SYSTEMIC ASPERGILLOSIS IN A CAT

An 8–year–old male domestic shorthair cat with partial anorexia, occasional cough and behavior change was found to have multiple pulmonary and cerebral lesions. At necropsy a diagnosis of systemic Aspergillosis was made. This report describes the clinical, radiographic and pathologic features of systemic Aspergillosis in a cat.     

URINARY BLADDER MURAL HEMORRHAGE ASSOCIATED WITH SYSTEMIC BLEEDING DISORDERS IN THREE DOGS

The sonographic appearance of three dogs with diffuse bladder wall thickening due to mural hemorrhage is described. Two dogs were diagnosed with immune-mediated thrombocytopenia and the third dog with vitamin K antagonist toxicity. Urinary bladder wall thickening ranged from 5 to 12 mm on initial sonographic examination. In the two surviving dogs, the bladder wall returned to normal thickness. One dog, euthanatized for refractory hematuria, had submucosal hemorrhage in the urinary bladder at necropsy. Urinary wall thickening sonographically resolved at a rate of approximately 1 mm per day. Mural hemorrhage should be considered in patients with concurrent bleeding disorder and urinary bladder wall thickening.     

家畜遗传特性系统保存数学模型及应用研究

为克服现有保种方法不利于品种选育提高，以及实际中带有选育的保种将造成许多遗传特性丢失的弊端，本文提出了家畜遗传特性系统保存数学模型，以期在统一确立保存目标的前提下，将保存目标系统地分配给各个品种，扩大遗传特性保存范围。该模型中目标函数一是遗传特必瓦可能在表现的品种中保存，二是保存特性与选育特性之间遗传正相关尽可能大，负相尽可能小；约速条件一是遗传特性ｊ最多在ｔｊ个品种中保存，二是品种ｉ最多保存ｂｉ     

病绵羊体内分离的拟似绵羊附睾种布氏菌的首次系统鉴定与分类

我们对新疆地方病防治研究所近年来从患附睾炎的公绵羊精液中分离出１５株拟似布氏菌，除按常规检定外，还采用了Ｓ群及Ｒ群噬菌体裂解试验、绵羊附睾种血清的试管凝集反应，并对有的菌株做了ＤＮＡ Ｇ＋Ｃｍｏｌ％含量测定，最后判定：在这十五株菌中有７株为绵羊附睾种布氏菌。     

IMAGING DIAGNOSIS—MAGNETIC RESONANCE IMAGING FINDINGS IN A CAT WITH SYSTEMIC REACTIVE ANGIOENDOTHELIOMATOSIS

A 10‐year‐old, castrated male domestic short‐haired cat was presented with an acute history of seizures, lethargy, anorexia, vomiting, and dyspnea. Magnetic resonance imaging of the brain showed multifocal areas of gray matter T2‐weighted hyperintensity. The lesions did not enhance with intravenous contrast. The cat was diagnosed at necropsy with feline systemic reactive angioendotheliomatosis, a rare vascular proliferative disorder for which a treatment has not yet been identified. This report is the first to describe associated magnetic resonance imaging changes for this disease.     

EFFICIENCY AND SAFETY OF METHIDATHION APPLIED AS A POUR-ON SYSTEMIC INSECTICIDE FOR CONTROL OF CATTLE LICE

Methidathion applied to cattle as a pour-on insecticide for control of lice (predominantly Linognathus vituli, but also Haematopinus eurysternus and Damalinia bovis) caused a reduction in the lice population of approximately 98% to 99% in laboratory trials at the minimum recommended dose of 4 mg/kg and a 98.8% to 100% efficiency was achieved in field trials. In a comparative efficiency trial in the laboratory methidathion at 3.5 to 5 mg/kg reduced the lice population by 98.8% to 99%, fenthion by 98.5% at 4.5 mg/kg and famphur by 99.7% at 16.5 mg/kg. Methidathion was tolerated by calves aged 15 to 20 weeks at dose rates up to 40 mg/kg indicating an approximate 7 fold safety margin, but 1 of 4 calves treated at 50 mg/kg died following treatment. Treatment with fenthion at 50 mg/kg, 7.4 times the average recommended rate, famphur at 75 mg/kg, 3 times the average rate and chlorpyrifos at 85 mg/kg, 5 times average rate, caused reductions in whole blood cholinesterase activity of 52%, 27% and 47% respectively which were similar to the reductions in cholinesterase activity found in calves treated with methidathion at similar levels above the recommended commercial dose rates. It was found that 2 day old calves were more sensitive to treatment with methidathion than calves 9 or 16 days old. A further 11,900 cattle of varying age, breed and sex were treated with methidathion under field conditions at the recommended rate of 4 to 8 mg/kg, and 534 cattle were treated at 24 mg/kg without any signs of toxicity.     

SCINTIGRAPHIC TRACKING OF MESENCHYMAL STEM CELLS AFTER PORTAL,SYSTEMIC INTRAVENOUS AND SPLENIC ADMINISTRATION IN HEALTHY BEAGLE DOGS

Mesenchymal stem cells have been proposed to treat liver disease in the dog. The objective of this study was to compare portal, systemic intravenous and splenic injections for administration of mesenchymal stem cells to target the liver in healthy beagle dogs. Four healthy beagle dogs were included in the study. Each dog received mesenchymal stem cells via all three delivery methods in randomized order, 1 week apart. Ten million fat‐derived allogeneic mesenchymal stem cells labeled with Technetium‐99m (99mTc)‐hexamethyl‐propylene amine oxime(HMPAO) were used for each injection. Right lateral, left lateral, ventral, and dorsal scintigraphic images were obtained with a gamma camera equipped with a low‐energy all‐purpose collimator immediately after injection and 1, 6, and 24 h later. Mesenchymal stem cells distribution was assessed subjectively using all four views. Pulmonary, hepatic, and splenic uptake was quantified from the right lateral view, at each time point. Portal injection resulted in diffuse homogeneous high uptake through the liver, whereas the systemic intravenous injection led to mesenchymal stem cell trapping in the lungs. After splenic injection, mild splenic retention and high homogeneous diffuse hepatic uptake were observed. Systemic injection of mesenchymal stem cells may not be a desirable technique for liver therapy due to pulmonary trapping. Splenic injection represents a good alternative to portal injection. Scintigraphic tracking with 99mTc‐HMPAO is a valuable technique for assessing mesenchymal stem cells distribution and quantification shortly after administration. Data obtained at 24 h should be interpreted cautiously due to suboptimal labeling persistence.     

EVALUATION OF THE POTENTIAL OF SYSTEMIC SLOW RELEASE CHEMICAL TREATMENTS FOR CONTROL OF THE CATTLE TICK (BOOPHILUS MICROPLUS) USING IVERMECTIN

SUMMARY Stall and field trials with cattle infested with various acaricide-resistant strains of cattle tick, have demonstrated the potential of ivermectin as a systemic tickicide. A dosage of 200 μg/kg, administered subcutaneously to animals naturally infested in the field, gave satisfactory tick control for 21 days, after an initial lag period of 2 days immediately following treatment, during which significant numbers of ticks survived. Daily subcutaneous treatments, administered so as to simulate slow release, indicated that a dosage of 15 μg/skg/day should give complete tick control if the chemical could be released continuously from a subcutaneous implant. The potency of ivermectin, assessed by in vitro tests against engorged adults, suggests that the tickicidal activity could be associated with the parent compound per se rather than a metabolite.