| DNA甲基化及其生物学功能 |
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| 引用本文： | 沈秀平,林月霞,徐琪. DNA甲基化及其生物学功能[J]. 中国畜牧兽医, 2012, 39(6): 83-86 |
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| 作者姓名： | 沈秀平 林月霞 徐琪 |
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| 作者单位： | 1. 上海交通大学农业与生物学院,上海 200240;2. 上海市农业科技服务中心,上海 200335;3. 上海市农业科学院,上海 201106;4. 江苏省动物遗传繁育与分子设计重点实验室,江苏扬州 225009 |
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| 摘 要： | DNA甲基化是一种主要的表观遗传修饰,是调节基因表达的重要手段。作者在介绍了DNA甲基化机制、DNA甲基化的模式、DNA甲基化特点的基础上,重点论述了DNA甲基化发育分化、X染色体失活、基因组印记和杂种优势等方面的作用。
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| 关 键 词： | DNA甲基化 甲基转移酶 基因组印记 杂种优势 |
| 收稿时间： | 2011-07-13 |
DNA Methylation and its Biological Functions |
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| SHEN Xiu-ping , LIN Yue-xia , XU Qi. DNA Methylation and its Biological Functions[J]. China Animal Husbandry & Veterinary Medicine, 2012, 39(6): 83-86 |
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| Authors: | SHEN Xiu-ping LIN Yue-xia XU Qi |
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| Affiliation: | 1. Shanghai Jiao Tong University School of Agriculture Biology, Shanghai 200240,China;2. Shanghai Agricultural Science and Technology Service Center,Shanghai 200335,China;3. Shanghai Academy of Agricultural Sciences,Shanghai 201106,China;4. Key Laboratory for Animal Genetics, Breeding, Reproduction and Molecular Design of Jiangsu Province,Yangzhou 225009,China |
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| Abstract: | DNA methylation is a major epigenetic modification of genome and plays crucial role in regulation of gene expression.The mechanism,mode and characteristic of DNA methylation were introduced.And the role of DNA methylation in development and differentiation,X chromosome inactivation,gemomic imprinting and heterosis were discussed. |
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| Keywords: | DNA methylation methyltransferase genomic imprinting heterosis |
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