皮康圣对犬猫螨病的离体灭螨试验与临床疗效观察

本试验通过皮康圣对犬猫螨病的离体灭螨试验及临床猫螨病的疗效观察,其结果表明,皮康圣离体灭螨效果显著优于双甲脒（Ｐ〈０．０１）,与进口伊维茵素没有明显差异（Ｐ〉０．０５）;临床犬猫螨病的疗效明显优于双甲脒（Ｐ〈０．０１）,与进口伊维菌素没有明显的差异（Ｐ〉０．０５）。     

皮康圣对犬猫螨病的离体灭螨试验与临床疗效观察

本试验通过皮康圣对犬猫螨病的离体灭螨试验及临床犬猫病的疗效观察,其结果表明：皮康圣离体灭螨效果显优于双甲脒（P＜0．01）,与进口伊维菌素没有明显差异（P＞0．05）;对临床犬猫病的疗效明显优于双甲脒（P＜0．01）,与进口伊维菌素没有明显差异（P＞0．05）。     

螨虫一针净注射液及癣螨净887溶液对犬螨病的疗效观察

犬螨病是由犬疥螨 ( Sarcoptes scabiei canis)或犬耳痒螨 ( Otodectescanis)寄生所致 ,其中以犬疥螨危害最大 ,多发于冬季 ,常发于皮肤卫生条件很差的犬。螨病主要由于健康犬与病犬直接接触或通过被螨及其卵污染的犬舍、用具等间接接触引起感染。也通过宠物爱好者或兽医人员的衣服和手等传播病原。1 997年 1月至 2 0 0 0年 3月 ,我在长春、吉林等地采用螨虫一针净注射液与癣螨净溶液配合应用取得了理想疗效。现将诊治 1 2 1 3只病犬的情况报告如下。1　诊断要点1 .1　症状　幼犬症状严重 ,先发生于头部 (鼻梁、眼眶、耳廓的基底部 ) ,有时…     

除癣螨乳剂治疗动物螨病

1　发病情况　临床诊疗中 ,中小动物皮肤病的发病率较高 ,其中由饲养管理不善导致螨的寄生而引起的皮肤病最多见。主要包括疥螨病、耳疥螨病、痒螨病、耳痒螨病、足螨病、蠕形螨病等 ,其中蠕形螨病最为难治 ,且易复发。尤其是蠕形螨病与其他螨虫或真菌混合感染 ,更难治疗。螨的     

癣螨净888注射液对犬螨虫真菌性皮肤病疗效观察

目的寻找有效防治犬蠕形螨和真菌混合感染性皮肤病药物。方法选取癣螨净888注射液进行稳定性、安全性和597条病犬临床药效试验,并与传统药物伊维菌素等进行疗效比较。结果4℃避光条件下3年内药效不变,犬按0.1~0.2 mL/kg皮下注射,未见不良反应。临床药效试验表明,888注射液对病犬的治愈率为67.18%,其杀螨抑菌总有效力为93.5%,明显高于伊维菌素组和中药组。结论癣螨净888注射液为防治犬螨虫真菌性皮肤病提供了有效药剂。     

癣螨净888注射液对犬螨虫真菌性皮肤病疗效观察

目的为了有效防治犬蠕形螨和真菌混合感染性皮肤病,研制了癣螨净888注射液。方法通过稳定性、安全性和597条病犬临床药效试验,并与传统药物伊维菌素等进行疗效比较。结果4℃避光条件下三年内药效不变,犬按0.1￣0.2ml/kg皮下注射,未见不良反应。临床药效试验表明,888注射液对病犬的治愈率为67.18%,其杀螨抑菌总有效力为93.5%,明显高于伊维菌素组和中药组。结论癣螨净888注射液为防治犬螨虫真菌性皮肤病提供了有效药剂。     

毛皮动物癣病、螨病、湿疹的鉴别诊断和治疗

本文对毛皮动物的癣病、螨病、湿疹的鉴别和治疗进行探讨。     

兔螨病的诊断与治疗

兔螨病通常是由兔疥螨和兔痒螨寄生于兔的表皮内或体表所引起以皮肤损伤、搔痒、消瘦、中耳炎、石灰脚为主的一种慢性接触性寄生虫病.笔者对四川省桂花镇某养殖场的一起兔螨病进行了诊断与治疗.根据流行病学、临床症状、病理变化,结合实验室诊断,确诊为疥螨和痒螨混合感染,部分病例因抓伤引起溶血性链球菌病造成死亡.采用伊维菌素、灭虫丁、双甲脒、敌百虫等杀虫药结合抗菌消炎进行比较治疗,结果表明,伊维菌素结合抗菌消炎对兔螨病的治愈率达到100%.     

中药对螨病的治疗作用及其机理研究进展

中药用于治疗螨病具有安全、高效、低毒等特点,从中药筛选杀螨成分,并进行结构改造及临床验证,已成为研制新型杀螨剂的重要途径.论文综述了中药对螨病的治疗作用及作用机理研究,旨在为进一步开发利用提供借鉴和参考.     

绵羊痒螨病的免疫学研究进展

羊痒螨成虫的盐水和吐温萃取物对已经发展到活跃期的痒螨病绵羊有显著的保护效应,通过PCR扩增获得了羊痒螨的cDNA编码免疫原Pso01,试验证实绵羊痒螨保护性抗原的成分复杂。在该病诊断方面,应用改进的ELISA法诊断自然感染的羊痒螨病,其敏感性为93．7％,免疫组织化学研究表明,在感染后4d受损伤的皮肤中CD4^＋和CD45RA^＋细胞的数量显著增加,并且γδT细胞和树突状细胞的CD1b^＋显著增加持续了8d。随着绵羊瘁螨cRNA表达文库的建立,为应用现代分子生物学技术开发抗绵羊瘁螨病的疫苗积累了有价值的资料,从而为应用免疫学方法防控绵羊瘁螨病展示了光明的前景。     

中药犬螨灵对犬蠕形螨的疗效试验

为筛选具有显著治疗犬蠕形螨的中药制剂,试验将中药小茴香、蛇床子、羊蹄根采用水煮醇沉及蒸馏等提取方法制备成中药制剂犬螨灵,并观察其对犬蠕形螨的疗效。将犬螨灵设为高、中、低3个浓度,其生药含量分别为2.0、1.0和0.5 g/mL,采用点滴法进行体外抑杀蠕形螨试验,在此基础上对12只接种蠕形螨的试验犬进行治疗试验,为验证治疗效果,对临床上已确诊的45只患有蠕形螨的病犬分3组进行临床治疗试验。结果显示,中药犬螨灵3种剂量均有较强的体外抑杀螨虫作用,高剂量组作用后4 h即可完全抑杀蠕形螨,1%伊维菌素对照组则为作用后8 h;高剂量组在治疗3周后,患处有大量新毛生长,红疹结节和皮屑消失,患处皮肤已痊愈,1%伊维菌素治疗组患犬皮肤好转,仅有少量新毛生长,不能达到痊愈标准;高、中剂量组皮肤刮取物螨虫数量平均比例及停药1个月后复发率均为0,1%伊维菌素治疗组皮肤刮取物螨虫数量平均比例及停药1月后的复发率分别为10.63%和9.17%。高剂量中药犬螨灵与1%伊维菌素两种药物联合治疗组,对临床上患病犬进行3周治疗,其虫卵平均转阴率、治愈率与平均治愈天数分别为100.00%、93.33%和19.56 d,其效果均优于中药犬螨灵与1%伊维菌素单独治疗组。结果表明,高剂量自制中药制剂犬螨灵对犬蠕形螨体外抑杀作用、接种蠕形螨试验犬与临床自然感染病例均有显著的治疗效果,优于1%伊维菌素对照组,犬螨灵作为中药杀螨虫制剂具有较好的市场开发前景。     

Efficacy of Chinese Herbal Medicine Canine Acariasis Spirit on Demodex canis

In order to screen the Chinese herbal medicine for the treatment of Demodex canis, canine acariasis spirit was prepared by Foeniculum vulgare, Fructus cnidii and Bauhinia by water alcohol precipitation and distillation extraction methods. To observe the effect on Demodex canis, canine acariasis spirit was set to high, medium and low concentrations, the content of crude drug were 2.0, 1.0 and 0.5 g/mL, respectively. The experiment of killing Demodex canis was carried out by drop method. On this basis, 12 dogs inoculated with Demodex canis were treated. In order to verify the therapeutic effect, 45 clinically diagnosed dogs with Demodex canis were divided into three groups. The results showed that 3 doses of the traditional Chinese medicine canine acariasis spirit all had strong inhibition effect to kill mites, the high dose group could completely kill Demodex canis only 4 h after treatment, the action of 1% ivermectin control group was 8 h after treatment; 3 weeks later, a large number of new hair grew, rash and skin nodules disappeared, the skin lesion had healed in the affected area of high dose group, in 1% ivermectin treatment group, the dog skin improved, only a small amount of new hair grew, it couldn't cure standard; In the high and middle dose group, the average number of the ratio of skin scraping mites and the recurrence rate after drug withdrawal was 0 in one month later; The average number of mites proportion and recurrence rates of skin scrapings in 1% ivermectin treatment group were 10.63% and 9.17% in one month later; After 3 weeks of treatment, the total average eggs negative rate, cure rate and average cure days were 100.00%, 93.33% and 19.56 d in high dose traditional Chinese medicine canine acariasis spirit and 1% ivermectin combined treatment group, the results were better than the traditional Chinese medicine canine acariasis spirit and 1% ivermectin alone treatment group. The results showed that the effect of the high dose group self-made Chinese medicine canine acariasis spirit on killing Demodex canis in vitro, inoculation of Demodex canis and clinical therapeutic effect of natural infection cases were significantly better than 1% ivermectin control group, canine acariasis spirit as a traditional Chinese medicine preparation would have a good market development prospects.     

天然植物药物防治家畜螨虫病的研究及其应用现状

螨虫病是引起家畜生产性能下降,影响消化吸收,甚至造成动物死亡,同时也威胁人类健康的疾病之一,而家畜螨病主要用化学药物防控,这类药物对生态环境具有不良影响,因此,寻找低毒、高效的天然植物杀螨药物受到人们的关注。作者对植物杀螨药物的研究现状及其存在问题进行了综述。     

五种外用中药制剂对兔螨病的疗效比较

分别采用药物与离体螨虫成虫直接接触法和药物外用于螨病患部,比较了花椒制剂、苦参水煎剂、苦楝皮水煎剂、明雄散、擦疥散5种外用中药制剂的杀螨作用和对兔螨病的疗效。通过5种中药制剂杀螨作用和治疗效果观察,结果表明花椒制剂杀螨效果最好,治愈螨病所需时间最短。     

金毛犬耳痒螨病引发耳血肿的诊断和治疗

犬耳痒螨病是由犬耳痒螨（Otodecees cymotis）寄生于耳道内引起的皮肤寄生虫病。犬耳血肿是在外力作用下致使犬耳部血管破裂、出血,血液集聚在耳软骨与耳廓内侧皮肤之间形成的肿胀。耳痒螨病是引发耳血肿的重要病因,一旦发病需要及时治疗,严重者采用手术疗法。对一例犬耳痒螨病引发耳血肿进行了诊治,特将诊治过程和相关分析做具体介绍,以供临床参考。     

Clinical Therapeutic Effect of Praziquantel Injection on Buffalo Schistosomiasis

To observe the clinical therapeutic effect of 30% praziquantel injection on buffalo schistosomiasis, the sick buffalos naturally infected with Schistosoma japonicum were selected by miracidium hatching method. In experimental clinical trials, sick buffalos were randomly divided into five groups, high-dose (20 mg/kg), middle-dose (10 mg/kg) and low-dose (5 mg/kg) praziquantel injection groups, praziquantel tablet group (30 mg/kg) and positive control group. After the treatment of 30 d, the negative conversion rate of miracidium were 100.0%, 100.0%, 77.8% and 85.7%, respectively, in praziquantel injection groups with the high, middle and low dose and oral medication group. In expanded clinical trials, the sick buffalos were randomly divided into two groups, praziquantel injection group (10 mg/kg, i.m.) and praziquantel tablet group (30 mg/kg). The results showed that, the negative conversion rate of miracidium were all 100% in the former 52 patients and the latter 6 patients after 30 d. The research confirmed that praziquantel injection was significantly effective in the treatment of buffalo schistosomiasis and convenient for administration. It was concluded that 30% praziquantel injection could replace the traditional oral praziquantel tablet for the treatment of buffalo schistosomiasis, and the recommended dose was 10 mg/kg.     

吡喹酮注射液对水牛血吸虫病的临床治疗效果

采用粪便毛蚴孵化法筛选自然感染血吸虫病水牛,考察30%吡喹酮注射液对水牛血吸虫病的临床治疗效果。在实验性临床试验中,将自然感染血吸虫病水牛随机分为5组,分别为吡喹酮注射液高（20 mg/kg）、中（10 mg/kg）、低（5 mg/kg）剂量组,吡喹酮片组（30 mg/kg）和阳性对照组（不用药组）。给药30 d后,吡喹酮注射液高、中、低剂量组及吡喹酮片组的粪便毛蚴孵化转阴率分别为100.0%、100.0%、77.8%和85.7%。在扩大临床试验中,将自然感染血吸虫病水牛随机分为2组,分别为吡喹酮注射液推荐剂量组（10 mg/kg）和吡喹酮片组（30 mg/kg）,给药30 d后,吡喹酮注射液组的52头患牛的粪便毛蚴孵化转阴率为100%,吡喹酮片组的6头患牛的粪便毛蚴孵化转阴率为100%。研究结果表明,30%吡喹酮注射液对水牛血吸虫病具有良好的治疗效果,给药方便,可以替代传统内服片剂,临床推荐剂量为10 mg/kg。