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Ovine scrapie was first recorded in Cyprus in 1985. Subsequently four dairy goats kept in two mixed flocks with affected sheep developed characteristic clinical signs similar to those seen in sheep. Fifteen goats from the two flocks were examined histologically and neurological lesions consistent with a diagnosis of scrapie were found in the four animals and in three others which had subsequently developed early neurological signs. These lesions were similar to those of naturally-affected sheep although neuronal degeneration and vacuolation were more severe in some cases. 相似文献
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P Toumazos 《The British veterinary journal》1991,147(2):147-154
Scrapie was first recorded in Cyprus in 1985 in two flocks of sheep and subsequently the disease was diagnosed in dairy goats kept in mixed flocks with affected sheep. By 1989 scrapie had been diagnosed in 23 flocks. Epidemiological data presented in the present study are essentially from clinicopathological investigations between 1985 and 1989. A total of 356 out of 957 sheep and 10 out of 30 goats examined from flocks in Nicosia, Larnaca and Limassol districts showed histopathological lesions consistent with a diagnosis of scrapie. 相似文献
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Scrapie in the welsh mountain breed of sheep and its experimental transmission to goats 总被引:1,自引:0,他引:1
I H Pattison 《The Veterinary record》1965,77(47):1388-1390
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Ellis B 《The Veterinary record》2004,154(26):830-831
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Penelope Papasavva-Stylianou Otto Windl Ginny Saunders Petroula Mavrikiou Pavlos Toumazos Charalambos Kakoyiannis 《Veterinary journal (London, England : 1997)》2011,187(2):245-250
In contrast to scrapie in sheep, the genetic basis of susceptibility to scrapie in goats is not well understood. To study the association of prion protein (PrP) alleles with susceptibility to scrapie in goats in Cyprus, the coding sequence of the caprine PrP gene was determined in 717 goats, including 218 scrapie positive animals. Several novel polymorphisms were detected, such as a novel octarepeat variant and a stop codon mutation. Amino acids at codons 146 and 154 were associated with susceptibility to goat scrapie. Animals heterozygous for serine (S) and aspartate (D) at codon 146 were significantly under-represented in scrapie positive animals and no positive animals were found that were homozygous for these amino acids at codon 146. These results might provide the basis for genetic control of scrapie in Cypriot goats. 相似文献
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