共查询到20条相似文献,搜索用时 109 毫秒
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1只12岁雄性松狮犬,因精神沉郁,颈背部有一个直径约4 cm的隆起,食欲不振,偶有咳嗽而就诊。该犬X射线检查结果无明显异常。颈背部皮下穿刺物镜检可见大量红细胞及少量增多的中性粒细胞。血细胞计数检查及血清生化指标检查结果显示,红细胞数、血红蛋白含量、血细胞比容及血小板总数均低于参考值。皮下异常增生组织呈暗紫红色,质地较硬,外有包囊包裹。异常增生组织H.E.染色镜检可见大量血管腔和血管裂隙,向中心分化程度逐渐降低,瘤细胞大量聚集,细胞核大且呈棕黄色。细胞呈梭形、多边形或卵圆形不等。免疫组织化学检测结果显示标志物Ki-67阳性染色率约为30%。综合相关检查结果,患犬确诊为皮肤血管肉瘤。说明犬皮肤血管瘤临床诊断手段主要有血清生化检测、胸腹腔影像学检查、非脏器型积液穿刺检查和组织病理学检查、免疫组织化学检查等,其中免疫组织化学检查准确、可靠,对患犬的确诊及后续治疗方案的选择至关重要。 相似文献
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犬阴茎肿瘤通常是纤维肉瘤,而且是平滑肌和纤维组织增生的混合物。1 病因1.1 滥用药物:许多养犬者为了尽快让犬配上种,往往大剂量使用睾酮类激素药物。1.2 环境不洁:环境不干净,犬自然感染而引起。1.3 不洁交配:犬生殖系统疾病,通过交配而传播。2 诊断2.1 病史调查:大多为配不上种而大剂量注射药物所致。2.2 临床检查:发现会阴部隆起,触诊坚硬,反应敏感,少数有血水自阴茎流出,气味恶臭难闻。滥用药物者,被毛多处脱落,形成皮炎,为充血性小丘疹,圆形、指尖大,上皮结痂,痂皮呈红色。当阴茎伸出包皮外时,一般可在阴茎… 相似文献
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介绍了一例苏格兰牧羊犬脾脏破裂临床检查、诊断及治疗,提出在术后的护理时,除去常规护理外,应该认识到由于脾脏摘除可能导致出现贫血症状,因此,在术后要及时补充营养。 相似文献
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Fabien Collard DVM Marie‐Eve Nadeau Diplomate ACVIM éric‐Norman Carmel DVM 《Veterinary surgery : VS》2010,39(7):870-872
Objective: To report laparoscopic splenectomy in a dog. Study Design: Clinical report. Animals: Mixed breed dog (n=1). Methods: Hemangiosarcoma was diagnosed by ultrasound‐guided fine‐needle aspiration of a splenic mass in an 11‐year‐old, 30 kg, mixed breed dog. No metastatic disease was identified during complete staging (chest radiographs, echocardiogram, and abdominal ultrasonography); however, cystic calculi were identified. Laparoscopic splenectomy using Ligasure V was performed through 3 portals and the calculi were removed by laparoscopic‐assisted cystoscopy. Results: Total surgical time was 2 hours and for laparoscopic splenectomy, 65 minutes. The celiotomy incision for splenic removal was 7 cm. The dog recovered uneventfully and was ambulatory 2 hours postoperatively. Conclusion: Laparoscopy with Ligasure V facilitated successful removal of a spleen with a 3 cm mass. Clinical Relevance: Laparoscopic splenectomy in dogs is feasible for removal of a normal‐sized spleen with a moderate‐sized mass. 相似文献
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A male golden retriever of unknown age presented with multiple cutaneous and subcutaneous masses from the left elbow to the digits. Histopathologically, multiple tumor foci had formed from the dermis to the subcutaneous tissue. Tumor foci consisted of a vascular structure, alveolar structure and solid proliferative area. The borders among these areas were not clear. Some neoplastic cells resembled a mature endothelium, while others were large pleomorphic cells. Immunohistochemically, the tumor cells were usually strongly positive for CD31 and often positive for PROX-1, the lymphatic endothelial cell marker. Based on these findings, the tumor was diagnosed as a hemangiosarcoma with lymphatic differentiation. 相似文献
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Shoko Fukuda Tetsuya Kobayashi Ian D. Robertson Fukiko Oshima Eri Fukazawa Yuko Nakano Shin Ono Donald E. Thrall 《Veterinary radiology & ultrasound》2014,55(4):374-379
The purpose of this retrospective study was to describe pre‐ and postcontrast computed tomographic (CT) characteristics of confirmed nonparenchymal hemangiosarcoma in a group of dogs. Medical records were searched during the period of July 2003 and October 2011 and dogs with histologically confirmed nonparenchymal hemangiosarcoma and pre‐ and postcontrast CT images were recruited. Two observers recorded a consensus opinion for the following CT characteristics for each dog: largest transverse tumor diameter, number of masses, general tumor shape, character of the tumor margin, precontrast appearance, presence of dystrophic calcification, presence of postcontrast enhancement, pattern of postcontrast enhancement, presence of regional lymphadenopathy, and presence of associated cavitary fluid. A total of 17 dogs met inclusion criteria. Tumors were located in the nasal cavity, muscle, mandible, mesentery, subcutaneous tissue, and retroperitoneal space. Computed tomographic features of nonparenchymal hemangiosarcoma were similar to those of other soft tissue sarcomas, with most tumors being heterogeneous in precontrast images, invasive into adjacent tissue, and heterogeneously contrast enhancing. One unexpected finding was the presence of intense foci of contrast enhancement in 13 of the 17 tumors (76%). This appearance, which is not typical of other soft tissue sarcomas, was consistent with contrast medium residing in vascular channels. Findings indicated that there were no unique distinguishing CT characteristics for nonparenchymal hemangiosarcoma in dogs; however, the presence of highly attenuating foci of contrast enhancement may warrant further investigation in prospective diagnostic sensitivity and treatment outcome studies. 相似文献
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Katsuhisa Shiraki Mihoko Ono Satoru Kajikawa Ayano Takeuchi Yuichi Murakami Yuji Oishi Masahiro Matsumoto 《Journal of toxicologic pathology》2012,25(4):273-276
The present report describes a rare case of spontaneous hemangiosarcoma in a nine-week-old
male Sprague-Dawley rat. At necropsy, multiple white nodules of various sizes were observed on
and within the enlarged spleen and liver and were histopathologically determined to be composed
of spindle- to oval-shaped cells that showed invasive growth without encapsulation and were
arranged solidly but partially in whorls or faint alveolar patterns with vascular-like spaces
containing small clefts or erythrocytes in the tumor mass. Immunohistochemical analysis
revealed that most of the tumor cells were strongly positive for vimentin, von Willebrand
factor (vWF) and CD34 but negative for podoplanin. In addition, electron microscopic
examination revealed the presence of Weibel-Palade bodies in the cytoplasm of the tumor cells.
Based on these findings, this case was diagnosed as a hemangiosarcoma. The splenic masses were
larger than the hepatic ones, with tumor cells mainly observed at periportal regions with tumor
embolism in the liver, suggesting that primary hemangiosarcoma initially developed in the
spleen before metastasizing. 相似文献
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K.M. Rassnick D.B. Bailey A.B. Flory C.E. Balkman M.A. Kiselow J.L. Intile K. Autio 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2008,22(6):1390-1396
Background: The optimal dosage and clinical efficacy of vinblastine (VBL) for treatment of mast cell tumors (MCTs) in dogs has not been established. Hypothesis: Single‐agent VBL has antitumor activity against MCTs in dogs. Animals: Fifty‐one dogs with nonresectable grade II or III cutaneous MCTs. Methods: Prospective, open clinical trial. Dogs were systematically allocated (by hospital record number) to receive IV treatment with VBL at a dosage of 2.0 mg/m2 (weekly for 4 treatments then biweekly for 4 treatments; VBL 2.0) or treatment with VBL at a dosage of 3.5 mg/m2 (biweekly for 5 treatments; VBL 3.5). The primary outcome measure was reduction in tumor size. Results: Twenty‐five dogs were allocated to the VBL 2.0 group and 26 were allocated to the VBL 3.5 group. In the VBL 2.0 group, 3 (12%) had a partial response (PR) for a median of 77 days (range, 48–229 days). Overall response rate in the VBL 3.5 group was 27%. One dog (4%) had a complete response for 63 days and 6 dogs (23%) had a PR for a median of 28 days (range, 28–78 days). Toxicoses were uncommon in the VBL 2.0 group. Twelve (46%) dogs in the VBL 3.5 group had <500 neutrophils/μL 7 days after treatment; 2 dogs with neutropenia developed concurrent fevers. Conclusions and Clinical Importance: VBL, when used as a single‐agent, has activity against MCTs in dogs although the response rate is lower than those reported for VBL‐containing combination protocols. Further, findings suggest VBL at a dosage of 3.5 mg/m2 should be considered for use in future phase II/III trials. 相似文献
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