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目的:观察由不同降压机制组成的小剂量四联复方降压制剂的临床疗效和不良反应,并与常规剂量二联复方降压制剂比较。方法:1~3级原发性高血压病人314例随机分组:Ⅰ组(n=102)服用硝苯地平(10mg)+阿替洛尔(25mg)组成的复方缓释制剂(1号),1片/次,2次/d;Ⅱ组(n=108)服用卡托普利(25mg)+氢氯噻嗪(12.5mg)组成的复方缓释制剂(2号),1片/次,2次/d;Ⅲ组(n=104)服用硝苯地平(5mg)+卡托普利(12.5mg)+阿替洛尔(12.5mg)+氢氯噻嗪(6.25mg)组成的四联复方缓释制剂(3号),1片/次,2次/d。观察治疗前与治疗8周后各组降压达标率、总有效率、偶测血压、24h动态血压及不良反应。结果:Ⅲ组达标率高于Ⅰ组和Ⅱ组(81.55%、64.29%、58.95%,P〈O.01)。Ⅲ组总有效率高于Ⅰ组和Ⅱ组(89.32%、74.47%、73.68%,P〈0.01)。治疗8周后,Ⅲ组偶测血压低于Ⅰ组和Ⅱ组(P〈0.01)。治疗8周后动态血压监测结果,Ⅲ组24h收缩压比Ⅰ组和Ⅱ组低(PdO.05),24h舒张压低于Ⅰ组(P〈0.01)和Ⅱ组(P〈0.05)。Ⅲ组头昏、头痛、面红、踝部水肿症状的发生率比Ⅰ组少(P〈0.05),干咳症状比Ⅱ组少(P〈0.01)。而Ⅲ组肝功能、肾功能、电解质、血脂、空腹血糖、血尿酸、血常规与Ⅰ组和Ⅱ组在治疗前后分别比较无统计学意义。结论:小剂量四联复方制剂在临床应用中疗效优于常规剂量二联复方制剂,且不良反应较少。 相似文献
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30日龄三黄鸡食欲不振,羽毛松乱,水样下痢,一肢脚踝关节肿大,从出现症状到死亡前后5天左右,用青霉素、链霉素、痢特灵治疗无效,部检发现全身皮下出血,肝脏、肾、胆囊肿大,镜检、细菌分离培养确诊为鸡副伤寒病,药敏试验,证实用环丙沙星、氯霉素肌注,可控制疫情。 相似文献
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牛结节性皮肤病,是由牛结节性皮肤病病毒引起的急性、亚急性传染病,虽然死亡率不高,但容易对牛机体造成永久性损伤和严重的后遗症,严重影响牛的育肥效果、泌乳量等。总结牛结节性皮肤病的流行病学特点,临床症状、剖检变化、诊断方法、治疗方法及预防措施,以期为该病的防控提供参考。 相似文献
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猪蓝耳病又称猪繁殖与呼吸综合征,是由猪繁殖与呼吸综合征病毒引起的,以繁殖障碍、呼吸困难、耳朵蓝紫、并发其他传染病为主要特征。目前,尚无特效治疗药物,因此,做好该病的诊断及预防十分必要。 相似文献
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An automatic procedure providing information about human systolic blood pressure at each successive heartbeat under routine laboratory conditions is described. Twenty normal male subjects were given feedback of their own systolic pressure, half operantly reinforced for increasing and half reinforced for decreasing their pressure. Significant differences in pressure were obtained in a single session. The apparatus and results suggest a possible approach to the treatment of essential hypertension. 相似文献
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Iwasa Y Arima T Fleming RM Siegrist T Zhou O Haddon RC Rothberg LJ Lyons KB Carter HL Hebard AF Tycko R Dabbagh G Krajewski JJ Thomas GA Yagi T 《Science (New York, N.Y.)》1994,264(5165):1570-1572
The fullerene C(60) can be converted into two different structures by high pressure and temperature. They are metastable and revert to pristine C(60) on reheating to 300 degrees C at ambient pressure. For synthesis temperatures between 300 degrees and 400 degrees C and pressures of 5 gigapascals, a nominal face-centered-cubic structure is produced with a lattice parameter a(o) = 13.6 angstroms. When treated at 500 degrees to 800 degrees C at the same pressure, C(60) transforms into a rhombohedral structure with hexagonal lattice parameters of a(o) = 9.22 angstroms and c(o) = 24.6 angstroms. The intermolecular distance is small enough that a chemical bond can form, in accord with the reduced solubility of the pressure-induced phases. Infrared, Raman, and nuclear magnetic resonance studies show a drastic reduction of icosahedral symmetry, as might occur if the C(60) molecules are linked. 相似文献
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Intelligence and blood pressure in the aged 总被引:4,自引:0,他引:4
Diastolic hypertension was related to significant intellectual loss over a 10-year period among individuals initially examined in their 60's. Such loss was not found in their age peers in association with normal or mild elevations of blood pressure. Of the subjects initially examined at 70 to 79 years of age, none with hypertension completed the follow-up program, and those with normal and mildly elevated blood pressure showed some intellectual decline over the decade. At the initial examination, hypertension was related to lower intelligence test scores only among those subjects who subsequently did not complete the follow-up program. The results suggest that hypertension is related to intellectual changes among the aged. 相似文献
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Melting of diamond at high pressure and the properties of liquid carbon at pressures greater than 1 megabar were investigated with a first-principles molecular dynamics technique. The results indicate an increase of the diamond melting temperature with pressure, which is opposite to the behavior of silicon and germanium. This is contrary to long-held assumptions, but agrees with recent experiments, and has important implications for geology and astrophysics. As is the case for the solid phase of carbon at low temperature, which changes greatly with pressure from graphite to diamond, the structural and bonding properties of liquid carbon vary strongly with pressure. 相似文献
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超高压技术在水果加工中的应用 总被引:2,自引:0,他引:2
超高压技术是一种新兴的食品加工技术.应用超高压技术能使水果中酶的活性降低、杀灭微生物、保留水果的风味和营养成分等.该文综述了超高压加工的基本原理及特点、超高压技术在水果加工中的应用以及超高压技术在水果加工中的应用前景. 相似文献