AN OUTBREAK OF DISEASE IN PIGEONS ASSOCIATED WITH A HERPESVIRUS

An outbreak of disease in young pigeons associated with a herpesvirus is reported. The clinical history, macroscopic and microscopic appearance of lesions and virus isolation are described. Most affected birds showed lesions in the upper alimentary tract epithelium as well as in skin, nasal mucosa and salivary glands. Lesions in liver, spleen and pancreas were uncommon. A herpesvirus capable of producing CPE on tissue culture and lesions on chorioallantoic membrane of developing chicken embryos was isolated and described. Inoculation of experimental pigeons with the virus failed to reproduce the disease.     

疱疹病毒gC基因及其编码蛋白研究进展

疱疹病毒gC基因属晚期基因．其编码的gC糖蛋白位于成熟病毒粒子囊膜表面,作为重要的结构蛋白参与病毒感染过程。同时,gC糖蛋白还构成病毒粒子表面抗原决定簇,是重要的免疫原,可全面诱导宿主的免疫反应。本文就gC基因及其编码蛋白的特点和相关功能等方面进行总结,以期为疱疹病毒gc基因的深入研究提供有用借鉴。     

双特异性单克隆抗体在治疗中的应用

双特异性抗体由于其独特的结构——两个不同抗原,引起研究机构广泛的重视。双特异性单克隆抗体有两个臂,研究者将治疗药物和针对疾病部位的特异目标分别放在两个臂上。治疗药物可以是药品、毒素、酶、DNA和放射性核素等。此外,双特异性单克隆抗体能使免疫效应细胞的细胞毒性作用于致病细胞或者诱导产生全身免疫应答。双特异性单克隆抗体从治疗来看,有很大的发展前景,这是由于:(1)最近重组DNA技术的重大突破;(2)人类基因组图谱工程的完成,提高了疾病的鉴别水平;(3)对人类免疫系统机制有了更好的了解。