg-1 with diazepam pre-medication 0.25 mg. kg-1 i.m., the course of narcosis in cats was similar to that in dogs, only its duration was on the average 29 minutes.     

Disposition kinetics of danofloxacin and ciprofloxacin in broiler chickens.

Disposition kinetics of danofloxacin and ciprofloxacin were studied in broiler chickens following intravenous, intramuscular and oral administration in a single dose of 5 and 10 mg/kg-1 body weight respectively. In addition, tissue distribution and residual pattern of both drugs were determined. The maximum serum concentration (Cmax) after intramuscular and oral administration were 1.03 and 0.55 mu/ml for danofloxacin and 2.92 and 1.24 mu/ml for ciprofloxacin attained at 0.8 and 2.43 and 0.55 and 1.27 hours for danofloxacin and ciprofloxacin respectively. The volume of distribution and systemic bioavailability were higher for danofloxacin (Vdss 2.21 L/kg and F% 96.56 and 81.4%) as compared with ciprofloxacin (Vdss 1.41 L/kg and F% 75.5 and 29.4%). Data relating to intravenous injection for both drugs were analyzed using a two compartment open model curve fit. Danofloxacin and ciprofloxacin were not detected in the serum of broilers at the 5th and 3rd day respectively following the drugs withdrawal while were detected in liver, kidneys, spleen and lungs. Danofloxacin completely disappeared from all tissues at the 13th day after stopping of the drug medication but ciprofloxacin disappeared after 5 days only.     

Systemic availability of o,p'-DDD in normal dogs, fasted and fed, and in dogs with hyperadrenocorticism

The systemic availability of o,p'-DDD was studied in 12 normal dogs and seven dogs with pituitary-dependent hyperadrenocorticism (PDH). The drug was given by mouth at 50 mg kg-1 and plasma o,p'-DDD concentrations were determined by gas-liquid chromatography. First, six normal dogs were given the drug three times at intervals of one week in a Latin square pattern. Systemic drug availability was found to be very poor from intact tablets in fasted dogs, better with pure drug dissolved in maize oil given by stomach tube, and best with ground tablets mixed in oil poured on dog food. Then six normal dogs and five with PDH were given one dose of o,p'-DDD as intact tablets in dog food. Systemic drug availability was good in the normal animals and, for unknown reasons, better in dogs with PDH. The half-time of elimination was shorter in dogs with PDH than in normal ones. There was evidence of a gradual rise in plasma o,p'-DDD concentrations in seven dogs with PDH treated with 25 mg kg-1 every 12 hours for 14 or 20 days. The interaction between food and o,p'-DDD probably contributes to the variation in clinical response of dogs treated with the drug. The efficiency of therapy with o,p'-DDD should be improved considerably by administering the drug with food.     

Effects of Mebendazole and Cambendazole on enterohelminths in pigs]

Mebendazole, administered at a dose of 30 mg active substance per 1 kg of feed, was found to have 100% effectiveness on Ascaris suum and Cambendazole, administered at a dose of 1.5 g per 1 kg of liver weight, showed the same effectiveness in the control of Ascaris suum and Oesophagostomum dentatum. The effectiveness of both drugs on Trichocephalus suis and Strongyloides ransomi was low. Mebendazole and Cambendazole can be recommended for mass dehelminthization of pigs in affected stocks. Helminthoovoscopical examination of sows and fattened pigs showed an 88.6% extensity of invasion in sows, and a 28.3% and 33.9% extensity in three- and five-month-old pigs, respectively. Coccidiosis was found in 51.4% of the sows and Balantidium coli had an occurrence rate of 80.7 to 98.2%.     

Therapeutic and prophylactic efficacy of imidocarb dipropionate on experimental Babesia ovis infection of lambs

The objective of this study was to evaluate the therapeutic and prophylactic efficacy of imidocarb dipropionate (IMDP) against babesiosis and to determine specific antibodies against Babesia ovis in experimentally infected lambs. Thirty-six 6-month-old splenectomized lambs were used. The lambs were randomly divided into six groups with six animals each, and were intravenously inoculated with 50 mL B. ovis-infected erythrocytes as follows: group I (therapy group) was treated with IMDP (1.2 mg/kg body weight) starting on the day of onset of clinical signs of babesiosis after the inoculation; group II (untreated control animals) was not treated with any therapeutic treatment after the inoculation; groups III, IV, V and VI (prophylaxis groups) were administered IMDP (2.4 mg/kg body weight) 1, 2, 3 and 4 weeks before the inoculation, respectively. The animals were housed in a tick-proof room with water and food ad libitum up to the 30th day post-inoculation (PI). The lambs were monitored from the first day PI by recording the manifestation of clinical disease, rectal temperature, and the degree of parasitaemia. All the lambs became infected with B. ovis, except five animals from group III, which were treated 1 week prior to experimental infection. Other animals showed signs of acute clinical babesiosis. The animals treated with IMDP (group I) were able to clear the parasite from the blood circulation after 48 h post-treatment. The recrudescence of B. ovis was observed in two lambs 7 days after treatment, and they were treated with the second similar dose of the drug. Six lambs (1, 1, 2 and 2 lambs in group III, IV, V and VI, respectively) from the prophylaxis groups died within 7-17 days after showing high parasitaemia and clinical symptoms of the disease. Regardless of the clinical symptoms, 83.30% and 66.66% of the lambs which were administered IMDP 1-2 and 3-4 weeks before, were determined to be protected against the virulent field strain of B. ovis.     

Plasma and histological changes in furazolidone treated chickens

Chickens were treated orally with furazolidone at dose rates of 40 or 80 mg kg-1 for five days or fed the drug at concentrations of 0.04 per cent w/w or 0.08 per cent w/w for 10 days. Plasma constituents, liver, heart, kidney, cerebrum, cerebellum and testes were examined. Furazolidone at the recommended therapeutic dose rate of 0.04 per cent w/w for 10 days or at a dose rate of 40 mg kg-1 for five days produced no significant changes in morphology or plasma parameters measured. At a dose rate of 0.08 per cent w/w for 10 days or 80 mg kg-1 for five days, furazolidone produced significant decreases in the concentrations of total protein and cholesterol and tended to increase the activity of cholinesterase. In the plasma, concentrations of potassium increased and concentrations of sodium decreased. Histologically, congestion and some degenerative changes were observed in the tissues examined.     

Pharmacokinetics of potassium bromide in adult horses

OBJECTIVE: To determine the pharmacokinetics of potassium bromide (KBr) in horses after a single and multiple oral doses. ANIMALS: Twelve adult Standardbred and Thoroughbred mares. PROCEDURE: Horses were randomly assigned into two treatment groups. In Part 1 of the study, horses were given a single oral dose of 120 mg/kg KBr. Part 2 of the study evaluated a loading dose of 120 mg/kg KBr daily by stomach tube for 5 days, followed by 40 mg/kg daily in feed for 7 days. Serum concentrations of bromide were determined by colorimetric spectrophotometry following drug administration to permit determination of concentration versus time curves from which pharmacokinetic parameters could be calculated. Treated horses were monitored twice daily by clinical examination. Serum concentrations of sodium, potassium and chloride ions and partial pressures of venous blood gases were determined. RESULTS: Maximum mean serum bromide concentration following a single dose of KBr (120 mg/kg) was 284 +/- 15 microg/mL and the mean elimination half-life was 75 +/- 14 h. Repeated administration of a loading dose of KBr (120 mg/kg once daily for 5 days) gave a maximum serum bromide concentration of 1098 +/- 105 microg/mL. The administration of lower, maintenance doses of KBr (40 mg/kg once daily) was associated with decreased serum bromide concentrations, which plateaued at approximately 700 microg/mL. Administration of KBr was associated with significant but transient changes in serum potassium and sodium concentrations, and possible changes in base excess and plasma bicarbonate concentrations. High serum concentrations of bromide were associated with an apparent increase in serum chloride concentrations, when measured on an ion specific electrode. CONCLUSIONS AND CLINICAL RELEVANCE: A loading dose of 120 mg/kg daily over 5 days and maintenance doses of approximately 90-100 mg/kg of KBr administered once daily are predicted to result in serum bromide concentrations consistent with therapeutic efficacy for the management of seizures in other species. The clinical efficacy of this agent as an anticonvulsant medication and/or calmative in horses warrants further investigation.     

连花柴芩可溶性粉的毒理学研究

研究连花柴芩可溶性粉的急性毒性与长期毒性,评价其临床用药的安全性,为临床用药提供科学依据。急性毒性实验以预实验的最高剂量组25.0 g·kg~(-1),设为试验高剂量组进行实验。长期毒性实验分为四个组,即试验高、中、低剂量组(剂量分别为25.0,12.5,6.25 g·kg~(-1))与空白对照组,每组大鼠20只,雌雄各半,每周给药7 d,连续给药30 d,观察一般症状、体重、摄食量、血液学、血液生化学及脏器系数,并作组织病理学检查。结果显示,急性毒性实验中小鼠灌胃给药后14 d内未见小鼠死亡,亦未见明显毒性反应,口服连花柴芩可溶性粉LD_(50)25.0 g·kg~(-1)。按照毒理学急性毒性剂量分级表,口服LD_(50)5000 mg·kg~(-1)时为实际无毒。长期毒性试验中连花柴芩可溶性粉对SD大鼠灌胃给药,所有检测指标未出现因给予受试物而引起相关的毒性变化,且未发现连花柴芩可溶性粉的目标脏器。连花柴芩可溶性粉口服给药具有较好的安全性。     

Successful therapy of balantidiosis of pigs with acetarsol and oxytetracycline

Severe clinical balabtidiosis in 2-month old piglets was treated with acetarsol alone and acetorsol in combination with oxytetracycline. Three groups of 15 animals each were used in this trial. Group 1 received acetarsol at a dose rate of 20 mg/kg body weight orally once daily for 4 days. Group 2 received acetarsol as group 1 plus oxytetracycline at a dose rate of 15 mg/kg body weight orally in feed concentrate twice daily for 4 days. Group 3 animals served as non-treated controls. As judged by clinical and parasitological examinations, acetarsol was found to be 85.7% effective and the combination of acetarsol and oxytetracycline 100% effective. No sign of intolerance or toxicity was observed.     

Efficacy evaluations of the use of oral tilmicosin in pneumonic calves

The therapeutic effect of oral tilmicosin was compared with enrofloxacin, and the efficacy of three doses of the drug was examined in two fully randomized blinded field trials. Pneumonic milk-fed calves between 3 days and 2.5 months of age were allocated into two groups in trial 1 (50 animals) and into three groups in trial 2 (69 calves). In the first trial, the animals were treated with 25 mg/kg/day tilmicosin or 2.5 mg/kg/day enrofloxacin in milk for 5 days. In the second trial, the calves received either 25 mg/kg/day tilmicosin for 5 days or 3 days, or else 12.5 mg/kg tilmicosin for 5 days. All calves were clinically examined for 10 days. In the first trial, oral tilmicosin at a dose of 25 mg/kg/day for 5 days proved to be effective for the treatment of endemic pasteurellosis of milk-fed calves. The efficacy was the same as that of enrofloxacin. All three doses in the second trial were effective and were statistically equivalent to the original dose tested.     

The anthelmintic efficacy of netobimin against naturally acquired gastrointestinal nematodes in sheep

The broad-spectrum anthelmintic efficacy of netobimin (SCH 32481, Schering Corporation) was evaluated using 30 cross-bred spring lambs with naturally acquired infections of gastrointestinal nematodes. Three groups of 10 animals each were allotted into either control (given a tap water drench as a placebo) or 7.5 and 20 mg kg-1 dosage groups (given the netobimin as an oral drench). Seven to fourteen days post-treatment, animals were necropsied and nematodes recovered by standard techniques. Examination of fecal samples taken on dates of necropsy showed median egg production was reduced in treated animals (61.98% with 7.5 mg kg-1 and 100% with 20 mg kg-1). The compound was highly effective in removal of adult nematodes representing a number of genera and species of trichostrongyloids at the 7.5 and 20 mg kg-1 dose levels (shown, respectively, below). These included Ostertagia spp., with O. circumcincta, O. trifurcata, O. ostertagi and Teladorsagia davtiani (96.20%; 100%), Trichostrongylus spp., with T. axei, T. vitrinus and T. colubriformis (100%; 98.72%), Nematodirus spp., with N. spathiger, N. filicollis and N. battus (100% both levels) and Haemonchus contortus (100% both levels). High efficacies against other species of nematodes (at both dose levels) were not statistically significant (Cooperia spp., Chabertia ovina and Oesophagostomum venulosum). At 20 mg kg-1, netobimin significantly reduced populations of early and late fourth stage larvae of Ostertagia spp. by 100%. The overall efficacy (all life stages included) was 90.16% at 7.5 mg kg-1 and 98.77% at 20 mg kg-1 dose levels. No adverse reactions or signs of toxicosis were observed.     

动物园肉、杂食动物消化道寄生虫感染情况调查及驱虫试验

应用饱和盐水漂浮法和麦克马斯特法对郑州动物园猞猁等11种48头（只）肉、杂食动物消化道寄生虫感染情况进行了调查,随后对寄生虫阳性动物进行治疗。结果表明：48头（只）肉、杂食动物消化道寄生虫感染率高达52％,但除1只雄性猞猁感染强度较大外,绝大多数阳性动物感染强度较小。用甲苯咪唑按5mg/kg体重的剂量随食物经口一次投服，用药5 d后检查粪样，虫卵完全转阴。试验结果证明该药对猞猁消化道线虫具有良好的驱除效果。