Self-stimulation alters human sensory brain responses

Human electrocortical potentials evoked by self-administered auditory and visual stimuli manifest much smaller amplitude and faster poststimulus timing than do average brain responses evoked by identical machine-delivered stimuli. Auditory evoked potentials show this "self-stimulation effect" to a greater degree than do visual responses. For visual evoked potentials, the effect appears greater at the vertex association area than over the occipital cortex. Individual differences in the magnitude of the "self-stimutlation effect" relate to level of intelligence.     

Evoked potential correlates of expected stimulus intensity

The electrophysiological responses to a flash of medium intensity have different wave shapes in trials in which the occurrence of bright stimuli or dim stimuli is expected. When a bright or dim stimulus is signaled, the potentials evoked by the medium stimulus resemble the responses evoked by a real bright or dim flash.     

CORTICAL EVOKED POTENTIALS AND PERCEPTION OF PAIRED FLASHES

Digital computer techniques have been employed to extract cortical evoked potentials to paired visual stimuli. Changes in the evoked potentials have been related to perceptual phenomena varying as a function of the interval between flashes. Evoked potentials to paired stimuli, which gave rise to perceptual interactions, could be approximated by algebraic summation of the responses to the stimuli when presented separately.     

Responses of human somatosensory cortex to stimuli below threshold for conscious sensation

Averaged evoked responses of somatosensory cortex, recorded subdurally, appeared with stimuli (skin, ventral posterolateral nucleus, cortex) which were subthreshold for sensation. Such responses were deficient in late components. Subthreshold stimuli could elicit sensation with suitable repetition. The primary evoked response was not sufficient for sensation. These facts bear on the problems of neurophysiological correlates of conscious and unconscious experience, and of "subliminal perception."     

Evoked potential correlates of signal recognition between and within modalities

Electrical responses evoked by clicks, flashes, changes in noise level, and changes in light level were recorded from the scalps of human subjects set to detect one of the stimuli. An early negative component of the evoked responses reflects selection between sensory modalities, whereas the later positive component reflects a more complex intramodal discrimination.     

Olfactory discrimination in the rabbit olfactory glomerulus

Slow potentials evoked by odor stimulation were recorded from individual glomeruli in the olfactory bulb. Systematic analysis of responses to nine different, arbitrarily selected stimuli strongly suggests a certain amount of discrimination. This fact seems to reflect in the first synapse of the olfactory tract the type of discrimination that was recently demonstrated within olfactory neuroepithelium.     

Auditory evoked response: meaningfulness of stimuli and interhemispheric asymmetry

Interhemispheric asymmetries of different magnitudes were observed in human cortical auditory evoked responses to speech and sound-effect stimuli. The wave with peak asymmetry occurred 100 milliseconds after signal onset. The amount of asymmetry of the amplitude of this wave was related to the meaningfulness to the subject of the auditory stimulus rather than to the mere use of verbal versus nonverbal materials.     

Differential cerebral processing of noise and verbal stimuli

Psychophysiological measurements have indicated that the right cerebral hemisphere processes noises and other nonverbal data and that the left cerebral hemisphere processes verbal material. Direct physiological measurements, as expressed in summated auditory evoked cortical responses, unequivocally demonstrate that click noises show a greater amplitude of initial output over the right brain, and that verbal stimuli produce either equal or higher amplitudes of output over the left cerebral hemisphere.     

Hemispheric asymmetry of electrocortical responses to speech stimuli

In a group of normal adults, averaged cortical evoked responses to natural speech stimuli were recorded from scalp electrodes placed symmetrically over the two cerebral hemispheres at frontal, Rolandic, and temporoparietal leads. The amplitude of the most prominent component was consistently larger in left hemisphere derivations, with the major hemisphere difference observed in the temporoparietal records. These electrophysiological measures may be sensitive indicators of hemispheric specialization of function.     

Taste receptor cells that discriminate between bitter stimuli

Recent studies showing that single taste bud cells express multiple bitter taste receptors have reignited a long-standing controversy over whether single gustatory receptor cells respond selectively or broadly to tastants. We examined calcium responses of rat taste receptor cells in situ to a panel of bitter compounds to determine whether individual cells distinguish between bitter stimuli. Most bitter-responsive taste cells were activated by only one out of five compounds tested. In taste cells that responded to multiple stimuli, there were no significant associations between any two stimuli. Bitter sensation does not appear to occur through the activation of a homogeneous population of broadly tuned bitter-sensitive taste cells. Instead, different bitter stimuli may activate different subpopulations of bitter-sensitive taste cells.     

Encoding predictive reward value in human amygdala and orbitofrontal cortex

Adaptive behavior is optimized in organisms that maintain flexible representations of the value of sensory-predictive cues. To identify central representations of predictive reward value in humans, we used reinforcer devaluation while measuring neural activity with functional magnetic resonance imaging. We presented two arbitrary visual stimuli, both before and after olfactory devaluation, in a paradigm of appetitive conditioning. In amygdala and orbitofrontal cortex, responses evoked by a predictive target stimulus were decreased after devaluation, whereas responses to the nondevalued stimulus were maintained. Thus, differential activity in amygdala and orbitofrontal cortex encodes the current value of reward representations accessible to predictive cues.     

Spontaneous cortical activity reveals hallmarks of an optimal internal model of the environment

The brain maintains internal models of its environment to interpret sensory inputs and to prepare actions. Although behavioral studies have demonstrated that these internal models are optimally adapted to the statistics of the environment, the neural underpinning of this adaptation is unknown. Using a Bayesian model of sensory cortical processing, we related stimulus-evoked and spontaneous neural activities to inferences and prior expectations in an internal model and predicted that they should match if the model is statistically optimal. To test this prediction, we analyzed visual cortical activity of awake ferrets during development. Similarity between spontaneous and evoked activities increased with age and was specific to responses evoked by natural scenes. This demonstrates the progressive adaptation of internal models to the statistics of natural stimuli at the neural level.     

Metacontrast: its relation to evoked potentials

Electrophysiological correlates of metacontrast were studied by means of averaged evoked potentials recorded from the scalp in man. Under conditions in which the brightness of the first of two successive stimuli appears diminished there is no accompanying attenuation of the evoked potentials to that stimulus. The results suggest that the amplitude and latency of evoked potentials correlate with stimulus intensity but not with brightness.     

Harmonic oscillation as model for cortical excitability changes with attention in cats

A single shock to the prepyri-form cortex with implanted electrodes caused a damped, sinusoidal oscillation in potential. The root-mean-square amplitudes of potentials evoked by short trains of stimuli, when plotted against the frequency of stimulation, fitted the equation for forced harmonic oscillation when the cat was attentive to the stimuli     

LONG-TERM STABILITY OF VISUALLY EVOKED POTENTIALS IN MAN

Although the variability of averaged evoked potentials as recorded from cortex in man has been a constant source of concern among investigators, the degree of variability has not received systematic treatment. The authors have accordingly undertaken an exploratory study of reliable differences that may occur in the first 300 msec of the averaged evoked response over long periods of time. Computer analysis of visually evoked responses in seven subjects over several weeks indicated stability of the response of each individual, with reliable intra-individual correlations. Inter-individual differences, however, were large. The evoked responses of different individuals were found to be unique.     

Evoked potentials: three-dimensional display

Procedures are described for displaying large numbers of evoked potentials. A photographic superposition of average evoked responses, with the concurrent modulation of the brightness of each trace, yields a display having the appearance of a three-dimensional surface formed from hundreds of average responses.     

The twitch in horses: a variant of acupuncture

The twitch procedure in horses attenuates the increase in the heart rate evoked by pain-inducing stimuli and the reaction of the animals to such stimuli. Endorphin systems are probably involved in the effectiveness of the twitch, since its action is blocked by naloxone and its application increases plasma concentrations of immunoreactive beta-endorphin. The mode of action of the twitch cannot be explained by the generally accepted theory of divertive pain and may resemble that of classical acupuncture.     

Recording of single unit activity in isolated central nervous tissue

The retina and attached segment of optic nerve isolated from the rabbit were maintained in a functioning state in vitro. Microelectrodes, introduced into the nerve, recorded unit discharges in response to light stimuli. The characteristics of these evoked discharges are described.     

Pavlovian conditioning with heat reinforcement produces stimulus-directed pecking in chicks

In a cooled chamber, chicks approached and pecked a small disk whose illumination preceded heat lamp activation, even when pecks prevented heat lamp onset. These behaviors did not occur when the disk and heat stimuli were randomly presented. Approach and contact of conditioned stimuli may develop even though these behaviors are not (i) evoked by the reinforcing stimulus, (ii) necessary for reinforcer reception, or (iii) ever followed by the reinforcer.     

Tobacco and evoked potential

Significant changes were found in two indices of the averaged visual evoked potentials in nine smokers after 12 and 36 hours of abstinence and after resumption of smoking. There was a decrease of the amplitude envelope accompanying withdrawal and an increase with resumption of smoking. These changes are consistent with the contention that tobacco increases arousal. Amplitude changes were found in a specific component of the evoked potential occurring between 100 and 125 milliseconds after the onset of the flash. The latter changes suggest the possibility that smoking selectively enhances the perceptiont of weak stimuli.