A new flavone glycoside from the seeds of Tecoma undulata

The new flavonoid 5,7-dihydroxy-6-methoxyflavone 7-O-α-l-rhamnopyranoside (1) was isolated from the seeds of Tecoma undulata.     

A new prenylated flavanone glycoside from the seeds of Glircidia maculata

A new flavanone glycoside, 5,4'-dihydroxy-6-prenylflavanone 4'-O-beta-D-xylopyranosyl-(1-->2)-alpha-L-rhamnopyranoside (1), was isolated from the seeds of Glircidia maculata.     

A novel flavone glycoside from the stem of Bauhinia purpurea.

A novel flavone glycoside, 5,6-dihydroxy-7-methoxyflavone 6-O-beta-D-xylopyranoside (1) was isolated from the chloroform-soluble fraction of the ethanolic extract of Bauhinia purpurea stems.     

A new flavone glycoside from the seeds of Shorea robusta

A new flavonoid, 3,7-dihydroxy-8-methoxyflavone 7-O-α- -rhamnopyranosyl-(1→4)-α- -rhamnopyranosyl-(1→6)-β- -glucopyranoside (1), was isolated from the seeds of Shorea robusta.     

A new flavone glycoside from Centaurea furfuracea

A new flavone glycoside, hispidulin 7-O-methylglucuronide (1) has been isolated from the aerial part of Centaurea furfuracea.     

A new flavone glycoside from the fruits of Luffa cylindrica

The methyl ester of diosmetin 7-O-beta-D-glucuronide (1) was isolated from the fruits of Luffa cylindrica. Its structure was determined by spectroscopic methods.     

A novel isoflavone glycoside from the leaves of Sphaeranthus indicus

A novel isoflavone glycoside, 5,4′-dimethoxy-3′-prenylbiochanin 7-O-β-d-galactoside (1), was isolated from the leaves of S. indicus.     

Artoindonesianin P,a new prenylated flavone with cytotoxic activity from Artocarpus lanceifolius

A new prenylated flavone, named artoindonesianin P (1), was isolated from the tree bark of Artocarpus lanceifolius, together with three known related compounds, artobiloxanthone (2), cycloartobiloxanthone (3) and artonol B (4). The structure of artoindonesianin P 1 was determined on the basis of spectral evidence (MS, 1H and 13C NMR) and by comparison with known related compounds. Compounds 1-4 exhibited significant cytotoxicity against murine P388 leukemia cells.     

A novel cytotoxic flavonoid glycoside from Physalis angulata.

A new flavonol glycoside, myricetin 3-O-neohesperidoside (1) was isolated from a cytotoxic MeOH extract of the leaves of Physalis angulata. Compound 1 showed remarkable cytotoxicity in vitro against murine leukemia cell line P-388, epidermoid carcinoma of the nasopharynx KB-16 cells, and lung adenocarcinoma A-549 with ED(50) values of 0.048, 0.50 and 0.55 microg ml(-1), respectively.     

Artoindonesianin L, a new prenylated flavone with cytotoxic activity from Artocarpus rotunda.

A new prenylated flavone, named artoindonesianin L (1), was isolated from Artocarpus rotunda (Hout) Panzer (Moraceae). Its structure was elucidated as on the basis of spectroscopic evidence. Along with this new compound, four known phenolic compounds were also isolated from this plant and identified as artonins M (2) and E (3), cycloartobiloxanthone (4) and artonin O (5). All these compounds showed significant cytotoxicity against murine P388 leukemia cells.     

A novel anthocyanidin glycoside from the rhizomes of Abacopteris penangiana

A novel anthocyanidin glycoside, abacopterin J (1), together with the known eruberin B (2) and eruberin C (3) was isolated from the fern Abacopteris penangiana (Hook.) Ching. The structure of the new compound 1 was elucidated on the basis of extensive spectroscopic analysis, including HSQC, HMBC, ¹H–¹H COSY and ROESY, and chemical evidence. Abacopterin J is the first example of an anthocyanidin glycoside isolated from natural sources, which is comprised of a flavan and an anthocyanidin moiety.     

Artoindonesianin L, a new prenylated flavone with cytotoxic activity from Artocarpus rotunda

A new prenylated flavone, named artoindonesianin L (1), was isolated from Artocarpus rotunda (Hout) Panzer (Moraceae). Its structure was elucidated as on the basis of spectroscopic evidence. Along with this new compound, four known phenolic compounds were also isolated from this plant and identified as artonins M (2) and E (3), cycloartobiloxanthone (4) and artonin O (5). All these compounds showed significant cytotoxicity against murine P388 leukemia cells.     

银杏组培繁殖及黄酮糖苷的产生

以银杏(Ginkgo biloba)腋芽为外植体进行组织培养，筛选出了适宜银杏芽萌发、增殖和生根的培养基配方和培养条件，其根芽诱导率都在89％以上，增殖倍数达8．1。通过银杏愈伤组织的诱导，建立了悬浮细胞培养系，在液体继代培养基中添加5mll^—1蜂蜜可明显促进细胞分裂、生长及黄酮糖苷的累积，提高细胞产量1倍以上。经过10次液体继代培养，悬浮细胞中黄酮糖苷含量达到成熟叶片含量的92．4％。     

A novel acylated flavonol glycoside from Morina nepalensis var. alba

A novel acylated flavonol glycoside, quercetin 3-O-[2' "-O-(E)-caffeoyl]-alpha-L-arabinopyranosyl-(1-->6)-beta-D-galactopyranoside (1), was isolated from whole plant of Morina nepalensis var. alba. Its structure was determined on the basis of chemical and spectroscopic methods.     

A novel cyclopropyl-containing fatty acid glucoside from the seeds of Litchi chinensis

3,12-Dihydroxy-cis-3,4-methylenedodecanoic acid 3-O-β-d-glucopyranoside, trivially named litchioside C (1), the first cyclopropyl-containing fatty acid glycoside, was isolated along with three previously uncharacterized galactosylacylglycerols from the seeds of Litchi chinensis. Its structure was established on the basis of spectroscopic analysis including HRESIMS and 2D NMR spectra. Its antioxidant and antibacterial activities were evaluated and its biogenetic pathway was discussed.     

A new isoflavanone from the stem bark of Erythrina latissima

Two isoflavonoids--including the new compound 5,7-dihydroxy-2',4',5'-trimethoxyisoflavanone (1)--six flavanones and a feruloyl ester were isolated from the stem bark of Erythrina latissima.     

3-Prenyl luteolin,a new prenylated flavone with melanin biosynthesis inhibitory activity from wood of Artocarpus heterophyllus

In our efforts to find new whitening agent from natural resources, we focused on wood of Artocarpus heterophyllus which shows anti-melanogenesis activity. By activity-guided fractionation of A. heterophyllus wood extract, a new prenylated flavonoid, 3-prenyl luteolin (1) was isolated. The IC₅₀ of mushroom tyrosinase inhibitotry activity of 1 was 76.3 µM. The results of the comparison with that of luteolin showed the prenyl substituent at C-3 position of 1 play an important role for revealing tyrosinase inhibition. In melanin formation inhibition on B16 melanoma cells, IC₅₀ of 1 was 56.7 µM with less cytotoxicity.     

A new prenylated arylnaphthalene lignan from Haplophyllum myrtifolium

A novel prenylated arylnaphthalene lignan, 7-O-(3-methyl-2-butenyl)isodaurinol, was isolated from Haplophyllum myrtifolium and identified on the basis of detailed spectral analyses, including 2D-NMR spectrometry. The known furoquinoline alkaloids, dictamnine, robustine, gamma-fagarine and skimmianine, the aryltetralin lignan (-)-1beta-polygamain and the flavone chrysosplenetin were isolated from the same source.     

A new prenylated flavanone from the roots of Sophora flavescens.

A new prenylated flavanone was isolated from the roots of Sophora flavescens. The structure of the new compound was elucidated as (2S)-7,4'-dihydroxy-5-methoxy-8-(gamma,gamma-dimethylallyl)-flavanone (1) on the basis of chemical and spectral evidence.     

Aqueous extract of Sri Lankan Erythrina indica leaves has sedative but not analgesic activity

In contrast to what was reported for the Indian plant, the aqueous leaf extract of Sri Lankan Erythrina indica showed potent sedative activity but no analgesic effects, as claimed by Sri Lankan Ayurvedic physicians.