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1.
Overwintering of horse cyathostomes as inhibited third stage larvae (L3) and the effect of repeated oxfendazole (OFZ) treatment on strongyle infections were studied in an experiment with two groups of three Shetland ponies. Both groups were grazed together from May 28 to November 11, 1986 and subsequently housed. Treatments with 10 mg OFZ kg-1 were given on May 26, July 1 and July 28 and again one week before each group was necropsied in December and April, respectively. Worm populations of both groups were dominated by inhibited early L3. The proportion of fourth stage larvae (L4) was significantly higher in April than in December. The faecal egg counts showed that the OFZ treatment in May was more effective than those in July. This resulted in high pasture larval counts from the end of August onwards. The final treatments revealed a low efficacy against L3 and L4 but not against adult worms. 相似文献
2.
The activity of fenbendazole and febantel was evaluated in 12 pony foals whichwere inoculated with 2600 P. equorum eggs. The foals were not maintained free of parasites before or after inoculation. Once patent for P. equorum, the foals were randomly assigned to groups and treated one time intraorally with either 0.5 ml corn syrup/kg of body weight (controls; n=4), 10 mg fenbendazole/kg (n=4), or 6 mg febantel/kg (n=4). Foals were necropsied and examined for parasites 10 days after treatment. Fenbendazole and febantel were highly effective against adult and immature P. equorum. Grosslesions attributed to P. equorum were evident in all foals. P. equorum were not foundin any of the fenbendazole-or febantel-treated foals. The mean number of adult and immature P. equorum found in the controls was 66.8 (15–166) and 65.0 (21–147), respectively. Strongyle infections were insufficient for efficacy evaluations to be done. Neither anthelmintic was effective against mature Drasehia megastoma, mature Habronema majus, immature H. muscae, Gasterophilus intestinalis or late 4th-stage larvae of Strongylus vulgaris. Adverse side effects due to treatment were not observed. 相似文献
3.
The efficacy of two recently introduced benzimidazole anthelmintics, albendazole and fenbendazole, was determined for six-day, 10-day and adult stages of resistant strains of Haemonchus contortus and Trichostrongylus colubriformis. Albendazole, at 3.8 mg/kg reduced H contortus worm counts by 92.4, 70.8 and 67.1 per cent while fenbendazole, at 5.0 mg/kg, reduced worm burdens by 51.7, 95.5 and 93.4 per cent against six-, 10- and 25-day-old parasites respectively. For T colubriformis, the corresponding reductions with albendazole were 97.7, 95.8 and 64.9 per cent and for fenbendazole 29.0, 66.3 and 33.4 per cent. Compared with susceptible strains of H contortus and T colubriformis, for which therapeutic doses of benzimidazole anthelmintics are generally highly active against all stages of development, the present results show that these drugs do not have a uniform level of activity against all developmental stages of resistant strains. 相似文献
4.
The study was undertaken to evaluate adverse effects of larvicidal treatment in horses naturally infected with cyathostomins. Out of 24 ponies kept on pasture, four animals were housed in September and anthelmintically cured to serve as worm-free controls (group C-0). The others were housed in December. Eight animals each were treated 8 weeks later with 5 x 7.5mg/kg fenbendazole (FBZ) or 1 x 0.4 mg/kg moxidectin (MOX). Four animals remained untreated (group C-i). Two, 4, 6 and 14 days after the end of treatment two animals of each of the treated groups were necropsied together with group C-0 and C-i animals. Infected animals before treatment showed weight loss, eosinophilia, increased plasma protein and globulin contents. Treatment was followed by weight gain and temporal plasma protein and globulin increase. Proportions of CD4+ and CD8+ T lymphocytes in the peripheral blood did not differ between the groups before treatment but dropped significantly temporally after FBZ treatment. Group C-0 was worm-free at necropsy. Group C-i animals contained variable numbers of luminal and tissue cyathostomins. Histological sections showed larval stages in the lamina propria und submucosa surrounded by macrophages. Either treatment was effective against luminal parasites and reduced the number of larvae in the bowel wall beginning 4-6 days after FBZ and 6-14 days after MOX treatment. Histologically, as a first reaction after FBZ application T lymphocytes accumulated around morphologically intact L4 in the submucosa. Subsequently T lymphocytes associated with eosinophils infiltrated the submucosa. Parasites became enclosed by granulomas with eosinophils adhering to and invading the larvae which started to disintegrate on day 4. Later on, particularly on day 14 inflammation extended into the mucosa and was frequently associated with ulcerations. Third stage larvae in general and L4 in the lamina propria, however, seemed not to be affected until day 14 and even then, parasites did usually not generate extensive inflammation. After MOX treatment severe morphologically detectable alterations of tissue larvae could not be observed earlier than day 14. Different from FBZ treatment, larvae disintegrated and were obviously resorbed without causing severe inflammation in the gut wall. In conclusion treatment with either drug was efficacious against tissue larvae of cyathostomins but there may be different clinical consequences: in contrast to MOX effects, killing of larvae due to FBZ was associated with severe tissue damage, which clinically may correspond to reactions caused by synchronous mass emergence of fourth stage larvae, i.e., may mimic larval cyathostominosis. 相似文献
6.
In total, 14 male donkeys aged between 2 and 10 years were obtained in July and November 1986, and January and April 1987 from a communal area in the Zimbabwean highveld, with the aim of studying their parasite populations. Thirteen species of small strongyles were found, numbers ranging between 3900 and 222 767 worms. The small strongyle populations consisted predominantly of adult worms in all donkeys. These results suggest that rather stable, small strongyle populations, mainly consisting of long-living adult worms, occur in Zimbabwean donkeys. The species found were, in order of abundance, Cyathostomum montgomeryi, Cylicostephanus minutus, Cylicocyclus nassatus, Cylicocylus auriculatus, Cyathostomum tetracanthum, Cylicostephanus bidentatus, Triodontophorus nipponicus, Cyathostomum coronatum, Cylicocyclus adersi, Cyathostomum alveatum, Triodontophorus serratus, Cylicocyclus elongatus and Cylicodontophorus bicoronatus. 相似文献
7.
In an investigation period over 8 months the natural course of infection was studied by means of coproscopic and serological methods in 27 mares and 29 foals. The examination of the stool showed in mares, before the beginning of the grazing season, an infection rate of 100% with small and a rate of 7.4% with large strongyles (Str. vulgaris). Serologically the ELISA showed in foals only a distinct increase of antibody activity with the somatic antigen. The mares retained the high IgG-values of activity, which were already found at the beginning of the investigations. Even though the agglutination test can be applied for control of the effectiveness of therapy in a horse population, individual diagnostic possibilities remain limited. This is due to the reduced sensitivity and specificity of the IgG(T)-concentration under natural conditions of infection. The double-antibody-sandwich-ELISA technique has shown to be basically feasible as a test for antigens from small strongyles. Somatic antigen could most sensitively be demonstrated by antibodies to ES-antigen, ES-antigen, however, by antibodies against somatic antigens. 相似文献
8.
In five trials it was found that the daily administration of fenbendazole in the food for 1 or 2 weeks at dosages of 1.25, 2.5 or 5 mg kg-1 live weight was highly effective against Muellerius capillaris infection in goats. Treated animals had significantly lower numbers of larvae in the faeces for up to 223 days after treatment. There was no obvious difference between the different dose levels. Daily treatment for 2 weeks seemed to be slightly more effective than treatment for 1 week. Treatment for 1 week twice with an intervening period of 1 week seemed to be more effective than treatment for 2 weeks continuously. Goats given a single treatment with fenbendazole at 25 mg kg-1 had a significantly lower number of M. capillaris larvae in their faeces on Days 34 and 69 after treatment than the controls, but on Days 126 and 156 after treatment there was no significant difference between these two groups. Albendazole given daily for 2 weeks at a dose of 1.0 mg kg-1 showed a significant effect for up to 153 days after treatment, which was similar to the result of daily treatment with 1.25 mg kg-1 fenbendazole. Goats treated with albendazole twice at 10 mg kg-1 with a 1 week interval showed a significant reduction in the number of Muellerius larvae in the faeces on Day 41 after treatment, but not on Days 97 and 153 after treatment.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
9.
Summary An investigation on the protection afforded to ponies, by quinapyramine suraminate and its constituents used singly, against Trypanosoma evansi infections of low and high intensity was conducted.
It was observed that full protection with the suraminate lasted for 61/2 to 231/2 months depending upon the dose of the drug
and intensity of the test infection employed. Considerable partial protection was evident up to 38 months. Prophylaxis with
suramin and quinapyramine extended up to 1 month and 11/2 months, respectively.
The protection period was observed to be directly related to the dose of the suraminate employed and inversely with the intensity
of the test infection.
Infections breaking through prophylaxis were characterized by sub-microscopic and low-grade parasitaemia which was mostly
detected by the rat-inoculation test only.
Sumario Se ha hecho una investigación sobre la protección conferida por varias dosis de suramina, sales de quinapiramina y MSb en
ponis contra infecciones simples deTrypanosoma evansi y suraminato de quinapiramina contra infecciones repetidas.
La protección completa con suramina, quinapiramina y su prosal y MSb se extendía hasta 1, 11/2, 2 y 3 meses, respectivamente.
La protección con suraminato de quinapiramina variaba de 61/2 a 261/2 meses contra el desafío ‘suave’ y 61/2 a 231/2 meses
contra el desafío ‘fuerte’. La protección parcial, sin embargo, era aparente por periodos de hasta 38 meses.
La profilaxis con suraminato de quinapiramina era directamente proporcional a la dosisintervalo de la droga usada y usualmente
inversamente proporcional a la cantidad del desafío empleado. Las infecciones recurrentes fueron caracterizadas por por una
parasitemia rara ó muy escasa. Algunas vecez las infecciones no eran detectadas por la prueba microscópica. Esta conducta
atípica de las infecciones fue demostrada no ser debida a una disminuida virulencia de le parásito.
Résumé Une étude à été faite sur la protection donnée aux chevaux par des doses variables de suramine, sels de quinapyramine et de
MSb contre une infection unique parTrypanosoma evansi et par le suraminate de quinapyramine contre les infections répétées.
Une protection complète par la suramine, la quinapyramine et son ‘prosalt’ et le MSb durait respectivement jusqu’ à 1, 11/2,
2 et 3 mois. La protection par le suraminate de quinapyramine contre l’épreuve légère variait de 6 mois et demi à 26 mois
et demi et, contre l’épreuve sévère, de 6 mois et demi à 23 mois et demi. Une protection partielle a néanmoins été observée
pendant des périodes allant jusqu’à 38 mois.
La durée de la prophylaxie par le suraminate de quinapyramine était directement proportionnelle à la dose du médicament utilisée,
habituellement inversement proportionnelle à la quantité des organismes utilisés pour l’épreuve. Les infections résultantes
étaient caractérisées par un type de parasitémie rare et faible. Elles n’ont parfois pas du tout été révélées par l’examen
microscopique. Il a été démontré que ce comportement atypique des infections n’était pas d? à une virulence diminuée du parasite.
相似文献
10.
Light Trichinella infections were established in three ponies given 1000, 5000 and 25000 T. spiralis spiralis infective larvae respectively by stomach tube. A predilection site of infection in all ponies was the tongue. Anti-Trichinella antibodies were detected in all ponies by the enzyme-linked immunosorbent assay using a T. spiralis spiralis excretory-secretory antigen. The ponies given 5000 and 25000 infective larvae reacted positively on days 26 and 24 postinfection, respectively, using a criterion of greater than or equal to 5 X mean optical density readings of preinfection sera as positive. The pony given 1000 larvae did not react positively although antibodies were present as indicated by 3 X to 4 X mean optical density readings of preinfection sera. The results of this limited study indicate that the enzyme-linked immunosorbent assay cannot be used to certify horsemeat free of Trichinella since the presence of detectable antibody levels appears to be related to the magnitude of the infection and duration of the infection when the animal is tested. 相似文献
11.
In order to assess the resistance situation against macrocyclic lactones in Parascaris equorum and against tetrahydropyrimidine derivatives in strongyles in Finnish trotter horses, 112 foals on 18 farms, mostly 1 year old, were examined for these parasites with a modified McMaster faecal flotation method. P. equorum positive foals (n=24) were given ivermectin orally at a dose of 200 μg/kg b.w., while strongyle positive but P. equorum negative foals (n=38) received pyrantel embonate orally at a dose of 19 mg/kg. Sixteen P. equorum infected foals, treated with ivermectin, also harboured strongyles. During the anthelmintic treatment visit to the farm, Faecal Egg Count Reduction Test (FECRT) reference (first) samples were collected. Fourteen days later, the second sampling (reduction samples) was done. The FECR was calculated for each foal/parasite combination. The reduction efficacies of ivermectin against P. equorum (mean 52%, calculated from the individual egg count reductions) and pyrantel against strongyles (43%) were strongly indicative of widespread resistance. Also indication of ivermectin resistance among strongyles was seen. The widespread use of anthelmintics for Finnish horses obviously has resulted in resistance, as has happened elsewhere, too. 相似文献
12.
A program of rotational anthelmintic treatments at eight-week intervals had failed to provide satisfactory equine strongyle control at a stable in southern USA. Anthelmintic resistance had rendered benzimidazoles ineffective, and intervals between treatments with other drugs were too great to prevent environmental contamination with ova. Ivermectin treatments at eight week intervals or pyrantel pamoate treatments at four week intervals successfully reduced egg counts for the majority of the summer grazing period. In southern temperate USA, translation of strongyle ova to larvae was most efficient during autumn and winter. Minimal larval translation occurred during summer when meteorological conditions limited pasture infectivity as effectively as anthelmintic treatments. 相似文献
13.
The efficacy of in-feed fenbendazole at a dose rate of 7.5 mg/kg bodyweight for three consecutive days was assessed in five Arabian oryx (Oryx leucoryx), six scimitar-horned oryx (Oryx dammah), 14 slender-horned gazelles (Gazella leptoceros), eight Soay sheep (Ovis aries aries soay), 13 alpine ibex (Capra ibex ibex), six red deer (Cervus elaphus hippelaphus) and 11 Nelson's elk (Cervus elaphus nelsoni) kept in five herds in a zoo. The efficacy was assessed by means of repeated faecal egg count reduction (fecr) tests and in vitro egg hatch assays. Fenbendazole was highly effective against nematodes in five of the seven species, consistently reducing egg shedding by more than 90 per cent. In the egg hatch assays of the five herds, 50 per cent inhibition of hatching (ld50) was observed at a concentration of thiabendazole below 0.1 microg/ml. In the Arabian oryx and alpine ibex the efficacy of fenbendazole was less than 90 per cent, and the ld50 in the egg hatch assays was between 0.1 and 0.2 microg/ml thiabendazole. 相似文献
14.
Fenbendazole (methyl-5-(phenylthio)-2-benzimidazole carbamate) at dose rates of 5 mg/kg and above was 100 per cent effective in eliminating a naturally acquired Dictyocaulus filaria infection in sheep. The drug was 100 per cent effective in eliminating concurrent infections of adult Trichostrongylus axei, Haemonchus contortus, Haemonchus placei, Ostertagia circumcincta, Ostertagia ostertagii, Cooperia oncophora, Cooperia mcmasterii, Nematodirus spathiger, Neumatodirus filcollis, Oesophagostomum venulosum and Chabertia ovina. Fenbendazole was 93 per cent and 97 per cent effective at doses of 5 and 10 mg/kg respectively in removing infection with adult T colubriformis, and post-treatment worm-egg production was completely suppressed in surviving female worms. No adverse side-effects were observed in treated sheep at either of the two dose rates used. 相似文献
15.
Abstract Extract C anine hip dysplasia was first recognized 40 years ago (Schnelle, 1935 Schnelle, G. B. 1935. Some new diseases in dogs. Am. Kennel Gaz., 52: 25–25. Cited by Schnelle, G. B. (1954): Proc. Am. vet. med. Ass., 91st annual meeting, p. 235. [Google Scholar]) and since then it has been accepted as a common pathological condition of the coxofemoral joint. It is a disease that is characterized by an abnormal laxity of the joint which may or may not cause clinical signs of hind-limb lameness. Although it appears to be most prevalent in the larger breeds of dogs (Schnelle, 1954 Schnelle, G. B. 1954. “Congential dysplasia of the hip and its sequelae”. In Proc. Am. vet. med. Ass., 91st annual meeting 253–253. [Google Scholar]; Riser 1963 Riser, W. H. 1963. A new look at developmental subluxation in hip dysplasia. J. small anim. Pract., 4: 421–434. [Crossref] , [Google Scholar]; Larsen and Corley, 1970 Larsen, J. S. and Corley, E. A. 1970. Radiographic evaluations in canine hip dysplasia control programs. J. Am. vet. med. Ass., 159: 989–992. [Google Scholar]), it does occur in smaller breeds and in crossbred animals (Gustaffson et al., 1972 Gustafsson, P. O., Kasstrom, H., Olsson, S. E. and Wenman, B. 1972. Skeletal development and sexual maturity in German Shepherds, Greyhounds and their crossbred offspring. Acta radiol. Suppl., 319: 187–190. [Google Scholar]; Lust et al., 1973 Lust, G., Geary, J. C. and Sheffy, B. 1973. Development of canine hip dysplasia in dogs. Am. J. vet. Res., 34: 87–89. [Google Scholar]). In recent years many of the large breeds of dogs have become more popular in New Zealand and this popularity has seemingly led to an increase, in the incidence of hip dysplasia. Because the condition is thought to be due to a heritable defect, attempts to eradicate it by selection and mating of “phenotypically normal” animals have been commonplace throughout the world. In addition, many methods of treatment or prevention of the disease in the individual animal have been recommended by veterinarians. 相似文献
16.
Faecal samples were collected from 500 cattle and 385 buffaloes belonging to backyard farmers from 24 villages in the province of Bukidnon, Mindanao, the Philippines. Strongyle nematode infections were studied on these samples by faecal egg counts and infective larvae differentiation. The effects of animal species and age on the prevalence and intensity of infections were studied. The overall prevalence of strongyle infection was 53% for cattle and 28% for buffaloes. The prevalence decreased with increasing age in both animal species. Faecal egg counts were significantly lower in buffaloes than in cattle. Adult animals had lower egg counts than calves. This age effect was most pronounced in buffaloes. Six genera of strongyle nematodes were identified from the faecal cultures in both animal species, Mecistocirrus, Haemonchus, Trichostrongylus, Cooperia, Bunostomum and Oesophagostomum. The distribution of larvae did not vary much with age. 相似文献
18.
Three of six ponies, 9 and 10 years of age, were each given in excess of 300 000 infective Trichonema larvae experimentally. Although all six ponies had both natural and experimental infections previously, they were virtually parasite-free during the 18-month period immediately preceding experimental reinfection.Appreciable resistance to Trichonema infections was indicated in these mature ponies by a longer prepatency and significantly smaller worm egg outputs than that which occurred when these animals were given comparable infections at a much younger age. Patent infections only developed in two of the three ponies beginning between 17 and 18 weeks post-reinfection with peak egg counts between 200 and 400 eggs per gram (epg) in one and 100 to 150 epg in the other. Within 10 days of reinfection, an abrupt rise in mean circulating eosinophils and an appreciable mean weight loss, which persisted for 2 years, occured in the reinfected but not the control ponies.The findings, particularly of unthriftiness characterized by persistent loss of weight in the reinfected but not the control ponies, demonstrated the pathogenesis of inhibited Trichonema larvae. 相似文献
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