猪传染性萎缩性鼻炎综合防制研究报告

以生物安全体系理论为依据，对一年出栏７０００多头猪，患传染性萎缩性鼻炎的猪场进行治疗、免疫接种、加强卫生管理等综合性防制，经半年的试验，取得了十分显著的效果。使总患病率下降８６．９２％；公猪和母猪的治愈率为９０．７４％；７０日龄仔猪的平均体重提高６．２２％，料肉比下降７．１７％，成活率提高 ３．１６％；育肥猪的日增重提高 ４．３４％，料肉比下降５．６６％，成活率提高１．５６％，残次率下降７６．４８％。     

猪传染性猪萎缩性鼻炎的研究进展

传染性萎缩性鼻炎(Swine infectious atrophic rhinitis,AR)又称慢性萎缩性鼻炎或猪萎缩性鼻炎,主要是由支气管败血波氏杆菌(Bordetella bronchiseptica,Bb)和产毒素多杀巴氏杆菌(Toxigenic Pasteurella multocida,T+Pm)引起猪的一种多发的慢性呼吸道传染病.该病的主要特征为慢性鼻炎、颜面部变形和鼻甲骨萎缩.哺乳仔猪感染本病后,除引起鼻甲骨甚至鼻腔变形、萎缩或消失外,还可以引起全身钙代谢障碍,致使仔猪发育迟缓、饲料利用率降低,有时伴发急、慢性支气管炎,导致仔猪死亡.T+Pm和Bb感染猪后损害呼吸道的正常结构和功能,使机体抵抗力降低,导致其他病原继发性感染,诸如支原体、嗜血杆菌、猪流感病毒、猪生殖.呼吸道综合征病毒等,引起猪呼吸道综合征,增加猪的死淘率川.     

猪传染性萎缩性鼻炎的诊断与防治

近年来 ,张掖地区某大型猪场发生以猪鼻甲骨萎缩 ,鼻部变形及生长迟缓等为特征的一种慢性疾病 ,造成巨大的经济损失。我们对该场病猪进行了临床诊断、病理剖检和微生物检查 ,最后确诊为支气管败血波氏杆菌引起的猪传染性萎缩性鼻炎。1　临床症状仔猪打喷嚏、流鼻涕、喷鼻息 ,有不同程度的卡他性鼻炎 ,产生不同量的浆液性或粘液性鼻分泌物 ,最早 1周龄 ,6～ 8周龄最显著。病猪表现不安 ,到处拱地、奔跑 ,以后病情逐渐加重 ,持续 3周以上开始发生鼻甲骨萎缩。病猪在整个病程中打喷嚏、流鼻涕、气喘 ,同时有不同量的浆液性、脓性分泌物流出。严…     

猪萎缩性鼻炎凝集反应抗原的制备及应用

为快速地诊断猪萎缩性鼻炎及监测其免疫状况,本试验在对支气管败血波氏杆菌保存菌种进行复苏和全面鉴定的基础上,制备了猪萎缩性鼻炎凝集反应抗原,经凝集反应试验表明,该抗原在PBS中不发生自凝,与猪传染性胸膜肺炎、猪喘气病和猪瘟的阳性血清均无凝集反应,而对猪萎缩性鼻炎标准阳性血清的凝集效价高达1∶10 240以上,具有较高的特异性和敏感性;对20份免疫母猪所产仔猪血清样本进行检测,检出率为95%.     

An experimental mouse model of progressive atrophic rhinitis of swine

Pasteurella multocida is responsible for a variety of diseases of veterinary importance, including the pig disease progressive atrophic rhinitis (PAR). The feasibility of using the mouse as an experimental model of PAR was evaluated. We experimentally infected the upper respiratory tract of immature mice with a pig isolate of P. multocida that produces the toxin responsible for causing the nasal lesions characteristic of PAR. We tracked the health status and weight gain of these mice for one month following infection, after which the mice were killed and the integrity of the nasal turbinates was examined. Mice infected with P. multocida appeared healthy throughout the study, although the growth rate of these mice was reduced significantly compared with non-infected control animals. Infected animals also demonstrated marked nasal atrophy analogous to that seen in naturally occurring PAR of swine, with shortening and thinning of the turbinate scrolls and inflammatory cell involvement. The mouse therefore provides a convenient model for the further investigation of PAR of swine.     

广东地区猪传染性萎缩性鼻炎流行病学调查

为了解广东地区猪传染性萎缩性鼻炎(AR)的流行情况,本研究采用细菌分离、鼻甲骨组织形态学测定(TPR值)等方法,对广东各区14个规模在500头母猪的养猪场随机抽样进行AR的流行病学调查。试验统计数据显示,调查的14个猪场均存在AR,平均发病率为58.58%,平均支气管败血波氏杆菌(Bb)感染率为46.74%;抽样猪场中猪的萎缩指数平均数为1.286,萎缩指数标准差为1.871。结果表明,AR在广东省广泛流行,Bb感染率高。     

规模化猪场猪传染性萎缩性鼻炎的防治研究

对新疆部分地区猪传染性萎缩性鼻炎进行调查,对病原进行了分离培养、生化鉴定、药敏试验及致病性试验等研究。结果表明,以本场灭活菌将进行免疫为主,结合使用抗生素和加强兽医卫生管理是防治该病的有效措施,为规模化猪场净化该病提供了科学依据。     

Effect of atrophic rhinitis on growth rate in Illinois swine herds

Influence of atrophic rhinitis (AR) on mean daily weight gain (MDG) was studied in hogs randomly selected from 7 farrow-to-finish herds in Illinois. Herds were selected to obtain a wide range of clinical signs and lesions of the disease; thus, prevalence of clinical signs of AR in finishing hogs ranged from 0% to 20% among herds, and in hogs examined at slaughter the proportion of hogs with turbinate lesions ranged from 5% to 92%. None of the herds investigated had any obvious problems with pneumonia; nevertheless, hogs with moderate to severe pneumonic lesions were excluded from the study, to minimize any combined effect of AR and pneumonia. In 3 herds, MDG in AR-free pigs was 15% to 18% better than in pigs with severe AR lesions. Prevalence of clinical signs ranged from 5% to 20%, and of turbinate lesions, from 66% to 92%. In 4 herds in which MDG appeared to be unaffected by AR, prevalence of clinical signs of the disease ranged from 0% to 5%, and of turbinate lesions, from 5% to 74%. No consistent pattern of influence on AR lesions was found for bacterial infections, as determined by culturing of nasal swab specimens on MacConkey agar and blood agar.