共查询到20条相似文献,搜索用时 15 毫秒
1.
Knowles TP Fitzpatrick AW Meehan S Mott HR Vendruscolo M Dobson CM Welland ME 《Science (New York, N.Y.)》2007,318(5858):1900-1903
Protein molecules have the ability to form a rich variety of natural and artificial structures and materials. We show that amyloid fibrils, ordered supramolecular nanostructures that are self-assembled from a wide range of polypeptide molecules, have rigidities varying over four orders of magnitude, and constitute a class of high-performance biomaterials. We elucidate the molecular origin of fibril material properties and show that the major contribution to their rigidity stems from a generic interbackbone hydrogen-bonding network that is modulated by variable side-chain interactions. 相似文献
2.
Toward self-organization and complex matter 总被引:1,自引:0,他引:1
Lehn JM 《Science (New York, N.Y.)》2002,295(5564):2400-2403
Beyond molecular chemistry based on the covalent bond, supramolecular chemistry aims at developing highly complex chemical systems from components interacting through noncovalent intermolecular forces. Over the past quarter century, supramolecular chemistry has grown into a major field and has fueled numerous developments at the interfaces with biology and physics. Some of the conceptual advances and future challenges are profiled here. 相似文献
3.
de Jong JJ Lucas LN Kellogg RM van Esch JH Feringa BL 《Science (New York, N.Y.)》2004,304(5668):278-281
In nature, key molecular processes such as communication, replication, and enzyme catalysis all rely on a delicate balance between molecular and supramolecular chirality. Here we report the design, synthesis, and operation of a reversible, photoresponsive, self-assembling molecular system in which molecular and supramolecular chirality communicate. It shows exceptional stereoselectivity upon aggregation of the molecules during gel formation with the solvent. This chirality is locked by photochemical switching, a process that is subsequently used to induce an inverted chiral supramolecular assembly as revealed by circular dichroism spectroscopy. The optical switching between different chiral aggregated states and the interplay of molecular and supramolecular chirality offer attractive new prospects for the development of molecular memory systems and smart functional materials. 相似文献
4.
Schnur JM Ratna BR Selinger JV Singh A Jyothi G Easwaran KR 《Science (New York, N.Y.)》1994,264(5161):945-947
Molecular self-assembly is of key importance for the rational design of advanced materials. To investigate the causal relation between molecular structure and the consequent self-assembled microstructure, self-assembled tubules of diacetylenic lipids were studied. Circular-dichroism studies give experimental evidence that the formation of tubules is driven by chiral molecular packing, in agreement with recent theories of tubules. On the basis of these results, a molecular mechanism for the formation of tubules is proposed. 相似文献
5.
Allosteric regulation of organometallic catalysts could allow for greater control over reactions. We report an allosteric supramolecular structure in which a monometallic catalytic site has been buried in the middle layer of a triple-layer complex. Small molecules and elemental anions can open and close this complex and reversibly expose and conceal the catalytic center. The ring-opening polymerization of ε-caprolactone can be turned on by the in situ opening of the triple-layer complex and then completely turned off by reforming it through the abstraction of Cl(-), the allosteric effector agent, without appreciable loss of catalytic activity. This process can regulate the molecular weights of the resulting polymers. 相似文献
6.
A biosynthetic approach was developed to control and probe cooperativity in multiunit biomotor assemblies by linking molecular motors to artificial protein scaffolds. This approach provides precise control over spatial and elastic coupling between motors. Cooperative interactions between monomeric kinesin-1 motors attached to protein scaffolds enhance hydrolysis activity and microtubule gliding velocity. However, these interactions are not influenced by changes in the elastic properties of the scaffold, distinguishing multimotor transport from that powered by unorganized monomeric motors. These results highlight the role of supramolecular architecture in determining mechanisms of collective transport. 相似文献
7.
由超分子化学重构的中医药基本理论可通过一系列方法和手段进行研究,但需借助优质的数学方法与技术从大量研究数据中挖掘其潜在的关联性、规律性等信息,进一步直观、清晰地阐明中医药超分子化学理论。诸多数据挖掘技术中,贝叶斯网络最为符合推理过程,是当前在不确定知识表达和推理领域中最有效的理论模型之一,尤其适合于中医药超分子复杂体系的研究。本文阐述了贝叶斯网络的发展历程及基本理论,对其在中医药研究中的现状作综述,探讨贝叶斯网络与中医药超分子化学相辅相成的关系,二者有机结合、联合应用可为中医药理论体系研究提供定性、定量的表征方法和手段,为中医药现代化提供强大臂助。 相似文献
8.
Deep UV photochemistry of chemisorbed monolayers: patterned coplanar molecular assemblies 总被引:3,自引:0,他引:3
C S Dulcey J H Georger V Krauthamer D A Stenger T L Fare J M Calvert 《Science (New York, N.Y.)》1991,252(5005):551-554
Deep ultraviolet (UV) irradiation is shown to modify organosilane self-assembled monolayer (SAM) films by a photocleavage mechanism, which renders the surface amenable to further SAM modification. Patterned UV exposure creates alternating regions of intact SAM film and hydrophilic, reactive sites. The exposed regions can undergo a second chemisorption reaction to produce an assembly of SAMs in the same molecular plane with similar substrate attachment chemistry. The UV-patterned films are used as a template for selective buildup of fluorophores, metals, and biological cells. 相似文献
9.
以2-甲基-5-羧基吡嗪为配体合成了1个三维超分子配合物Cu(2-mpac)Cl(H2O).H2O(1)(2-mpac:2-甲基-5-羧基吡嗪),并利用元素分析、IR、X-射线单晶衍射及热重分析等手段对配合物(1)进行了结构表征.结果表明:配合物(1)属于三斜晶系,P-1空间群,P-1,a=3.8306(6),b=11.395 7(18),c=11.5596(18),α=111.321(2)°,β=96.282(2)°,γ=98.667(2)°,V=457.25(12)°3,Z=2,S=1.019,,最终残差因子(I>2σ(I))R1=0.0375,wR2=0.0945,对于全部数据R1=0.0423,wR2=0.0991. 相似文献
10.
Kerfeld CA Sawaya MR Tanaka S Nguyen CV Phillips M Beeby M Yeates TO 《Science (New York, N.Y.)》2005,309(5736):936-938
Bacterial microcompartments are primitive organelles composed entirely of protein subunits. Genomic sequence databases reveal the widespread occurrence of microcompartments across diverse microbes. The prototypical bacterial microcompartment is the carboxysome, a protein shell for sequestering carbon fixation reactions. We report three-dimensional crystal structures of multiple carboxysome shell proteins, revealing a hexameric unit as the basic microcompartment building block and showing how these hexamers assemble to form flat facets of the polyhedral shell. The structures suggest how molecular transport across the shell may be controlled and how structural variations might govern the assembly and architecture of these subcellular compartments. 相似文献
11.
In a reaction proceeding within a nanoscopic volume, supramolecular clusters were transformed to polymer objects while retaining their shape and size. Spatial isolation of the cross-linkable blocks of oligobutadiene that were involved in this stitching reaction was achieved by self-assembly of the molecules that made up the clusters. Thermal activation of cross-linking yielded macromolecules (molecular weight of 70,000) with a narrow size distribution that was similar to that of the supramolecular clusters. The macromolecules obtained have an anisotropic shape (2 nanometers by 8 nanometers), as determined by electron microscopy and small-angle x-ray scattering, and form materials that exhibit a liquid crystalline state. 相似文献
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13.
本文总结了一类新型大环化合物--半瓜环的发展历程,包括半瓜环的合成及结构特点;半瓜环与金属离子、阴离子及小分子主客体作用;半瓜环在超分子催化中的应用及底物结构对其催化性能的影响;新型半瓜环,例如环己基半瓜环和竹节半瓜环的合成及其超分子化学性质;作为一种新型的大环化合物,半瓜环的研究目前处于起步阶段,在超分子化学的基础研究及相关的应用研究方面有着广阔的前景. 相似文献
14.
Cossaro A Mazzarello R Rousseau R Casalis L Verdini A Kohlmeyer A Floreano L Scandolo S Morgante A Klein ML Scoles G 《Science (New York, N.Y.)》2008,321(5891):943-946
The structure of self-assembled monolayers (SAMs) of long-chain alkyl sulfides on gold(111) has been resolved by density functional theory-based molecular dynamics simulations and grazing incidence x-ray diffraction for hexanethiol and methylthiol. The analysis of molecular dynamics trajectories and the relative energies of possible SAM structures suggest a competition between SAM ordering, driven by the lateral van der Waals interaction between alkyl chains, and disordering of interfacial Au atoms, driven by the sulfur-gold interaction. We found that the sulfur atoms of the molecules bind at two distinct surface sites, and that the first gold surface layer contains gold atom vacancies (which are partially redistributed over different sites) as well as gold adatoms that are laterally bound to two sulfur atoms. 相似文献
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16.
Kraack H Ocko BM Pershan PS Sloutskin E Deutsch M 《Science (New York, N.Y.)》2002,298(5597):1404-1407
The structure of organic monolayers on liquid surfaces depends sensitively on the details of the molecular interactions. The structure of a stearic acid film on a mercury surface was measured as a function of coverage with angstrom resolution. Unlike monolayers on water, the molecules were found here to undergo a transition from surface-parallel to surface-normal orientation with increasing coverage. At high coverage, two condensed hexatic phases of standing-up molecules were found. At low coverage, a two-dimensional (2D) gas phase and condensed single- and double-layered phases of flat-lying molecular dimers were revealed, exhibiting a 1D longitudinal positional order. This system should provide a broader tunability range for nanostructure construction than solid-supported self-assembled monolayers. 相似文献
17.
Crystal structure of the eukaryotic 60S ribosomal subunit in complex with initiation factor 6 总被引:1,自引:0,他引:1
Klinge S Voigts-Hoffmann F Leibundgut M Arpagaus S Ban N 《Science (New York, N.Y.)》2011,334(6058):941-948
Protein synthesis in all organisms is catalyzed by ribosomes. In comparison to their prokaryotic counterparts, eukaryotic ribosomes are considerably larger and are subject to more complex regulation. The large ribosomal subunit (60S) catalyzes peptide bond formation and contains the nascent polypeptide exit tunnel. We present the structure of the 60S ribosomal subunit from Tetrahymena thermophila in complex with eukaryotic initiation factor 6 (eIF6), cocrystallized with the antibiotic cycloheximide (a eukaryotic-specific inhibitor of protein synthesis), at a resolution of 3.5 angstroms. The structure illustrates the complex functional architecture of the eukaryotic 60S subunit, which comprises an intricate network of interactions between eukaryotic-specific ribosomal protein features and RNA expansion segments. It reveals the roles of eukaryotic ribosomal protein elements in the stabilization of the active site and the extent of eukaryotic-specific differences in other functional regions of the subunit. Furthermore, it elucidates the molecular basis of the interaction with eIF6 and provides a structural framework for further studies of ribosome-associated diseases and the role of the 60S subunit in the initiation of protein synthesis. 相似文献
18.
Bayer M Hawrylak P Hinzer K Fafard S Korkusinski M Wasilewski ZR Stern O Forchel A 《Science (New York, N.Y.)》2001,291(5503):451-453
We demonstrate coupling and entangling of quantum states in a pair of vertically aligned, self-assembled quantum dots by studying the emission of an interacting electron-hole pair (exciton) in a single dot molecule as a function of the separation between the dots. An interaction-induced energy splitting of the exciton is observed that exceeds 30 millielectron volts for a dot layer separation of 4 nanometers. The results are interpreted by mapping the tunneling of a particle in a double dot to the problem of a single spin. The electron-hole complex is shown to be equivalent to entangled states of two interacting spins. 相似文献
19.
The charge transport mechanism of a wire can be revealed by how its electrical resistance varies with length. We have measured the resistance and current-voltage characteristics of conjugated molecular wires ranging in length from 1 to 7 nanometers, connected between metal electrodes. We observe the theoretically predicted change in direct-current transport from tunneling to hopping as a function of systematically controlled wire length. We also demonstrate that site-specific disruption of conjugation in the wires greatly increases resistance in the hopping regime but has only a small effect in the tunneling regime. These nanoscale transport measurements elucidate the role of molecular length and bond architecture on molecular conductivity and open opportunities for greater understanding of electrical transport in conjugated polymer films. 相似文献
20.
The combination of their electronic properties and dimensions makes carbon nanotubes ideal building blocks for molecular electronics. However, the advancement of carbon nanotube-based electronics requires assembly strategies that allow their precise localization and interconnection. Using a scheme based on recognition between molecular building blocks, we report the realization of a self-assembled carbon nanotube field-effect transistor operating at room temperature. A DNA scaffold molecule provides the address for precise localization of a semiconducting single-wall carbon nanotube as well as the template for the extended metallic wires contacting it. 相似文献