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犬脓皮病诊治中一些临床问题的分析与研究 总被引:1,自引:0,他引:1
犬蠕形螨病及皮肤继发细菌感染(脓皮病)是犬的临床常见病,尤其在炎热、潮湿的夏季发病率最高,有的病例迁延不愈导致患犬衰竭死亡;查明继发感染的细菌种类及其对抗菌药物的敏感性对选择正确的治疗方法非常重要.了解健康犬皮肤正常菌群有助于认识脓皮病.在国外,对犬皮肤正常菌群、脓皮病病原菌及治疗方法的研究已广泛开展.在国内,这方面的报道很少,在犬蠕形螨病及皮肤继发细菌感染(脓皮病)的诊断和治疗过程中缺乏理论依据. 相似文献
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1病因犬脓皮病是化脓菌感染引起的皮肤化脓性疾病,是犬病中最普遍的症候群。根据病犬感染深度常分为表层脓皮病、浅层浓皮病和深层脓皮病。病犬常有骚痒、掉毛、脓疱疹、脓疱等症状。犬脓皮病分为原发性和继发性的两种,在犬脓皮病中葡萄球菌是主要致病菌。过敏、外寄生虫感染、代谢性和内分泌性疾病是脓皮病的主要病因。病犬皮肤表面的酸碱度、湿度、温度等微生态环境因素的改变是脓皮病发生的诱因。 相似文献
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犬蠕形螨病 (Demodiosis)是犬蠕形螨过量繁殖引起的皮肤炎症性病变 ,由于毛囊和皮肤局部生态环境遭到破坏 ,病原菌即可通过虫体或皮肤伤口进入宿主体内引起继发感染[1] 。犬蠕形螨病继发性皮肤细菌感染 (脓皮病 )和其他原因引起的脓皮病是小动物临床最常见的皮肤病之一 [2 ,3] 。脓皮病一年四季均有发病 ,以夏季发病率最高 ,由于气温高 ,温度大 ,皮肤浸渍等原因 ,致病菌更易侵入皮肤繁殖 [4 ] 。病原菌主要是中间型葡萄球菌 (Staphyloccusintermedius) [5,6 ] 。治愈脓皮病需要在正确诊断和治疗原发病的基础上 ,给予有效的抗菌药物治疗继发… 相似文献
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为了研究犬脓皮病病原菌的致病机制、筛选有效的临床外用药物,采用砂纸打磨皮肤的方法,选取临床犬脓皮病病例中分离得到的伪中间葡萄球菌(Staphylococcus pseudintermedius)和金黄色葡萄球菌(Staphylococcus aureus)各1株,进行分点皮内注射感染小鼠,并于室内常规湿度(30%~40%相对湿度)和高湿度(60%~65%相对湿度)环境下饲养96 h,记录临床表现、剖检变化及病理组织学观察。结果显示:常规湿度下感染小鼠均于2~3 d结痂康复,而在高湿度环境下造模小鼠均出现明显的临床症状。病理切片结果显示,在高湿度环境下,2种菌感染小鼠的皮肤各层及皮下组织病理变化与临床上犬脓皮病病例相似,伪中间葡萄球菌感染组小鼠皮肤多出现脓肿灶,可见明显囊膜结构;而金黄色葡萄球菌感染组多为弥散性变化。结果表明,60%~65%相对湿度环境有利于犬脓皮病病原葡萄球菌感染小鼠皮肤。 相似文献
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《江西畜牧兽医杂志》2017,(6)
<正>犬脓皮病是指犬皮肤感染化脓性细菌而引起的化脓性皮肤病~([1]),现代研究表明,伪中间型葡萄球菌为犬脓皮病的最主要致病菌~([2~3]),而随着抗菌药物的大量使用,已有越来越多的细菌出现耐药表型~([3])。2017年6月16日,江西农业大学兽医院接诊一例拉布拉多犬皮肤发炎病例,经临床诊断、实验室化验,确诊为脓皮病,经治疗,愈后良好,现报告如下。1病史调查及临床症状患犬为拉布拉多犬,雄性,2岁,体重30kg,主诉 相似文献
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Canine pyoderma is the most common skin disease in dogs, which not only affects the appearance of the dog, but also leads to itching or pain, and even increases the risk of dog owners suffering from pyoderma.Canine pyoderma is harmful to health of animals and human beings.Canine pyoderma could be diagnosed according to illness history survey, clinical symptoms, clinical cytology, isolation and identification of pathogens and histopathological examination.In order to curing canine pyoderma effectively, systemic therapy combined with topical administration, scientific and rational use of antibiotics, and improvement of canine feeding management should be carried. 相似文献
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犬脓皮病是一类主要由耐甲氧西林伪中间型葡萄球菌(MRSP)感染而引起的化脓性皮肤病。葡萄球菌是一种人与动物均易感的细菌,常引起各种化脓性疾病,其中,MRSP作为一种动物源葡萄球菌还会成为耐药基因贮存库,可将耐药基因通过环境或食物链传给人类。近年来MRSP造成的皮肤疾病病例大幅上升,给感染的控制带来挑战。笔者综合了犬脓皮病致病菌的抗菌药耐药性及其消毒剂抗性的相关研究,从MRSP的致病机制出发,总结了MRSP通过破坏细胞免疫系统的功能导致感染发生的相关机制,简述了多个国家MRSP对抗菌药的显著耐药性与相关耐药基因,如mecA和cat基因等,介绍了MRSP对胍类消毒剂与季铵盐类消毒剂的抗性及抗性机制,对外排泵、基因调控与抗性基因的可转移性等多种机制进行了论述,同时为避免MRSP对抗菌药与消毒剂的共同耐药性对犬脓皮病的治疗造成干扰,笔者从移动遗传元件介导的获得性抗性与依赖于细菌细胞结构的固有抗性等方面系统地分析了MRSP对消毒剂抗性和抗菌药耐药性之间的争议与联系,以期寻找一种科学合理的治疗方案,为犬脓皮病的临床用药提供参考。 相似文献
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Canine and feline dermatomycosis is the common skin disease in small animal,which not only affects the appearance of the canine and feline, but also leads to itching or pain, and even increases the risk of dog and cat owners suffering from dermatomycosis. Dermatomycosis is harmful to health of animals and human beings. The dermatomycosis is difficult to identify, has long treatment cycle and high recurrence, and affected by regional or/and environmental factors, lead to its prevalent and brought great difficulties to the clinical diagnosis and treatment. Canine and feline dermatomycosis could be diagnosed according to illness history survey, clinical symptoms, isolation and identification of pathogens and histopathological examination. In order to curing canine and feline dermatomycosis effectively, systemic therapy combined with topical administration, scientific and rational use of antibiotics, and improvement of animal feeding management should be carried. 相似文献
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This study investigated the in vitro adherence of Staphylococcus intermedius to canine corneocytes, collected from a healthy dog using double-sided adhesive tape. Adherence was shown to depend on duration (P < 0.001) and temperature of incubation (P < 0.001) and the concentration of bacteria (P < 0.001). Isolates of S. intermedius from lesions of pyoderma were not generally more adherent to healthy canine skin than were isolates from healthy dogs. Significant differences in adherence were demonstrated between individual isolates within both groups (P < 0.001). The study suggests that among S. intermedius there is no correlation between virulence and adherence to canine corneocytes in vitro. The finding may be important for the potential use of avirulent variants of S. intermedius as antagonistic strains against canine pyoderma. However, more studies are needed to compare the adherence of the isolates to skin cells obtained from dogs with diseases predisposed to pyoderma. 相似文献
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对流行病学调查、临床症状检查和ELISA检测为犬瘟热阳性的自然发病犬,取肠内容物为病料,采用同步培养方法接种于犬肾细胞系(MDCK)进行病毒的分离,并对分离株进行了形态学特征、血凝特性、动物感染及RT-PCR鉴定。结果表明:病料接种MDCK细胞产生明显的细胞病变(CPE),电镜负染观察接毒细胞培养物见有典型的犬瘟热病毒粒子。分离株不凝集鸡及人“O”型红细胞,接种犬出现明显的临床症状和病理变化。用RT-PCR技术检测病毒细胞培养液,扩增出的片段长为760 bp,与预期设计的长度相同,由此确证分离株为犬瘟热病毒,命名为CDV-GZ2株。 相似文献
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Canine serum alpha 1-proteinase inhibitor is not a major acute phase reactant in the dog, unlike the equivalent protein in humans. The possibility that an alternative protease inhibitor system is stimulated during the acute phase response in the dog was investigated. alpha 2-macroglobulin was not an acute phase reactant, but an inhibitor of elastase was identified in canine serum which could be separated from proteinase inhibitor by gel filtration and which was shown to be an acute phase reactant. This protein has been named canine elastase inhibitor. 相似文献