Effects of administration of antimicrobials in feed on growth rate and feed efficiency of pigs in multisite production systems

OBJECTIVE: To evaluate effect of various regimens for administration of antimicrobials in feed on growth rate and feed efficiency (feed/gain) of pigs in multisite production systems. DESIGN: Controlled trial. ANIMALS: 24,099 growing pigs in 3 multisite production systems. PROCEDURE: 10 trials involving various regimens for administration of antimicrobials in feed were evaluated. Trial 1 compared effects of 2 antimicrobial regimens on finishing pig performance. Trials 2 through 10 compared growth rate and feed efficiency of nursery and finishing pigs given antimicrobials in feed with values for control pigs not given antimicrobials. RESULTS: In trial 1, no significant differences were observed between the 2 antimicrobial regimens. In the remaining trials, growth rate of nursery pigs fed antimicrobials was significantly improved, compared with growth rate of control pigs. However, growth rate of finishing pigs and feed efficiency of nursery and finishing pigs were not significantly improved by adding antimicrobials to the feed. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that use of antimicrobials in the feed to promote growth should be limited to the nursery phase in multisite pig production systems. Use of antimicrobials in the feed of finishing pigs should be limited to therapeutic applications in which a diagnosis of bacterial infection susceptible to the antimicrobial to be used has been confirmed.     

Effects of sperm pretreatment on efficiency of ICSI-mediated gene transfer in pigs

Intracytoplasmic sperm injection (ICSI)-mediated gene transfer has recently been shown to be an effective technique for producing transgenic pigs; however, the types of sperm pretreatment having the most beneficial effects on post-ICSI embryogenesis or transgenic efficiency have not been clarified. In the present study, we performed ICSI-mediated gene transfer using pig sperm subjected to various pretreatments and determined the developmental potential of sperm-injected oocytes and introduction efficiency of exogenous DNA. Embryos were then transferred to recipient pigs to confirm gene transfer efficiency during the fetal period. When ICSI was performed using unfrozen sperm heads with tails removed by piezo-pulse, the rates of blastocyst formation (14.2%, 17/120) and transgene (EGFP) expression (11.8%, 2/17) were both low. When unfrozen sperm heads were used that were removed by sonication, EGFP expression efficiency (11/21, 52.4%) improved significantly (P<0.05). Pretreatment of unfrozen sperm with a surfactant or acrosomal reaction did not further improve the rates of blastocyst formation and EGFP expression. However, use of the heads of sperm frozen-thawed with or without a cryoprotective agent resulted in rates of blastocyst formation and EGFP expression that tended to be generally high (23.0%, 14/61-33.8%, 26/77 and 42.9%, 6/14-66.7%, 10/15). A total of 219 in vitro matured oocytes were fertilized by ICSI-mediated gene transfer using the heads of frozen-thawed sperm and then transferred into two recipient pigs. Seven fetuses were obtained, and EGFP expression and integration of the transgene (10-30 copies) were confirmed in two of the seven fetuses. Use of unfrozen sperm thus confers no advantages on ICSI-mediated gene transfer, and although further investigations are needed, frozen-thawed sperm heads appear to be useful in ICSI-mediated gene transfer.     

光照对猪生产性能及生理节律的影响

光照作为重要环境参数之一,通过影响动物的生理节律调控动物生产。合理的光照环境可以促进猪的生长发育和性腺活动,提高生产性能和繁殖性能,增加猪场经济效益。本文综述了光照强度、光照周期及光照波长等方面对不同生理阶段猪的生产性能或繁殖性能影响的研究进展及光照影响动物生理节律的机制,以期为养猪生产的光照控制提供一定的理论依据和参考数据。     

肥育猪饲粮中添加苜蓿草粉对其生产性能、消化率及血清指标的影响

本研究目的在于评价在玉米－豆粕型基础饲粮中添加苜蓿草粉对肥育猪的利用价值。选取体重约５０ｋｇ的杜×长×大三元杂交猪４０头,采用单因子完全随机设计,分为５个组,每组４个重复,分别在饲粮中添加不同比例的苜蓿草粉,依次为：０（对照组）,１０％（试验Ｉ组）,１５％（试验ＩＩ组）,２０％（试验ＩＩＩ组）,２０％＋０．１％纤维素酶（试验ＩＶ 组）,各组主要营养指标相同。测定肥育猪饲喂含不同水平苜蓿草粉饲粮后主要生产性能、消化率及血清中主要生化指标的变化。结果表明,１）试验ＩＩ、ＩＩＩ、ＩＶ 组平均日增重、采食量较对照组明显提高,而试验ＩＩ、ＩＶ 组的料肉比明显降低,因此,添加１５％的苜蓿草粉或２０％的苜蓿草粉＋０．１％ 纤维素酶有利于提高肥育猪的体重及饲料转化率。２）试验Ｉ、ＩＩ组和对照组相比,其干物质、粗蛋白质、粗灰分、中性洗涤纤维的表观消化率均不同程度提高;虽然试验ＩＩＩ、ＩＶ 组上述４项指标的表观消化率和对照组相近或稍高,但试验ＩＶ 组各主要指标优于试验ＩＩＩ组,说明添加１０％和１５％的苜蓿草粉有利于提高营养物质的表观消化率,苜蓿草粉添加至２０％时加纤维素酶对各项指标消化率有改进。３）肥育猪饲粮中添加苜蓿草粉,降低了其血液甘油三酯、胆固醇及低密度脂蛋白胆固醇含量,升高了高密度脂蛋白胆固醇含量。试验证明,在肥育猪饲粮中添加１５％紫花苜蓿草粉对肥育猪生产性能、营养物质消化率及血清生化指标的改善有利,苜蓿草粉降低血液胆固醇的功能可能是其中皂苷的作用。     

不同赖氨酸蛋白质比例对肥育猪氮利用效率的影响

试验选用5头平均体重为60.5kg的杜长大三元杂交猪,研究日粮中赖氨酸与粗蛋白质的比例对肥育猪氮利用效率的影响。日粮中赖氨酸的含量固定为0.8%,按照赖氨酸与粗蛋白质的比例(即4.6%、5.0%、5.6%、6.1%、6.6%)分为5个处理组,采用5×5拉丁方设计。试验结果表明:①赖氨酸与粗蛋白质的比例对粪氮的含量没有影响(P>0.05);②赖氨酸与粗蛋白质的比例对尿氮的含量影响显著(P<0.05);尿氮的含量随氮的摄入量的增加而增加;③氮的沉积和氮的利用效率在赖氨酸与粗蛋白质的比例为5.0%时最大,氮的存留量随日粮粗蛋白质水平的增加而增加(P<0.05),但是赖氨酸与粗蛋白质的比例对干物质和氮的消化率没有影响。     

Effects of prepartum administration of 1,3-butanediol to sows on growth and survival of neonatal pigs

In six trials, 158 late-term gravid sows were fed isocaloric amounts (8,500 kcal metabolizable energy/d) of a corn-soybean meal-based diet in which 20% of their daily metabolizable energy (ME) intake was supplied by either cornstarch or 1,3-butanediol (butanediol) from about d 105 of gestation to parturition. After parturition, all sows were allowed to consume a standard, corn-soybean meal-based lactation diet, ad libitum, during a 28-d lactation. Prepartum administration of butanediol, a stable, nonvolatile liquid that possesses anesthetic, antimicrobial and ketogenic properties, did not alter the voluntary feed intake or body weight changes of sows pre- or post-partum. Number of pigs born per litter, average pig birth weight and incidence of stillbirths were not influenced by the prepartum diet of the sows. However, the addition of butanediol to the prepartum diet increased (P less than .10) the number of pigs weaned per litter at 28 d by .51 pigs (8.17 vs 7.66) and improved (P less than .10) the survival rate of pigs from birth to weaning by 5.7 percentage units (84.1 vs 78.4%) compared with those of sows fed isocaloric additions of starch. Average pig weights at 28 d of age were similar for the two treatment groups (6.18 vs 6.08 kg) even though greater numbers of pigs were nursing sows fed the butanediol diet prepartum. The rate and efficiency of gain and survivability of weanling pigs during a 28-d postweaning period were not influenced by the prepartum diet of their dam.     

Effects of dietary additions of 1,3-butanediol or lard for sows on survival of neonatal pigs

In nine trials, 278 late-term gravid sows were fed isocaloric amounts (8,500 kcal metabolizable energy (ME)/d) of a fortified, corn-soybean meal based diet in which 20% of their daily ME intake was supplied by corn starch, 1,3-butanediol or lard from about d 106 of gestation to parturition. After parturition, the sow's daily ME intake was increased to 18,000 kcal. Sows fed starch and lard remained on their respective diets for the duration of a 28-d lactation; whereas, those initially fed butanediol were switched to the starch diet after parturition. Number of pigs born per litter, average pig birth weight and incidence of stillbirths were not influenced (P greater than .30) by the prepartum diet of the sow. However, the inclusion of isocaloric levels of butanediol for starch in the preparatum diet and lard for starch in the pre- and postpartum diets increased the number of pigs weaned per litter by .45 (P less than .13) and .16 pigs (8.25, 7.96 vs 7.80) and improved the survival rate of pigs from birth to weaning by 4.3 (P less than .13) and 2.7 percentage units (84.5, 82.8 vs 80.1%), respectively. Average pig weights at 28 d of age for litters of sows fed butanediol prepartally were similar to those of sows fed starch, but were less (P less than .01) than those of sows fed lard throughout lactation.     

发酵蛋白饲料对生长育肥猪生产性能和猪肉品质的影响

本试验探讨了在日粮中使用发酵蛋白原料替代普通蛋白原料对生长育肥猪生产性能和猪肉品质的影响。结果表明,以发酵豆粕、发酵棉粕为主要蛋白原料的育肥猪无抗饲料配方产品与常规饲料相比,能显著提高育肥猪末重及平均日增重;能使每头猪养殖增收78.72元,提高毛利33.98%;能显著降低猪肉剪切力和滴水损失,提高猪肉氨基酸水平,改善了肉品质,提高了猪肉营养。     

添加苜蓿草粉对育肥猪生产性能和肉品质的影响

本研究旨在通过为期3个月的舍内连续饲喂试验,探讨在饲粮中添加苜蓿(Medicago sativa)草粉对育肥猪生产性能和肉品质的影响。试验选取60kg左右、胎次相近、体重相近、健康状况良好的杜×长×大育肥猪160头,公母各半。本试验共设置5个处理,即对照组和试验1、2、3、4组,每组4个重复,每个重复8头猪。饲粮中苜蓿草粉水平依次为0、5%、10%、15%和20%。结果表明,1)10%苜蓿草粉添加量显著(P0.05)提高了育肥猪的末重,且10%和15%苜蓿草粉添加量显著(P0.05)提高了育肥猪的日增重,显著(P0.05)降低了育肥猪的料重比。2)当苜蓿草粉添加量为10%、15%和20%时,猪眼肌面积显著(P0.05)高于其他各处理,当苜蓿草粉添加量为5%、10%和15%时,育肥猪肌内脂肪含量显著(P0.05)高于其他各处理,但是各苜蓿草粉添加量对猪肉的pH、系水率、熟肉率等指标均无显著影响(P0.05)。综合认为,苜蓿草粉添加量对育肥猪的生产性能和肉品质有一定的改善,其中10%的添加量效果最好。     

Effects of acute asphyxia at birth on subsequent heat production capacity in newborn pigs

The effect of acute asphyxia at birth on subsequent ability to produce heat was investigated in 30 newborn pigs. A model of experimentally induced asphyxia consisting of the prevention of breathing within the first four minutes of life was used. Blood was sampled from an umbilical artery catheter within the first 75 minutes of life for blood gas, pH, glucose, lactate and catecholamine analysis. After the treatment and 24 hours later, heat production capacity, shivering intensity and rectal temperature were measured 10 degrees C below thermoneutrality. Effects on blood gas parameters were severe but transient whereas alterations in carbohydrate metabolism were maintained during the first 75 minutes (P < 0.05). Acute asphyxia at birth induced only minor alterations of thermoregulatory abilities during the first day of life: rectal temperature was lower one hour after birth (P < 0.05) and the postnatal increase in heat production capacity was less pronounced than in controls. It is suggested that the lower viability usually reported for piglets suffering from asphyxia during delivery is most likely to result from reduced vigour and colostrum intake, as well as altered carbohydrate metabolism early after birth.     

日粮中添加乳清粉和膨化豆粕对断奶仔猪生产性能影响

选择30日龄断奶三元杂交仔猪(杜×长×大)64头。随机分成对照组、Ⅰ、Ⅱ、Ⅲ组,对照组饲以基础日粮,试验Ⅰ组日粮以膨化豆粕替代普通豆粕,试验Ⅱ组由3%的乳清粉替代3%的豆粕。试验Ⅲ组中膨化豆粕替代普通豆粕同时由3%的乳清粉替代3%的膨化豆粕。试验结果:对照组培育仔猪需46d,试验Ⅰ组(膨化豆粕组)培育仔猪需40d,试验Ⅱ组(乳清粉组)培育仔猪需43d,试验Ⅲ组(膨化豆粕+乳清粉组)培育仔猪需39d;平均日增重试验Ⅱ组显著高于对照组(P<0.05),试验Ⅰ、Ⅲ组极显著高于对照组(P<0.01),试验Ⅲ组极显著高于Ⅱ组(P<0.01)、显著高于试验Ⅰ组(P<0.05);饲料利用率试验Ⅲ组最高,对照组饲料利用率最差;腹泻率试验Ⅰ组下降了38.13%,试验Ⅱ组下降了34.63%,试验Ⅲ组下降了47.08%。结果表明利用膨化大豆或乳清粉等优质蛋白。调整日粮结构,可显著降低TI等抗营养因子和抗原物质的含量,减少腹泻率,提高生长性能。     

Modeling the efficiency of phosphorus utilization in growing pigs

Microbial phytase has been used to reduce P excretion from swine to mitigate environmental pollution. The objective of the study was to quantify the effect of feeding a low-P phytase-supplemented diet on growth and P utilization in growing pigs using mathematical models. A total of 20 weaned piglets (BW = 6.5 kg) housed in metabolism cages were randomly assigned to a standard diet (STD) or P-amended diet containing reduced P content and supplemented with phytase (AMN) with 10 pigs/diet. Body weight and feed consumption were recorded weekly so complete growth and cumulative P intake (cPI) curves could be modeled. A function with fixed point of inflexion (Gompertz) and a variable point of inflexion (generalized Michaelis-Menten) were considered in determining bioequivalence by analyzing BW vs. age relationships, whereas the monomolecular function was used to describe BW vs. cPI. All functions were incorporated into a nonlinear mixed effects model, and a first-order autoregressive correlation structure was implemented to take into account repeated measures. There was no difference between the 2 groups in final BW when the Gompertz equation was fitted (176 vs. 178 kg with SE of 7 kg for the STD and AMN, respectively) or the rate parameter (0.0140 vs. 0.0139 with SE of 0.0004 for the STD and AMN, respectively). The generalized Michaelis-Menten equation also showed a similar trend. When BW was expressed as a function of cPI the derivative with respect to cPI represented P efficiency, so it was possible to analyze the expected difference of the 2 diets in using P for BW gain and express it as a continuous function of cPI. The analysis showed through the entire growth period the difference in P efficiency was different from zero. On average, 56 g of supplemented inorganic P was consumed by a pig fed the AMN to reach market weight. In contrast, 309 g of supplemented inorganic P was consumed by the group fed the STD to reach similar BW. It would depend on other factors, but feeding pigs the AMN can result in economic benefit. Pigs fed the AMN excreted 19% less P compared with those fed the STD. In conclusion, nonlinear mixed model analysis (with repeated measures) was suitable for growth and efficiency analysis and showed that pigs fed the AMN consumed less than 20% of the inorganic P and performed as well as those fed the traditional inorganic P supplemented diet. The implications for mitigating P pollution, especially in areas where P loading is already problematic, are substantial.     

Experimental sarcoptes scabiei infestation in pigs: (2) Effects on production.

A study on the development and effect of experimental Sarcoptes scabiei var suis infestations in growing pigs is described. Pigs were infested at either weekly or fortnightly intervals throughout each experimental and individual growth rates and feed conversion ratios were determined. The animals were fed diets which contained either optimal or sub-optimal levels of protein. They were housed either intensively or extensively. In all experiments the majority of infested animals developed a generalised hypersensitivity to sarcoptes mites and performed significantly less efficiently than non-infested littermates. Mean growth rates were depressed from 9.2 to 12.5 per cent and feed conversion efficiencies by a similar margin. Well fed, intensively housed pigs developed a more severe hypersensitivity reaction than poorly fed, extensively housed pigs.     

吡啶甲酸铬对生长猪生产性能和组织中铬残留的影响

选用96头体重(24.67±0.36)kg,公母各半达兰猪,随机分为4组,每组4个重复,每个重复6头。对照组饲喂基础日粮,3个试验组分别添加200、400μg/kg和800μg/kg吡啶甲酸铬(以铬计)。另外,选用8头体重(24.98±0.56)kg达兰猪,随机分为2组,添加1600μg/kg和3200μg/kg吡啶甲酸铬(以铬计),试验期28d。结果表明,添加200～800μg/kg吡啶甲酸铬对猪平均日增重和饲料转化效率无显著影响(P>0.05),但可提高饲料采食量,800μg/kg处理组的采食量显著高于其他3个处理组(P=0.01)。添加200～3200μg/kg吡啶甲酸铬猪组织中铬残留量为0.08～0.35mg/kg。     

优化教槽料脂肪源对断乳仔猪生长性能及生产效益的影响

在断乳仔猪日粮中添加脂肪酸优化的脂肪源,同时以椰子油粉作为对照,研究优化的脂肪源对断乳仔猪生长性能、腹泻情况及生产效益的影响。试验选取120头断乳仔猪,随机分为2个处理组:A组添加4%结构脂脂肪粉(商品名:乳脂能Ⅱ型),B组添加4%椰子油粉(商品名:椰香50),每组6个重复,每个重复10头猪,试验为期12 d。结果表明:A组仔猪的采食量、日增重及成活率均高于B组,且A组仔猪的腹泻率显著低于B组。经济效益分析表明:试验期间,A组每头猪增重回报比B组增加15.52元/头,净盈利增加13.54元/头。由此可见,脂肪酸优化的结构脂可促进仔猪采食,提高仔猪增重,减少仔猪腹泻,且其经济效益优于B组。     

圈舍卫生状况及日粮色氨酸对断奶仔猪生产性能的影响

卫生状况的改变会影响动物色氨酸的代谢．可能会导致色氨酸供应不足。本试验旨在研究轻度炎症与色氨酸对动物生长性能、色氨酸代谢、血浆氨基酸浓度、血浆球蛋白、谷胱甘肽浓度等方面的影响。试验显示脏乱圈舍环境不仅可造成断奶仔猪轻度炎症反应．还会引起仔猪对色氨酸代谢的改变,表明充足的色氨酸有益于断奶仔猪生长．     

不同绿色预混料对商品肉猪生产性能的影响

选择体重 15kg左右的杜×长×本三元杂交仔猪 12 0头 ,分为 3组 ,每组设 5个重复 ,每重复 8头猪进行试验 ,以观察不同绿色预混料对商品肉猪生产性能的影响。各组基础日粮完全相同 ,对照组饲喂含有药物添加剂的商品性预混料 ,2个试验组分别饲喂不含药物添加剂的自配预混料。试验结果表明 ,2个试验组的平均日增重明显高于对照组 (P <0 .0 5 ) ,而料重比和腹泻率明显低于对照组 (P <0 .0 5 ) ,肌肉pH值及肌内脂肪含量无明显差异 (P >0 .0 5 ) ,试验 2组与对照组相比 ,肌肉总色素含量明显提高 (P <0 .0 5 ) ,滴水损失明显下降 (P <0 .0 5 )。     

Model calculations on the economic efficiency of sheep production

The answers to the questionnaire by the Commission on Sheep and Goat Production show quite large differences in the price relationships, particularly between meat and wool.It is at first shown from model calculations, how the optimum duration of using the ewes changes with a change of the relationship between mutton price and lamb meat price. In all cases, in which mutton is very cheap in comparison with lamb meat, a longer utility period is generally more efficient than a shorter one and vice versa (Fig.1).The relative importance of lamb carcases of different weight, in relationship to varying concentrate costs shows according to the conditions given in the model that when the price per kg meat is equal regardless of the carcase weight, that a 25 kg carcase is more efficient than producing a 20 kg carcase. On the other hand, if the meat of a 25 kg carcase is only valued at 90% of that of the 20 kg carcase, then the 20 kg carcase is preferable (Fig.2).Using the formula formerly developed for meat production and now expanded for other purposes 64 000 model calculations were made. The change of efficiency through changing of wool price, through increasing the level of fertility, through altering of working time and cost per hour as well as other factors, was illustrated by means of a few examples (Fig.3 and 4).The results of special calculations of efficiency should not be generalised even through they could be of valuable help in breeding, management techniques and making economic decisions in business under given conditions.     

Effects of uterus and prostaglandin F2alpha on corpora lutea in Mongolian gerbils and guinea pigs.

One or both uterine horns were removed on postpartum day 6 day 1=parturition in pseudopregnant gerbils. On dy 16, the corpora lutea (C) in unilaterally hysterectomized gerbils were smaller (P less than 0.05) in the ovary adjacent to an intact horn than in the ovary adjacent to a removed horn. The cL were smaller in uterine-intact than in completely hysterectomized gerbils. I n another experiment, the cl were smaller (P less than 0.05) in pseudopregnant gerbils given a single intrauterine injection of a 30- or 20-mug dose of prostaglandin F2alpha) (PGFalpha) on postpartum day 6 and theen necropsied on day 10 than in gerbils given 10-, 5-, 1-, and 0-mug doses; CL were smaller (P less than 0.05) on the side ipsilateral to the treated horn than on the opposite side, although the interaction of dose and side was not significant...