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In this study, the in vitro degradation of yarns made from PCL electrospun fibers containing various concentrations of ampicillin sodium salt was investigated.
PCL fibers were electrospun and collected as well-aligned fiber bundles and then twisted into yarns. Yarn weight loss, morphology
changes in the yarns, and morphology changes in the fiber microstructure with degradation were evaluated. Results showed that
the electrospun PCL yarns degraded slowly with a weight loss less than 3 % in 12 weeks. The addition of various concentrations
of ampicillin salt increased the degradation rate slightly. The morphological changes observed in fiber microstructure suggested
that the degradation underwent bulk erosion and the degradation began with the amorphous regions. Revealed by the fiber morphological
changes with degradation, the microstructure of electrospun PCL fibers followed the fringed fibril fiber model. The fiber
arrangement in the yarn was impaired by the in vitro degradation environment as well. 相似文献