Is there a link between bacteriuria and a reversible encephalopathy in dogs and cats?

Bacteriuria has been associated with abnormal neurological status in humans, especially geriatric patients. In this report, we review 11 cases (seven dogs and four cats) that suggest an association between bacteriuria and abnormal neurological status in veterinary medicine. These cases showed diffuse forebrain signs with or without brainstem signs, but primary brain disease was excluded by MRI and cerebrospinal fluid analysis. Bacteriological culture of urine was positive in each animal and neurological deficits improved or resolved with initiation of antibiosis ± fluid therapy and levetiracetam. While further studies are needed to definitively confirm or refute the link between bacteriuria and a reversible encephalopathy, urine bacteriological culture should be considered in veterinary patients presented with acute onset forebrain neuro-anatomical localisation, even in the absence of clinical signs of lower urinary tract inflammation.     

Canine obesity: is there a difference between veterinarian and owner perception?

Objectives : The overall aim of this study was to examine the nature of the relationship between dog‐ownership and canine obesity, explored in two cohorts of overweight/obese or non‐overweight dogs (n=125). This paper concentrates on the owners’ perception of dog weight. Methods : A researcher‐mediated questionnaire was used to collect data from dog owners attending a small veterinary practice. Interviewees (n=121) were asked qualitative and quantitative questions, designed to examine the owners’ views of their relationship with their dogs. Results : Although a high proportion of owners claimed to have discussed the dog's weight with their veterinarian, some discrepancies were apparent between owner perception of animal weight and the veterinarian's evaluation of body condition score. Owner disagreement was significantly greater for the veterinarian‐defined overweight dogs (P=0·005). Owners often provide personal narratives to account for their dog's weight status. Clinical Significance : This study confirms the important role of the vet in providing information about the issue of dog weight but also suggests that providing verbal information is sometimes insufficient. The study also indicates the potential value of qualitative research methods to further understand client perception of complex animal care issues and highlights the need for further in‐depth research.     

Is there a predictable correlation between time of birth, birth and the puerperal period and clinical and hormonal findings in horses?

The investigations were done on 108 mares (78 warm-blooded horses, 25 cold-blooded horses and 5 trotters). To pursue the question in the title, progesterone and estradiol values in jugular vein-blood were examined starting from 30 days before the calculated date of parturition until 30 days after that event. In parallel to that Ca/Mg ratio was measured by means of a semiquantitative test-strip in the milk. Clinical signs of the birth, parturition itself and the post partum period were recorded. In respect to the P4 and E2 values it was that the P4:E2 ratio changed towards parturition in favour to E2 which was interpreted as a sign for the beginning of labour contractions as well as a signal to the ovarian hormonal activity and feed-back regulation. The "predict of the foal-test" by measuring Ca/Mg ratio is helpful only in combination with clinical findings. This test can be used for the decision to induce parturition. Concerning the colour and viscosity of the milk, it was observed to change from grey-aqueous 48 h a.p. through grey-brownish 24 h a.p. to white-yellow and viscous 12 h a.p. The results show that heavy mares more often retain the fetal membranes. They often bear lighter offspring with equally lighter fetal membranes, and the surfaces of the microvilli of the microcotyledonas seem to be smaller. Beside this it is concluded that during pregnancy disturbances in the fetomaternal relations probably exist as a result of a deficiency in placental development that finally results in retention secundinarum.     

Electroacupuncture analgesia in dogs: is there a difference between uni- and bi-lateral stimulation?

OBJECTIVE: To compare the analgesic effect of uni- and bi-lateral electroacupuncture (EA) in response to thermal and mechanical nociceptive stimuli and to investigate the cardiorespiratory, endocrine, and behavioral changes in dogs submitted to EA. STUDY DESIGN: Prospective, randomized cross-over experimental study. ANIMALS: Eight adult, clinically healthy, cross-breed dogs, weighing 13 +/- 4 kg. METHODS: Dogs underwent electrostimulation at false acupoints (T-false); bilateral EA at acupoints, stomach 36, gall bladder 34 and spleen 6 (T-EA/bil); unilateral EA at the same points (T-EA/uni) or were untreated (T-control). All animals received acepromazine (0.05 mg kg(-1)) IV; and heart rate, pulse oximetry, indirect arterial blood pressure, respiratory rate, Pe'CO(2), rectal temperature, and plasma cortisol concentration were measured before, during, and after EA. Analgesia was tested using thoracic and abdominal cutaneous thermal and mechanical stimuli, and an interdigital thermal stimulus. Behavior was classified as calm or restless. Analysis of variance for repeated measures followed by Tukey's test was used for analysis of the data. RESULTS: There were no cardiorespiratory differences among the treatments. The cutaneous pain threshold was higher after EA, compared with false points. The latency period was shorter and analgesia was more intense in T-EA/bil than T-EA/uni, when both were compared with T-false and T-control. Six out of eight animals treated with EA were calm during treatment, and 5/8 and 4/8 of the T-false and T-control animals, respectively, were restless. Latency to interdigital thermal stimulation increased in T-EA/bil compared with the others. There was no difference in plasma cortisol concentrations among the treatments. CONCLUSIONS: Bilateral EA produced a shorter latency period, a greater intensity, and longer duration of analgesia than unilateral stimulation, without stimulating a stress response. CLINICAL RELEVANCE: Bilateral EA produces a better analgesic effect than unilateral EA.     

Is there a relationship between clinical presentation,diagnostic and radiographic findings and outcome in horses with osteoarthritis of the small tarsal joints?

Reasons for performing study: Despite the possibility that sound horses may have radiographic signs consistent with osteoarthritis of the small tarsal joints (OA‐STJ), a diagnosis of ‘bone spavin’ as a cause of lameness is often made based only on radiographic examination. Objectives: To determine whether severity of radiographic change and response to treatment are correlated with the duration and degree of lameness and the response to intra‐articular anaesthesia in horses with OA‐STJ. Methods: A retrospective study of all horses that showed a positive response to intra‐articular anaesthesia of the STJ was performed. Details of history, clinical presentation and diagnostic findings were recorded. Radiographs of affected tarsi were evaluated and scored independently by 2 observers. Follow‐up was via a telephone questionnaire with the owner. Statistical analysis was used to assess the association between the duration and degree of lameness, the response to intra‐articular anaesthesia and radiographic findings. Response to treatment was compared with the findings from the diagnostic work‐up. Results: Ninety‐one horses were included (61 unilateral and 30 bilateral lameness). Fifty‐nine percent of horses had been lame for over 2 months. There was no association between the duration and degree of lameness, or between duration or degree of lameness, intra‐articular anaesthesia and radiographic findings. Response to treatment showed a significant positive association with less severe radiographic changes within the tarsometatarsal (TMT) joint. Follow‐up was available for 48% of cases, with 52% horses returning to the same level of exercise. Conclusions: There is no association between the duration and degree of lameness, the response to intra‐articular anaesthesia and radiographic findings in horses with OA‐STJ. However, horses that improved following treatment tended to have less marked TMT joint pathology. Potential relevance: Response to intra‐articular anaesthesia should remain the gold standard for diagnosis of OA‐STJ. Predicting which cases are likely to improve following treatment remains difficult.     

Rectally Guided or Hysteroscopic Insemination: Is there a difference?

The increasing use of frozen semen, the high cost of a dose of semen from some stallions, and the inability of some stallions to cope with their demand has triggered an incentive to reduce the number of spermatozoa from the traditional 500 PMS to significantly lower numbers per insemination. Two techniques have been described to deposit low sperm numbers in the uterus. Although experimental results have been reported for the rectally guided deep horn insemination (RGDHI) and endoscopic deep horn insemination (EDHI) techniques, little information is available in clinical settings with respect to the results of either method. This article reports on a comparison of the rectally guided insemination and hysteroscopic techniques in a clinical setting over three breeding seasons. Semen frozen in 0.5-mL straws and concentrations of 40 to 200 million per straw was available from 88 stallions whose fertility with frozen semen ranged between 0% and 100%. Of the 2544 inseminations performed 1279 were done by RGDHI, which resulted in a 43% seasonal pregnancy rate compared with 45% for the 1265 inseminations using the EDHI technique. There was an overall, but nonsignificant, advantage for the EDHI technique over the RGDHI and semen usage was slightly lower when using the EDHI procedure. There was no difference in fertility among breeding seasons for either technique. However, fertility of some stallions was increased by increasing the sperm numbers in the inseminates. From these data and results from others, it is evident that lower sperm numbers deposited by rectally guiding a flexible pipette to the tip of the horn or by using an endoscope to deliver the semen will result in acceptable pregnancy rates with frozen semen in commercial settings.     

Compromised neutrophil function and bovine E. coli mastitis: Is C5a the missing link?

During early lactation, dairy cow are prone to developing severe mastitis in responses to intramammary Escherichia coli infections. These severe inflammatory responses have been correlated with reduced neutrophil function during the periparturient period. However, the causative mechanism of neutrophil dysfunction has not been elucidated. Studies in murine sepsis models have shown that during sepsis neutrophils are functionally paralysed due to the presence of high concentrations of complement factor 5a (C5a). In this review, we hypothesize that C5a as a critical early mediator in the development of severe E. coli mastitis. Furthermore, preliminary data suggest that crosstalk between C5a and TLR4 signalling in neutrophils may provide a positive feedback mechanism that may be involved in the pathogenesis of a severe mastitis response. Finally, we focus on the therapeutic potential of disrupting the C5a signalling pathway as an important strategy for treatment of severe E. coli mastitis in dairy cattle.